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"Herbal medicines in general are safer than modern drug. This matter is caused by the less side effect of herbal medicines than modern drug. Side effects of herbal medicines can be reduced with the used of right materials, accurat dose, accurat usage time, accurat way of usage, accurat analyze information, and without abusing of herbal medicines itself. Accuracy of materials determine the effect of herbal medicines. Dose measuring in set of gram can lessen possibility the happening of effect which do not be expected. Information which is not supported by adequate basic knowledges and enough study can make traditional drug return to endangering."

"Penyakit COVID-19 yang merebak di seluruh dunia pada akhir tahun 2019 diakibatkan oleh virus SARS-CoV-2. Penelitian ini membahas simulasi penambatan serta dinamika molekuler dari beberapa senyawa herbal dari tumbuhan Anredera cordifolia (binahong) yaitu procyanidin, metil linoleat, asam oleat dan vitexin dengan protein target (Mpro SARS-CoV-2). Simulasi dinamika molekuler dilakukan selama 20 ns. Selain itu, analisis toksikologi dan farmakologi (ADMET) dilakukan untuk setiap ligan. Hasil simulasi ini dibandingkan dengan ligan kontrol quercetin yang sudah terbukti memiliki interaksi yang baik dengan protein target (Mpro SARS-CoV-2). Hasil prediksi ADMET menunjukkan bahwa semua ligan baik untuk dijadikan obat, kecuali metil linoleat dan asam oleat. Simulasi penambatan molekuler menunjukkan procyanidin serta vitexin memiliki skor penambatan dan binding energy paling baik. Hasil dinamika molekuler juga membuktikan procyanidin, vitexin dan quercetin memiliki nilai RMSD dan RMSF paling baik dan menunjukkan interaksi paling stabil dan kompleks dengan protein target. Sehingga, secara keseluruhan, procyanidin dan vitexin berpotensi untuk menjadi inhibitor Mpro SARS-CoV-2.

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COVID-19 that spread across the globe at the end of 2019 is caused by the SARS-CoV-2. This virus attacks human respiratory cell. Until now, there is no efficacious drug to treat this disease. This sudy discusses molecular docking and molecular dynamics simulations of four herbal compounds from Anredera cordifolia (binahong), which are procyanidin, methyl linoleate, oleic acid, as well as vitexin with Mpro SARS-CoV-2 as the protein target. The molecular dynamics simulations were carried out for 20 ns. In addition, toxicological and pharmacological analyses (ADMET) were performed for each ligand. The results were compared to quercetin as the control ligand, which has been shown to have good interaction with the protein target. ADMET prediction results show that all ligands are good for use as drugs, except methyl linoleic and oleic acid. Molecular docking simulation results show that procyanidin and vitexin have the docking scores and binding energy scores. The results of molecular dynamics also prove that procyanidin, vitexin and quercetin have the best RMSD and RMSF values ​​and show the most stable as well as complex interactions with target proteins. Thus, procyanidin and vitexin have the potential to be Mpro SARS-CoV-2 inhibitors."

"Pemakaian obat herbal dimasyarakat diiringi dengan berkembangnya industri obat tradisional. Khusus untuk Industri Kecil Obat Tradisional (IKOT) setiap tahun pertumbuhannya semakin meningkat. IKOT turut berkontribusi sebesar 20% dari omset nasional produk herbal. Permasalahan utama yang dihadapi oleh IKOT adalah ketersediaan bahan baku dan kualitas produksi yang belum terstandar. Penelitian ini bertujuan untuk menganalisis ketersediaan bahan baku untuk produk IKOT dan kontribusi dari kualitas produk IKOT terhadap pemakaian produk herbal masyarakat. Metode yang digunakan adalah survey dan wawancara kepada 4 IKOT di kota Depok dan responden yang menggunakan produk herbal sebanyak 84 orang. Berdasarkan analisa hasil penelitian diperoleh Y = 0,549 X atau pemakaian produk = 0,549 kualitas produk. Artinya apabila kualitas produk ditingkatkan satu kali maka pemakaian produk akan meningkat 1/0,549 atau sekitar dua kali. Kualitas produk berkaitan secara bermakna dengan kualitas bahan baku herbal. Kontinuitas produksi di IKOT tergantung pada bahan baku yang berasal dari bukan hasil budidaya. Kemitraan dengan petani penyedia bahan baku melalui pola penanaman sistem Good Agriculture Practice (GAP). Pembinaan petani diarahkan pada cara budidaya, pengelolaan panen dan pasca panen serta cara penyimpanan bahan baku yang sesuai dengan Cara Pembuatan Obat Tradisional yang Baik (CPOTB). Kerjasama dengan pihak perguruan tinggi dalam hal pengujian bahan baku herbal harus dilakukan oleh IKOT agar kualitas bahan terstandar.

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The use of herbs remedies in industrial growth accompanied by traditional medicine. Specifically for Small traditional medicine Industry (IKOT) increasing its growth each year. IKOT contribute 20% of the national turnover of herbs products. The main problems faced by IKOT is the availability of raw materials and production quality that has not been standardized. This research aims to analyze the availability of raw materials for the product and IKOT contributions from IKOT product quality to the use of herbs products community. The method used was a survey and interviews to 4 IKOT in Depok and respondents who use herbs products as much as 84 people. Based on an analysis of the research results obtained Y = 0.549 X or product usage = 0.549 product quality. It means that, when the quality of products improved once and then use the product to rise 1/0.549 or about twice. The quality of the product concerned significantly to the quality of raw herbs. Continuity of production at IKOT depending on the raw material comes from is not the result of cultivation. Partnership with farmers providing raw materials through a system of planting pattern of Good Agriculture Practice (GAP). The construction of the farmers directed at how the cultivation, harvest and post harvest management and storage of the raw materials according to the way of making a good traditional medicine (CPOTB). Cooperation with the College in terms of raw herbs material testing must be carried out by the quality of the ingredients, standardized so that the IKOT."