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Rachmania Diandini
Pengamh pekerjaan dengan pajanan debu silika tefhadap risiko tuberkulosis paru (tinjauan pada puskesmas di kawasan Industri Tangerang) = Effect of occupation with silica dust exposure on pulmonary tuberculosis (study at community health centres in Industrial area of Tangerang District)
"Latar Belakang: Pajanan debu silika telah diketahui sebagai salah satu faktor risiko infeksi TB paru. Diketahuinya besar risiko pajanan debu silika terhadap timbulnya TB paru dapat menjadi suatu aset dalam upaya advokasi program pemberantasan TB baik di pusat pelayanan kesehatan, maupun di tempat kerja, terutama tcrhadap sektor industri yang terkait pajanan debu silika seperti keramik, gelas, konstruksi, etc.
Metode: Penelitian ini menggunakan desain kasus kontrol dengan kasus 129 orang, dan kontrol 129 orang yang dipadankan menurut usia dan jenis kelamin. Wawancara riwayai pajanan debu silika dilalcukan dengan kuesioner yang telah diujicoba sebelumnya. Diagnosis TB paru diambil dari data sekunder hasil pemeriksaan basil tahan asam (BTA) sputum 3x dan foto toraks di awal diagnosis. Pengaruh pajanan debu silika terhadap TB pam dianalisis regresi logistik, disesuaikan terhadap sejumlah faktor risiko lainnya.
Hasil: Dari analisis bivariat ditemukan bahwa faktor pajanan debu silika sedang-tinggi memiliki OR kasar = ll.05 (95% Cl = l.39~87-69, p = 0_023). Namm; analisis multivariat tidak menunjukkan kemaknaannya terhadap TB pam. Faktor risiko yang bermakna adalah pendidikan tamat SMP (OR suaian = 2.26, 95% CI = 0.97-5.27), tamat SD hingga tidak sekolah (OR suaian 2.16, 95% Cl = 0.95-4.92), penghasilan rendah (OR suaian = 2.64, 95% CI = 1.21-5.84), Indeks massa tubuh (IMT) kurang (OR suaian = 15.76, CI = 6.95-3546), riwayat minum alkohol sedang-berat (OR suaian = 6.77, 95% CI = 2.27-1 9.78).
Simpulan dan saran: Tidak terdapat perbedaan dalam zisiko TB paru antara riwayat pekeljaan terkait pajanan debu silika dengan pekerjaan lainnya_ Keterbatasan popuiasi penelitian di puskesmas tempat penelitian diperkirakan mempunyai andil terhadap hasil yang diamati_ Penelitian selanjutnya perlu dilakukan pada populasi yang lebih spcsifik yaitu pada pekerja industri dengan pajanan debu silika.
Silica dust exposure has long been known as risk factor for tuberculosis. Therefore, the risk on silica dust exposure can be an asset for health promotion to eradicate tuberculosis in the industrial setting, especially in silica-related industries such as ceramic, pottery, glass, construction, etc.
Methods: The study design is case-control with cases (129 persons) and control (129 persons) selected and matched by age with 5-year interval, and gender. History of occupation with silica dust exposure was taken by interview using questionnaire which had been tested its validity and reliability. Diagnosis of tuberculosis which are acid-fast bacilli.sputum.smear and.thorax.photo interpretation were taken. secondary available. The relationship between pulmonary TB and silica dust exposure was evaluated by logistic regression analysis adjusted for other confounding factors.
Result: Bivariate analysis shows that moderate to high silica dust exposure has crude OR=ll.05 (95% CI = 1.39-87.69, p=0.023). Meanwhile, multivariate analysis does not show its effect towards pulmonary TB. Factors that increases risk are junior high-school graduates (adjusted OR = 2.26, 95% CI = 0.97-5.27), illiterate up to elementary graduate (adjusted OR = 2.16, 95% CI = 0.95-4.92), low income (adjusted OR = 2.64, 95% CI = 1.21-5.s4), new body mass index (BMI) (adjusted OR = 15.76, 95% CI = 6.95-3546), and moderate-heavy drinking (adjusted OR = 6.77, 95% CI = 2.27-l9_78).
