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"ABSTRACTBACKGROUND: hypertension remains a global burden. Complications of unrecognized hypertension might increase mortality as shown by a WHO 2013 report that hypertension caused 9.4 million deaths worldwide. There is no prior data in Indonesia on blood pressure status in young adults with similar education levels. Medical students are at high risk of developing early hypertension due to modern lifestyle habits. This study aimed to determine the blood pressure profile of medical students as representative of the young adult population. METHODS: we measured the prevalence of hypertension in medical students. All medical students who agreed to participate completed a questionnaire. Afterwards, we conducted a physical examination and obtained blood and urine samples to screen for blood pressure, estimated glomerular filtration rate, and the lipid profile. RESULTS: the prevalence of students with prehypertension or hypertension was 29.6%. The mean eGFR was 105.45 ml/min/m2. The mean total cholesterol was within normal limits. CONCLUSION: the prevalence of hypertension in medical students was high. This study shows that early detection of hypertension is key to treating it early and therefore to reducing morbidity and mortality."

"Tujuan penelitian adalah diketahuinya pengaruh pemberian jus bayam 100 gram per hari selama empat minggu berturut-turut terhadap kadar NOx serum dan tekanan darah pada laki-laki dewasa muda. Penelitian ini merupakan uji klinis paralel, membandingkan 17 orang kelompok yang mendapat jus bayam disertai penyuluhan gizi (P) dengan 17 orang kclompok yang hanya mendapat penyuluhan gizi saja (K). Sebanyak 34 mahasiswa taki-lakt semester dua Fakultas Kedokteran Universitas Udayana yang memenuhi kriteria dibagi dalam dua kelompok secara randomisasi blok. Data yang diambil meliputi usia. aktivitas fisik, indeks massa tubuh, asupan energi, natrium, dan nitrat anorganik dengan food recal/2 x 24 jam dan food recoNi, Pemeriksaan kadar nitrit, nitrat, dan NOx serum serta tekanan darah dilakukan pada awal dan akhir pcr!akuan. Anal isis data menggunakan uji t tidak berpasangan dan uji Mann Whitney dengan batas kemaknaan 5%. Sebanyak 17 orang kclompok P dan 16 orang kelompok K dengan median usia 18 (17~ 19) tahun yang mengikuti penelitian secara lengkap. Indeks aktivitas tisik subyek kedua kelompok termasuk rendah. Data awal tidak menunjukkan perbedaan bermakna (p>Q,05). Setelah empat minggu perlakuan, didapatkan persentase as11pan energi dibandingkan kebutuhan energi total termasuk kategori cukup pada kedua kelompok {8:4,93± 10,lebih rendah dibandingkan dengan angka kecukupan gizi 2004 (1083.00 {834,84-1797,50) mg/hari vs 923,95 (676,20-2494,05) mg/hari. Asupan nimH anorganik lebih tinggl pada kelompok perlakuan dibandingkan kelompok kontrol (130,33 (107,28-195,85) mglhari vs 30,79 (9,47- 118,38) mg/hari. Pada kedua kelompok didapatkan peningkatan kadar nitrit, nitrat dan NO,. serum yang tebih tinggi pada kelompok perlakuan, namun secara statistik tidak bermakna (p->0,05). Tidak didapatkan penurunan tekanan darah sistolik dan diastolik yang bemakna pada kelompok perlakuan (p>O,OS). Pemberian 1 00 gram jus bayam selama empat minggu berturut-turut tidak didapatkan peningkatan kadar nitrat, nltrit, dan NO,. serum sejak penurunan tekanan darah sistolik dan diastolk pada kelompok perlakuan.

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The aims of this study were to investigate the effect of 100 gram per day spinach juice during four weeks on serum NO level and blood pressure in young adult male. The study was a parallel! randomized clinical trial Thirty four subjects of second semester male student Medical faculty of Udayana University were selected using certain criteria. The randomly (block randomization) thirty four subject were divided into two group. The treatment group {nc-·cJ7) received spinach juice and nutrition counseling; the control group (n"" 17) received nutrition counseling alone. Data collected included age, physical activity, body mass index, intake of energy, sodium, and inorganic nitrate using 2 x 24 hours food recall and food record. Laboratory findings {semm nitrite, nitrate, and NO.; levels) and blood pressure examination were done before and after intervention, For statistical analysis, unpaired Hest and Mann Whitney were used with the level of significance was 5%. Seventeen subjects in the treatment group and sixteen subjects in the control group completed the study and analyzed. Median of age were 18 (l7-19) years old. The physical activity index in both groups were low. The characteristic of the two groups were closely matched pH base line (p>0,05). After four weeks intervention, all subjects consumed energy achieved the recommended diet with an average of 84.93± 10,60 % in the treatment group and 88,19±5,47 % in the control group. The average intake of sodium in both groups were lower than Indonesian recommended dietary allowance 2004 (I 083,00 (834,84-1797,50) mg/day vs 923,95 (676,20-2494,05) mg/day). The average intake of inorganic nitrate in the treatment group increased significantly than in the control group (130,33 (107,28-195,85) mg/day vs. 30.79 (9,47-118,38) mg/day), 1n conclusion, there were increase in serum nitrite, nitrate and NOll levels which were higher in the treatment group, although not statistically significant (p>O,OS). There were also no significant decrease in systolic and diastolic blood pressure in the treatment group (p>0,05). In conclusions, the effects of lOO gram per day spinach juice during four weeks did not increase serum nitrite, nitrate and NOx level and also were not decrease systolic and diastolic blood pressure in the treatment group. "

