Mahasiswa profesi ners sebagai calon perawat profesional diharapkan dapat memberikan asuhan yang komprehensif, termasuk pada anak down syndrome. Penelitian ini dilakukan untuk mengidentifikasi pengetahuan mahasiswa profesi ners tentang down syndrome dan faktor-faktor yang mempengaruhinya. Penelitian ini termasuk deskriptif analitik dengan desain cross-sectional, dimana melibatkan 197 mahasiswa profesi ners di Jabodetabek yang direkrut online. Alat ukur penelitian menggunakan prenatal screening test for down syndrome yang telah di modifikasi. Data dianalisis dengan uji chi-square. Hasil penelitian, 112 responden (56,85%) berpengetahuan baik dan 85 responden (43,15%) berpengetahuan kurang. Hasil bivariat, tidak ada hubungan antara pengetahuan dengan usia (p-value = 0,464), pelatihan (p-value = 0,304), dan pengalaman kontak (p-value = 0,888). Faktor-faktor yang diteliti terbukti tidak mempengaruhi pengetahuan mahasiswa. Oleh karenanya, terdapat asumsi bahwa ada faktor-faktor lain yang mempengaruhi pengetahuan mahasiswa tentang down syndrome.

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Nursing student during professional stage as prospective professional nurses are expected to provide comprehensive nursing care, including for children with Down syndrome. This study was conducted to determine the knowledge of nursing profession students about Down syndrome and the factors that influence it. This study is a descriptive-analytic study with a cross-sectional design, involving 197 nursing professional students throughout Greater Jakarta who were recruited online. The size of this study used a modified prenatal screening test for Down's syndrome. Data were analyzed by chi-square test. The results showed that 112 respondents (56.85%) had good knowledge and 85 respondents (43.15%) had poor knowledge. In bivariate results, there is no relationship between knowledge and age (p-value = 0.464), training (p-value = 0.304), and contact experience (p-value = 0.888). The factors studied were proven not to affect students' knowledge. Therefore, there is an assumption that other factors affect students' knowledge about Down Syndrome.