Penggunaan obat rasional (POR) merupakan penggunaan obat yang sesuai dengan kriteria, seperti tepat obat, tepat diagnosis, tepat indikasi, tepat cara pemakaian, tepat waktu pemberian, tepat kondisi pasien, tepat lama pemberian, dan waspada efek samping. Pada penelitian ini dilakukan tinjauan terhadap penggunaan obat dengan mengkaji rekam medik dan dilihat persentase peresepan antibiotik pada penyakit ISPA non-pneumonia dan diare non selektif sebagai bentuk penerapan evaluasi penggunaan obat rasional di Puskesmas Kecamatan Kramat Jati. Penelitian dilakukan dengan mengkaji secara retrospektif berdasarkan rekam medik kasus ISPA non-pneumonia dan diare non spesifik bulan Januari- Maret 2023. Data pasien diambil dari register harian e-puskesmas dengan dipilih 25 sampel kasus per diagnosis terpilih setiap bulan. Kesimpulan dari penelitian ini adalah rata-rata penggunaan antibiotik pada kasus ISPA non pneumonia dan diare non spesifik sudah sesuai dengan standar Kemenkes dengan nilai 9,3%  dan 7%. Penerapan penggunaan obat rasional pada kasus ISPA non pneumonia dan diare non spesifik di Puskesmas Kramat Jati telah berjalan dengan baik.

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The use of rational drugs (POR) is the use of drugs that are in accordance with the criteria, such as the right drug, the right diagnosis, the right indication, the right way of use, the right time of administration, the right patient's condition, the right time of administration, and the right side effects. In this study, a review of drug use was carried out by reviewing medical records and looking at the percentage of antibiotic prescribing in non-pneumonia and non-selective diarrhea as a form of implementation of rational drug use evaluation at the Kramat Jati District Health Center. The study was conducted retrospectively based on medical records of non-specific cases of ISPA and non-specific diarrhea from January to March 2023. Patient data is taken from the daily register of the e-puskesmas with 25 sample cases selected per selected diagnosis every month. The conclusion of this study is that the average use of antibiotics in cases of non-pneumonia and non-specific diarrhea is in accordance with the Ministry of Health's standards with values of 9.3% and 7%. The application of rational drug use in cases of non-pneumonia and non-specific diarrhea at the Kramat Jati Health Center has gone well.