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Purwowibowo
Program Pascasarjana Universitas Indonesia, 2008
T24256
UI - Tesis Open  Universitas Indonesia Library
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Purwowibowo
"Akurasi adalah nilai yang menyatakan tingkat kebenaran hasil pengukuran sesuai dengan standard. Untuk mengetahui akurasi sebuah linear transducer diperlukan kalibrasi. Namun sering ditemukan, setelah dilakukan kalibrasi, akurasinya sudah keluar dari batas toleransi yang diijinkan, sehingga tidak layak digunakan lagi. Agar dapat digunakan kembali, perlu dilakukan perbaikan, sayangnya perbaikan secara hardware sangat mahal. Disini disampaikan rancangan metode perbaikan akurasi menggunakan software, dengan memanfaatkan data kalibrasi yang diproses dengan genetic algorithm. Keuntungannya adalah, hanya dengan memasukan data kalibrasi ke software untuk diolah menjadi parameter koreksi. Kemudian diprogramkan ke microcontroller sebagai kompensator maka akan segera diperoleh hasil peningkatan akurasinya.
Dalam metode peningkatan akurasi ini, linear transducer didekati hanya dengan monomial dengan membagi sepanjang linear transducer menjadi segmen-segmen kecil dengan suatu algoritma khusus, kemudian dibentuk chromosome untuk monomial pada genetic algorithm (GA) dengan parameternya berupa bilangan integer untuk memudahkan pemrograman pada microcontroler. Kemudian melakukan modifikasi internal GA khususnya pada selection dan crossover operator. Dalam penelitian ini selection operator yang digunakan adalah stochastic universal sampling, dan crossover operator adalah multi point, ternyata kombinasi kedua operator tersebut menghasilkan nilai sum of squares error (SSE) terbaik, sekitar 68.6% dari SSE rata rata.
Langkah berikutnya menerapkan metode elitisasi dengan memasukan kembali sebagian elite chromosome ke populasi generasi berikutnya. Dari percobaan diperoleh bahwa dengan 10% elite chromosome menghasilkan nilai root mean squared (RMS) lebih baik yaitu sekitar 38.9 % dari RMS rata rata.
Untuk meningkatkan kinerja GA dilakukan segmentasi sepanjang linear transducer. Segmentasi adalah membatasi rentang kerja dengan membagi daerah kerja menjadi beberapa segmen kecil menggunakan nilai golden ratio (GR). Hasilnya ternyata, golden ratio segmentation method mempunyai kinerja lebih tinggi bila dibandingkan dengan hierarchical segmentation method. Nilai RMS menjadi sekitar 49.0% dan jumlah segmen sekitar 85.9%.
Selanjutnya untuk mengetahui kinerja metode peningkatan akurasi yang merupakan gabungan dari genetic algorithm dan golden ratio (GA-GR) dilakukan simulasi. Tujuannya adalah untuk meyakinkan bahwa algoritma yang dikembangkan telah berjalan sesuai dengan tujuan penelitian. Dalam simulasi, GA-GR digunakan untuk tracking kurva karakteristik linear transducer. Hasilnya, nilai RMS dari metode GA-GR sekitar 50 - 900 kali lebih baik dari pada menggunakan polinomial.
Kemudian untuk mengetahui hasil nyata metode GA-GR dalam meningkatkan akurasi, maka dilakukan percobaan pada linear transducer yang dipasang pada mechanical positioning system, lalu dilakukan kalibrasi menggunakan standard laser interferometer system calibrator dan prosedur British Standard BS 4656. Hasilnya diperoleh bahwa metode GA-GR dapat meningkatkan akurasi sampai dengan 45.1%.
Accuracy is the value stating the true level of a measurement result according to the standard. To find out the accuracy of linear transducer, calibration is required. However, it is often found that after calibration is done, the accuracy is out of the permitted tolerance limit. Therefore, it is no longer appropriate to be used. In order to make it useable again, repair is needed to be done but hardware repair is definitely very costly. This dissertation designs a method to increase accuracy by using software, by utilizing calibration data processed by genetic algorithm (GA). The advantage is that it simply needs to enter the calibration data in the software to be processed as correction parameter and the procedure is to be programmed in the microcontroller as the compensator. Then it will soon get the result of the accuracy increment as required.
