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"Tujuan: Penelitian ini membandingkan kadar 25- OH -vitamin D3 pada serum maternal, darah tali pusat dan jaringan plasenta pada ibu hamil normal dan preeklamsia. Metode: Penelitian ini merupakan studi potong lintang dengan jumlah sampel 86 pasien yang melakukan persalinan di RS Cipto Mangunkusumo dan RSUD Tangerang. Setelah itu data disajikan dalam tabel dan dianalisis dengan uji parametrik, yaitu uji-t berpasangan bila sebaran data normal atau uji non parametrik, yaitu uji Mann-Whitney bila sebaran data tidak normal Hasil: Didapatkan kadar 25- OH -vitamin D3 serum maternal kelompok preeklamsia sebesar 16.30 6.20-49.00 ng/mL sedangkan pada sampel kelompok tidak preeklamsia, sebesar 13.50 4.80 ndash; 29.20 ng/mL di mana didapatkan nilai p = 0,459, dengan tidak ada perbedaan bermakna secara statistik. Didapatkan kadar 25- OH -vitamin D3 tali pusat kelompok preeklamsia sebesar 11.80 3.50 ndash; 38.60 ng/mL sedangkan kelompok tidak preeklamsia sebesar 11.70 1.00 ndash; 28.80 ng/m, di mana didapatkan nilai p = 0.964, dengan tidak ada perbedaan bermakna secara statistik. Didapatkan kadar 25- OH -vitamin D3 jaringan plasenta kelompok preeklamsia sebesar 49.00 22.00 ndash; 411.00 ng/mL. sedangkan kelompok tidak preeklamsia, sebesar 43.40 11.80 ndash; 153.00 ng/mL, di mana didapatkan nilai p 0.354 dengan tidak ada perbedaan bermakna secara statistik Didapatkan hasil kadar 25- OH -vitamin D3 serum kelompok preeklamsia awitan dini sebesar 10.80 6.20 ndash; 41.90 ng/mL sedangkan kelompok preeklamsia awitan lanjut sebesar 18.00 7.00 ndash; 49.00 ng/mL dengan nilai p = 0,133, di mana tidak didapatkan perbedaan bermakna secara statistik. Didapatkan hasil kadar 25- OH -vitamin D3 tali pusat kelompok preeklamsia awitan dini sebesar 10.65 3.50 ndash; 38.60 ng/mL. sedangkan pada kelompok preeklamsia awitan lanjut, sebesar 12.65 6.40 ndash; 33.20 ng/mL. di mana didapatkan nilai p = 0.377 dengan tidak didapatkan perbedaan bermakna secara statistik. Didapatkan kadar 25- OH -vitamin D3 pada jaringan plasenta kelompok preeklamsia sebesar 79.00 36.00 ndash; 411.00 ng/g. sedangkan pada kelompok tidak preeklamsia sebesar 40.00 22.00 ndash; 171.00 ng/g. di mana didapatkan nilai p 0.006, dengan didapatkan perbedaan bermakna secara statistik pada rerata kadar 25- OH -vitamin D3 jaringan plasenta Kesimpulan: Tidak terdapat perbedaan bermakna secara statistik pada rerata kadar 25- OH -vitamin D3 pada darah serum, tali pusat dan jaringan maternal pada wanita preeklamsia dan tidak preeklamsia. Tidak terdapat perbedaan bermakna secara statistik pada rerata kadar 25- OH -vitamin D3 pada darah serum dan tali pusat pada wanita preeklamsia dan tidak preeklamsia Terdapat perbedaan bermakna secara statistik pada rerata kadar 25- OH -vitamin D3 pada plasenta wanita preeklamsia dan tidak preeklamsiaKata kunci: 25- OH -vitamin D3, preeklamsia, serum, tali pusat, jaringan plasenta

