Hasil Pencarian  ::  Simpan CSV :: Kembali

"Oessofago-gastro-duodenoscopy (OGD) dilakukan pada pasien yang diterima melalui sistem "open access" dan sistem biasa."

"Obat anti-inflamasi nonsteroid (OAINS) berhubungan dengan meningkatnya insidens komplikasi tukak gastrointestinal yang mendadak dan menetap. Penelitian ini bertujuan untuk menemukan kelainan-kelainan endoskopik yang ditemukan pada duodenum dan jejunum proksimal karena obat OAINS. Tiga puluh delapan pasien yang mengkonsumsi OAINS untuk penyakit arthritis atau rematiknya dimasukkan dalam penelitian ini. Pemeriksaan gastro-duodeno-jejunoskopi dilakukan dengan alat Olympus PCF-10. Gambaran endoskopik entero-gastropati-OAINS dievaluasi dengan sistim skor. Gambaran enterogastropati-OAINS secara endoskopik terlihat berupa hiperemis, erosi dan tukak. Keluhan diare terjadi pada 7,9% pasien dan dispepsia terjadi pada 71,1% pasien. Dari pemeriksaan endoskopi di bulbus duodenum, ditemukan 79% kasus dengan hiperemis, 39,5% kasus dengan erosi dan 7,9% kasus tukak. Di duodenum bagian kedua (pars desendens) ditemukan 28,9% kasus dengan hiperemis, 15,8% kasus dengan erosi dan 2,6% kasus tukak. Di jejunum, ditemukan 7,9% kasus dengan hiperemis, 2,6% kasus dengan erosi dan tidak ditemukan tukak. Disimpulkan bahwa kelainan endoskopik terbanyak yang ditemukan pada enteropati-OAINS yaitu hiperemis. Lokasi kelainan enteropati-OAINS tersering yaitu di bulbus duodenum. (Med J Indones 2005; 14: 225-9)

---

Non Steroidal Anti Inflammatory Drugs (NSAID) have been associated with a sudden and sustained rise in the incidence of gastrointestinal ulcer complications. The aim of the study was to reveal the endoscopical abnormalities found in the duodenum & proximal jejunum due to NSAID. Thirty eight patients taking NSAID for their arthritis or rheumatism were included in this study. Gastro-duodeno-jejunoscopy was done with Olympus PCF-10. The endoscopical appearances of NSAID entero-gastropathy were evaluated with a scoring system. The NSAID-entero-gastropathy appearances were endoscopically seen as hyperemia, erosion and ulcer. From all patient recruited, 7.9% complaint of diarrhea and 71.1% complaint of dyspepsia. Endoscopically, in the duodenal bulb we found 79% cases of hyperemia, 39.5% cases of erosion and 7.9% cases of ulcer. In the second part (descending part) of the duodenum we found 28.9% cases of hyperemia, 15.8% cases of erosion and 2.6% case of ulcer. In the jejunum, we found 7.9% cases of hyperemia, 2.6% case of erosion and no ulcer. It is concluded that the most frequent abnormal endoscopical appearances in NSAID- enteropathy was hyperemia. The most frequent site of NSAID-enteropathy abnormal findings was in the duodenal bulb. (Med J Indones 2005; 14: 225-9)"

"Man's innate curiosity to study the internal organs ofthe human body dates back to the time of Hippocrateswhere basic speculums were invented to peer into thebuccal cavity and vagina. The tirst instruments used tointubate the esophagus and stomach in the 16th and 17thcenturies, were designed for the purpose of extractingforeign bodies stuck in the esophagus or pushing themdown into the stomach."

"Latar belakang: Pada penelitian terdahulu disebutkan bahwa pembedahan hidung dapat memperbaiki keluhan subjektif dan meningkatkan kualitas hidup pada pasien sleep disordered breathing (SDB), namun secara objektif yang dinilai dengan polisomnografi masih terdapat kontroversi. Diperlukan suatu evaluasi lain yaitu dengan drug induced sleep endoscopy (DISE) yang dapat menilai sesuai patofisologi utama SDB yaitu adanya kolaps jalan napas pada saat tidur. Tujuan penelitian: untuk mengetahui efektivitas pembedahan hidung endoskopik pada pasien SDB yang disertai sumbatan hidung secara subjektif dengan menilai perbedaan skor Nasal Obstruction Symptom Evaluation (NOSE) dan Epworth Sleepiness Scale (ESS), secara objektif menilai perbedaan parameter polisomnografi (PSG) dan Drug Induce Sleep Endoscopy (DISE) dengan melihat perbedaan lokasi, konfigurasi dan derajat sumbatan jalan napas atas sebelum dan sesudah pembedahan hidung endoskopik. Metode: Penelitian ini menggunakan desain pre-eksperimental jenis pre-post intervention pada subjek SDB dengan sumbatan hidung yang di dapat dengan total population sampling. Pengumpulan data sebelum pembedahan diperoleh secara sekunder (nilai kuesioner, PSG, video DISE) dan data evaluasi sesudah pembedahan diperoleh secara primer selama rentang waktu Agustus 2019 hingga Desember 2019. Hasil: Terdapat perbedaan bermakna pada parameter subjektif menggunakan skor NOSE (p=0,005) dan ESS (p=0,003) dan objektif pada parameter PSG untuk sleep architechture yaitu REM sleep (p=0,020). Belum terdapat kemaknaan secara statistik untuk parameter respiratory disturbance index (RDI), respiratory effort related arousal (RERA),deep sleep, light sleep. Perbedaan secara statistik untuk parameter DISE belum dapat dibuktikan namun terdapat perbaikan secara klinis pada lokasi derajat dan konfigurasi kolaps pada beberapa subjek setelah pembedahan terutama pada level velum dan orofaring. Diperlukan penelitian lanjutan untuk parameter-parameter tersebut dengan jumlah sampel sesuai hasil akhir hitung ulang jumlah sampel pada penelitian ini.