In this method, the linear transducer is tracked by using only monomial form each small segment of the transducer along its length with a special method of segmenting the linear transducer. Then using the GA to find the parameters of the monomial by putting them into the form of chromosome. To ease the programming in the microcontroller, the parameter values only use integer numbers. The next step the GA internal mechanism is modified, especially in the selection and crossover operators. In this research, the selection operator used is stochastic universal sampling, while the crossover operator is multi point because the combination of those two operators produces the best sum of squares error (SSE), around 68.6% from the average SSE.
The following step is to apply the elitism method by re-entering a subset of elite chromosomes to the next generation population. From the experiments, it can be seen that by re entering 10% of elite chromosomes it will produce better root mean squared (RMS) value, which is around 38.9% from the average RMS.
To increase the GA performance, segmentation a long the length of the linear transducer is done. Segmentation means limiting the work span by dividing the working area into several segments using golden ratio (GR). The result shown that, the golden ratio segmentation method has a higher performance if compared to that with the hierarchical segmentation method. The value of RMS becomes around 49.0% and the number of segments is around 85.9%
Furthermore, to find out the performance of the accuracy increase method which is a combination of genetic algorithm and golden ratio (GA-GR), simulation is conducted. The aim is to make is to make sure that the development algorithm runs in accordance with the objective of the research. In the simulation, GA-GR is used for tracking the curve characteristics of linear transducer. The result is the value of RMS from the GA-GR method is around 50 to 900 times better than using polynomial.
Moreover, to find out the real result of the GA-GR method in increasing accuracy, an experiment on linear transducer on the mechanical positioning system is conducted, using the standard laser interferometer system calibrator and the procedure of British Standard BS 4656. The result obtained is that the GA-GR method can increase accuracy up to 45.1%.
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Depok: Fakultas Teknik Universitas Indonesia, 2008
D1190
UI - Disertasi Open  Universitas Indonesia Library
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Muhammad Yudistira Hanifmuti
"Morphological analyzer merupakan sebuah alat yang digunakan untuk melihat bagaimana proses pembentukan kata, menentukan kata dasar pembentuk, dan menge- tahui informasi linguistik yang terkandung pada suatu kata. Universal Dependencies (UD) merupakan sebuah framework acuan yang digunakan pada proses anotasi morfologi untuk berbagai bahasa. Sayangnya, belum ditemukan morphological analyzer untuk bahasa Indonesia yang menerapkan pedoman UD ini. Penelitian ini mengembangkan morphological analyzer untuk bahasa Indonesia yang diberi nama Aksara. Aksara dibangun menggunakan finite state compiler bernama Foma yang digunakan pada Mor- phind, morphological analyzer pada penelitian sebelumnya. Foma dapat memodelkan aturan-aturan pembentukan kata dalam bentuk finite state transducer. Pada Aksara juga dikembangkan tokenizer yang hasilnya menyesuaikan dengan hasil tokenisasi pada treebank UD. Implementasi Aksara menerapkan pedoman UD versi terbaru yaitu UDv2. Pengujian Aksara dilakukan dengan membandingkan performa Aksara dengan Morhpind. Hasil pengujian menunjukkan bahwa komponen tokenizer Aksara berhasil memiliki akurasi tokenisasi sebesar 96.60%, meningkat 23.89% dari akurasi tokenisasi oleh Mor- phind. Evaluasi POS tagging Aksara juga berhasil melewati hasil pemetaan Morphind dengan akurasi F1-score sebesar 87%, dengan kenaikan relatif sebesar 18% dari baseline.

Morphological analyzer is a tool used to do an analysis on word formation process, to identify the lemma for each word, and to do an analysis on the linguistic information. Universal Dependencies (UD) is a framework commonly used in morphological annota- tion process. Unfortunately, there is not a single Indonesian morphological analyzer that applies UDv2. This research is a development of morphological analyzer for Indonesian language named Aksara. Aksara was build using finite state compiler named Foma, which was used in Morphind, the previous research on Indonesian morphological analyzer. Foma can model the rules of word formation which is represented in the form of finite state transducer. This research also develops a tokenizer which its results are adjusted to the tokenization example on UD treebank. The Aksara implementation applies the latest UD guidelines, UDv2. Testing of Aksara is done by comparing the performance of Aksara with Morphind. The test results show that the tokenizer component of Aksara managed to have a tokenization accuracy of 96.60%, an increase of 23.89% from the accuracy of tokenization by Morphind. Evaluation of POS tagging with Aksara also managed to pass Morphind with an accuracy of F1-score of 87%, with a relative increase of 18% from the accuracy of Morphind."