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Abstract Objective: This study is designed for comparing 25- OH -vitamin D3 levels in maternal serum, cord blood and placental tissue in non preeclampsia and preeclampsia pregnant women.Methods: This study is a cross sectional study with the number of samples of 86 patients who deliver in Cipto Mangunkusumo Hospital and Tangerang District Hospital. After that the data is presented in the table and analyzed by parametric test, ie paired t-test when the distribution of normal data or non parametric test, ie Mann-Whitney test when the data distribution is not normal..Results: The serum maternal 25- OH -vitamin D3 levels of preeclampsia group were 16.30 6.20-49.00 ng / mL while in the non-preeclamptic sample group, 13.50 4.80 - 29.20 ng / mL were obtained p = 0.459, with no statistically significant difference . The umbilical cord 25- OH -vitamin D3 levels of preeclampsia group were 11.80 3.50 - 38.60 ng / mL while the preeclampsia group was 11.70 1.00 - 28.80 ng / m, where p = 0.964 was obtained, with no statistically significant difference. Obtained 25- OH -vitamin D3 levels of placental tissue in the preeclampsia group by 49.00 22.00 - 411.00 ng / mL. while the group did not preeclampsia, amounting to 43.40 11.80 - 153.00 ng / mL, where p value of 0.354 was obtained with no statistically significant difference Earning serum 25- OH -vitamin D3 serum pre-eclampsia group onset was 10.80 6.20 - 41.90 ng / mL whereas the onset of pre-eclampsia group was 18.00 7.00 - 49.00 ng / mL with p value = 0.133, where no statistically significant difference was obtained. The results of the umbilical cord 25- OH -vitamin D3 levels of early onset preeclampsia group were 10.65 3.50 - 38.60 ng / mL. whereas in the onset of pre-eclampsia group, it was 12.65 6.40 - 33.20 ng / mL. where obtained p value = 0.377 with no statistically significant difference. Obtained 25- OH -vitamin D3 levels in placental tissue preeclampsia group of 79.00 36.00 - 411.00 ng / g. while in the pre-eclampsia group was 40.00 22.00 - 171.00 ng / g. where obtained p value of 0.006, with statistically significant difference in mean 25- OH -vitamin D3 levels of placental tissueConclusion: There was no statistically significant difference in mean serum 25- OH -vitamin D3 levels in serum, cord blood and maternal tissue in women with preeclampsia and not preeclampsia. There was no statistically significant difference in mean 25- OH -vitamin D3 levels in serum and umbilical blood in pre-eclampsia and non-preeclampsia women. There were statistically significant differences in mean 25- OH -vitamin D3 levels in female placenta preeclampsia and not preeclampsia Keywords: 25- OH -vitamin D3, preeclampsia, serum, umbilical cord, placental tissue "

"Salah satu peran sistem imunitas terhadap infeksi M.leprae adalah respons makrofag melalui interaksinya dengan vitamin D dan reseptor vitamin D (RVD). Interaksi vitamin D dengan RVD pada berbagai sel imun akan menstimulasi ekspresi katelisidin. Penelitian ini bertujuan untuk menganalisis kadar serum 25-hydroxyvitamin D (25(OH)D) dan kadar plasma RVD serta hubungannya dengan IB pada pasien kusta. Penelitian ini berupa observasional-analitik dengan desain potong lintang. Sebanyak 28 subjek penelitian (SP) menjalani pemeriksaan slit-skin smear kemudian diagnosis kusta ditegakkan berdasarkan tanda kardinal kusta. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan. Kadar serum 25(OH)D diperiksa dengan metode chemiluminescent immunoassay (CLIA) dan kadar plasma RVD dilakukan dengan metode enzyme linked immunosorbent assay (ELISA). Median kadar serum 25(OH)D adalah 12,68 ng/ml (4,88 – 44,74). Median kadar plasma RVD adalah 1,36 ng/ml (0,26 – 8,04). Berdasarkan analisis regresi multivariat, tidak terdapat hubungan antara IB dengan kadar serum 25(OH)D dan kadar plasma RVD (R square = 0,055). Tedapat korelasi positif kuat antara kadar serum 25(OH)D dengan skor pajanan sinar matahari (r = 0,863; p < 0,001).

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One of many immunity system’s roles against M. leprae infection is macrophage response through its interaction with vitamin D and vitamin D receptor (VDR). The interaction between vitamin D and VDR in various immune cells will stimulate the expression of cathelicidin. The objective is to analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with IB in leprosy patients. This observational analytic study was performed with cross-sectional design. A total of 28 subjects underwent a slit-skin smear examination and then the diagnosis of leprosy was made based on the cardinal signs. This study also assessed the patient’s sun exposure with weekly sun exposure questionnaire. Serum 25(OH)D level was assessed with chemiluminescent immunoassay (CLIA) method and RVD plasma level was measured by enzyme linked immunosorbent assay (ELISA). Median serum level of 25(OH)D was 12.68 ng/ml (4.88 – 44.74). Median plasma level of VDR was 1.36 ng/ml (0.26 – 8.04). Based on multivariate regression analysis, there was no significant association between BI and serum level of 25(OH)D and plasma level of VDR (R square = 0.055). There was strong positive correlation between serum level of 25(OH)D and sun exposure score (r = 0.863; p < 0.001)."