Conclusion and Recommendation: Effect of occupation with silica dust exposure on pulmonary 'l`B is not shown in this study. Limitation of the study population was assumed as the cause. Further research is needed to be done in more specific population such as community of worker in industry with silica dust."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2008
T29185
UI - Tesis Open  Universitas Indonesia Library
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Siska Primasari
Hubungan pencahayaan alami dalam rumah dengan kejadian TB paru BTA positif pada usia ≥15 tahun di Kota Solok tahun 2017 = Natural home lighting relationship with pulmonary tuberculosis positive incidence at age ≥15 years in Solok City in 2017
"MPHTB merupakan masalah darurat global karena menyebabkan lebih banyak kematian dibandingkan penyakit menular lainnya. Berdasarkan WHO Global Tuberculosis 2016 menyatakan bahwa Indonesia dengan jumlah penduduk 254.831.222, menempati posisi kedua dengan beban TB tertinggi didunia.Timbulnya penyakit tuberculosis TBC di masyarakat dipengaruhi oleh beberapa faktor resiko determinan, salah satunya kurangnya sinar matahari masuk kedalam rumah. Tujuan Penelitian ini adalah mengetahui hubungan antara pencahayaan alami dalam rumah dengan kejadian TB paru BTA positif pada usia ge;15 tahun keatas di Kota Solok Sumatera Barat pada tahun 2017. Desain Penelitian ini adalah case control dengan melakukan wawancara, obeservasi dan pengukuran terhadap pencahayaan dan kelembaban. Penelitian ini dilakukan pada bulan April s/d Mei 2018. Hasil Peneilitian ini Pencahayaan yang dalam rumahyang < 60 lux beresiko terkena TB Parur 3,732 kali 95 CI 1,584-8,793 setelah di kontrol oleh variabel Kepadatan Hunian dan Status Gizi.
MPH Tuberculosis is a global emergency issue because it causes more deaths than other infectious diseases. According to WHO Global Tuberculosis 2016 states that Indonesia with a population of 254,831,222, occupies the second position with the highest burden of TB in the world. The incidence of tuberculosis TB in the community is influenced by several determinant risk factors, one of which is the lack of sunlight into the house. The purpose of this research is to know the relationship between natural light in the house with the incidence of positive smear pulmonary tuberculosis at age ge 15 years and above in Solok city of West Sumatera in 2017. Design This research is case control by conducting interview, obeservasi and measurement to lighting and humidity. This study was conducted from April to May 2018. The results of this study The in house lightings "
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2018
T49928
UI - Tesis Membership  Universitas Indonesia Library
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Ari Ardi
Pengembangan model sistem basis data program penanggulangan penyakit TB Paru puskesmas Mekar Wangi Kota Bogor
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2010
S26621
UI - Skripsi Open  Universitas Indonesia Library
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Kemampuan diagnostik pemeriksaan xpert MTB/RIF dengan acuan kultur media cair pada pasien HIV
"Tuberculosis is one of the most common presenting illness and the leading cause of death among people living with HIV. The clinical features of pulmonary tuberculosis in HIV-infected patients are not typical ..."
UI-IJCHEST 2:3 (2015)
Artikel Jurnal  Universitas Indonesia Library
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Tiara Saraswati
Tatalaksana nutrisi pada tuberkulosis paru dengan komplikasi = Medical nutrition therapy in pulmonary tuberculosis with complications
"[ABSTRAK
Serial kasus ini bertujuan untuk mempelajari dan menerapkan terapi nutrisi sebagai bagian dari terapi tuberkulosis (TB) paru. Komplikasi yang menyertai TB paru dapat meningkatkan morbiditas dan mortalitas. Seluruh pasien serial kasus ini dalam kondisi malnutrisi dan terdapat komplikasi yang menyertai masingmasing kasus berupa drug-induced hepatotoxicity, peritonitis TB, diabetes melitus tipe 2, dan pneumotoraks dengan dispepsia. Pemberian nutrisi disesuaikan dengan kondisi, penyakit penyerta, dan kebutuhan yang bersifat individual. Kebutuhan energi basal dihitung dengan persamaan Harris-Benedict dengan kebutuhan energi total setara dengan 35?40 kkal/kg BB. Makronutrien diberikan dalam komposisi seimbang dengan protein 15?20% kebutuhan energi (1,2?1,5 g/kg BB). Saran pemberian mikronutrien minimal mencapai angka kecukupan gizi. Pasien yang mendapat obat antituberkulosis berupa isoniazid disarankan mendapat suplementasi vitamin B6 dengan dosis tertentu untuk mencegah neuritis perifer. Outcome yang dinilai meliputi kondisi klinis, asupan, dan toleransi asupan. Pemberian terapi nutrisi sebagian besar pasien dimulai dari kebutuhan energi basal yang pada akhir masa perawatan dapat mencapai target kebutuhan energi total. Pemantauan jangka panjang pasca rawat inap, disarankan tidak hanya menilai outcome berdasarkan perubahan berat badan, namun dilakukan penilaian komposisi tubuh, terutama massa lemak, karena pada kasus TB terjadi abnormalitas metabolisme yang disebut anabolic block.
