Hasil Pencarian  ::  Simpan CSV :: Kembali

"With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What?s New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available."

"Latar belakang:Kondisi hiperglikemia pada diabetes melitus (DM) yang tidak terkontrol dan berlangsung lama dapat menimbulkan dampak negatif. Salah satu konsekuensi dari DM adalah munculnya penyakit arteri perifer (PAP) dan neuropati perifer diabetik (NPD). NPD merupakan komplikasi diabetes yang menunjukkan tanda dan gejala gangguan motorik dan sensorik, sementara PAP adalah kondisi aterosklerosis yang berkembang perlahan pada pembuluh arteri. Kedua penyakit ini menunjukkan gejala kelainan motorik dan sensorik yang saling tumpang tindih.Tujuan:Penelitian ini bertujuan untuk mengetahui hubungan stenosis arteri yang dinilai menggunakan arteriografi terhadap gangguan saraf yang dinilai menggunakan pemeriksaan kecepatan hantar saraf (KHS) pada pasien DM tipe 2 dengan PAP dan NPD.Metode:Penelitian ini merupakan penelitian potong lintang yang mengambil data sekunder dari data penelitian sebelumnya yang dilakukan pada Juli 2018 hingga Juni 2021 RSUPN Cipto Mangunkusumo. Subjek penelitian ini adalah penyandang DM yang memiliki NPD dan PAP yang memenuhi kriteria inklusi dan tidak memenuhi kriteria eksklusi. Subjek penelitian kemudian menjalani pemeriksaan arteriografi untuk menilai stenosis pada A. Peroneal, A. Tibialis Anterior dan A. Tibialis Posterior. Subjek penelitian juga menjalani pemeriksaan kecepatan hantar saraf (KHS) pada N. Peroneal Communis, N. Peroneal Superficialis, N. Tibialis dan N. Suralis. Korelasi antar kedua variabel kemudian diuji dengan Uji Korelasi Spearman.Hasil:Hasil menunjukkan bahwa stenosis A. Peroneal memiliki korelasi negatif derajat sedang (r = - 0.420) dengan KHS sensorik N. Peroneal Superficialis yang bermakna secara statistik (p = 0.023). Sementara itu, hubungan stenosis dan gangguan KHS pada A. Peroneal dengan N. Peroneal Communis, A. Tibialis Anterior dengan N. Tibialis dan A. Tibialis Posterior dengan N. Suralis memiliki korelasi yang tidak bermakna secara statistik (p >0.05). Hal ini dapat dijelaskan oleh kemungkinan kolateral yang dapat muncul pada penyandang PAP, struktur anatomi vaskular terhadap syaraf, dan jumlah sampel yang kecil.Kesimpulan:Terdapat korelasi negatif derajat sedang antara derajat stenosis A. Peroneal dan KHS sensorik N. Peroneal Superficialis. Namun hasil yang tidak bermakna ditemukan pada hubungan A. Peroneal dengan N. Peroneal Communis, A. Tibialis Anterior dengan N. Tibialis dan A. Tibialis Posterior dengan N. Suralis.

---

Background:

The condition of hyperglycemia in uncontrolled and prolonged diabetes mellitus (DM) can have negative impacts. One consequence of DM is the emergence of peripheral artery disease (PAD) and diabetic peripheral neuropathy (DPN). DPN is a complication of diabetes that presents signs and symptoms of motor and sensory disturbances, while PAD is an atherosclerosis condition that gradually develops in the arterial vessels. Both diseases exhibit overlapping symptoms of motor and sensory abnormalities.

Objective:

This study aims to determine the correlation of arterial obstruction assessed using arteriography and the nerve impairment assessed using nerve conduction velocity (NCV) in DM patients with PAD and DPN.

Methods:

This is a cross-sectional study that takes secondary data from previous research data conducted from July 2018 to June 2021 RSUPN Cipto Mangunkusumo. The subjects of this study were people with DM who had NPD and PAP who met the inclusion criteria and did not meet the exclusion criteria. The research subjects then underwent an arteriography examination to assess the stenosis in the peroneal artery, anterior tibial artery and posterior tibial artery. Research subjects also underwent nerve conduction velocity (KHS) examinations in the Peroneal N. Communis, N. Peroneal Superficialis, N. Tibialis and N. Suralis. The correlation between the two variables was then tested using the Spearman Correlation Test.

Results:

The results showed that the Peroneal Artery stenosis had a moderate negative correlation (r = - 0.420) with the sensory NCV of the Superficial Peroneal Nerve which was statistically significant (p = 0.023). Meanwhile, the correlation of stenosis and NCV disorders in the Peroneal Nerve with the Common Peroneal Nerve, Anterior Tibial Nerve with Tibialis Nerve and Posterior Tibial Nerve with Sural Nerve had a correlation that was not statistically significant (p > 0.05). This can be explained by the possibility of collaterals appearing in people with PAD, the structure of vasculature on the nerves, and the small number of samples.

Conclusion:

There is a moderate negative correlation between the degree of stenosis of the Peroneal nerve and the sensory NCV of the Peroneal Superficialis. However, insignificant results were found in the correlation between Peroneal Artery with Common Peroneal Nerve, Anterior Tibialis Artery with Tibial Nerve and Posterior Tibial Artery with Sural Nerve."

"The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 120 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system.Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the "why" behind illness and treatment."