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"Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). The book begins with discussions on key HMM and related profile methods, including the HMMER package, the sequence analysis method (SAM), and the PSI-BLAST algorithm. It then provides detailed information about various types of publicly available HMM databases, such as Pfam, PANTHER, COG, and metaSHARK. After outlining ways to deve."

"Hidden Markov models (HMMs) are discrete-state, discrete-time, stochastic dynamical systems. They are often used to approximate systems with continuous state spaces operating in continuous time. In addition to introducing the basic ideas of HMMs and algorithms for using them, this book explains the derivations of the algorithms with enough supporting theory to enable readers to develop their own variants. The book also presents Kalman filtering as an extension of ideas from basic HMMs to models with continuous state spaces.Although applications of HMMs have become numerous (396,000 Google hits) since they emerged as the key technology for speech recognition in the 1980s, no introductory book on HMMs in general is available. This text aims to fill that gap.Hidden Markov Models and Dynamical Systems features illustrations that use the Lorenz system, laser data, and natural language data. The concluding chapter presents the application of HMMs to detecting sleep apnea in experimentally measured electrocardiograms. Algorithms are given in pseudocode in the text, and a working implementation of each algorithm is available on the accompanying website."

"This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective."

"Thoroughly revised and updated, Exploring Bioinformatics: A Project-Based Approach, Second Edition is intended for an introductory course in bioinformatics at the undergraduate level. Through hands-on projects, students are introduced to current biological problems and then explore and develop bioinformatic solutions to these issues. Each chapter presents a key problem, provides basic biological concepts, introduces computational techniques to address the problem, and guides students through the use of existing web-based tools and software solutions. This progression prepares students to tackle the On-Your-Own Project, where they develop their own software solutions. Topics such as antibiotic resistance, genetic disease, and genome sequencing provide context and relevance to capture student interest. With a focus on developing students' problem-solving skills, the Second Edition of Exploring Bioinformatics: A Project-Based Approach is a contemporary and comprehensive introduction to this rapidly growing field. New to the thoroughly updated Second Edition: Offers a flexible approach to understanding key bioinformatics algorithms with exercises that can be used with or without programming. For programming courses, pseudocode allows students to implement algorithms in any desired programming language. Includes more substantive web-based projects for a more comprehensive, hands-on introduction to bioinformatics in non-programming courses. Contains updated material reflecting changes in how bioinformatics is used: next-generation sequencing, metagenomic analysis, statistical methods, etc. Contains more instructive and relevant case studies as well as more cohesive connections between the case studies and the exercises."