Hasil Pencarian  ::  Simpan CSV :: Kembali

"Petanda molekuler yang dapat menunjukkan perbedaan dalam derajat progresivitas Osteoartritis (OA) akan memberikan kemudahan bagi penelitian klinik. Deoksipiridinolin (DPD) urin dan osteokalsin (OC) serum telah digunakan secara luas untuk petanda metabolisme tulang, sedangkan penggunaannya sebagai petanda molekuler OA belum banyak data yang mendukung. Berbagai penelitian terdahulu menunjukkan hasil yang saling bertentangan dalam hal eskresi DPD urin dan kadar OC serum pada berbagai derajat OA lutut. Tujuan penelitian ini untuk melihat perbedaan ekskresi DPD urin dan kadar OC serum diantara derajat dari OA lutut. Penelitian ini merupakan studi potong-lintang pada satu kelompok dari 69 pasien OA lutut. Derajat OA ditentukan menurut skala derajat Kellgren dan Lawrence. Kelompok pasien dengan OA lutut derajat 2 dinyatakan sebagai kelompok OA awal dan kelompok pasien dengan derajat 3 dan 4 dinyatakan sebagai kelompok OA lanjut. DPD urin diukur dengan metode Immunochemilunescence dan OC serum menggunakan metode Elisa. Nilai rerata eskresi DPD urin pada pasien OA lebih tinggi dari nilai normal (9.79 + 7.28 nM DPD/mM Creatinin), tetapi nilai rerata OC serum dalam batas normal (8.49 + 4.68 ng/mL). Tidak ada perbedaan bermakna di antara OA awal dan OA lanjut dalam hal usia, indeks massa tubuh (IMT),lama sakit, eskresi DPD urin dan kadar serum OC. Disimpulkan, pada model penelitian potong lintang ini didapatkan tidak ada perbedaan bermakna dalam hal ekskresi DPD urin dan kadar OC serum di antara derajat OA lutut. Oleh karena hasil dari berbagai penelitian tidak konstan maka penggunaan DPD urin dan serum OC sebagai petanda molekuler untuk progresivitas OA masih memerlukan lagi penelitian prospektif jangka panjang. (Med J Indones 2004; 13: 96-101)

---

The identification of molecular markers, which reflects differences in disease progression rates in Osteoarthritis (OA), would greatly facilitate clinical studies. Urinary Deoxypyridinoline (UDPD) and serum osteocalcin (OC) had been widely used for marker of bone metabolism, but the use for molecular marker in OA was lack of data. Recent studies show that there were conflicted results between urinary excretion of DPD and serum OC value within knee OA grading. The aim of this study is to compare of urinary excretion of DPD and the level of serum OC as destructive parameter of cartilage within the knee OA grading. This cross sectional study comprise of 69 patients with OA of knee joints. Kellgren and Lawrence scale was use for grading of OA. Group of patients with knee OA grade 2 call as group of early OA and group of patients with knee OA grade 3 and 4 calls as group of late OA. DPD in urine was measured using Immunochemilunescence, serum osteocalcin was measured using Elisa method. The mean value of urinary concentrations of DPD in OA patients was higher than normal value (9.79 + 7.28 nM DPD/mM Creatinin), and the mean value of serum OC within normal value (8.49 + 4.68 ng/mL). There were no significant differences of age, body mass index (BMI), duration of illness, urinary excretion of UDPD and serum OC level between early and late OA. In conclusion, there is no significant difference of urinary excretion of DPD and serum OC level within knee OA grading. The use of urinary DPD and serum OC as molecular markers of progression of OA needed to be explored by other longitudinal study. (Med J Indones 2004; 13: 96-101)."

