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"Pati singkong telah lama digunakan dalam bentuk pasta sebagai bahan pengikat pada tablet. Tetapi ada keterbatasan dalam penggunaannya yaitu tablet menjadi rapuh. Untuk memperbaiki kelemahan diatas perlu dilakukan modifikasi terhadap pati alami tersebut. Modifikasi dapat dilakukan secara fisika dan kimia dengan membuat pregel pati singkong propionat. Pregel pati singkong propionat dibuat dengan cara mereaksikan pregel pati singkong dengan asam propionat.Tujuan penelitian ini adalah untuk mengetahui kemampuan pregel pati singkong propionat sebagai bahan pengikat pada tablet. Pada penelitian ini dibuat tablet menggunakan PPSP sebagai pengikat dengan konsentrasi 5 ? 20%, yang prosesnya dilakukan secara cetak langsung dan granulasi basah. Sebagai model obat digunakan diltiazem HCl. Tablet yang dihasilkan dievaluasi sesuai dengan evaluasi yang tertera pada Farmakope Indonesia edisi III dan IV.Hasil evaluasi tablet menunjukkan bahwa tablet yang diproses secara cetak langsung dan granulasi basah menggunakan PPSP dengan konsentrasi 5% memberikan hasil yang baik.

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Pregelatinize Cassava starch has been used for a long time as tablet binder material. However, it have a limitation because of brittle tablet. For solving that problem the cassava starch should be modified by making pregelatinize propionic cassava starch. Pregelatinize propionic cassava starch is made by reacted pregelatinize cassava starch with propanoic acid.The aim of this research was to study the ability of pregelatinized propionic cassava starch in tablet formulation. Formula of the tablet werw made by using 5, 10,15, and 20% pregelatinize propanoic cassava starch as a binder respectively. and the tablets was proceed by directeed compression and wet granulation which diltiazem HCl as a model drug. The tablets were evaluation according with Farmakope Indonesia III and IV.The result show, both of the tablets that were used pregelatinize propionic cassava starch 5% have a good character."

"Pati merupakan bahan penolong yang telah lama digunakan pada pembuatan tablet sebagai pengisi, pengikat, pelincir dan fungsi lainnya sebagai penghancur. Salah satu pati yang belum pernah digunakan sebagai bahan penghancur adalah pati biji durian. Tujuan penelitian ini adalah untuk mengetahui kemampuan pati biji durian sebagai bahan penghancur eksternal dalam pembuatan tablet parasetamol secara granulasi basah yang memenuhi persyaratan Farmakope Indonesia edisi IV. Pati biji durian diperoleh dengan metode ekstraksi dan pengeringan. Pati biji durian digunakan sebagai bahan penghancur eksternal dalam pembuatan tablet secara granulasi basah dengan parasetamol (71,4%) sebagai model obat; dikalsium fosfat sebagai bahan pengisi; pasta amilum 10% sebagai bahan pengikat, magnesium stearat (1%) dan talk (3%) sebagai pelincir. Formula A merupakan formula standar dengan menggunakan 20% pati singkong sebagai penghancur. Formula F merupakan pengembangan dari formula A dengan mengganti 20% pati singkong dengan 20% pati biji durian. Formula F menghasilkan tablet dengan kekerasan, waktu hancur, dan disolusi yang lebih baik dibandingkan dengan formula A. Selanjutnya konsentrasi pati biji durian dikurangi untuk masing-masing tablet pada formula B, C, D, dan E yaitu 5%,10%, 12.5%, dan 15%. Dari keempat formula B-E hanya formula E yang menghasilkan tablet dengan kekerasan, waktu hancur, dan disolusi yang paling baik. Uji disolusi untuk semua formula tablet parasetamol hanya formula E dan F yang memenuhi persyaratan Farmakope Indonesia edisi IV.Starches are the most common additional materials in tablet formulation which have been used for a long time as diluent, binder, lubricant, dan others fuction as disintegrant. One of the starch that haven’t been developed as disintegrant in tablet formulation is durio seed starch. The objective of this research was to observe the ability of durio seed starch as disintegrant in wet granulation of parasetamol tablet formulation which are appropriate to pharmacopeial requirements. Durio seed starch obtained by extraction and drying method. Durio seed starch used as external disintegrant in wet granulation tablet formulation with paracetamol (71,4%) as a drug model; calcium phosphate dihidrate as a diluent; cassava starch paste 10% as a binder; magnesium stearat (1%) and talk (3%) as a lubricant. Formula A represent a standard formula with use cassava starch 20% as disintegrant. Formula F is a development of formula A with change cassava starch 20% with durio seed starch 20%. Formula F produce tablet with a better hardness, disintegrant time, and dissolution test than formula A. Furthermore durio seed starch concentration are reduced for each tablet in formula B, C, D, and E (5%, 10%, 12,5%, and 15%). Starting at formula B to formula E, only formula E produce tablet with the best hardness, disintegrant time, and dissolution test. The dissolution test for all paracetamol tablet formula only formula E and F which are appropriate to pharmacopeial requirements."

"Many type of starch from various plants can be exploited as an alternative for additional materials in tablet formulation. One of the source that have been developed as a pharmaceutical excipient is durian seed starch, which relatively easy to find in tropic area such as Indonesia. The objective of this research was to observe theability of durio seed starch as binder in wet granulation of ketoprofen tablet formulation. Durio seed starch obtained by extraction and drying methode. Starch as a paste used in wet granulation as a binder. Tablet made by wet granulation withketoprofen (25%) as a drug model; calcium phosphate dihidrate as a diluent; Avicel® PH 102 as a disintegrant; magnesium stearat (1%) and talc (2%) as a lubricant. Placebo formula with various durio seed starch concentration (5%, 6%, 8%, 10%) in tablet compared to other binder that is cassava starch. Placebo tablet formula withbetter hardness and friability used in ketoprofen tablet formula and compared to cassava starch as a binder with the same concentration. Formula with durio seed starch as binder have smaller hardness and more friable than cassava starch as a binder. Thereby tablet with durio seed starch as binder have faster disintegration time than tablet with cassava starch as a binder. The dissolution test for both ketoprofen formula did not meet the pharmacopeial requirements."