Penerapan keselamatan pasien yang baik dan bertanggung jawab diharapkan dapat membawa perasaan yang aman dan nyaman terhadap pasien sebagai pengguna jasa layanan kesehatan. Tujuan penelitian ini adalah untuk mengetahui hubungan gaya kepemimpinan kepala ruangan menurut persepsi perawat dengan efikasi diri perawat pelaksana dalam pelaksanaan patient safety di ruang rawat inap. Metode penelitian menggunakan pendekatan analitik kuantitatif dengan desain cross-sectional. Sampel dalam penelitian ini berjumlah 96 perawat pelaksana di instalasi rawat inap. Instrumen yang digunakan berupa kuesioner Multifactor Leadership Questioner dan General Self Efficacy Scale. Proses pengumpulan data menggunakan paper-based dan google form digunakan untuk menjangkau tingkat partisipasi responden yang belum mengisi kuesioner paper-based. Hasil penelitian menunjukkan terdapat hubungan gaya kepemimpinan kepala ruangan menurut persepsi perawat dengan efikasi diri perawat pelaksana dalam pelaksanaan patient safety di ruang rawat inap dengan p value 0,007. Pada penelitian ini, gaya kepemimpinan yang dipersepsikan perawat pelaksana terhadap gaya kepemimpinan kepala ruangan, yaitu gaya kepemimpinan transformasional sebesar 88,5%. Kemudian, gambaran dari efikasi diri perawat pelaksana dalam penelitian ini secara statistik sudah cukup baik, yaitu sebesar 47,9%. Rekomendasi berdasarkan hasil penelitian ini, yaitu kepala ruangan diharapkan dapat meluangkan waktu dalam melatih dan mengedukasi perawat pelaksana, serta diharapkan kepala ruangan memiliki kemampuan yang baik dalam mitigasi masalah sebelum masalah tersebut membesar dan kepala ruangan dapat terlibat dalam pemecahan masalah, bukan malah menghindar.

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The application of good and responsible patient safety is expected to bring a feeling of security and comfort to patients as users of health services. The purpose of this study was to determine the relationship between the leadership style of the head of the room according to the perception of nurses and the self-efficacy of the implementing nurses in implementing patient safety in the inpatient room. The research method uses a quantitative analytic approach with a cross-sectional design. The sample in this study was 96 nurses in the inpatient installation. The instruments used were the Multifactor Leadership Questionnaire and the General Self Efficacy Scale. The data collection process uses paper-based and Google forms are used to reach the level of participation of respondents who have not filled out paper-based questionnaires. The results showed that there was a relationship between the leadership style of the head of the room according to the nurse's perception and the self-efficacy of the implementing nurse in implementing patient safety in the inpatient room with a p value of 0.007. In this study, the leadership style perceived by the implementing nurse towards the leadership style of the head of the room, namely the transformational leadership style, was 88.5%. Then, the description of the self-efficacy of the implementing nurses in this study was statistically good enough, namely 47.9%. Recommendations based on the results of this study, namely that the head of the room is expected to be able to spend time in training and educating the implementing nurse, and it is hoped that the head of the room has good ability in mitigating problems before the problem grows and the head of the room can be involved in problem solving, not even avoiding it.