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"Virus Zika adalah penyakit neurologis yang penyebarannya disebabkan oleh nyamuk Aedes aegypti. Ciri khas dari penyakit neurologis dibandingkan penyakit yang lain adalah kerusakannya bersifat permanen. Virus Zika tidak memberikan gejala pada orang yang terinfeksi. Akan tetapi, virus ini dapat diturunkan kepada bayi sehingga menghasilkan potensi keturunan yang cacat secara fisik dan kognitif dengan cara meninhibisi pembelahan sel saraf pada bayi. Virus Zika merupakan suatu permasalahan global dimana belum ada obat yang telah paten untuk mengobati atau inhibisi kerja Virus Zika. Walaupun demikian, terdapat peptida yang disintesis dari sel epitel mamalia, yaitu human cathelicidin LL-37, dan telah terbukti untuk menunjukkan aktivitas inhibisi dari berbagai jenis virus termasuk Virus Zika. Di sini akan dilakukan penelitian secara In Silico untuk menjelaskan bagaimana human cathelicidin LL-37 berinteraksi dengan Virus Zika secara molekuler. Penelitian kali ini akan menggunakan satu protein struktural, yaitu envelope, dan satu protein nonstruktural, yaitu Non-struktural 1. Penelitian ini memiliki tiga tahap utama, yaitu melengkapi struktur menggunakan AVOGADRO dan MODELLER, penambatan molekuler menggunakan HDOCK, serta dinamika molekuler menggunakan GROMACS. Hasil dari dinamika molekuler ini adalah peptida LL-37 yang terbukti baik untuk menginhibisi protein pada Virus Zika, tetapi D-LL-37 lebih unggul karena membuat protein bergerak lebih banyak. Akan tetapi, pergerakan protein ini juga membuat struktur D-LL-37 menjadi lebih mudah hancur.

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The Zika Virus is a neurological disease that is spread by the Aedes aegypti mosquito. The distinctive feature of neurological diseases compared to other diseases is that the damage is permanent. The Zika virus does not cause symptoms in infected people. However, this virus can be passed on to babies, resulting in potential offspring who are physically and cognitively disabled by inhibiting nerve cell division in babies. The Zika virus is a global problem where there is no patented drug to treat or inhibit the action of the Zika virus. However, there is a peptide synthesized from mammalian epithelial cells, namely human cathelicidin LL-37, and has been proven to exhibit inhibitory activity against various types of viruses including the Zika Virus. Here, In Silico research will be carried out to explain how human cathelicidin LL-37 interacts with the Zika Virus molecularly. This study will use one structural protein, namely the envelope, and one non-structural protein, namely Non-structural 1. This research has three main stages, namely completing the structure using AVOGADRO and MODELLER, molecular docking using HDOCK, and molecular dynamics using GROMACS. The result of these molecular dynamics was the LL-37 peptide which proved to be good at inhibiting proteins in the Zika Virus, but D-LL-37 is superior because it makes the protein move more. However, this protein movement also makes the structure of D-LL-37 more easily destroyed."

"Stroke merupakan penyakit neurologi yang dapat menyebabkan berbagai kerusakan neurologis seperti paralisis, afasia, disfagia, gangguan sensorik. Suwita (2012), mengatakan bahwa 30-50% pasien stroke sering mengalami disfagia. Tingginya kejadian disfagia, membuat penderita stroke memiliki resiko tinggi dalam aspirasi dan terjadinya infeksi pernapasan. Sehingga perawatan mulut (Oral Hygiene) sangat diperlukan bagi pasien stroke. Studi kasus ini merupakan penerapan oral hygiene menggunakan Chlorhexidine 0,2 % dalam menjaga kebersihan mulut dan mencegah infeksi. Metode yang dilakukan dalam melakukan studi ini adalah dengan melakukan pengkajian tentang tingkat kebutuhan perwatan pasien. Kemudian dilakukan dengan pengkajian tingkat kebersihan mulut pasien dengan instrument AOG (oral assessment guide ), dan pasien dilakukan perawatan mulut menggunakan sikat gigi anak dan menggunakan Chlorhexidine 0,2%. Perawatan mulut dilakukan selama 3-5 menit dua kali dalam sehari dan dievaluasi setelah 6 hari. Evaluasi dilakukan menggunakan AOG (oral assessment guide). Setelah dilakukan perawatan mulut selama 6 hari didapatkan nilai AOG menurun yang menandakan terjadi perbaikan dalam tingkat kebersihan mulut