Depok: Fakultas Ilmu Komputer Universitas Indonesia, 2020
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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"Telah diperoleh peningkatan akurasi prediksi curah hujan bulanan di wilayah Jakarta yang ditandai dengan peningkatan nilai koefisien korelasi data Tropical Rainfall Measuring Mission (TRMM) hasil simulasi jaringan syaraf tiruan. Dengan melibatkan faktor sinar kosmik sebagai masukan jaringan, diperoleh peningkatan akurasi sampai dengan 7,2% yang dicapai saat prediksi lima bulan ke depan. Untuk prediksi tiga dan empat bulan ke depan peningkatan akurasi yang diperoleh sebesar 4,8%. Hasil ini melengkapi bukti adanya kontribusi sinar kosmik dalam mempengaruhi curah hujan di wilayah Jakarta.
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600 JADIR 11:1 (2013)
Artikel Jurnal  Universitas Indonesia Library
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Hans Wibowo Putra
"Pengukuran arus dapat diartikan sebagai kegiatan mengukur arus yang mengalir melalui sebuah rangkaian tertutup. Hal ini dapat dilakukan dengan berbagai metode, sebagai contoh dengan menggunakan ampere-meter, trafo arus (trafo penurun tegangan), meter jepit. Metode yang paling umum diketahui adalah dengan menggunakan ampere-meter, dikarenakan oleh faktor teknik dan ekonomi. Namun, ada sebuah fenomena alam yang disebut Efek Hall yang dapat membawa pembaruan dalam mengukur arus. Efek Hall adalah perbedaan tegangan diantara konduktor elektrik, hasil dari perubahan arus listrik di konduktor dan medan magnet yang tegak lurus dengan arus. Kelebihan menggunakan metode ini dalam mengukur arus ialah tahan terhadap debu, kotoran, lumpur, dan air. Karakteristik ini yang membuat alat Efek Hall lebih baik dalam penginderaan optic dan elektromekanik. Efek ini diaplikasikan di dalam alat yang disebut transduser arus. Proyek ini bertujuan untuk melakukan eksperimen menggunakan transduser arus dan toroidal. Toroida dibuat dan diuji untuk memperagakan dan mensimulasikan keadaan di dalam transduser arus dengan menggunakan berbagai macam resistansi dan ukuran toroid, sehingga hasil dari kedua buah alat dapat dibandingkan. Hasil yang diinginkan dari proyek ini adalah pengertian mengenai cara kerja transduser arus dan toroidal termasuk efek memagnetisasi dan demagnetisasi, termasuk membandingkan hasil dari toroida dengan transduser arus. Software skema dan software untuk merancang PCB juga digunakan sebagai bagian dari proyek, bersamaan dengan eksperimen dan simulasi.

Current measurement is defined as measure current that flows through a closed circuit. This measurement can be done in many ways, such as using an ammeter, current transformer (step down transformer), clamp meter, etc. The most commonly known techniques of measuring current are using an ammeter, because of technical and economic reasons. However, there is a natural phenomenon called Hall Effect that can lead a new way of measuring current. The Hall Effect is the production of a voltage difference across an electrical conductor, transverse to an electric current in the conductor and a magnetic field perpendicular to the current. The advantage of using this method to measure a current is immune to dust, dirt, mud, and water. These characteristics make Hall Effect devices better for optical and electromechanical sensing. This effect is applied in a device called current transducer. This project is aimed to conduct experiments using the current transducer and toroidals. The toroidals were used to replicate and simulate the inside of the current transducer in various resistance and diameter of toroid condition, so the results from both devices can be compared. The expected outcomes of this project are the understanding of the operation of current transducer and toroidals including the magnetized and demagnetized effect. Schematics software and PCB design software are performed as part of this project, along with experiments, calculation, and simulations."