"Pada penelitian ini telah dilakukan analisis pembentukan senyawa 8-hidroksi-2’-deoksiguanosin (8-OHdG) sebagai penanda kerusakan oksidatif DNA yang diakibatkan oleh paparan senyawa akrilamida dan logam kromium heksavalen (Cr(VI)). Studi in vitro dilakukan melalui reaksi senyawa 2’-deoksiguanosin dengan akrilamida, logam Cr(VI), asam askorbat, dan H₂O₂ berdasarkan prinsip reaksi Fenton-like pada variasi pH inkubasi 7,4 dan 8,4, suhu inkubasi 37 dan 60 °C, serta waktu inkubasi 7 dan 12 jam. Analisis senyawa 8-OHdG dilakukan menggunakan UHPLC fasa terbalik dengan fasa gerak berupa campuran penyangga natrium fosfat pH 6,7 : metanol (85:15). Hasil yang diperoleh menunjukkan bahwa paparan akrilamida dan Cr(VI) secara in vitro menyebabkan pembentukan 8-OHdG dengan konsentrasi rendah, serta penambahan asam askorbat mampu meningkatkan pembentukan 8-OHdG. Konsentrasi 8-OHdG tertinggi pada sampel tanpa asam askorbat diperoleh dengan kondisi suhu inkubasi 60 °C, serta pada sampel dengan asam askorbat diperoleh dengan kondisi pH inkubasi 7,4, suhu inkubasi 37 °C, dan waktu inkubasi 7 jam.

---

This research aims to investigate 8-hydroxy-2’-deoxyguanosine (8-OHdG) formation as a biomarker of DNA oxidative damage following acrylamide and hexavalent chromium (Cr(VI)) exposure. In vitro study was carried out through reactions between 2’-deoxyguanosine, acrylamide, Cr(VI),  and reducing agent with respect to Fenton-like principles. Samples at pH 7.4 and 8.4 were incubated for 7 and 12 hours under 37 and 60ºC to find the correlation between 8-OHdG concentration over several pH, time, and temperature conditions. Analysis was performed by reversed-phase UHPLC using sodium phosphate buffer pH 6.7 : methanol (85:15) as mobile phase. Results show that low concentration of 8-OHdG could be linked to acrylamide and Cr(VI) exposure, and ascorbic acid might have a role in increasing 8-OHdG to higher concentration. The highest concentration of 8-OHdG was obtained at 60°C in samples without the presence of ascorbic acid, and at pH 7.4, 37 °C, and 7 hours of incubation in samples with the presence of ascorbic acid."

"Background: Glucosamine, chondroitinsulfate are frequently used to prevent further joint degeneration in osteoarthritis (OA). Methylsulfonylmethane (MSM) is a supplement containing organic sulphur and also reported to slow anatomical joint progressivity in the knee OA. The MSM is often combined with glucosamine and chondroitin sulfate. However, there are controversies whether glucosamine chondroitin sulfate or their combination with methylsulfonylmethane could effectively reduce pain in OA. This study is aimed to compare clinical outcome of glucosamine chondroitin sulfate (GC), glucosamine chondroitin sulfate methylsulfonylmethane (GCM), and placeboin patients with knee osteoarthritis (OA) Kellgren Lawrence grade I II. Methods: a double blind, randomized controlled clinical trial was conducted on 147 patients with knee OA Kellgren Lawrence grade I II. Patients were allocated by permuted block randomization into three groups: GC (n=49), GCM (n=50), or placebo (n=48) groups. GC group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of saccharumlactis; GCM group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of MSM; while placebo group received three matching capsules of saccharumlactis. The drugs were administered once daily for 3 consecutive months VAS and WOMAC scores were measured before treatment, then at 4th, 8th and 12th week after treatment. Results: on statistical analysis it was found that at the 12th week, there are significant difference between three treatment groups on the WOMAC score (p=0.03) and on the VAS score (p=0.004). When analyzed between weeks, GCM treatment group was found statistically significant on WOMAC score (p=0.01) and VAS score (p<0.001). Comparing the score difference between weeks, WOMAC score analysis showed significant difference between GC, GCM, and placebo in week 4 (p=0.049) and week 12 (p=0.01). In addition, VAS score also showed significant difference between groups in week 8 (p=0.006) and week 12 (p<0.001). Conclusion: combination of glucosamine chondroitinsulfate methylsulfonylmethane showed clinical benefit for patients with knee OAK ellgren Lawrence grade I II compared with GC and placebo. GC did not make clinical improvement in overall groups of patients with knee OA Kellgren Lawrence grade I II."