ABSTRACT
The aim of this case series was to study and apply nutrition therapy as integral part of pulmonary tuberculosis (TB) therapy. Pulmonary TB with complications was associated with increased of morbidity and mortality. Malnutrition was coexisted with several complications such as drug-induced hepatotoxicity, peritoneal TB, type 2 diabetes mellitus, and pneumothorax with dyspepsia. HarrisBenedict equation was used to calculate basal energy requirement with total energy requirement equivalent to 35?40 kcal/body weight. Balanced macronutrient composition was given with protein 15?20% energy requirement (1,2?1,5 g/body weight). Micronutrient recommendation was given to fulfill one fold recommended daily allowance. Patients with isoniazid therapy needed to get pyridoxine supplementation to prevent peripheral neuritis. Outcome measurements included clinical condition, amount of intake, and intake tolerance. Most patients were given initial nutrition therapy from basal energy requirement and has shown increment. At the end of hospitalization, all of patients could achieve total energy requirement. Due to abnormality of metabolism, usually termed as anabolic block, it was recommended not only to measure body weight as primary outcome, but also body composition., The aim of this case series was to study and apply nutrition therapy as integral part of pulmonary tuberculosis (TB) therapy. Pulmonary TB with complications was associated with increased of morbidity and mortality. Malnutrition was coexisted with several complications such as drug-induced hepatotoxicity, peritoneal TB, type 2 diabetes mellitus, and pneumothorax with dyspepsia. HarrisBenedict equation was used to calculate basal energy requirement with total energy requirement equivalent to 35–40 kcal/body weight. Balanced macronutrient composition was given with protein 15–20% energy requirement (1,2–1,5 g/body weight). Micronutrient recommendation was given to fulfill one fold recommended daily allowance. Patients with isoniazid therapy needed to get pyridoxine supplementation to prevent peripheral neuritis. Outcome measurements included clinical condition, amount of intake, and intake tolerance. Most patients were given initial nutrition therapy from basal energy requirement and has shown increment. At the end of hospitalization, all of patients could achieve total energy requirement. Due to abnormality of metabolism, usually termed as anabolic block, it was recommended not only to measure body weight as primary outcome, but also body composition.]"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Titi Sekarindah
Pengaruh pemberian Vitamin A terhadap profil imun pasien Tuberkulosis Paru dengan terapi obat anti Tuberkulosis = The effect of vitamin A supplementation on the immune profile of pulmonary Tb patient during oral anti tuberculosis treatment
"ABSTRAK
Ruang Lingkup dan Cara Penelitian : Penyakit tuberkulosis paru masih merupakan masalah di negara berkembang termasuk Indonesia. Tuberkulosis menduduki urutan ke 2 sebagai penyebab kematian menurut hasil survey nasional 1992. Dari kepustakaan diketahui bahwa pada penderita tuberkulosis didapati kelainan imunitas seluler, sehingga untuk penyembuhan penyakit tuberkulosis diperlukan pengaktifan sistem imun testa imunitas seluler. Vitamin A sudah lama dikenal sebagai imunomodulator. Dari penelitian terdahulu pemberian retinoid dapat meningkatkan respon imun seluler antara lain kenaikan sel T penolong dan T penolong/supresor. Pada penelitian ini diharapkan pemberian vitamin A sejumlah 2x 200000IU pada penderita TB paru dengan OAT dapat meningkatkan imunitas seluler. Tujuan penelitian ini adalah menilai pengaruh pemberian vitamin A pada penderita tuberkulosis paru yang sedang mendapat OAT terhadap jumlah limfosit total, limfosit T total, sub populasi limfosit T, kadar retinol plasma, dan keadaan klink penderita. Vitamin A 200.000 IU diberikan pada awal penelitian dan setelah 4 minggu. Penelitan dilakukan secara uji klinik tersamar ganda pada 40 penderita TB paru. Penderita dibagi dalam 2 kelompok masing-masing 20 orang yang diberi vitamin A dan placebo. Pada akhir penelitian yaitu setelah 8 minggu, ada 5 orang drop out.