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Stroke is a neurological disease that can cause various neurological damage such as paralysis, aphasia, dysphagia, sensory disorders. Suwita (2012), said that 30-50% of stroke patients often experience dysphagia. The high incidence of dysphagia, making stroke patients have a high risk of aspiration and respiratory infections. So that oral care (Oral Hygiene) is very necessary for stroke patients. This case study is the application of oral hygiene using Chlorhexidine 0.2% in maintaining oral hygiene and preventing infection. The method used in conducting this study is to conduct an assessment of the level of patient needs. Then it was carried out by assessing the level of oral hygiene of the patients with the AOG instrument (oral assessment guide), and the patients having oral care using a childs toothbrush and using Chlorhexidine 0.2%. Oral care is carried out for 3-5 minutes twice a day and evaluated after 6 days. Evaluation is done using AOG (oral assessment guide). After 6 days of oral care, the AOG value was decreased which indicated improvement in the level of oral "

"Latar Belakang Neuroinflamasi adalah kaskade pada cedera otak traumatik (COT) yang memiliki waktu lebih panjang dibandingkan kaskade lain sehingga memberikan kesempatan intervensi untuk mencegah kerusakan lebih lanjut. Berbagai penelitian telah dilakukan untuk mengetahui patofisiologi neuroinflamasi COT, namun belum semua diketahui dengan jelas. Tujuan penelitian ini untuk mengungkapkan alur kaskade neuroinflamasi akibat COT dengan mempelajari ekspresi dan konsentrasi HIF-1α, IL-1β, dan IL-6 di otak tikus COT yang diberi intervensi propofol. Metode Studi eksperimental in vivo ini menggunakan 51 tikus Sprague Dawley (SD) dan dilakukan pada bulan Maret 2019 – Maret 2021 di Fakultas Kedokteran Universitas Indonesia (FKUI) dan Fakultas Kedokteran Hewan Institut Pertanian Bogor (FKH IPB). Tikus dibagi 5 kelompok perlakuan (kontrol negatif/KN, Sham/S, propofol/P, COT/C dan COT yang diberi propofol/CP). Kelompok KN tidak diberi perlakukan dan Kelompok S diberi plasebo (NaCl). Manipulasi COT menggunakan model Marmarou weight-drop. Pada Kelompok P dan CP, tikus diberi propofol secara kontinu. Fungsi neurologis dan gangguan biokimia diperiksa dengan revised neurobehavioral severity scale/NSS-R. Ekspresi serta konsentrasi HIF-1α, IL-1β, IL-6 diperiksa dengan qRT-PCR, ELISA, dan imunohistokimia. Hasil Pada observasi hingga 5 hari, penurunan NSS-R lebih cepat pada Kelompok CP dibandingkan kelompok C. Uji Kruskal-Wallis pada ekspresi IL-6 Subkelompok Observasi 24 Jam menunjukkan perbedaan bermakna dan dengan post hoc Mann-Whitney didapatkan perbedaan bermakna pada Kelompok S dengan CP (1,48±0,52 vs. 3,29±0,7; p=0,011), P dengan CP (1,83±0,55 vs. 3,29±0,7; p=0,001), dan C dengan CP (1,81±0,49 vs. 3,29±0,7; p<0,001). Pada uji statistik, HIF-1α dan IL-1β tidak berbeda bermakna antar kelompok. Terdapat korelasi positif antara ekspresi dan konsentrasi HIF-1α dengan IL-1β dan IL-6 terutama di jaringan otak tikus kelompok P, C, dan CP. Kesimpulan Propofol memperbaiki fungsi neurologis model tikus COT, meningkatkan ekspresi IL-6 namun tidak memengaruhi ekspresi serta konsentrasi HIF-1α dan IL-1β.

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Background Neuroinflammatory is the cascades in TBI that has a longer time than other cascades, thus providing an opportunity for intervention to prevent further damage. Various studies have been conducted to investigate the pathophysiology of TBI and the management, but none have been clarified. The purpose of this study was to investigate changes in neurological function, expression, and concentration of HIF-1α, IL-1β, and IL-6 in the brain tissue of TBI rats given propofol intervention. Methods This was an in vivo experimental study using 51 Sprague Dawley (SD) rats in March 2020 – March 2021 at the Faculty of Medicine, University of Indonesia and the Faculty of Veterinary, Bogor Agricultural University. Rats were divided into five groups (negative control/NC, Sham/S, propofol/P, TBI/T, and TBI given propofol/TP). TBI manipulation using the Marmarou weight-drop model. The KN group was not treated. Group S was given placebo treatment. In the P and TP groups, the rats were given propofol continuously. Neurological function and biochemical alterations of the experimental animal were examined using NSS-R; HIF-1α, IL-1β, and IL-6 expression and contents by means of qRT-PCR, ELISA, and immunohistochemistry. Result In the 5-day Observation Sub-group, the improvement in the NSS-R value in the TP group occurred faster than in the T group. The results of Kruskal-Wallis test on the IL-6 expression of the 24-hour Observation Subgroup showed a significant difference, then continued with Mann-Whitney post hoc, the results obtained group S with TP (1.48±0.52 vs. 3.29±0.7; p=0.011), P with TP (1.83±0.55 vs. 3.29±0.7; p=0.001), and T with TP (1.81±0.49 vs. 3.29±0.7; p<0.001). In the statistical analysis of HIF-1α and IL-1, no significant differences were found between groups. There was a positive correlation between the expression and concentration of HIF-1α with IL-1β and IL-6, especially in the brain tissue of rats in groups P, T, and TP. Conclusion Propofol improves neurological function in TBI rats, causing increased IL-6 expression but it does not affect expression and concentration of HIF-1α and IL-1β."