"ABSTRAKLatar Belakang. Vitamin D diketahui berperan penting dalam memodulasi sistem imunitas. Defisiensi vitamin D sering dihubungkan dengan peningkatan risiko kerentanan dan keparahan terhadap berbagai penyakit infeksi. Penelitian yang meninjau hubungan antara vitamin D dan dengue sangat terbatas. Dengue adalah penyakit dengan beban kesehatan global yang besar, eksplorasi terhadap faktor imunomodulator yang berpotensi untuk menjadi bagian dari upaya pencegahan dan tatalaksana infeksi dengue termasuk vitamin D masih diperlukan.Tujuan. Penelitian ini bertujuan untuk melihat apakah ada perbedaan rerata kadar vitamin D serum pada berbagai derajat keparahan infeksi dengue di masing-masing fase infeksi.Metode. Penelitian potong lintang ini dilakukan dari Oktober 2016-Januari 2018 terhadap 61 pasien dengan infeksi dengue di RSUP dr. Mohammad Hoesin Palembang. Data dikumpulkan melalui rekam medik, hasil pemeriksaan ultrasonografi, kadar 25(OH)D, serta foto rontgen toraks decubitus kanan. Analisis dilakukan dengan uji anova, kai kuadrat, Fisher exact, regresi linear dan logistik dengan interval kepercayaan 95% dan nilai kemaknaan 0.05.Hasil. Rerata kadar vitamin D serum pada infeksi dengue dengan kebocoran plasma (DD) adalah 24.6 ng/ml. Pada infeksi dengue dengan kebocoran plasma (DBD dan SSD) rerata kadar vitamin D pada fase demam adalah 26.66 ng/ml, 21.91 ng/ml pada fase kritis, dan 25.36 ng/ml pada fase konvalesens. Tidak ditemukan adanya perbedaan dan hubungan bermakna antara kadar serta status kecukupan vitamin D dengan derajat keparahan infeksi dengue. Kadar vitamin serum pada fase akut infeksi dengue memiliki korelasi positif dengan hitung trombosit terendah (p=0.03).Simpulan. Kadar vitamin D serum pada berbagai derajat infeksi dengue di masing-masing fase infeksi pada anak tidak berbeda bermakna. Kadar vitamin D serum pada fase demam berhubungan dengan hitung trombosit terendah pada kasus dengue.

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ABSTRACTBackground. Vitamin D has an important role in modulating the immune system. Low level of vitamin D is frequently associated with higher risk of susceptibility and severity to various infectious disease. Studies on dengue infection and vitamin D are still limited. Until today dengue is known to have a high global burden of disease. Therefore, a continouing investigation on potential modulating factors that may be beneficial in the efforts of dengue prevention and management which includes vitamin D is still required.Objectives. The purpose of this study is to evaluate the difference of vitamin D serum values in various levels of dengue infection severity in children in each phase of disease.Methods. A cross sectional study was conducted from October 2016 until January 2018 at Mohammad Hoesin Hospital Palembang. Sixty-one children with dengue infection were included in this study. Data were collected from medical records, ultrasonograpy, 25(OH)D laboratory test, and right lateral decubitus xray. Statistical analysis was calculated with anova, chi-square, fisher exact, linear and logistic regression with 95% confidence interval and 0.05 level of significance.Results. The mean value of 25(OH)D in dengue infection without plasma leakage (Dengeu Fever) is 24.6 ng/ml, while in dengue infection with plasma leakage (Dengue Hemorhaggic Fever and Dengue Shock Syndrome) the mean value are 26.66 ng/ml in febrile phase, 21.91 ng/ml in critical phase, and 25.36 ng/ml in convalescence phase. No significant difference and association were found between the values and status of vitamin D among various level of dengue infection severity. A positive linear correlation was found between the level of vitamin D in the febrile phase dengue infection and thrombocyte lowest count (p=0.03)Conclusions. There are no difference between the value of vitamin D among children with various levels of dengue infection severity in each phase of disease. Vitamin D serum level during febrile phase may have a role in predicting thrombocyte lowest count during dengue infection."

"Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut (usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5 (0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi. Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan kadar hsCRP pada usila (r=0,168, p=0,162).

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The prevalence of cardiovascular disease (CVD) increases in the elderly. Atherosclerosis is a major cause of CVD which stimulate inflammation and followed by increase production of C-reactive protein (CRP). Vitamin D is a vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The aim of this cross sectional study was to find the correlation between serum vitamin D level and hsCRP in elderly. Data collection was conducted during December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling method. A total of 71 elderly subjects had met the study criteria. Data were collected through interviews including age, vitamin D intake and weekly score of sunlight exposure. Anthropometry measurements to assess the nutritional status and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the subjects were less than recommended dietary allowances (RDA). Majority of the subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels 38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects were at moderate and high risk of CVD. No significant correlation was found between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162)."

"Pendahuluan: Pada usia lanjut (usila) terjadi perubahan dalam berjalan dan keseimbangan, penurunan kekuatan otot rangka, dan perlambatan integrasi sensorik dan motorik oleh sistem saraf pusat. Di sisi lain, usila rentan terhadap defisiensi vitamin D yang diketahui berkaitan dengan sistem muskuloskeletal dalam koridor fungsi mobilitas seseorang untuk melaksanakan aktivitas sehari-hari. Belem. ada penelitian mengenai konsentrasi vitamin D dan korelasinya dengan mobilitas fungsional perempuan usila.Tujuan: Menentukan konsentrasi vitamin D serum, hasil nilai uji the timed up and go (TUG), dan korelasi antara konsentrasi vitamin D serum dan nilai uji TUG perempuan usi laMetode: Penelitian di tiga panti werdha di DK1 Jakarta dan satu panti werdha di Bekasi ini dilakukan dengan desain korelatif secara potong lintang yang dilakukan pada bulan Januari 2005 terhadap perempuan berusia 60 tahun atau lebih. Uji TUG digunakan untuk menilai mobilitas fungsional dasar dengan mengukur berapa detik waktu yang diperlukan subyek untuk melakukan aktivitas berturut-turut: bangkit dari kursi bertinggi duduk 46 cm dengan sandaran lengan dan punggung, berjalan sejauh tiga meter, berbalik arah kembali menuju kursi, dan duduk kembali. Konsentrasi vitamin D serum diukur dengan metode ELBA. Sebagai variabel perancu adalah usia, indeks massa tubuh, dan konsentrasi ion kalsium serum yang diukur dengan metode NOVA.Hasil: Dari 42 perempuan usila-yang memenuhi kriteria inklusi dan eksklusi penelitian, 30 orang yang ditentukan secara random propotsional diikutsertakan dalam penelitian. Rerata (SB) konsentrasi vitamin D adalah 68,0 (SB 21,1) nmol/L, dengan konsentrasi <50 nmol/L sebesar 23,3%, nilai uji TUG 10,7 (SB 2,1) detik, IMT 22,3 (SB 3,7) kglm2, dan usia 70,2 (SB 6,4) tahun, sedangkaiu median (minimal-maksimal) konsentrasi ion kalsium serum adalah 1,095 (1,030-1,230) mmol/L. Konsentrasi vitamin D serum belum menunjukkan korelasi yang bermakna dengan TUG (r = -0,008; p = 0,968). Antara variabel perancu dan TUG juga belum menunjukkan korelasi yang bermalma. Hasil korelasi dengan TUG untuk indeks massa tubuh r = 0,014; p = 0,942, konsentrasi ion kalsium serum p = 0,287;p = 0,124, dan usia r = 0,315;p = 0,09.Simpulan: Rerata konsentrasi vitamin D serum perempuan usila dalam penelitian ini adalah 68,0 (SB 21,1) nmollL, 23,3% mengalami defisiensi vitamin D sedangkan sisanya memiliki konsentrasi vitamin D serum normal. Rerata basil nilai uji TUG perempuan usila yang diteliti adalah 10,7 (SB 2,1) detik, sebagian besar (60%) memiliki basil nilai uji TUG 10-<20 detik yang menunjukkan kemandirian _untuk berbagai . aktivitas. Konsentrasi vitamin D serum belum menunjukkan korelasi yang bermakna dengan mobilitas fungsional dasar perempuan usila, semakin tinggi konsentrasi vitamin D serum tidak diikuti dengan semakin sedikit waktu yang diperlukan untuk melakukan.uji TUG; proporsi subyek dengan nilai uji TUG <10 detik (mobilitas fungsional dengan kemandirian penuh), lebih sedikit pads responden yang mengalami defisiensi vitamin D.