Hasil dan kesimpulan : Dari 40 orang peserta penelitian 10% kadar retinol plasma rendah (<20pg/dl), 30%normal, rendah(20-30pg/d.l), 60% normal. Pada pemeriksaan imunitas seluler 53,85% ada gangguan dan 46,15% normal. Nilai rata rata hitung (X) retinal plasma kelompok placebo dan perlakuan sebelum pemberian vit. .A/placebo berturut-turut adalah 30,24 ± 7,51 µg/dl dan 30,82 ±7,31 µg/dl. Setelah pemberian adalah 36,85 ± 9,74 µg/dl dan 38,02 ± 8,29 µg/dl. Pada uji t berpasangan dari kelompok perbkkan kenaikannya bermakna (p
ABSTRACT
Scope and Method of Study : Pulmonary tuberculosis is still a major health problem in the developing countries including Indonesia. Tuberculosis is number 2 as cause of death (National Survey's data, 1992). According to literature study tuberculosis patients are suffering from an immune defect. To recover from the disease the immune response especially the cellular immune response needs to be activated, because mycobacterium TB are living intracellular. Vitamin A is known as an immunomodulator. From earlier research it is known that retinoid could enhance cellular immune response, ie. increasing T helper cells and the ratio Thelperffsupresor. The hypothesis is that supplementation of vitamin A 2x2000001U to pulmonary TB patients could increase the cellular immunity. The aim of this study was to asses the vitamin A supplementation on the immune?s profile of pulmonary TB patient who are on oral anti tuberculosis treatment. Plasma retinot, nutrients intake, BMI, clinical findings were examined. Vitamin A 200.000M was given twice, in the beginning of the study and after 4 weeks. The design of the study was a randomized double blind clinical trial. Forty patients were selected and divided into 2 groups, a placebo and treatment (vitamin A) group. At the end of the study (after the 8th week), 5 patients dropped out.
Findings and Conclusions : Among 40 patients 10% showed plasma ret noK20 p g/dl), 30% normal low (20-30pgldl) and 60% normal. (03011g041). The cellular immunity was 53,85% abnormal and 46,15% normal The means (X) of plasma retinol of the placebo and study group before supplementation were 30.24 ± 7,51 µg/dl and 30.82 ± 7.31µg/dl respectively; after supplementation 36.85±9.74µg/dl and 38.02 ± 8.29µgldl respectively. Statistical analysis using paired t test showed that the study group was increasing s' 0,05), however there was no Significant difference between the 2 groups. The mean (X) of total lymphocyte before supplementation of the placebo and study group were 22.61 ± 6.51% and 22.63 ± 8,62%; after supplementation 38.09 ± 19.91% and 35.20 + 10.71%. Both were increasing significant; however there was no significant difference between the 2 groups. The T lymphocyte, T helper and ratio Thelper CT supresor were decreasing. T helper more in the placebo group 5.75% 2.29% but there was no significant difference. This study concluded that although vitamin A supplementation 2 X 200.000 IU could increase the plasma retinol but could not yet improve the immune response and clinical status significantly."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 1996
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Henny Vidiawaty
Faktor risiko kejadian tuberkulosis paru di wilayah Kecamatan Duren Sawit Kota Jakarta tahun 2016 = Risk factors of pulmonary tuberculosis in Duren Sawit Subdistrict Jakarta 2016
"Penyakit Tuberkulosis paru TB paru masih menjadi penyebab tingginya angka kesakitan dan kematian di dunia, termasuk Indonesia. Angka penemuan kasus TB paru di wilayah Kecamatan Duren Sawit berada di urutan ketiga tertinggi yang ada di Kotamadya Jakarta Timur, yaitu mencapai 249 jiwa. Tujuan penelitian ini adalah untuk menganalisis faktor-faktor yang berhubungan dengan kejadian TB paru.Desain penelitian yang digunakan adalah kasus kontrol dengan jumlah sampel sebanyak 110 responden. Sampel penelitian terdiri dari 55 kelompok kasus dan 55 kelompok kontrol. Sampel yang digunakan adalah pasien yang terdata dan terdiagnosa sesuai dengan konfirmasi laboratorium di Puskesmas. Sampel berusia minimal 15 tahun, bertempat tinggal di wilayah Kecamatan Duren Sawit dan tidak merenovasi rumah sebelum terdiagnosa TB paru. Kriteria kasus adalah pasien Puskesmas yang terdiagnosa TB paru BTA sedangkan kriteria kelompok kontrol adalah pasien Puskesmas yang dinyatakan TB paru BTA - oleh petugas Puskesmas.Hasil dalam penelitian ini menunjukkan bahwa faktor risiko yang berpengaruh terhadap kejadian TB paru di wilayah Kecamatan Duren Sawit adalah jenis kelamin OR 4,3; 95 CI 1,9-9,9 , tingkat pendidikan OR 4,2; 95 CI 1,9-9,4 , pekerjaan OR 3,2; 95 CI 1,3-7,7 , perilaku merokok OR 3,3; 95 CI 1,5-7,6 , pencahayaan OR 17,5; 95 CI 6,0-51,1 , suhu OR 6,6; 95 CI 2,9-15,4 , kepadatan hunian OR 9,5; 95 CI 4,0-22,6.