"

Latar Belakang : Osteoartritis lutut merupakan artritis tersering menyebabkan disabilitas. MagneticResonance Imaging (MRI) adalah modalitas pilihan untuk evaluasi struktur intraartikular terutama kartilago. Pengukuran nilai waktu relaksasi T2 pada sekuen T2 mapmendeteksi penurunan proteoglikan dan perubahan awal biokimia kartilago pada osteoartritis, namun pemeriksaan ini membutuhkan perangkat lunak. Sistem semi kuantitatif MagneticResonance Imaging Osteoartritis Knee Score (MOAKS) dapat mengevaluasi tujuh aspek lutut pada osteoartritis dengan menggunakan protokol rutin MRI. Terapi sel punca mesenkimal asal tali pusat meregenerasi kartilago dan menghambat proses inflamasi pada osteoartritis lutut.  Tujuan :  Mengetahui korelasi nilai waktu relaksasi T2 dan nilai skor MOAKS pada osteoartritis pra dan pasca terapi implantasi sel punca Metode : Penelitian ini menggunakan desain potong lintang dengan data sekunder pada osteoartritis lutut derajat Kellgren Lawrence satu hingga empat. Sampel penelitian adalah 63 lutut pra dan 47 lutut pasca implantasi sel punca. Menganalisis nilai MOAKS dengan sekuens proton density (PD), T2 fat saturated, T1W dan T1 fat saturated pada 14 subregio lutut.  Pengukuran nilai relaksasi T2 dengan sekuens T2 map pada 12 subregio lutut.  Hasil : Korelasi sedang antara nilai waktu relaksasi T2 dan nilai MOAKS pra sel punca (Ï? : 0,4, p: 0,001) dan korelasi lemah (Ï?: 0,22, p: 0,142) `pasca terapi sel punca. Korelasi kuat pada derajat osteoartritis Kellgren Lawrence dan nilai MOAKS pada pra (Ï?: 0,68, p: 0,000)  dan pasca terapi sel punca (Ï?: 0,71, p: 0,000).Simpulan: Sistem semi kuantitatifMOAKS dapat digunakan untuk diagnosis osteoartritis tapi tidak untuk evaluasi pasca terapi. Kellgren Lawrence berpotensi memprediksi lesi intraartikular.

---

Background : Knee osteoarthritis is the leading cause of dysability.  MRI is the modality of choice for evaluating intra- articular structure, specifically cartilage in osteoarthritis. T2 Relaxation time of T2 maps sequence can detect decrease of proteoglycan and early biochemical changes in osteoarthritic cartilage, but it needs special software. Magnetic Resonance Imaging Osteoartritis Knee Score (MOAKS), a semiquantitative system can evaluate seven aspects of osteoarthritic knee with routine protocol sequence. Mesenchymal stem cell from umbilical cord can  regenerate cartilage and inhibit inflammation process. Objective : ToDetermine the correlation between MOAKS and T2 relaxation time of knee osteoarthritis before and  after implantation of stem cell . Methods : This study used cross sectional design with secondary data on knee osteoartrthritis classified as Kellgren Lawrence grade one to four.  The study included 63 knees before and 47 knees after implantation of stem cell. MOAKS was analized  with proton density (PD), T2 fat saturated, T1W dan T1 fat saturated sequence on 14 sub-region and T2 relaxation time was calculated with T2 map sequens on 12 sub-region. Result : We foundModerate correlation between MOAKS and T2 relaxation time of knee osteoarthritis before implantation (Ï? :0,4, p :0,001). and weak corellation after implantation of stem cell (Ï?: 0,22, p: 0,142). We also found strong corellation between  Kellgren Lawrence grading of osteoarthritis and MOAKS before (Ï?: 0,68, p: 0,000)  and after implantation of stem cell (Ï?: 0,71, p: 0,000). Conclusion :MOAKS, asemiquantitative system can be used  to diaognose osteoarthritis but not reliable for post treatment evalution. Kellgren Lawrence grading has potential to predict intra articular lesion. 

"