"Pelayanan kefarmasian di puskemas berdasarkan berdasarkan Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Puskemas meliputi standar pengelolaan sediaan farmasi dan bahan medis habis pakai serta pelayanan farmasi klinik. Salah satu kegiatan pelayanan farmasi klinik yang dilakukan apoteker di Puskesmas Kecamatan Palmerah adalah Pelayanan Informasi Obat (PIO). Angka kejadian anemia di Indonesia terbilang cukup tinggi. Anemia gizi pada remaja putri merupakan penyebab tingkat tinggi kematian ibu, tingginya insiden bayi berat lahir rendah, kematian prenatal tinggi dan akibatnya tingkat kesuburan yang tinggi. Hal ini memunjukkan pentingnya mengontrol dan memastikan kebutuhan zat besi pada remaja putri terpenuhi. Pemberian Tablet Tambah Darah (TTD) merupakan cara yang efektif untuk mengatasi masalah anemia, apabila dikonsumsi rutin akan terjadi peningkatan pada kadar hemoglobin. Dengan demikian mengingat salah satu peran apoteker di puskesmas adalah PIO maka dapat dilakukan PIO melalui edukasi kesehatan terkait dengan pentingnya TTD untuk remaja putri sebagai upaya meningkatkan kesadaran remaja putri akan pentingnya konsumsi TTD sebagai langkah pencegahan anemia. Tujuan ditulisnya laporan ini yaitu untuk mempelajari peran apoteker di Puskesmas Kecamatan Palmerah dalam memberikan PIO melalui edukasi kesehatan terkait dengan pentingnya TTD untuk remaja putri sebagai upaya meningkatkan kesadaran remaja putri akan pentingnya konsumsi TTD sebagai langkah pencegahan anemia. Kegiatan edukasi kesehatan oleh Apoteker di Puskesmas Kecamatan Palmerah dilakukan melalui media cetak pamflet yang ditelakkan di Instalasi Farmasi dan media online video edukasi kesehatan yang dibagikan melalui media sosial Instagram Puskesmas Kecamatan Palmerah yaitu @pharmacist.palmerah serta dilakukan melalui media cetak pamflet yang diletakkan di Instalasi Farmasi. Edukasi kesehatan terkait dengan pentingnya TTD untuk remaja putri diharapkan dapat meningkatkan kesadaran remaja putri akan pentingnya konsumsi Tablet Tambah Darah sebagai langkah pencegahan anemia.

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Pharmaceutical services at puskesmas are based on Regulation of the Minister of Health of the Republic of Indonesia Number 74 of 2016 concerning Pharmaceutical Service Standards at Puskemas including management standards for pharmaceutical preparations and consumable medical materials as well as clinical pharmacy services. One of the clinical pharmacy service activities carried out by pharmacists at the Palmerah District Health Center is the Drug Information Service (PIO). The incidence of anemia in Indonesia is quite high. Nutritional anemia in adolescent girls is a cause of high rates of maternal mortality, high incidence of low birth weight babies, high prenatal mortality, and consequently high fertility rates. This shows the importance of controlling and ensuring that the iron needs of young women are met. Giving Blood Supplement Tablets (TTD) is an effective way to overcome the problem of anemia, when consumed regularly there will be an increase in hemoglobin levels. Thus, bearing in mind that one of the roles of pharmacists at the community health center is PIO, PIO can be carried out through health education related to the importance of iron supplements for young women as an effort to increase awareness of young women on the importance of taking iron supplements as a measure to prevent anemia. The purpose of writing this report is to study the role of pharmacists at the Palmerah District Health Center in providing PIO through health education related to the importance of iron supplements for young women as an effort to increase young women's awareness of the importance of taking iron tablets as a measure to prevent anemia. Health education activities by pharmacists at the Palmerah District Health Center are carried out through printed media pamphlets that are posted at the Pharmacy Installation and online media health education videos which are shared via Instagram social media at the Palmerah District Health Center, namely @pharmacist.palmerah and carried out through printed pamphlets placed at the Pharmacy Installation. Health education related to the importance of iron supplementation for young women is expected to increase young women's awareness of the importance of taking Blood Supplement Tablets as a measure to prevent anemia."

