World Health Organization (WHO) state that breast cancel is second cause of death among ether cancer illness. Up to wow, what become a a major factor that caused the breast cancer has known yet, but it mas believed that the relation of some factors can improve the risk of breast cancer. Breast cancer is believed happened because of a complicated interaction between many factors like genetic, environment and hormonal, which one of them is abundant estrogen hormone rate in women's body. This research is aim to knoe the risk level that caused by She use of combination contraception pills, which is combination of estrogen and progesterone with the breast cancer risk. The research use case control method in hospital based with period of September-Desember 2004 at Perjan RS Dr. Cipto Mangunkusumo.Hie research results show Shut the user of combination contraception pill has the risk to have breast cancer 1,864 tunes bigger compare with them who doesn't take that pills. However, the combination contraception pills is not the major risk factor but it's only a light factor to increase the risk of breast cancer.