"Latar Belakang: Obesitas merupakan faktor resiko terjadinya osteoartritis (OA). Penelitian terdahulu bahwa faktor mekanik belum cukup untuk menjelaskan hubungan OA dengan obesitas. Faktor resiko ini dapat menurunkan fungsi dan aktifitas fisik pasien OA. Lemak viseral tempat ditemukan White Adipose Tissue (WAT), dapat mengeluarkan hormon leptin, dan leptin dapat mensekresi sitokin proinflamasi yang berdampak pada degradasi kartilago sendi, yang diduga berhubungan dengan kejadian OATujuan: Mendapatkan gambaran leptin serum dan kadar IL-1β cairan sendi pasien OA lutut wanita dengan obesitas sentral.Metode: Studi potong lintang pada pasien OA lutut wanita yang berobat di poliklinik Rheumatologi RSCM dalam kurun waktu Maret–Juli 2017. Pengambilan sampel dilakukan secara berturutan. Diagnosis OA lutut berdasarkan kriteria ACR 1986. Dilakukan pemeriksaan lemak viseral dengan menggunakan alat BIA Karada Scan .HBF 375. Pemeriksaan leptin serum dan IL-1ß cairan sendi dengan metode ELISA.Hasil: Didapatkan 22 subjek wanita yang memenuhi kriteria penelitian. Nilai median lemak viseral 12,5 (5 – 27,5 ) %, nilai median leptin serum 19735,5 (2998–81782) pg/ml, dan nilaimedian IL-1ß 1,23 (0,76 – 6,11).Simpulan: Didapatkan kadar rerata leptin serum 19735,5 (2998-81782) pg/ml dan rerata kadar IL-1β cairan sendi 1,23 ( 0,76 – 6,11).

---

Background: Obesity is a well recognized risk faktor for osteoarthritis. However, the relationship between obesity and OA may not simply due to mechanical factor, may be a risk factor for declining function and physical activity. Viseral fat is that founded white adipocite tissue is product quantities of leptin. It's to secrete higher levels of proinflammatory cytokine and implicated in cartilage degradation.

The aim: of this study was to examine Profile of serum leptin and IL-1β synovial fluid in central obecity with knee osteoarthritis woman patients

Methods: This study was cross sectional study in OA patients visiting Rheumatology outpatients clinic in Cipto Mangunkusumo Hospital during March – July 2017. Sample were collcted using consecutive sampling methood. Knee OA diagnosed according to the 1986 American College of Rheumatology criteria. Viseral fat were measred by BIA Karada Scan HBF 375. Blood serum and synovial fluid was collected from 22 knee OA patients, serum leptin and synovial fluid were measured by ELISA,

Results : Of twenty two subjects met the inclution criteria, median of viseral fat was 12,5 (5 – 27,5) % and median of serum leptin was 19735,5 ( 2998 – 81782) pg/ml and median of IL-1 β was 1,23 ( 0,76 - 6,11) pg/ml.

Conclusion: :Serum leptin was 19735,5 (2998 – 81782) pg/ml and median of IL-1 β was 1,23 ( 0,76 - 6,11) pg/ml."

"Background: Platelet-Rich Plasma is believed to repair cartilage degeneration by stimulating tissue regeneration, however the clinical evidence is still insufficient. The aim of this research is to compare the efficacy of intra-articular hyaluronic acid injection (HA) and combined hyaluronic acid and platelet-rich plasma (HA-PRP) on osteoarthritis of the knee, and the association on gender, age, body mass index and osteoarthritis degree towards the efficacy. Methods: This is a cross-setional study using 58 patients’ medical records. 27 patients received HA injections, and 31 patients received HA-PRP injections. Patients were evaluated weekly using IKDC and WOMAC score until 2 months after the injections. Results: On the 2nd month of follow up, AH-PRP shows greater increase in IKDC (p=0,146) and WOMAC (Pain p=0,004; Stiffness p=0,008; Knee function p=0,007) score compared to HA injection. There’s no association on gender, age, and body mass index towards the IKDC and WOMAC score increase on either HA or combined HA-PRP injection. There’s no significant difference on osteoarthritis degree towards IKDC and WOMAC score increase on HA injection. However, there’s a significant difference between osteoarthritis degree 2 and 4 towards IKDC (p=0,002) and WOMAC score (Pain p=0,042; Stiffness p=0,018; Knee function p=0,042) and between osteoarthritis degree 2 and 3 towards WOMAC Pain (p=0,008) and WOMAC Knee function (p=0,018). Conclusions: HA-PRP injection shows better results to reduce osteoarthritis symptoms compared to HA injections. Better results were observed in patients with less severe osteoarthritis degree."