Depok: Fakultas Teknik Universitas Indonesia, 2013
S44660
UI - Skripsi Membership  Universitas Indonesia Library
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Azzahra Adelia Armando
"Latar Belakang: Estimasi usia dalam kedokteran gigi forensik memiliki peran penting dalam identifikasi individu dan penentuan status hukum seseorang. Metode estimasi usia menggunakan rasio panjang dan lebar pulpa (PL/W) pada gigi insisif lateral maksila melalui radiograf panoramik digital telah dikembangkan, namun akurasinya pada berbagai kelompok usia masih perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk menganalisis korelasi antara rasio PL/W dengan usia kronologis, validitas persamaan regresi yang dihasilkan, dan akurasi metode PL/W pada berbagai kelompok usia dalam estimasi usia. Tujuan: Penelitian ini bertujuan untuk menganalisis akurasi metode estimasi usia kronologis menggunakan rasio panjang dan lebar pulpa (PL/W) pada insisif lateral maksila melalui radiograf panoramik pada berbagai kelompok usia. Metode Penelitian: Penelitian cross-sectional dilakukan pada 125 subjek (75 laki-laki, 50 perempuan) berusia 18-60 tahun menggunakan radiograf panoramik digital. Pengukuran panjang pulpa (PL) dan lebar pulpa (W) dilakukan pada insisif lateral maksila menggunakan software NOVApacs dan i-Dixel. Analisis statistik meliputi uji reliabilitas, korelasi, regresi linear, dan validasi model. Hasil Penelitian: Metode rasio PL/W menunjukkan korelasi positif yang kuat dengan usia kronologis. Model regresi menunjukkan tingkat akurasi yang moderat, dengan hasil terbaik pada kelompok usia 30-39 tahun. Estimasi usia pada kelompok perempuan lebih akurat dibandingkan laki-laki. Kesimpulan: Metode rasio PL/W pada insisif lateral maksila dapat digunakan sebagai metode alternatif untuk estimasi usia pada populasi Indonesia, dengan akurasi terbaik pada kelompok usia 30-39 tahun. Namun, diperlukan penelitian lanjutan dengan distribusi sampel yang lebih seimbang untuk validasi lebih lanjut.

Background: Age estimation in forensic dentistry plays a crucial role in individual identification and legal status determination. The age estimation method using pulp length and width ratio (PL/W) on maxillary lateral incisors through digital panoramic radiographs has been developed; however, its accuracy across different age groups requires further investigation. This study aimed to analyze the correlation between PL/W ratio and chronological age, the validity of the resulting regression equation, and the accuracy of the PL/W method across different age groups in age estimation. Objective: This study aimed to analyze the accuracy of chronological age estimation using pulp length and width ratio (PL/W) on maxillary lateral incisors through panoramic radiographs across different age groups. Methods: A cross-sectional study was conducted on 125 subjects (75 males, 50 females) aged 18-60 years using digital panoramic radiographs. Pulp length (PL) and width (W) measurements were performed on maxillary lateral incisors using NOVApacs and i-Dixel software. Statistical analysis included reliability testing, correlation, linear regression, and model validation. Results: The PL/W ratio method showed a strong positive correlation with chronological age. The regression model demonstrated a moderate predictive capability, with better accuracy in the 30-39 age group. Females had a lower estimation error compared to males. Conclusion: The PL/W ratio method on maxillary lateral incisors can be used as an alternative method for age estimation in the Indonesian population, with the best accuracy in the 30-39 age group. However, further research with a more balanced sample distribution is needed for further validation."
Depok: Fakultas Kedokteran Gigi Universitas Indonesia, 2025
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UI - Skripsi Membership  Universitas Indonesia Library
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Melani Syafridhal
"ABSTRAK
Breakwater adalah bangunan penahan gelombang yang memiliki karakteristik pekerjaan yang bersifat repetitif dalam volume yang besar. Karakteristik dari proyek ini menuntut perencana untuk membuat suatu metode perencanaan penjadwalan yang berbeda dari bentuk metode biasa seperti CPM dan bar chart, dimana metode ini tidak cocok untuk penjadwalan pekerjaan yang repetitif. Metode penjadwalan yang cocok untuk digunakan dalam pembangunan proyek yang bersifat repetitif ialah metode penjadwalan linier. Penelitian ini bertujuan untuk mengaplikasikan metode penjadwalan linier dengan pendekatan multi-objective genetic optimization menggunakan software Evolver pada pembangunan breakwater di Pelabuhan Kalibaru. Pengoptimalisasian ditinjau dari segi jumlah tim pekerja dan total interupsi pekerjaan yang akan meminimalisasikan total durasi dan biaya proyek. Setelah dilakukan pengaplikasian dengan menggunakan metode ini, terjadi penurunan durasi sebesar 31,79% dan penurunan biaya sebesar 3,04%. Metode ini dapat digunakan dalam pengaplikasian dan pengoptimalisasian pembangunan breakwater di Pelabuhan Kalibaru.