Pulmonary tuberculosis TB is still the cause of the high number of morbidity and mortality in the world, including Indonesia. The number of pulmonary tuberculosis cases found in Duren Sawit subdistrict is the third highest in East Jakarta, reaching 249 people. The purpose of this study is to analyze factors related to pulmonary TB occurance.The research design used was case control with total 110 respondents. The study sample consisted of 55 case groups and 55 control groups. The samples used were patients who were recorded and diagnosed in accordance with laboratory confirmation at the Puskesmas Central Public Health . The sample is at least 15 years old, living in Duren Sawit sub district and not renovating the house before being diagnosed with pulmonary tuberculosis. Case criteria were Puskesmas Central Public Health patients who were diagnosed with pulmonary tuberculosis while the control group criteria were Puskesmas Central Public Health patients who have been declared pulmonary TB AFB by Puskesmas Central Public Health officers.The results of this study indicated that the risk factors affecting pulmonary TB occurance in Duren Sawit sub district are gender OR 4.3, 95 CI 1.9 9.9 , education level OR 4.2, 95 CI 1.9 9.4 , occupations OR 3.2, 95 CI 1.3 7.7 , smoking behavior OR 3.3, 95 CI 1.5 7.6 , exposure OR 9,5 95 CI 6,0 51,1 , temperature OR 6,6,95 CI 2,9 15,4 , occupancy density OR 9,5 95 CI 4, 0 22,6. "
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2017
S69011
UI - Skripsi Membership  Universitas Indonesia Library
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Christofan Lantu
Proporsi tuberkulosis paru pada pasien penyakit paru obstruktif kronik di Rumah Sakit Umum Pusat Persahabatan Jakarta = Proportion of pulmonary tuberculosis in chronic obstructive pulmonary disease patients at Persahabatan Hospital
"[ABSTRAK
Penyakit paru obstruktif kronik (PPOK) merupakan penyebab utama morbiditas dan mortalitas di dunia.Beberapa faktor risiko PPOK juga merupakan faktor risiko terjadinya tuberkulosis (TB).Beberapa penelitian di luar ditemukan prevalens TB paru pada pasien PPOK sekitar 2,6% - 10%.Indonesia khususnya di RSUP Persahabatan belum ada data proporsi TB paru pada pasien PPOK.Objektif: tujuan penelitian ini adalah mendapatkan angka proporsi TB paru pada pasien PPOK di RSUP Persahabatan Jakarta.Metode: desain penelitian ini adalah potong lintang. Pasien PPOK (belum diobati dengan obat anti tuberkulosis) yang berkunjung di poliklinik Asma/PPOK RSUP Persahabatan yang memenuhi kriteria inklusi dan eksklusi.Subjek diperiksa dahak BTA dan pemeriksaan Xpert MTB/RIF. Saat pasien berkunjung, dilakukan anamnesis gejala, eksaserbasi, riwayat merokok, penggunaan kortikosteroid (oral atau inhalasi), komorbid, skor CAT, penilaian status gizi, spirometri dan foto toraks. Semua data dilakukan analisis dengan uji chisquare.Hasil: subjek terbanyak adalah laki-laki (97,3%) dengan kelompok usia 60-79 tahun (74,3%), dengan komorbid terbanyak penyakit jantung (41,9%), gejala klinis terbanyak batuk berdahak (81,1%). Berdasarkan derajat PPOK terbanyak adalah GOLD 3 (44,6%) dan frekuensi eksaserbasi tersering 0-1 (78,4%) dengan menggunakan steroid sebanyak 59,5%. Pada penelitian ini didapatkan pemeriksaan dahak BTA positif 1,4% dan Xpert MTB/RIF positif 2,7%, artinya pemeriksaan Xpert MTB/RIF mempunyai angka kepositifan lebih tinggi dibanding dahak BTA. Dalam penelitian ini didapatkan proporsi TB paru pada pasien PPOK sebanyak 2,7%.Dalam Penelitian ini tidak terdapat hubungan bermakna secara statistik antara derajat PPOK, status gizi, penggunaan kortikosteroid, status merokok dengan prevalens TB paru pada pasien PPOK (p > 0,05).Pada