"Neuronal noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations. The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise : synaptic noise. It also provides the specialist with a summary of the large body of sometimes contrasting experimental data, and different theories proposed to explore the computational power that various forms of "noise" can confer to neurons."

"Comprehensive guide to diagnosis and management of neurological infectious diseases using MRI. Begins with introduction to tropical diseases of the central nervous system, and their epidemiology, then technique of MRI, and its use for infectious and noninfectious conditions."

"Inspired by response to a workshop at the 2008 OCNS meeting, this book tracks advances in the application of phase response (PR) analysis to the study of electrically excitable cells, focusing on applications of PR analysis in the computational neurosciences."

"The neurologic diagnosis : a practical bedside approach is an introductory text that simplifies the often unwieldy method of making a neurologic diagnosis. Medical students are often intimidated by a deluge of data, extensive differential diagnoses, and have no organizational structure to follow. Diagnostic techniques of general medicine are not applicable. Neurology is a unique specialty since it requires the intermediary step of an anatomic diagnosis prior to proffering a differential diagnosis. Yet the required knowledge of neuroanatomy need not be profound for the student who will specialize in any field other than neurology and neurosurgery. This text is directed to medical students and residents who will all be regularly faced with numerous patients who have neurologic symptomatology. Typical one-month neurology rotations out of four years of medical school is clearly inadequate training to make a cogent neurologic diagnosis, especially since subsequent instruction is commonly provided by upper level residents who have the same background and numerous misconceptions. This is not a comprehensive text. The emphasis in this concise and practical title is on establishing a neuroanatomic diagnosis before formulating a differential diagnosis. In addition, treatment is seldom discussed since it is likely to change radically over time. Focused and succinct."

"Latar Belakang. Perbaikan fungsi berjalan adalah target fungsional yang paling relevan pasca-stroke. Oleh karena itu diperlukan alat ukur yang dapat menilai kemampuan fungsional pasca-stroke yang aman dan tidak menimbulkan kelelahan. Tujuan dari penelitian ini untuk menilai korelasi antara Fatigue Severity Scale dan Skala Borg dengan uji jalan 2 menit pada penderita stroke.Metode. Studi potong lintang pada 35 subjek stroke subakut dan kronik di RSUPN Cipto Mangunkusumo. Dilakukan uji korelasi Pearson antara Fatigue Severity Scale dan Skala Borg dengan hasil pengukuran uji jalan 2 menit.Hasil. Pada pasien stroke terdapat korelasi sedang yang signifikan pada Skala Borg kaki lelah ge;3 dengan uji jalan 2 menit baik pada jarak tempuh r=-0,505, p=0,046 maupun kecepatan r=-0,498, p=0,050 namun tidak terdapat korelasi antara FSS dengan hasil pengukuran uji jalan 2 menit. Tidak terdapat korelasi antara Skala Borg usaha dan sesak dengan jarak tempuh uji jalan 2 menit.Kesimpulan. Terdapat korelasi sedang yang bermakna secara statistik antara Skala Borg kaki lelah dengan hasil pengukuran uji jalan 2 menit.Tidak terdapat korelasi antara FSS dengan uji jalan 2 menit.

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Background. Improvement of walking function is the most relevant functional target post stroke Therefore we need a measuring tool that can assess the functional ability of post stroke that is safe and does not cause fatigue. Aim of this study to assess the correlation between Fatigue Severity Scale and Borg Scale with 2 minute walking test in stroke patient.Method. Cross sectional study on 35 subacute and chronic stroke subjects at RSUPN Cipto Mangunkusumo. A Pearson correlation test was conducted between FSS and Borg Scale with 2 minute walking test.Result. In stroke patients there was a significant moderate correlation between Borg Scale leg fatigue ge 3 with 2 minute walking test on distance r 0,505, p 0.046 and walking speed r 0,498, p 0,050 but there was no correlation between FSS and 2 minute walking test. There was no correlation between the Borg Scale dypsnea and leg fatigue with 2 minute walking test.Conclusion. There was a statistically significant correlation between Borg Scale leg fatigue with 2 minute walking test. There was no correlation between FSS with 2 minute walking test."