ABSTRACT
Breakwater is a wave barrier building which has the characteristic of repetitive work in large volume of activities. Characteristics of this project requires planners to make a method of scheduling that is different from the usual form of scheduling method such as CPM and bar chart, where this method is not suitable for scheduling repetitive work. The scheduling method that suitable for repetitive construction project is linear scheduling method.This study aims to apply the linear scheduling method with multi-objective genetic optimization approach using Evolver software in breakwater Kalibaru Port construction. Optimizing in terms number of crew and total work interuption that will minimize total project duration and cost. After the application of this method, there is a decrease in duration of 31,79% and an impairment charge of 3,04%. This method can be used in application and optimization breakwater Kalibaru Port construction."
2014
S56036
UI - Skripsi Membership  Universitas Indonesia Library
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Agam Aidil Fahmi
"ABSTRAK
Karya tulis ini melaporkan hasil proses pembentukan nanopartikel Ba0.7Sr0.3TiO3 dan Ba0.3Sr0.7TiO3 melalui pemaduan mekanik dan destruksi ultrasonik daya tinggi. Proses destruksi ultrasonik dilaksanakan dalam 3 kondisi berbeda yaitu menggunakan variasi rasio diameter transduser dan reaktor 1:1.4, 1:1.6, dan 1:1.8 terhadap media mengandung partikel kosentrasi 3.0 gr/l selama waktu destruksi 3 jam. Secara spesifik, tujuan dari penelitian ini adalah mempelajari efek rasio diameter transduser dan diameter reaktor (dt/Dr) terhadap pembentukan nanopartikel Ba0.7Sr0.3TiO3 dan Ba0.3Sr0.7TiO3. Karakterisasi partikel yang diperoleh menggunakan XRD, PSA, dan SEM. Hasil identifikasi fasa material dari evaluasi difraksi sinar X memastikan bahwa material Ba0.7Sr0.3TiO3 dan Ba0.3Sr0.7TiO3 adalah material berfasa tunggal dan destruksi ultrasonik tidak menyebabkan perubahan fasa material. Kedua material berbeda dalam ukuran rata-rata partikel sebelum destruksi ultrasonik yaitu 538 nm untuk partikel Ba0.7Sr0.3TiO3 dan 480 nm untuk partikel Ba0.3Sr0.7TiO3. Kedua nilai ukuran rata-rata partikel ini mengalami penurunan selama proses destruksi ultrasonik. Namun, ukuran partikel terkecil masing-masing material adalah 38 nm dan 24 nm diperoleh pasca destruksi dengan (dt/Dr) adalah 1.8. Ukuran rata-rata partikel ini hampir sama dengan ukuran rata kristalitnya masing-masing 22 nm dan 14 nm. Dengan demikian hanya terdapat 1 kristalit dalam masing-masing partikel. Dapat disimpulkan bahwa nanopartikel baik material Ba0.7Sr0.3TiO3 maupun Ba0.3Sr0.7TiO3 dapat dihasilkan dari dua tahapan proses yaitu tahapan sintesis dengan pemaduan mekanik dan tahapan destruksi dengan metode destruksi ultrasonik daya tinggi. Partikel monokristalit Ba0.7Sr0.3TiO3 dengan ukuran 38 nm dan Ba0.3Sr0.7TiO3 dengan ukuran 24 nm telah dihasilkan dari destruksi ultrasonik menggunakan parameter proses (dt/Dr) 1.8 dalam durasi destruksi selama 3 jam.

ABSTRACT
We report results of research on the formation of Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 nanoparticles through the mechanical alloying process and followed by high power ultrasonic destruction. Ultrasonic destruction process carried out in three different modes of the transducer and reactor diameter ratios respectively 1:1.4, 1:1.6, and 1:1.8 against the media containing particles of 3.0 g/l concentration during 3 hours destruction time. The specific goal of this work was to study the effect of transducer and reactor diameter ratio (dt/Dr) on the formation of Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 nanoparticles. Particle characterizations were carried out under the employment of XRD, PSA, and SEM. Results of material phase identification by XRD ensure that the synthesized Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 material are both single phase. In addition, the ultrasonic destruction to the particle materials did not cause the phase change. Prior to ultrasonic destruction, the two materials are different in their average particle size in which Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 respectively has particles with mean sizes 538 nm and 480 nm. The average value for both particles was decreased during ultrasonic destruction. However, the smallest mean particle size of each material was 38 nm and 24 nm which were obtained after the ultrasonic destruction by (dt/Dr) of 1.8. These average sizes are almost equal to the average size of their crystallites which are respectively 22 nm and 14 nm. Thus there is only one crystallite within each particle. It can be concluded that both Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 nanoparticles can be produced by a two-stage process. The first stage is a phase formation by mechanical alloying and the formation of Ba0.7Sr0.3TiO3 and Ba0.3Sr0.7TiO3 nanoparticle obtained in the second stage in which the particle sizes were further reduced by the high power ultrasonic destruction. Single crystallite particles with a mean size of 38 nm for Ba0.7Sr0.3TiO3 and that of 24 nm for Ba0.3Sr0.7TiO3 have been successively obtained by ultrasonic destruction process with a parameter (dt/Dr) of 1.8 within 3 hours destruction time."