penelitian ini didapatkan hubungan bermakna pada frekuensi eksaserbasi PPOK, hasil pemeriksaan dahak BTA dan hasil pemeriksaan Xpert MTB/RIF dengan proporsi TB paru (p < 0,05).Kesimpulan: proporsi TB pada pasien PPOK di RSUP Persahabatan Jakarta adalah 2,7%. Terdapat hubungan yang bermakna secara statistik antara frekuensi eksaserbasi PPOK dengan proporsi TB paru pada pasien PPOK (p = 0,0006). Terdapat hubungan yang bermakna secara statistik antara hasil pemeriksaan dahak BTA dan hasil pemeriksaan Xpert MTB/RIF dengan proporsi TB paru pada pasien PPOK dengan nilai p < 0,05 (p = 0,000).
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. Some of the risk factors for COPD are also risk factors for tuberculosis (TB). Some studies abroad have found the prevalence of pulmonary tuberculosis in COPD patients were 2.6 - 10%. There are no data on the prevalence of pulmonary tuberculosis patients with COPD in Indonesia, particularly in The Department of Pulmonology PersahabatanHospital, Jakarta. Objective: the purpose of this study is to obtain proportion of pulmonary TB in COPD patients in The Department of Pulmonology Persahabatan Hospital, Jakarta. Methods: this is a cross-sectional study. COPD patients (anti-tuberculosis drugs naive) who visit the Asthma/COPD clinic PersahabatanHospital which meet the inclusion and exclusion criteria. Subjects went through acid-fast bacilli sputum smear and Xpert MTB/RIF examination. On patients visit, symptoms, exacerbations history, history of smoking, use of corticosteroids (oral or inhaled), comorbidities, CAT scores, assessment of nutritional status, spirometry and chest X-ray data had been obtained. All data were analyzed with chi-square test. Results: most subjects were male (97.3%) in the age group 60-79 years (74.3%), with mostly found comorbid was heart disease (41.9%), and mostly found clinical symptoms was productive cough (81.1%). Based on classification of COPD is GOLD 3 (44.6%) and the most exacerbation frequency was 0-1 (78.4%) with 59.5% history of steroid usage. In this study, examination of AFB sputum smear positive 1.4% and the Xpert MTB/RIF positive 2.7%, It shows Xpert MTB/RIF examination has a higher positivity rate than AFB sputum smear. The proportion of pulmonary tuberculosis in patients with COPD was 2.7%. We also found no statistically significant relationship between classification of COPD, nutritional status, use of corticosteroids, smoking status with the proportion of pulmonary tuberculosis in COPD patients (p> 0.05) but we found a significant difference in the exacerbations frequency of COPD, the results of sputum smear examination and the results of Xpert MTB/RIF with proportion of pulmonary TB (p <0.05).Conclusion: the proportion of tuberculosis in patients with COPD in The Department of PulmonologyPersahabatan Hospital Jakarta is 2.7%. There is astatistically significant difference between the frequency of exacerbations of COPD with proportion of pulmonary TB in patients with COPD (p = 0.0006). An association is statistically significant different between the results of sputum smear examination and the results of Xpert MTB/RIF with the proportion of pulmonary tuberculosis in patients with COPD with a value of p <0.05 (p = 0.000)., Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and
mortality in the world. Some of the risk factors for COPD are also risk factors for
tuberculosis (TB). Some studies abroad have found the prevalence of pulmonary
tuberculosis in COPD patients were 2.6 - 10%. There are no data on the prevalence of
pulmonary tuberculosis patients with COPD in Indonesia, particularly in The Department
of Pulmonology Persahabatan Hospital, Jakarta. Objective: the purpose of this study is to