"Latar BelakangPenyakit degeneratif merupakan salah satu masalah kesehatan yang krusial dan memerlukan perhatian serius. Salah satu faktor risiko yang turut berkontribusi terhadap perkembangan penyakit degeneratif adalah obesitas. Pada kondisi obesitas, terjadi perubahan fisiologis yang dapat memengaruhi respons adaptasi seluler, termasuk terhadap asidifikasi. Penelitian ini bertujuan untuk mengetahui pengaruh asidifikasi ekstraseluler terhadap ekspresi mRNA HIF-1α sebagai respons adaptasi pada sel mononuklear darah tepi (SMDT) orang dewasa muda dengan IMT>23.MetodeSel mononuklear darah tepi (SMDT) diisolasi lalu dikultur pada berbagai pH medium. Pengaturan pH medium dilakukan dengan penambahan larutan asam klorida (HCl) 0,01M. Sel-sel tersebut diinkubasi selama 72 jam, dengan penggantian medium kultur dilakukan setiap 24 jam. Perubahan pH ekstraseluler diukur menggunakan pH meter. Viabilitas sel juga dihitung menggunakan metode trypan blue. Selanjutnya, dilakukan isolasi RNA dari sel yang telah di-harvest. Ekspresi relatif mRNA HIF-1α dianalisis menggunakan metode Livak berdasarkan nilai CT pada qRT-PCR.HasilTidak ditemukan perbedaan ekspresi mRNA HIF-1α yang signifikan pada SMDT antarkelompok perlakuan pH. Terjadi peningkatan ∆pHe setelah kultur asidifikasi ekstraseluler pada setiap kelompok pH setelah 72 jam inkubasi. Viabilitas sel tidak menunjukkan perbedaan yang signifikan antarkelompok pH.KesimpulanIsolasi SMDT serta kultur dan asidifikasi ekstraseluler pada SMDT subjek dewasa muda dengan IMT>23 berhasil dilakukan. Respons adaptasi seluler pada SMDT orang dewasa muda dengan IMT>23 sudah mulai mengalami gangguan ditandai dengan ekspresi mRNA HIF-1α yang tidak menunjukkan perbedaan nilai yang signfikan antarkelompok pH. Pada SMDT, perbedaan viabilitas sel tidak signifikan antarkelompok pH.

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Degenerative diseases are a critical health issue that require serious attention. One of the risk factors contributing to the progression of degenerative diseases is obesity. In obesity, physiological changes occur that can affect cellular adaptation responses, including adaptation to acidification. This study aims to investigate the effect of extracellular acidification on the expression of HIF-1α mRNA as an adaptation response in young adults peripheral blood mononuclear cells (PBMCs) with a BMI >23.

Method

PBMCs were isolated and cultured in medium with varying pH levels. The pH adjustment of the medium was done by adding 0.01 M HCl. The cells were incubated for 72 hours. The culture medium being replaced every 24 hours. Changes in extracellular pH were measured using pH meter. Cell viability was assessed using the trypan blue method. RNA was isolated from the harvested cells. The relative expression of HIF-1α mRNA was analyzed using the Livak method based on CT values in qRT-PCR.

Results

No significant differences were found in HIF-1α mRNA expression in SDMT between pH treatment groups. An increase in ∆pHe was observed after extracellular acidification culture in each pH group after 72 hours of incubation. Cell viability did not show significant differences between pH groups.

Conclusion

Isolation of SMDT as well as culture and extracellular acidification in SMDT of young adult subjects with BMI>23 were successfully performed. The cellular adaptation response in. The cellular adaptation response in PBMCs of young adults with a BMI >23 appears to be impaired, as indicated by the lack of significant differences in HIF-1α mRNA expression between the pH groups. In PBMCs, the difference in cell viability across the pH groups is not significant."

"Summary: Branna O'Dwyer has a rich and remarkable life. Her little shop in County Mayo is thriving and her close circle of friends and family have found love and happiness. But Branna's own heart remains closed - to protect herself and the man she loves from a terrible threat. She reached out once to Finbar Burke - and it almost destroyed them both. Fin and Branna have both inherited a gift for magic, but Fin shares his blood with an old and terrible enemy. And so the two friends have kept their distance, both secretly yearning for the impossible. That distance has kept them safe - and unhappy. But as a final battle draws close, Branna and Fin are brought irresistibly together. And while they succumb to the heat between them, there can be no promises for tomorro"