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"This authoritative reference provides practical, easy-to-use guidance on the histopathologic diagnosis of gynecologic lesions. This visual resource clearly describes the cardinal clinical, gross, and microscopic features of each lesion, as well as the staging system for tumors at each site. Clinical correlations of surgical pathology, clinical data, and immunohistochemical data help in weighing all of the available evidence to form the most decisive diagnoses. "

"Henti jantung masih merupakan penyebab kematian utama di dunia. Walau telah ada kemajuan dalam hal tatalaksana kegawatdaruratan kardiovaskular, angka ketahanan hidup mereka dengan henti jantung di luar rumah sakit tetap rendah. Pedoman resusitasi jantung paru dan kegawatdaruratan kardiovaskular meski telah diperbaharui namun pendekatan terhadap keadaan henti jantung di luar rumah sakit masih jauh dari optimal. Hal ini memberi peluang bagi resusitasi kardioserebral untuk menjadi alternatif resusitasi pada keadaan henti jantung di luar rumah sakit. Resusitasi kardioserebral layak menggantikan resusitasi jantung paru pada keadaan henti jantung di luar rumah sakit karena telah terbukti memperbaiki ketahanan hidup dan fungsi serebral pada pasien dengan henti jantung.

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AbstractCardiac arrest remains a leading cause of death in the world. Although advances in emergency cardiac care has been achieved, the survival rate of those with out-of-hospital cardiac arrest remains low. Guidelines for CPR and emergency cardiovascular care though have been updated, their approach to out-of-hospital cardiac arrest is far from optimal. This provides an opportunity to advocate cardiocerebral resuscitation as an alternative to traditional cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Because cardiocerebral resuscitation results in improved survival and cerebral function in patients with witnessed cardiac arrest and a shockable rhythm whom have greatest chance of survival, it should replace CPR especially for out-of-hospital cardiac arrest."

"Cognitive Screening Instruments: A Practical Approach provides a practical and structured overview of some of the most commonly used and easily available cognitive screening instruments applicable in the outpatient clinic and bedside setting. Dementia and cognitive disorders are now recognised as an increasing public health problem, both in terms of patient numbers and cost, as populations age throughout the world. Despite this, many patients with dementia never receive a formal diagnosis, with implications for their appropriate care and management. Diagnostic tests which identify cases of dementia therefore have an important role. Expert authors from around the world equip the reader of Cognitive Screening Instruments: A Practical Approach with clear instructions on the usage of each screening instrument, its strengths and weaknesses, the time required for administration, and rules on scoring, such as how to correct for variations in the patient's age or education, and suggested cut-off scores. Cognitive Screening Instruments: A Practical Approach is a handy, illustrated guide and a valuable diagnostic aid for practitioners working closely with patients with dementia and mild cognitive impairment. This volume will be of use both to clinicians and to professionals in disciplines allied to medicine who are called upon to assess patients with possible cognitive disorders, including neurologists, old age psychiatrists, neuropsychologists, primary care physicians, dementia support workers, and members of memory assessment teams."

"Clinical cardiac MRI is a comprehensive textbook intended for everyone involved in magnetic resonance imaging of the heart. It is designed both as a useful guide for newcomers to the field and as an aid for those who routinely perform such studies. Providing theoretical background information, this illustrated volume examines imaging acquisition and potential pitfalls. It presents guidelines on the interpretation of clinical data in a range of cardiac pathology that can be encountered. In this second edition, the aim has been to maintain the same quality while incorporating the newest insights and developments in this rapidly evolving domain of medical imaging. Finally, the selection of 100 real-life cases, added as online material, will further enhance the value of this textbook."