obtain proportion of pulmonary TB in COPD patients in The Department of Pulmonology
Persahabatan Hospital, Jakarta. Methods: this is a cross-sectional study. COPD patients
(anti-tuberculosis drugs naive) who visit the Asthma/COPD clinic Persahabatan Hospital
which meet the inclusion and exclusion criteria. Subjects went through acid-fast bacilli
sputum smear and Xpert MTB/RIF examination. On patients visit, symptoms,
exacerbations history, history of smoking, use of corticosteroids (oral or inhaled),
comorbidities, CAT scores, assessment of nutritional status, spirometry and chest X-ray
data had been obtained. All data were analyzed with chi-square test. Results: most
subjects were male (97.3%) in the age group 60-79 years (74.3%), with mostly found
comorbid was heart disease (41.9%), and mostly found clinical symptoms was productive
cough (81.1%). Based on classification of COPD is GOLD 3 (44.6%) and the most
exacerbation frequency was 0-1 (78.4%) with 59.5% history of steroid usage. In this
study, examination of AFB sputum smear positive 1.4% and the Xpert MTB/RIF positive
2.7%, It shows Xpert MTB/RIF examination has a higher positivity rate than AFB
sputum smear. The proportion of pulmonary tuberculosis in patients with COPD was
2.7%. We also found no statistically significant relationship between classification of
COPD, nutritional status, use of corticosteroids, smoking status with the proportion of
pulmonary tuberculosis in COPD patients (p> 0.05) but we found a significant difference
in the exacerbations frequency of COPD, the results of sputum smear examination and
the results of Xpert MTB/RIF with proportion of pulmonary TB (p <0.05). Conclusion:
the proportion of tuberculosis in patients with COPD in The Department of Pulmonology
Persahabatan Hospital Jakarta is 2.7%. There is a statistically significant difference
between the frequency of exacerbations of COPD with proportion of pulmonary TB in
patients with COPD (p = 0.0006). An association is statistically significant different
between the results of sputum smear examination and the results of Xpert MTB/RIF with the proportion of pulmonary tuberculosis in patients with COPD with a value of p <0.05 (p = 0.000).]"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Riska Yuanda Silviana
Studi ekologi kasus tuberkulosis paru di Kabupaten Bogor berdasarkan faktor lingkungan rumah tahun 2018-2020 = Ecological study of pulmonary tuberculosis cases in Bogor Regency based on home environmental factors in 2018-2020
"Tuberkulosis paru salah satu masalah kesehatan yang masih dihadapi di dunia termasuk di wilayah Indonesia, dan masalah kesehatan ini memiliki kaitan dengan lingkungan disekitarnya. Penelitian ini bertujuan untuk mempelajari hubungan antara cakupan rumah sehat, cakupan rumah tangga ber-PHBS, fasilitas kesehatan dan kepadatan penduduk terhadap kasus tuberkulosis paru di Kabupaten Bogor pada tahun 2018-2020. Penelitian dilakukan dengan desain studi ekologi pada populasi kecamatan di Kabupaten Bogor sebanyak 40 kecamatan. Hasil penelitian menunjukkan variabel yang berhubungan signifikan dengan tuberkulosis paru yaitu fasilitas kesehatan, dengan keeratan hubungan yang kuat dan berpola positif (r = 0.564). Variabel kepadatan penduduk juga berhubungan signifikan dengan tuberkulosis paru, dengan keeratan hubungan yang sedang dan berpola positif (r = 0.393). Sedangkan variabel cakupan rumah sehat dan cakupan rumah tangga ber-PHBS tidak berhubungan signifikan dengan tuberkulosis paru. Oleh sebab itu, perlu mengoptimalkan program pencegahan dan pengendalian tuberkulosis paru terutama wilayah kecamatan dengan jumlah kasus yang tinggi.