---

Background : Previous studies mentioned that nasal surgery can improve subjective complaints and improve quality of life in patients with sleep disordered breathing (SDB), but objectively assessed by polysomnography there is still controversy. Another evaluation is needed, drug induced sleep endoscopy (DISE) is a tool that can evaluate according to the primary pathophysology of SDB, the presence of airway collapse during sleep. Objective : to find out the success rate of endoscopic nasal surgery in SDB patients with nasal obstruction by subjectively assessing differences in scores of Nasal Obstruction Symptom Evaluation (NOSE) and Epworth Sleepiness Scale (ESS), objectively assessing differences in polysomnographic parameters (PSG) and Drug Induce Sleep Endoscopy (DISE) by looking at differences in location, configuration and degree of upper airway obstruction before and after endoscopic nasal surgery. Method: This is pre-experimental study design type of pre-post intervention on SDB subjects with nasal obstructions obtained with total population sampling. Data collection before surgery was obtained secondary (questionnaire values, PSG, DISE video) and evaluation data after surgery were obtained primarily during the period of August 2019 to December 2019. Result : There were significant differences in subjective parameters using NOSE scores (p = 0.005) and ESS (p = 0.003) and objective in PSG parameters for sleep architechture, namely REM sleep (p = 0.020). There is no statistical significance for the respiratory disturbance index (RDI) parameters, respiratory related related arousal (RERA) parameters, deep sleep, light sleep. The statistical difference for DISE parameters has not been proven yet but there is a clinical improvement in the degree location and collapse configuration in some subjects after surgery, especially at the velum and oropharyngeal level. Further research is needed for these parameters with the number of samples in accordance with the final results recalculate the number of samples in this study."

"Latar Belakang: HER2 merupakan protoonkogen menjadi dasar pemberian terapi sel target pada adenokarsinoma gaster stadium lanjut. Penelitian hubungan antara gambaran klinis, endoskopi dan histopatologi dengan ekspresi HER2 masih menunjukkan hasil yang berbeda. Penelitian tentang HER2 sebagai prediktor kesintasan juga menunjukkan hasil yang berbeda. Penelitian ini bertujuan untuk mengetahui hubungan gambaran klinis, endoskopi, histopatologi dengan ekspresi HER2 dan hubungan antara ekspresi HER2 dengan kesintasan dua tahun.Metode: Penelitian kohort retrospektif pada subyek adenokarsinoma gaster yang baru terdiagnosis, berusia ³ 18 tahun di 4 rumah sakit di Jakarta, berobat dari 2015-2019, memenuhi kriteria inklusi: memiliki rekam medis yang lengkap, hasil pemeriksaan gastroskopi, blok parafin hasil biopsi. Slide biopsi diwarnai dengan pewarnaan imunohistokimia HER2 dan diinterpretasi dengan kriteria ToGA. Analisis statistik deskriptif dan bivariat dengan menggunakan chi square/tes fisher untuk menilai hubungan antara gambaran klinis, endoskopi, dan histopatologi dengan ekspresi HER2. Analisis kesintasan, bivariat dan multivariat dengan Cox-regresi menentukan pengaruh ekspresi HER2 terhadap kesintasan dua tahun.Hasil: Ekspresi HER2 positif ditemukan pada 12,3% subyek (15 dari 122 subyek). Ekspresi HER2 cenderung lebih tinggi pada metastasis ke hati, klasifikasi Borrman tipe I/II, diferensiasi baik/sedang, tipe intestinal berdasarkan Klasifikasi Lauren memiliki dengan proporsi masing-masing: 17.6% RR(IK95%)=1.726 (0.665-4.480), 16.1% RR(IK95%)=1,768(0,670-4,662), 14.3% RR(IK95%)=1,304(0,505-3,363), 13.9% RR(IK95%)=1,389(0,505-3,817).Ekspresi HER2 positif tidak berhubungan dengan kesintasan dua tahun, HR (IK95%)=1,12(0,609-2,058).Simpulan: Matastasis hati, klasifikasi Borrman, letak tumor, diferensiasi tumor dan klasifikasi Lauren tidak berhubungan bermakna secara statistik terhadap ekspresi HER2. Ekspresi HER2 positif tidak berhubungan dengan kesintasan dua tahun pada adenokarsinoma gaster.

