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"Integrative therapies in lung health and sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders--emphasizing the scientific bases for these therapies; and their implementation into clinical practice. This volume focuses on complementary and alternative medicine (CAM) treatments, modalities, and practices that are integrated with conventional medical treatment and for which there is some evidence of safety and efficacy. Whole medical systems, with a specific focus on traditional Chinese medicine , are also addressed. Individual chapters are devoted to specific health conditions or illnesses, addressing the current state of the science in the four organizing CAM domains, including available information regarding benefits, risks, or safety considerations. Unique aspects of this volume are the chapters related to evaluation of the evidence base for integrative therapies, new animal model research with herbal preparations focused on the serious problem of sepsis in the ICU, guidance for counseling patients with chronic lung illnesses who may be desperate for a cure; and palliative and end-of-life care for patients with chronic lung conditions. "

"ABSTRAKSkripsi ini membahas tentang anak autis yang mengalami permasalahan padapenerimaan dan pemrosesan integrasi sensori. Permasalahan ini dapat di-treatmentdengan penyesuaian pada pengalaman sensori dan integrasinya melalui aspekarsitektural berupa penyesuaian atribut sensori dan narasi sequence. Penanganan inijuga dapat dilakukan melalui game komputer. Skripsi ini menganalisis game RufusGoes to School dan keterkaitan aspek arsitektural tersebut dengan ruang game. Atributsensori visual hadir melalui representasi game komputer dengan treatment sensorisecara spesifik. Sedangkan narasi sequence diciptakan dari sifat yang muncul dalamassigned qualities yaitu pengoperasian ruang game dan elemen game sebagaipenanaman adaptasi terhadap karakter repetitif dari anak autis

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ABSTRACTThis thesis discusses the autistic child who had problems with sensory processing andintegration. This problem can be treated with sensory experience and integration witharchitectural aspects such as adjustment of sensory attributes and narrative sequences.The teratment can be conducted through computer games. This thesis analyzes thegame Rufus Goes to School by exploring the architectural aspects in the game space.Visual sensory attributes are present through representation of computer games withsensory specific treatment. While the narrative sequence is present in the charactersthat appear in the assigned qualities, namely the operation of gaming space andelements of the game as a learning treatment for adaptation to repetitive character ofchildren with autism."

"Tujuan: untuk meninjau efikasi dan keamanan terapi diabetes melitus tipe 2 berbasis inkretin (incretin-based therapy) yang saat ini beredar (eksenatid, liraglutid, sitagliptin, vildagliptin) pada populasi Asia. Metode: Kami melakukan pencarian data uji klinik acak yang relevan pada MEDLINE mengenai terapi berbasis inkretin pada diabetes mellitus tipe 2 populasi Asia. Data yang digunakan adalah data efi kasi dan keamanan GLP-1 (glucagon-like peptide-1) mimetik dan penghambat DPP-4 (dypeptidyl peptidase-4). Hasil: Empat belas uji klinik acak terapi berbasis inkretin yang mengikutsertakan 3567 pasien diabetes melitus tipe 2 pada populasi Asia (Jepang, Cina, Korea, India). Terapi berbasis inkretin memperbaiki HbA1c lebih besar (hingga -1,42% pada eksenatid 10 mcg bid, -1,85% pada liraglutid 0,9 mg qd, -1,4% pada sitagliptin 100 mg dan -1,4% pada vildagliptin 50 mg bid) dibandingkan dengan yang ditemukan pada uji klinik populasi Kaukasia, dengan profi l keamanan yang setara. Kesimpulan: Efi kasi terapi berbasis inkretin pada populasi Asia memperbaiki parameter glikemik lebih besar pada beberapa parameter glikemik dibandingkan dengan pada populasi Kaukasia. Hasil ini mengindikasikan bahwa terapi berbasis inkretin lebih efektif pada populasi Asia dibandingkan dengan populasi Kaukasia.

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AbstractAim: To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population. Methods: We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the effi cacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used. Results: We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profi le. Conclusion: The effi cacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian"

"This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications."