Nyeri merupakan salah satu alasan utama bagi kebanyakan individu untuk mencari bantuan medis, terutama saat berusia produktif. Dampak terburuk nyeri kronis ada pada Health-Related Quality of Life (HRQoL) individu. Faktor yang memperngaruhi HRQoL diantaranya koping religius positif, resiliensi, dan pain interference. 437 individu dengan nyeri kronis berpartisipasi dalam penelitian ini dan mengisi alat ukur Religious Coping Scale (RCOPE), Brief Resilience Scale (BRS), Pain Interference – Short Form (PI-SF), dan Health-related Quality of Life Short Form 12 version 2 (HRQoL SF-12v2). Hasil analisis statistik serial multiple mediator model menunjukkan bahwa resiliensi dan pain interference menjadi partial mediator (c = 0.34 > c' = 0.23). Pengaruh koping religius positif terhadap HRQoL dapat terjadi langsung maupun melalui perantara mediator berupa resiliensi dan pain interference secara berturut-turut (a1d21b2 = 0.02, 95% CI [0.004, 0.05]). Individu yang menjalin kedekatan dengan Tuhan dan komunitas spiritualnya akan terbantu untuk bangkit dan berfungsi kembali, sehingga hambatan akibat nyeri kronisnya terminimalisir. Meskipun nyeri kronis masih ada, namun individu akan mempersepsikan bahwa kesehatannya meningkat karena ia dapat kembali beraktivitas fisik dan sosial. Penggunaan koping religius positif dan pengembangan resiliensi bermanfaat untuk praktik psikologis dalam menangani individu dengan nyeri kronis.

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Pain became leading caused for most people seeking medical care, especially during their productive age. Health related quality of life (HRQoL) is the most negatively affected by chronic pain. Apparently religious copying, resilience, and pain interference influence HRQoL. However, how their influence is unclear. This study examine how those factors effecting HRQoL of individuals with chronic pain using Health-related Quality of Life Short Form 12 version 2 (HRQoL SF-12v2), Religious Coping Scale (RCOPE), Brief Resilience Scale (BRS), and Pain Interference – Short Form (PI-SF). There were 437 participants (Indonesian ≥18 years) whose data was collected online and offline. Statistical analysis using serial multiple mediator model found that resilience and pain interference are partial mediator (c = 0.34 > c' = 0.23). The relationship between religious copying and HRQoL can be directed and went through resilience and pain interference consecutively as mediators (a1d21b2 = 0.02, 95% CI [0.004, 0.05]). Getting close with God and his spiritual community help individuals to rise and refunctioning, so chronic pain interference is minimized. Although chronic pain is still present, individuals will perceive that their health is improving because they can return to their physical and social activities. The use of positive religious coping and development resilience are beneficial for psychological practice in managing chronic pain.