"Objectives: Osteoarthritis of the knee can caused by sosiolis. The Purpose of this study is to find out the influence of scoliosis caused secondary osteorthritis of the knee in athlete, based on cobbs degree, Scolisis curve. Materials and Method: This research use an analytic cross-sectional design. The total sample of 92 athletes scoliosis taken by simple random sampling technique. The data were analyzing with Chi-square test, fisher and prevalence rasio. Result: The result show that there were influences on the incidence of scoliosis towards secondary osteoarthritis of the knee in athletes at the national sports hopsital.Based on the cirteria in the cobbs angle had the results (p=0.022 (p<0.05)), moderate cobbs angle degree were 7.5 times more at risk of cousing secondary osteoarthritis on the knee than a mild degree. The other hand shape of the curve scoliosis had results (p=0.038(p<0.05)), the shape of the S cirve scoliosis 3.2 Times more at risk of causing secondary osteoarthritis on the knee than the curve C. Conclusion: It had to be concluded that there was influcence between cobbs degree scoliosis and shape curve towards incidence of secondary osteoarthritis on the knee"

"Tujuan: Mengetahui perbandingan efek latihan isokinetik dan isometrik terhadap nyeri, kekuatan otot dan kemampuan fungsional pada pasien osteoarthritis lutut. Disain: Eksperimental paralel. Subjek: 28 orang pasien berusia antara 50-64 tahun, dibagi secara acak menjadi dua kelompok. Tempat: Bagian Ilmu Kedokteran Fisik dan Rehabilitasi. Perjan RS Dr. Hasan Sadikin. Bandung. Intervensi: Pasien menjalani program latihan isokinetik atau isometrik selama 6 minggu. Parameter: VAS, peak torque, indeks Lequesne yang diukur setiap minggu. Hasil: Kedua kelompok menunjukkan penurunan yang bermakna pada intensitas nyeri (p<0,001) dan indeks Lequesne (p<0,001), juga peningkatan yang bermakna pada peak torque (p<0,001) setelah 6 minggu. Tidak terdapat perbedaan yang bermakna antara kedua kelompok. Kesimpulan: Kedua jenis latihan berguna pada pasien osteoarthritis berusia lanjut Pada kelompok isokinetik tidak didapatkan subjek yang mengeluh nyeri yang bermakna.

---

Objective: To compare the effect of isokinetic and isometric strengthening exercise on pain, strength and functional capacity of patients with knee osteoarthritis.

Design: Experimental parallel.

Participants: 28 patients, age 50-64 years, were randomly assigned into two groups.

Setting: Department of Physical Medicine and Rehabilitation. Hasan Sadikin Hospital Bandung.

Interventions: Patients received either a regimen of isokinetic exercise or a regimen of isometric exercise for 6 weeks.

Main outcome measure : VAS, peak torque and Lequesne index were measured each week.

Result: Both training groups showed significant decrease in pain score (pc0, 001) and Lequesne index (p<0, 001) and an increase in peak torque (p<0,001). However there is no significant difference of those parameters between groups.

Conclusion: Both exercises can benefit elderly patients with knee osteoarthritis as shown by the increase of strength and functional capacity. In the isokonetic group there were no subjects who experienced an increase in pain."