[;Unversitas Indonesia. Fakultas Ilmu Pengetahuan Alam, Unversitas Indonesia. Fakultas Ilmu Pengetahuan Alam], 2015
S59835
UI - Skripsi Membership  Universitas Indonesia Library
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Annisa Sri Devi
"ABSTRAK
Kanker payudara merupakan penyebab kematian pertama akibat kanker pada wanita. Pria juga dapat terkena kanker payudara. Penanganan kanker payudara terdiri dari operasi, terapi radiasi, dan terapi sistemik yang menggunakan obat. World Health Organization WHO telah mendaftarkan tiga puluh cytotoxic dan obat antikanker untuk mencegah dan mengurangi kanker payudara. Para ilmuwan sudah berusaha untuk menemukan obat lain untuk membantu orang yang terkena kanker payudara. Oleh karena itu, desain obat menjadi penting dalam menemukan obat baru yang potensial untuk menangani kanker payudara. Pada skripsi ini diajukan pendekatan multiple linear regression MLR menggunakan metode quantitative structure activity relationship QSAR untuk memodelkan desain obat kanker payudara dengan pemilihan variabel menggunakan metode algoritma genetika GA . Data yang diperoleh dari bank protein umum lebih sedikit dibandingkan banyaknya variabel, yang menyebabkan asumsi Analisis MLR gagal dan menyebabkan multikolinearitas. Model QSAR diragukan saat terjadi multikolinearitas. Algoritma Genetika GA diimplementasikan untuk menghilangkan multikolinearitas. GA bertindak sebagai penyeleksi variabel untuk mencari variabel yang signifikan dan membantu mendapatkan model QSAR yang paling cocok. Hasil eksperimen menunjukkan bahwa GA dan MLR dapat diimplementasikan pada desain obat kanker payudara.

ABSTRACT
Breast cancer is the first cause of death by cancer in women. Even so, men could have breast cancer. In the treatment of breast cancer there are surgery, radiation therapy and systemic therapy which treatments using drugs. World Health Organization WHO has listed thirty cytotoxic and anticancer drugs to prevent and reduce breast cancer risk. Researchers have been trying to find other drugs to help people with breast cancer. Thus, drug design becomes more important in discovering new potential drugs to treat breast cancer. In this study, we proposed multiple linear regression MLR approach using quantitative structure activity relationship QSAR method for modelling drug design of breast cancer with variable selection using genetic algorithm GA. The obtaining data from public protein bank leads to have lower number of compounds than the number of variables, it failed the assumptions of MLR analysis and led to multicollinearity. QSAR model appeared uncertain when multicollinearity arise. We implemented genetic algorithm GA to resolve multicollinearity. GA acted as a variable selector to obtain the most significant variables and helped getting the most fitted QSAR model. The experimental result shows that combining of GA and MLR can be implemented in breast cancers drug design."
2018
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Weny Yusnita
"ABSTRAK
Latar belakang: Fibroadenoma dan tumor filodes jinak merupakan tumor
fibroepitelial dengan gambaran histopatologik yang tumpang tindih. Saat ini
banyak pengambilan jaringan tumor payudara secara core biopsy, termasuk pada
tumor fibroepitelial. Jumlah jaringan yang sedikit dan gambaran histopatologik
yang tumpang tindih sering menyulitkan Dokter Spesialis Patologi Anatomik
dalam menentukan diagnosis fibroadenoma dan tumor filodes jinak. Penelitian ini
bertujuan untuk mengetahui gambaran histopatologik apa saja yang bermakna
untuk mendiagnosis fibroadenoma dan tumor filodes jinak dan untuk menguji
apakah diagnosis fibroadenoma dan tumor filodes jinak pada core biopsy dengan
menggunakan sistem skoring lebih baik dibandingan tanpa skoring.