"Background: cardiac function in patients with septic shock at the cellular level can be assessed by measuring troponin I and NT Pro BNP levels. Venous oxygen saturation is measured to evaluate oxygen delivery and uptake by organ tissue. Our study may provide greater knowledge and understanding on pathophysiology of cardiovascular disorder in patients with septic shock. This study aimed to evaluate the roles of echocardiography, cardiovascular biomarkers, venous oxygen saturation and renal function as predictors of mortality rate in patients with septic shock.Methods: this is a prospective cohort study in patients with infections, hypotension (MAP < 65 mmHg) and serum lactate level of > 2 mmol/L. On the first and fifth days, septic patients underwent echocardiography and blood tests. Statistical analysis used in our study included t-test or Mann-Whitney test for numeric data and chi-square test for nominal data of two-variable groups; while for multivariate analysis, we used Cox Regression model.Results: on 10 days of observation, we found 64 (58%) patients died and 47 (42%) patients survived. The mean age of patients was 48 (SD 18) years. Patients with abnormal left ventricular ejection fraction (LVEF) had 1.6 times greater risk of mortality than those with normal LVEF (RR 1.6; p = 0.034). Patients with abnormal troponin I level showed higher risk of mortality as many as 1.6 times (RR: 1.6; p = 0.004). Patients with impaired renal function had 1.5 times risk of mortality (RR 1.5; p = 0.024). Patients with abnormal troponin I level and/or impaired renal function showed increased mortality risk; however, those with normal troponin I level and impaired renal function also showed increased mortality risk. Multivariate analysis revealed that left ventricular ejection fraction and troponin I level may serve as predictors of mortality in patients with septic shock. (HR 1.99; 95% CI: 1.099 - 3.956 ; p = 0.047 and HR: 1.83 ; 95%CI: 1.049 - 3,215 ; p = 0.043). Conclusion: left ventricular ejection fraction and biomarkers such as troponin I level are predictors of mortality in septic shock patients.

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Latar belakang: fungsi jantung pada pasien dengan syok septik pada tingkat sel dapat dinilai dengan mengukur tingkat troponin I dan NT Pro BNP. Saturasi oksigen vena diukur untuk mengevaluasi pengiriman dan pengambilan oksigen oleh jaringan organ. Studi kami dapat memberikan pengetahuan dan pemahaman yang lebih besar tentang patofisiologi gangguan kardiovaskular pada pasien dengan syok septik. Penelitian ini bertujuan untuk mengevaluasi peran ekokardiografi, biomarker kardiovaskular, saturasi oksigen vena dan fungsi ginjal sebagai prediktor tingkat kematian pada pasien dengan syok septik.

Metode: ini adalah studi kohort prospektif pada pasien dengan infeksi, hipotensi (MAP <65 mmHg) dan tingkat serum laktat >2 mmol/L. Pada hari pertama dan kelima, pasien septik menjalani pemeriksaan ekokardiografi dan darah. Analisis statistik yang digunakan dalam penelitian kami meliputi uji-t atau uji Mann-Whitney untuk data numerik dan uji chi-square untuk data nominal kelompok dua variabel; sedangkan untuk analisis multivariat, kami menggunakan model Cox Regression.

Hasil: pada 10 hari pengamatan, kami menemukan 64 (58%) pasien meninggal dan 47 (42%) pasien selamat. Usia rata-rata pasien adalah 48 (SB 18) tahun. Pasien dengan fraksi ejeksi ventrikel kiri abnormal (LVEF) memiliki risiko kematian 1,6 kali lebih besar dibandingkan dengan LVEF normal (RR 1,6; p = 0,034). Pasien dengan level troponin I yang abnormal menunjukkan risiko kematian yang lebih tinggi sebanyak 1,6 kali (RR: 1,6; p = 0,004). Pasien dengan gangguan fungsi ginjal memiliki risiko kematian 1,5 kali (RR 1,5; p = 0,024). Pasien dengan tingkat troponin I yang abnormal dan / atau gangguan fungsi ginjal menunjukkan peningkatan risiko kematian; Namun, mereka yang memiliki kadar troponin I normal dan gangguan fungsi ginjal juga menunjukkan peningkatan risiko kematian. Analisis multivariat mengungkapkan bahwa fraksi ejeksi ventrikel kiri dan level troponin I dapat berfungsi sebagai prediktor mortalitas pada pasien dengan syok septik. (HR 1,99; 95% CI: 1,099 ̶ 3,956; p = 0,047 dan HR: 1,83; 95% CI: 1,049 ̶ 3,215; p = 0,043).

Kesimpulan: fraksi ejeksi ventrikel kiri dan biomarker seperti level troponin I merupakan prediktor mortalitas pada pasien syok septik"