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Ditemukan 3266 dokumen yang sesuai dengan query
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"This resource provides an integrated and comprehensive overview of modern approaches to drug lead discovery. Each chapter in this book reviews the theoretical background and application of a key technology in drug discovery, complemented by relevant case studies. The coverage includes the key approaches for drug design and discovery, high-throughput screening, fragment screening, multi-target drugs, de novo design, ADMET, natural products. This cutting-edge reference helps medicinal chemists in biotech, pharmaceutical, and other research contexts consider all possible avenues in starting their drug research programs."
Hoboken, New Jersey: John Wiley & Sons, 2010
e20394228
eBooks  Universitas Indonesia Library
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"This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies."
Weinheim, Germany: Wiley-VCH, 2006
e20395918
eBooks  Universitas Indonesia Library
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"Extracting and applying knowledge from chemical, biological, and clinical data is one of the biggest problems for the pharmaceutical industry. Focusing on diverse data mining approaches for drug discovery, including chemogenomics, toxicogenomics, and individual drug response prediction, Pharmaceutical Data Mining links theory to applications to illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development. The book is of vital interest to pharmaceutical scientists, principal investigators and scientists, research directors, industrial."
Hoboken, New Jersey: John Wiley & Sons, 2010
e20394490
eBooks  Universitas Indonesia Library
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"This book contains case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics.
The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary."
Hoboken, New Jersey: Wiley-Interscience, 2006
e20395928
eBooks  Universitas Indonesia Library
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"The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specif"
Hoboken, N.J. : Wiley-Interscience , 2005
R 615.19 DRU
Buku Referensi  Universitas Indonesia Library
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"This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process. With the user rather than the developer of chemoinformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using chemoinformatics tools-from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition. "
Weinheim, Germany: Wiley-VCH Verlag, 2005
e20376582
eBooks  Universitas Indonesia Library
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"Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development."
Weinheim: Wiley-Vch, 2010
e20375683
eBooks  Universitas Indonesia Library
cover
"The drug discovery handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: genomics, proteomics, high-throughput screening, and systems biology; summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more; and, specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques.
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Hoboken, New Jersey: John Wiley & Sons, 2005
e20385333
eBooks  Universitas Indonesia Library
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"The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability."
Weinheim: Wiley-VCH, 2006
e20395920
eBooks  Universitas Indonesia Library
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