Bahan dan cara: Penelitian ini merupakan suatu uji diagnostik. 57 kasus
fibroadenoma dan tumor filodes jinak yang memiliki slaid core biopsy dan
mastektomi/lumpektomi/eksisi dinilai ulang tanpa sistem skoring dan
menggunakan skoring. Gambaran histopatologik yang dinilai pada sistem skoring
adalah selularitas stroma, atipia inti, fragmentasi jaringan, infiltrasi lemak, mitosis
dan heterogenitas stroma. Kemudian dilakukan analisis statistik, uji diagnostik
dan uji kappa.
Hasil: Selularitas stroma, heterogenitas stroma dan fragmentasi jaringan lebih
sering ditemukan pada tumor filodes jinak dan berbeda bermakna (p=0,001;
p=0,000; p=0,021). Spesifisitas pada sistem skoring meningkat sebesar 17,9%.
Nilai duga positif dan nilai duga negatif pada sistem skoring meningkat sebesar
11,9% dan 5,1%. Area under curve (AUC) meningkat 8,9%. Uji Cohen?s kappa
antara diagnosis core biopsy tanpa dan dengan skoring bernilai rendah (0,545).
Kesimpulan: Adanya peningkatan spesifisitas, nilai duga positif dan AUC
menunjukkan bahwa penilaian core biopsy sistem skoring lebih baik
dibandingkan tanpa skoring dan dapat menjadi acuan untuk diagnosis fibroadenoma dan tumor filodes jinak.
ABSTRACT
Background: Fibroadenoma and benign phyllodes tumor are kinds of fibroepithelial tumor which have overlapping histopathological features. Recently, core biopsy is commonly performed to determine breast tumor, including fibroepithelial tumor. Small amount of tissue and overlapped histopathological features often complicate the Pathologist in diagnosing both. This study aims to describe the histopathological appearance which needed to diagnose fibroadenoma and benign phyllodes tumor and to verify if the diagnosis of fibroadenoma and benign phyllodes tumor in core biopsy using scoring system is more accurate than without scoring system.
Method: This study was a diagnostic test, in which 57 cases of fibroadenoma and benign phyllodes tumor which had undergone core biopsy and mastectomy/excision were re-assessed using and without using scoring system. Histopathologic features which assessed using scoring system were stromal cellularity, nuclear atypia, tissue fragmentation, fat infiltration, mitotic figure, stromal heterogeneity. Analytical statistic, diagnostic test, accuracy test and Kappa test were done.
Results: Stromal cellularity, stromal heterogeneity and tissue fragmentation mostly found in benign phyllodes tumor and significantly different (p=0,001; p=0,000; p=0,021).There were significant differences between stromal cellularity (p=0,001), stromal heterogeneity (p=0,000), and tissue fragmentation (p=0,021) in diagnosis of benign phyllodes tumor. Specificity in scoring system increased by
17,9 %. Positive predictive value, negative predictive value and accuracy increased in scoring system (11,9% and 5,1%). Area under curve (AUC) increased by 8,9%. Cohen's Kappa test between core biopsy diagnosis without using and using scoring system had low result(0,545).
Conclusion: The increasing of specificity, positive predictive value, accuracy and AUC proved that core biopsy with scoring system is more accurate than without scoring. This can be used as reference to diagnose fibroadenoma and benign phyllodes tumor.;Background: Fibroadenoma and benign phyllodes tumor are kinds of fibroepithelial tumor which have overlapping histopathological features. Recently, core biopsy is commonly performed to determine breast tumor, including fibroepithelial tumor. Small amount of tissue and overlapped histopathological features often complicate the Pathologist in diagnosing both. This study aims to describe the histopathological appearance which needed to diagnose fibroadenoma and benign phyllodes tumor and to verify if the diagnosis of fibroadenoma and benign phyllodes tumor in core biopsy using scoring system is more accurate than without scoring system.
Method: This study was a diagnostic test, in which 57 cases of fibroadenoma and benign phyllodes tumor which had undergone core biopsy and mastectomy/excision were re-assessed using and without using scoring system. Histopathologic features which assessed using scoring system were stromal cellularity, nuclear atypia, tissue fragmentation, fat infiltration, mitotic figure, stromal heterogeneity. Analytical statistic, diagnostic test, accuracy test and Kappa test were done.