"ABSTRAKSaat ini terdapat perbaikan Angka Harapan Hidup (AHH) penduduk Indonesia dan penambahan populasi penduduk lanjut usia. Pada tahun 2017, AHH mencapai 71,06 tahun, dan jumlah lansia 23,4 juta orang (8,97% dari seluruh penduduk Indonesia). Hal ini berisiko meningkatkan kejadian penyakit degeneratif. Osteoartritis (OA) adalah penyakit yang sering dikaitkan dengan kondisi degeneratif dan mengakibatkan ketidakaktifan fisik. Pada Riskesdas 2013, penyakit Artritis berada di urutan kedua penyakit terbanyak diderita lansia dengan prevalensi 45% (55-64 tahun), 51,9% (65-74 tahun) dan 54,8% (usia >75 tahun). Pengobatan simtomatik dengan OAINS yang berkepanjangan dapat mengakibatkan efek samping yang fatal. Terdapat berbagai faktor risiko berkembangnya OA lutut, di antaranya konsentrasi serum Vitamin D (25(OH)D. Proporsi perempuan lansia dengan defisiensi 25(OH)D pada penelitian di Jakarta dan Bekasi mencapai 35,1%. Terdapat hubungan antara kadar Vitamin D (25(OH)D) yang rendah dengan nyeri lutut dan perubahan kartilago sendi lutut pada OA. Serum Cartilage Oligomeric Matrix Protein (COMP) merupakan produk degradasi penting dari kartilago sendi dan dapat menjadi marker diagnosis untuk OA lutut. Penelitian ini bertujuan mengetahui pengaruh pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu terhadap derajat nyeri berdasarkan indikator WOMAC, dan kondisi obyektif kartilago sendi dengan perubahan marker serum COMP pada penderita OA lutut lansia. Disain penelitian uji klinis teracak, tersamar ganda, dan terkontrol plasebo. Subyek dengan OA lutut simtomatis direkruit secara consecutive sampling dan dilakukan anamnesis, diperiksa kondisi fisik, radiologi lutut, kadar serum Vitamin D (25(OH)D), serum Calcium dan marker COMP. Subyek dialokasikan secara acak (random allocation) pada kelompok perlakuan yang diberikan suplemen Vitamin D (Alphacalcidol) atau kelompok kontrol yang diberikan plasebo. Populasi sumber xviii Universitas Indonesia pada penelitian ini ialah pasien OA lutut lanjut usia yang berobat ke KPKM FKIK UIN Jakarta. Dari hasil pemeriksaan konsentrasi serum Vitamin D 25(OH)D sebelum dilakukan intervensi, 53,4% responden mengalami insufisiensi dan 12,3% responden mengalami defisiensi Vitamin D. Pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu, mempengaruhi penurunan derajat nyeri berdasarkan indikator WOMAC pada penderita OA lutut lansia yang bermakna secara statistik dengan perbedaan perubahan skor pra dan pascaintervensi pada kelompok intervensi dibanding kontrol sebesar 2,174 (p=0,00). Pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu, mempengaruhi penurunan konsentrasi serum COMP pada penderita OA lutut lansia, dengan perbedaan perubahan skor pra dan pascaintervensi pada kelompok intervensi dibandingkan kelompok kontrol sebesar 38,15 ng/ml namun tidak bermakna secara statistik (p=0,39)

---

ABSTRACTAt present there are improvements in the Life Expectancy (AHH) of the Indonesian population and the addition of the elderly population. In 2017, AHH reached 71.06 yo and the number of elderly people reached 23.4 million people (8.97% of the total population of Indonesia). This has the potential to increase degenerative diseases. Osteoarthritis (OA) is a disease that is often associated with degenerative conditions and physical inactivity. Riskesdas in 2013 stated that Arthritis was the second most common disease suffered by the elderly with a prevalence of 45% (55-64 yo), 51.9% (65-74 yo) and 54.8% (>75 yo). Symptomatic treatment with prolonged NSAIDs can cause fatal side effects. There are various risk factors for developing knee OA, including serum Vitamin D (25(OH)D) concentrations. The proportion of elderly women with 25(OH)D deficiency in studies in Jakarta and Bekasi reaches 35.1%. It has been found an association between low Vitamin D levels (25(OH)D) with knee pain in OA and changes in the knee joint cartilage. Cartilage Oligomeric Matrix Protein (COMP) is an important degradation product of joint cartilage and can be act as a diagnostic marker of knee OA. This study aims to determine the effect of Vitamin D supplementation (Alphacalcidol) for 12 weeks on the degree of pain based on WOMAC indicators, and the objective conditions of joint cartilage with changes in COMP serum markers in patients with knee OA in the elderly. The research design is a randomized, double-blind, and placebo-controlled clinical trials. Subjects with symptomatic knee OA will be recruited by consecutive sampling and continued with history taking, physical conditions examinatons, knee radiology, and blood test for serum vitamin D (25(OH)D), serum calcium and marker COMP. Subjects were then randomly allocated to the treatment group given Vitamin D supplements (Alphacalcidol) or the control group given a placebo. The source population in this study was elderly with knee OA patients xx Universitas Indonesia who went to Primary Health Care Clinic (KPKM) of FKIK UIN Jakarta. We found that before intervention was done, 53.4% of respondents had Vitamin D insufficiency and 12.3% of respondents had Vitamin D deficiency. The administration of Vitamin D supplements (Alphacalcidol) for 12 weeks, influenced the decrease in the degree of pain based on the WOMAC indicator in knee OA of elderly patients significantly, with differences in changes in pre and post intervention scores of 2.174 compare with control (p=0.00). The administration of Vitamin D supplements (Alphacalcidol) for 12 weeks, affected the decrease in the serum concentration of COMP in knee OA of elderly patients, with differences in changes in pre and post intervention scores in the intervention group compared to the control group of 38.15 ng/ml but not statistically significant (p=0.39)."