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Background: In elderly there are changes both in gait and balance, muscle strength decline, and slowing of sensory and motoric integration by central nervous system. On the other hand, elderly are susceptible to vitamin D deficiency which is known associated with musculosceletal system in the light of functional mobility in order to perform daily Iiving activities independently. Study on vitamin D and its correlation with basic functional mobility in elderly women has not been conducted yet.

Objective: to determine vitamin D serum concentration, the timed up and go (TUG) test score, and the correlation between vitamin D serum concentration and TUG test score of elderly women.

Method: a correlative cross sectional study of institutionalized elderly women age 60 years old or greater was conducted in three nursing homes in DKI Jakarta and one nursing home in Bekasi in January 2005. TUG test was.performed to evaluate basic functional mobility by measuring the time in seconds to stand from 46 cm height armchair, walk three meters, turn around, and return to full sitting in chair. Vitamin D serum concentration was measured by ELISA method. Calcium ion serum concentration that was measured by NOVA method, age and body mass index (BMI) were confounding variables.

Result: Of forty-two elderly women who met the inclusion and exclusion criteria, thirty subjects which proportional randomly assigned were participated in this study. Mean (SD) vitamin D serum concentration was 68.0 (SD 21.1) nmoUL, with concentration S50 nmolIL was 23.3%, TUG score was 10.7 (SD 2.1) seconds, BMI was 223 (3.7) kglm2, age was 70.2 (SD 6.4) years, and median (minimal-maximal) ionized calcium serum concentration was 1.095 (1.030-1.230) mmolfL. Vitamin D serum concentration had not shown significant correlation yet with TUG (r = -0.008; p = 0.968). There were also no significant correlation among the confounding variables and TUG. The correlation with TUG for BMI r = 0.014; p = 0.942, ionized calcium serum concentration p = 0.287; p = 0.124, and age r=0.315;p=0.09.

Conclusion: The mean vitamin D serum concentration of elderly women in this study was 68.0 (SD 21.1) nmolIL, 23.3% had vitamin D deficiency, while the rest of other subjects still had normal vitamin D serum concentration. The mean TUG score of elderly women in this study was 10.7 (SD 2.1) seconds, more than half (60%) had TUG score 10-<20 seconds which means they were mostly independent to perform daily living activities. Vitamin D serum concentration had not shown significant correlation yet with basic functional mobility of elderly women, the higher vitamin D serum concentration was not followed by lesser time to perform TUG test; the proportion of subjects with TUG score <10 seconds (freely mobile in functional mobility) were lesser in vitamin D deficiency respondents."

"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat  85% subjek memiliki asupan vitamin D yang kurang dan  94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum  adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).

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Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."

"ABSTRAKBerbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat.Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D.Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat.Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

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ABSTRACTRecent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient.This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups.According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05).It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively."

"Latar Belakang. Sepsis neonatal awitan dini SNAD masih merupakan masalah di Indonesia. Vitamin D memiliki efek pada fungsi imunitas. Neonatus kurang bulan NKB berisiko mengalami defisiensi kadar vitamin D. Hubungan kadar vitamin D dengan kejadian SNAD pada NKB belum jelas.Tujuan. Menganalisis hubungan kadar vitamin D dengan kejadian SNAD pada NKB.Metode. Duapuluh NKB dengan klinis dan pemeriksaan laboratorium menyokong SNAD kelompok kasus dan 20 NKB tanpa hasil laboratorium SNAD kelompok kontrol ikut dalam penelitian ini. Subjek penelitian adalah NKB usia gestasi ge; 28 sampai dengan < 37 minggu dirawat di RSUPN Cipto Mangunkusumo selama bulan Juli - September 2017. Pemeriksaaan kadar vitamin D 25 OH D dengan metode competitive chemiluminescense immunoassay CLIA direk dengan alat Diasorin Liaison.Hasil. Median kadar vitamin D pada NKB dengan SNAD 8,95 4,10 - 16,30 ng/mL dengan rerata usia gestasi 33,25 1,71 minggu dan rerata berat lahir 1863,75 415,06 gram. Median kadar vitamin D tanpa SNAD 11,75 5,80 - 42,80 ng/mL dengan rerata usia gestasi 34,67 1,53 minggu dan rerata berat lahir 2125,0 340,55 gram. Median kadar vitamin D NKB SNAD lebih rendah secara bermakna dibandingkan NKB tanpa SNAD.