Results: Stromal cellularity, stromal heterogeneity and tissue fragmentation mostly found in benign phyllodes tumor and significantly different (p=0,001; p=0,000; p=0,021).There were significant differences between stromal cellularity (p=0,001), stromal heterogeneity (p=0,000), and tissue fragmentation (p=0,021) in diagnosis of benign phyllodes tumor. Specificity in scoring system increased by
17,9 %. Positive predictive value, negative predictive value and accuracy increased in scoring system (11,9% and 5,1%). Area under curve (AUC) increased by 8,9%. Cohen's Kappa test between core biopsy diagnosis without using and using scoring system had low result(0,545).
Conclusion: The increasing of specificity, positive predictive value, accuracy and AUC proved that core biopsy with scoring system is more accurate than without scoring. This can be used as reference to diagnose fibroadenoma and benign phyllodes tumor.;Background: Fibroadenoma and benign phyllodes tumor are kinds of fibroepithelial tumor which have overlapping histopathological features. Recently, core biopsy is commonly performed to determine breast tumor, including fibroepithelial tumor. Small amount of tissue and overlapped histopathological features often complicate the Pathologist in diagnosing both. This study aims to describe the histopathological appearance which needed to diagnose fibroadenoma and benign phyllodes tumor and to verify if the diagnosis of fibroadenoma and benign phyllodes tumor in core biopsy using scoring system is more accurate than without scoring system.
Method: This study was a diagnostic test, in which 57 cases of fibroadenoma and benign phyllodes tumor which had undergone core biopsy and mastectomy/excision were re-assessed using and without using scoring system. Histopathologic features which assessed using scoring system were stromal cellularity, nuclear atypia, tissue fragmentation, fat infiltration, mitotic figure, stromal heterogeneity. Analytical statistic, diagnostic test, accuracy test and Kappa test were done.
Results: Stromal cellularity, stromal heterogeneity and tissue fragmentation mostly found in benign phyllodes tumor and significantly different (p=0,001; p=0,000; p=0,021).There were significant differences between stromal cellularity (p=0,001), stromal heterogeneity (p=0,000), and tissue fragmentation (p=0,021) in diagnosis of benign phyllodes tumor. Specificity in scoring system increased by
17,9 %. Positive predictive value, negative predictive value and accuracy increased in scoring system (11,9% and 5,1%). Area under curve (AUC) increased by 8,9%. Cohen's Kappa test between core biopsy diagnosis without using and using scoring system had low result(0,545).
Conclusion: The increasing of specificity, positive predictive value, accuracy and AUC proved that core biopsy with scoring system is more accurate than without scoring. This can be used as reference to diagnose fibroadenoma and benign phyllodes tumor.;Background: Fibroadenoma and benign phyllodes tumor are kinds of fibroepithelial tumor which have overlapping histopathological features. Recently, core biopsy is commonly performed to determine breast tumor, including fibroepithelial tumor. Small amount of tissue and overlapped histopathological features often complicate the Pathologist in diagnosing both. This study aims to describe the histopathological appearance which needed to diagnose fibroadenoma and benign phyllodes tumor and to verify if the diagnosis of fibroadenoma and benign phyllodes tumor in core biopsy using scoring system is more accurate than without scoring system.
Method: This study was a diagnostic test, in which 57 cases of fibroadenoma and benign phyllodes tumor which had undergone core biopsy and mastectomy/excision were re-assessed using and without using scoring system. Histopathologic features which assessed using scoring system were stromal cellularity, nuclear atypia, tissue fragmentation, fat infiltration, mitotic figure, stromal heterogeneity. Analytical statistic, diagnostic test, accuracy test and Kappa test were done.
Results: Stromal cellularity, stromal heterogeneity and tissue fragmentation mostly found in benign phyllodes tumor and significantly different (p=0,001; p=0,000; p=0,021).There were significant differences between stromal cellularity (p=0,001), stromal heterogeneity (p=0,000), and tissue fragmentation (p=0,021) in diagnosis of benign phyllodes tumor. Specificity in scoring system increased by
17,9 %. Positive predictive value, negative predictive value and accuracy increased in scoring system (11,9% and 5,1%). Area under curve (AUC) increased by 8,9%. Cohen's Kappa test between core biopsy diagnosis without using and using scoring system had low result(0,545).
Conclusion: The increasing of specificity, positive predictive value, accuracy and AUC proved that core biopsy with scoring system is more accurate than without scoring. This can be used as reference to diagnose fibroadenoma and benign phyllodes tumor."
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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