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"This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed."

"Prevalensi paparan asap rokok yang tinggi di rumah di Indonesia semakin mengancam anak-anak sebagai pihak mayoritas yang secara sukarela terpapar. Studi ini menyelidiki hubungan antara paparan asap rokok pada masa prenatal dan usia dini dan hasil kognitif anak-anak berusia 7-12 tahun, menggunakan data dari Survei Aspek Kehidupan Rumah Tangga Indonesia (SAKERTI) 2014. Dengan model regresi probit, hasilnya menunjukkan bahwa paparan asap rokok sangat penting dalam mempengaruhi hasil kognitif anak bahkan setelah dikendalikan oleh karakteristik keturunan, karakteristik anak-anak, dan karakteristik sosial ekonomi ibu. Status merokok ibu memiliki dampak negatif yang signifikan terhadap hasil kognitif anak.

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The high prevalence of secondhand smoke at home in Indonesia is increasingly threatening children as the majority party who voluntarily exposed. The study investigated the relation between exposure to secondhand smoke on prenatal and early childhood development and cognitive outcome of children aged 7-12 years, using data from Indonesia Family Life Survey (IFLS) 2014. With probit regression model, the result indicates that exposure to secondhand smoke is significant in affecting children cognitive outcome even after controlled by heredity characteristic, children characteristics, and socioeconomic characteristics. Maternal smoking status has negatively significant impact on children cognitive outcome."