This volume of the Computer-Aided Chemical Engineering series puts together a selection of the contributions presented at the 32th European Symposium on Computer Aided Process Engineering (ESCAPE), held in Toulouse, France, from June 12th to 15th, 2022 ... The main focus for ESCAPE-32 is on the methodical approaches in process systems engineering with emphasis on uncertainty towards sustainability. The themes of ESCAPE-29 have been selected after a comprehensive discussion with the CAPE Working Party members and the scientific community. The particular topics within these overarching themes have been formulated to allow researchers from CAPE-related sciences to present their results and exchange valuable knowledge and experience