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"This book about protein-protein Interactions as drug targets, targeting the MDM2-p53 protein-protein interaction for new cancer therapeutics, the development of small-molecule IAP antagonists for the treatment of cancer, protein-protein interaction targets to inhibit HIV-1 infection, inhibitors of protein-protein interactions paramyxovirus fusion ? a focus on respiratory syncytial virus, rational design strategies for developing synthetic inhibitors of helical protein interfaces, and the discovery of navitoclax, a Bcl-2 family inhibitor."

"Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications:* Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins* Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes* Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors* Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting* Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules"

"ABSTRAKPenduduk bumi telah mencapai lebih dari 7 milyar jiwa dan pertumbuhannyaterus meningkat. Kondisi ini menimbulkan tekanan pada penyediaan panganterutama sumber protein. Peternakan konvensional banyak menyebabkanterjadinya degradasi dan pencemaran lingkungan. Masyarakat kawasan karstGunung Sewu (KKGS) dikenal sejak lama memanfaatkan serangga sebagaisumber protein, namun tidak ada data penelitian tentang pemanfaatan serangga.Tujuan penelitian ini adalah mengumpulkan data jenis serangga yangdimanfaatkan sebagai sumber protein pada masyarakat KKGS, menganalisisfaktor yang mempengaruhi konsumsi serangga pada masyarakat KKGS, danmengkaji dampak pemanfaatan serangga sebagai sumber protein pada masyarakatdi KKGS. Penelitian ini menggunakan pendekatan kuantitatif. Pengumpulan datadilakukan dengan observasi lapangan, penyebaran kuesioner, dan wawancarakemudian dilakukan telaah pustaka. Hasil penelitian menunjukkan masyarakat dikawasan Karst Gunung Sewu memanfaatkan 18 jenis serangga yang sebagianbesar berasal dari ordo Coleoptera (kumbang), Orthoptera (belalang dan jangkrik),dan Lepidoptera (kupu-kupu dan ngengat) sebagai sumber protein, karena padamusim tertentu memiliki kelimpahan yang sangat tinggi. Faktor Internal (seranggamempunyai rasa yang enak dan lezat) dan faktor eksternal (lingkungan, ekonomi,dan sosial) mempengaruhi dan saling berkaitan dalam membentuk perilakukonsumsi serangga pada masyarakat di kawasan karst. Pemanfaatan seranggasebagai sumber protein pada masyarakat di kawasan karst Gunung Sewumempunyai dampak yang positif terutama pada aspek lingkungan dan ekonomiyaitu dapat membantu menggantikan peran predator alami serangga yang hilangdan juga mampu meningkatkan perekonomian masyarakat setempat

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ABSTRACTEarth's population has reached more than 7 billion people and its growth continuesto increase. These conditions led to pressure on the provision of food, especiallyprotein sources. Many conventional farms cause environmental degradation andpollution. The community of Gunung Sewu karst area (GSKA) known since longtime been using edible insects as a protein source, but there is no research data onthe use of insects. The purpose of this study is to collect data species of insectused as a protein source on GSKA community, to analyze factors influencing theconsumption of edible insects on GSKA community, and examines the impact useof edible insects as a protein source on GSKA community. This study uses aquantitative approach. The data collection is done by field observations,questionnaires and interviews later conducted literature review. The resultsshowed people in the Gunung Sewu Karst Area use of 18 species of insects arelargely derived from the order Coleoptera (beetles), Orthoptera (grasshoppers andcrickets), and Lepidoptera (butterflies and moths) as a protein source because in aparticular season has an abundance of very high. Environmental factors andeconomic factors, has the highest influence on the consumption of insects inGSKA community. Internal factors (insect has a good flavor and delicious) andexternal factors (environmental, economic, and social) influence and interrelatedin the consumption activities of insects. Utilization of insects as a protein sourcein the GSKA community has a positive effect especially on environmental andeconomic aspects, which can help replace the role of natural predators of insectswere lost and also able to improve the local economy"

"While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. The knowledge in this book will help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area."

"Protein of seaweed . Seeaweds are consumed by people,especially who lived in the coastal areas....."

"Latar Belakang. Prevalensi balita wasting di Provinsi Nusa Tenggara Baratmencapai 10%, hal ini dapat memengaruhi tumbuh kembang anak balita. Hasilpenelitian sebelumnya menyimpulkan bahwa terdapat hubungan antara infeksi danasupan nutrisi terhadap wasting. Penelitian ini ditujukan untuk mengetahuikarakteristik balita, prevalensi wasting, dan asupan karbohidrat, protein, dan lemakserta hubungannya terhadap wasting pada balita di Desa Sembalun Bumbung, NTB.Metode. Studi potong lintang telah dilaksanakan dengan melibatkan 112 balita usia6-59 bulan di Desa Sembalun Bumbung, Kecamatan Sembalun, Lombok Timur,NTB pada Agustus 2019. Data antropometri berupa tinggi badan dan berat badandiukur untuk menentukan status gizi. Wawancara menggunakan kuesionerdilakukan untuk mendapatkan data demografi, sedangkan untuk mendapatkanasupan makronutrien balita menggunakan multiple-pass 2x24 hour food recallterhadap ibu balita. Data antropometri diolah menggunakan WHO Anthro SurveyAnalyser, sedangkan kuesioner diolah dengan bantuan perangkat lunak Epidataversi 4.4. Data asupan makanan dari food recall diolah menggunakan Nutrisurvey2004. Data dianalisis menggunakan uji Fisher’s Exact Test pada SPSS versi 20.Hasil. Prevalensi balita wasting di Desa Sembalun Bumbung adalah 7%. Ujibivariat menyatakan bahwa asupan karbohidrat, protein, dan lemak tidak memilikihubungan yang signifikan terhadap wasting (p>0.05).Kesimpulan. Asupan karbohidrat, lemak, dan protein tidak memiliki hubunganterhadap wasting pada balita usia 6-59 bulan di Desa Sembalun Bumbung

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Background. Wasting prevalence in children under-five in Nusa Tenggara BaratProvince is 10%, while wasting is an important factor affecting children’s growthand development. Current research shows that infection and nutrition intake affectwasting. This research is aimed to identify characteristics, prevalence of wasting,and association between carbohydrate, protein, and fat intake on wasting in childrenunder-five at Sembalun Bumbung Village, NTB.Method. A cross sectional study was conducted in Desa Sembalun Bumbung,Kecamatan Sembalun, Lombok Timur, NTB in August 2019; 112 children of 6-59months age were recruited. Anthropometry data including height and weight wasobtained to analyze nutritional status. Children’s mothers were interviewed tocollect sociodemographic data and macronutrient intake through multiple multiplepass2x24 hour food recall using food portion pictures from Indonesian Ministry ofHealth. Anthropometry and questionnaire data were processed using WHO AnthroSurvey Analyser and Epidata version 4.4. According to Indonesian Ministry ofHealth Food Composition Data, macronutrient intake from dietary recall wasprocessed using Nutrisurvey 2004. Statistical data was analyzed with Fisher’s ExactTest using SPSS version 20.Result. Wasting prevalence of children under-five in Sembalun Bumbung Villagewas 7%. Bivariate analysis showed that carbohydrate, protein, and fat intake werenot statistically significant on wasting prevalence (p>0.05).Conclusion. Carbohydrate, fat, and protein intake was not associated with wastingin children under-five in Sembalunbumbung Village"