Pulmonary Tuberculosis is one of the health problems in the world, including in Indonesia and it is related to the environment. This study aims to study the relationship between healthy home coverage, household PHBS coverage, health facilities, and population density in cases of pulmonary tuberculosis in Bogor Regency in 2018-2020. The research was conducted with an ecological study design on a population of as many as 40 sub - districts in Bogor District. The result of this research is the variable of a significant relation with pulmonary tuberculosis was health facilities, with strong relation and positive pattern correlation (r = 0.564). The population density variable was also significantly associated with pulmonary tuberculosis, with medium relation and positive pattern correlation (r = 0.393). Meanwhile the variables of healthy home coverage and PHBS household coverage do not have a significant correlation with pulmonary tuberculosis. Therefore, it is necessary to optimize the pulmonary tuberculosis prevention and control program, especially in sub-districts with a high number of cases."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Siregar, Nina Aspasia Harli
Hubungan kadar retinol serumdengan derajat bacterial load pada pasien tuberkulosis paru kasus baru di puskesmas = Correlationbetween serum retinol level and semi-quantitative bacterial load in new case of pulmonary tuberculosis at a community health center
"Latar belakang dan tujuan: Tuberkulosis (TB) sampai saat ini merupakan tantangan dan ancaman besar bagi kesehatan masyarakat di dunia. Insidens TB paru di kota Bekasi tahun 2014 adalah 1359/2.510.951 penduduk dan 3099 total kasus selama tahun 2014. Defisiensi mikronutrien seperti retinol dapat terjadi akibat hilangnya nafsu makan, gangguan absorbsi usus halus yang menyebabkan keadaan imununosupresi sehingga meningkatkan risiko infeksi TB. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar retinol serum dengan derajat bacterial TB paru kasus baru di tingkat pelayanan primer.
Metode: Penelitian mempergunakan desain potong lintang dengan 135 sampel yang diambil dengan cara cluster consecutive sampling di puskesmas wilayah kota Bekasi pada penderita TB paru kasus baru yang belum mendapatkan terapi obat anti tuberkulosis (OAT).
Hasil: Karakteristik subjek TB paru kasus baru di puskesmas menurut usia dengan nilai tengah 35,5 tahun (IQR 18-65), laki-laki 62,3%, perokok 44,9%, IMT gizi kurang 56,5%, hipoalbumin 17,4%, kadar retinol serum defisien 40,6%. Lesi kavitas 30,4?% dan derajat bacterial load mayoritas scanty dan +1 dengan persentase berturut-turut 10,1% dan 39,1%. Terdapat perbedaan bermakna kadar albumin, IMT, lesi kavitas dengan bacterial load dengan nilai p=0,003, p=0,014, p=0,011 namun tidak terdapat hubungan bermakna antara kadar retinol serum dengan bacterial load.
Kesimpulan: Kadar retinol serum tidak berhubungan dengan derajat bacterial load pasien TB paru kasus baru di wilayah kerja kota Bekasi serta terdapat hubungan bermakna antara IMT, kadar albumin dan lesi radiologis dengan bacterial load.
Background: Tuberculosis (TB) remains a threat for community health across the globe including Indonesia. The incidence of pulmonary TB in Bekasi, Indonesia in 2014 is 1,395/2,510,951 people and there were 3.099 cases in 2014. Micronutrient deficiency such as retinol can be caused by loss of appetite and disorder in intestinal absorption which could lead to immunosuppressive condition that increased the risk of TB. This study aims to find the correlation between serum retinol level and semi-quantitative bacterial load in new case of pulmonary TB at a community health center.
Methods: This cross-sectional study involved 135 subjects collected through cluster consecutive sampling in a primary health care in Bekasi, Indonesia. The study included new pulmonary TB cases which had no history of taking any anti-TB drugs.
Results: The median age of the subjects was 35.5 years old (IQR 18-65) and most of subjects were males (62.3%), smokers (44.9%), had low body mass index (BMI) (56.5%), had hypoalbuminemia (17.4%), serum retinol deficient (40.6%), presented with cavity lesion (30.4%) and presented with scanty and +1 semi-quantitative bacterial load (10.1% and 39.1%, respectively). There was no significant correlation between serum retinol level and semi-quantitative bacterial load. However, there were significant correlations between serum albumin level, BMI and presence of cavity lesion and semi-quantitative bacterial load (p=0.003, p=0.014, and p=0.011, respectively).
Conclusion: There was no correlation between serum retinol level and semi-quantitative bacterial load in new cases of pulmonary TB patients. There were significant correlations between serum albumin level, BMI and presence of cavity lesion and semi-quantitative bacterial load."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Tugas Akhir  Universitas Indonesia Library
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