Latar Belakang: Kematian pasien Penyakit Ginjal Kronik (PGK) pada usia dewasa yang menjalankan hemodialisis setelah tiga bulan adalah jarang. Namun, masih mungkin terjadi. Padahal layanan hemodialisis dibutuhkan seumur hidup.Tujuan: Mengetahui faktor – faktor risiko yang berhubungan dengan kematian pasien PGK usia dewasa yang menjalankan hemodialisis reguler.Metode: Kasus kontrol tanpa pencocokkan (matching) dengan perbandingan 1:2. Uji statistik yang digunakan adalah regresi logistik.Hasil: Faktor risiko yang berhubungan terhadap kematian adalah riwayat gagal jantung (OR = 2,3; IK 95% = 1,2 – 4,4; nilai p = 0,009), riwayat obstruksi pasca ginjal (OR = 3,5; IK 95% = 1,6 – 7,6; nilai p = 0,002), glukosa sewaktu ≥140 mg/dl (OR = 2,1; IK 95% = 1,2 – 3,6; nilai p = 0,011), Gangguan Ginjal Akut (GGA) (OR = 6,5; IK 95% = 3,8 – 11,1; nilai p = 0,000), dan Indeks Massa Tubuh (IMT) <18,5 kg/mm2 (OR = 3,0; IK 95% = 1,2 – 7,6; nilai p = 0,019).Kesimpulan: Faktor – faktor risiko yang berhubungan dengan kematian pasien PGK pada usia dewasa yang menjalankan hemodialisis reguler adalah riwayat gagal jantung, riwayat obstruksi pasca ginjal, glukosa sewaktu ≥140 mg/dl, GGA, dan IMT <18,5 kg/mm2

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Background: Mortality of Chronic Kidney Disease (CKD) patients in adults undergoing hemodialysis after three months is rare. However, it is still possible. Even though hemodialysis services are needed for life.

Objective: To determine the risk factors associated with the death of adult CKD patients undergoing regular hemodialysis.

Method: Unmatched control case with a ratio of 1:2. The statistical test used was logistic regression.

Results: Risk factors were history of heart failure (OR = 2.3; CI 95% = 1.2 – 4.4; p value = 0.009), history of obstruction post renal (OR = 3.5; CI 95% = 1.6 – 7.6; p value = 0.002), random glucose ≥140 mg/dl (OR = 2.1; CI 95% = 1.2 – 3.6; p value= 0.011), Acute Kidney Injury (AKI) (OR = 6.5; CI 95% = 3.8 – 11.1; p value = 0.000), and Body Mass Index <18.5 kg/mm2 (OR = 3.0; CI 95% = 1.2 – 7.6; p value = 0.019).

Conclusion: Risk factors associated with mortality in adult CKD patients undergoing regular hemodialysis are a history of heart failure, a history of post-renal obstruction, random glucose ≥140 mg/dl, AKI, and IMT <18.5 kg/mm2.