---

Background: HER2 is a proto-oncogene which important for administering of target cell therapy in advanced gastric adenocarcinoma. Research on clinical, endoscopic, and histopathological features shown conflicting in association with HER2 expression. Studies on HER2 as a predictor of survival still show different results. This study aims to determine association of the clinical, endoscopic, and histopathological features with HER2 expression and association of HER2 expression with 2-year survival.

Methods: A retrospective cohort study on newly diagnosed gastric adenocarcinoma subjects, aged 18 years old at 4 hospitals in Jakarta, receiving treatment from 2015-2019, meeting the inclusion criteria: having complete medical record, results of gastroscopy examination, and paraffin block tumor biopsy results. The biopsy slides were stained with HER2 immunohistochemical staining and interpreted according to the ToGA criteria. Descriptive and bivariate analysis by using chi-square or fisher's test assessed the relationship between clinical, endoscopic, and histopathological features with HER2 expression. Survival, bivariate and multivariate analysis with cox regression method were used to determine the effect of HER2 expression on 2-year survival.

Results: Positive HER2 expression was found in 12.3% of subjects (15 of 122 subjects). HER2 expression tends to be higher in metastases to the liver, Borrman classification type I/II, good/moderate differentiation, intestinal type based on Lauren's classification has the respective proportions:17.6% RR (95%CI)=1.726 (0.665-4.480), 16.1% RR (95%CI)=1,768 (0,670-4,662), 14.3% RR (95%CI)=1,304 (0,505-3,363), 13.9% RR (95%CI)=1,389 (0,505-3,817). Positive HER2 expression was not associated with 2-year survival with HR (95%CI) =1.12 (0.609-2.058)."

"Endoscopic procedure is commonly used to make diagnosis or therapy. Endoscopy has risk on the procedure or after the procedure. Patient with antithrombotic therapy, both antiplatelet and/or anticoagulant, for underlying diseases has higher risk for bleeding and thromboembolic events in this procedure. The physician should consider risk and benefit for adjusting the antithrombotic therapy, in addition to minimize bleeding and thromboembolic events. For low risk procedure, adjustments in antithrombotic therapy usually not necessarily needed. For high risk procedure, there are several adjustments based on the type of medication and patient’s condition in specific. European Society of Gastrointestinal Guidelines Endoscopy (ESGE) and British Society of Gastrointestinal (BSG); American Society of Gastrointestinal Endoscopy (ASGE); and lastly Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) have published guidelines to help physician to make decisions regarding antithrombotic therapy management during endoscopy. This article compares and contrasts the approach of each guideline, in design to help the decision-making process. However, each patient’s clinical condition may differ from one to another and should be considered carefully in making a final decision

---

Prosedur endoskopi seringkali digunakan untuk mendiagnosis ataupun terapi. Endoskopi memiliki risiko baik saat prosedur maupun setelah prosedur. Pasien dengan terapi antitrombotik, baik antiplatelet dan/atau antikoagulan, sebagai terapi penyakit yang mendasari memiliki risiko tinggi untuk perdarahan dan tromboemboli pada prosedur ini. Dokter perlu mempertimbangkan risiko dan keuntungan untuk melakukan penyesuaian pada terapi antitrombotik, dengan tujuan untuk menurunkan risiko perdarahan dan tromboemboli. Untuk prosedur risiko rendah, pada umumnya tidak memerlukan penyesuaian terapi. Untuk prosedur risiko tinggi, ada beberapa penyesuaian berdasarkan tipe medikasi dan kondisi pasien secara spesifik. European Society of Gastrointestinal Guidelines Endoscopy (ESGE) dan British Society of Gastrointestinal (BSG); American Society of Gastrointestinal Endoscopy (ASGE); dan terakhir Asian Pacific Association of Gastroenterology (APAGE) dan Asian Pacific Society for Digestive Endoscopy (APSDE) telah mengeluarkan panduan untuk membantu dokter dalam mengambil keputusan pada kasus pasien endoskopi dengan terapi antitrombotik. Artikel ini bertujuan untuk membandingkan setiap pedoman untuk memudahkan proses pengambilan keputusan. Walapun demikian, kondisi pasien dapat berbeda satu sama lain, sehingga pengambilan keputusan akhir perlu dipertimbangkan secara cermat pada setiap kondisi pasien"

"This publication is dedicated to all the aspects involved in the endoscopic diagnosis of terminal ileum. The most experienced endoscopists, gastroenterologists and pathologists will focus on and discuss the principles of diagnosis and treatment of the main pathologies involved in this district. The technique of ileoscopy with all the newest advances in endoscopic imaging will be discussed. Another chapter will be dedicated to the possible flow chart of diagnosis of the principles diseases after ileoscopy, from capsule endoscopy to double balloon ileoscopy. A final session will be completely aimed at presenting clinical cases of relevant interest."