Defisit perawatan diri adalah salah satu gejala negatif dari skizoprenia, merupakan ketidakmampuan melakukan perawatan diri. Tujuan penulisan karya ilmiah akhir ini adalah memberikan gambaran penerapan terapi generalis, terapi aktivitas kelompok, terapi perilaku dan psikoedukasi keluarga terhadap tanda dan gejala serta kemampuan klien defisit perawatan diri. Metode yang digunakan adalah deskriptif analitik melalui pendekatan model stres adaptasi Stuart dan model adaptasi Roy di Rumah Sakit Jiwa. Penerapan terapi generalis dan terapi aktivitas kelompok pada 40 klien, dengan hasil 16 klien mengalami penurunan tanda dan gejala serta peningkatan kemampuan perawatan diri. Penerapan terapi perilaku dan psikoedukasi keluarga merupakan terapi lanjutan hanya terhadap 24 klien, hasilnya 23 klien mengalami penurunan tanda dan gejala serta peningkatan kemampuan klien dan keluarga dalam perawatan diri klien. Direkomendasikan kombinasi terapi perilaku dan psikoedukasi keluarga dengan pendekatan model stres adaptasi Stuart dan model adaptasi Roy menjadi standar terapi spesialis keperawatan jiwa untuk klien defisit perawatan diri.

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Self-care deficit is one of the negative symptoms of schizophrenia, an inability to perform self-care. The purpose of writing this final scientific work is to provide a description of the application of generalist therapy, group activity therapy, behavior therapy and family psychoeducation for signs and symptoms as well as the client's ability to self-care deficit. The method used is descriptive analytic approach stress adaptation model of Stuart and Roy adaptation model at the Mental Hospital. Application of generalist therapy and groups therapeutic activity at 40 client, with the results of 16 clients decreased signs and symptoms as well as improving self-care ability. The application of behavior therapy and family psychoeducation is an advanced therapy only for 24 clients, the result is 23 clients decreased signs and symptoms as well as improving the ability of clients and families in self-care clients. Recommended combination of behavior therapy and family psychoeducation with stress adaptation model approach Stuart and Roy adaptation model become standard therapy for the soul of nursing specialist client self-care deficit.