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Background. Early onset neonatal sepsis EONS is still a problem in Indonesia. Vitamin D has effect on immune function. Preterm infants have a risk of deficiency of vitamin D levels. The association between vitamin D levels with EONS were unclear.Objective. To determine the association between vitamin D levels with EONS in preterm infants.Methods. Twenty preterm infants with clinical and laboratory finding of EONS study group and 20 preterm infants with no signs of laboratory infection control group were enrolled this study. The subjects were preterm infants of gestational age ge 28 37 weeks in Cipto Mangunkusumo Hospital during July September 2017. Vitamin D 25 OH D levels were measured using Diasorin Liason with competitive chemilunescence immunoassay CLIA technique.Results. Median vitamin D levels with EONS was 8,95 4,10 16,30 ng mL, mean of gestational age and birth weight were 33,25 1,71 weeks and 1863,75 415,06 g, respectively. Median vitamin D levels without EONS was 11,75 5,80 42,80 ng mL, mean of gestational age and birth weight were 34,67 1,53 weeks and 2125,0 340,55 g, respectively. Median vitamin D levels of preterm infants with EONS was significantly lower than without EONS.Conclusion. Vitamin D levels are associated with EONS in preterm infants."

"KORELASI ANTARA KADAR VITAMIN D DENGAN FUNGSI KOGNITIF PADA SISWA SMA DI DEPOK, JAWA BARATThia Juniaty Manik1, Novi Silvia Hardiany2, Erfi Prafiantini1 1. Departemen Ilmu Gizi, Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo, Fakultas Kedokteran Universitas Indonesia2. Departemen Biokimia dan Biologi Molekuler, Fakuktas Kedokteran Universitas IndonesiaE-mail :tjmanik@gmail.com AbstrakKeberhasilan dalam pendidikan tidak hanya ditentukan oleh sistem pendidikan, tetapi juga kemampuan kognitif para siswa. Siswa dengan kemampuan kognitif tinggi akan dapat menyerap pelajaran dengan baik. Nutrisi yang dikonsumsi merupakan faktor penting yang berkontribusi pada pengembangan daya kognitif. Penelitian-penelitian sebelumnya telah menghubungkan mikronutrien vitamin D dengan berbagai hasil yang berkaitan dengan kesehatan. Namun, hanya sedikit yang meneliti hubungan vitamin D dengan fungsi kognitif dan hasilnya masih belum konklusif terutama pada remaja. Penelitian ini mengeksplorasi hubungan vitamin D dengan fungsi kognitif pada siswa sekolah menengah atas di Kota Depok. Sebanyak 64 siswa dari 4 SMA di Kota Depok, menjalani tes fungsi kognitif. Hasil utama yang dinilai adalah tes kognisi untuk fleksibilitas kognitif BCST test , planning tower test , dan working memory digit span backward test . Hasil sekunder adalah status sosial ekonomi, asupan vitamin D, skor paparan sinar matahari, kadar haemoglobin, skor family assessment device, skor strenght and difficulties dan aktivitas fisik siswa. Tiga jenis tes yang digunakan adalah : BCST test, Tower Hanoi test, dan Digit backward test. Dari 64 subyek yang ikut penelitian ini 62,5 mengalami kekurangan vitamin D

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Success in education is not only determined by the education system, but also the cognitive power of the students. The students with high cognitive abilities will be able to absorb the lessons well. Nutrition consumed is one of the important factors that contributes to cognitive power development. Previous studies have linked micronutrient vitamin D to various health related outcomes. However, only few examined the correlation of vitamin D to cognitive function, and the result is still inconclusive especially in adolescent. This study explores the correlation of vitamin D to cognitive function in high school students. A samples of 64 adolescents from 4 high schools in Depok City, underwent cognitive function tests. The main outcomes assessed were cognitive flexibility, planning, and working memory test. The secondary outcomes were social economic status, dietary intake of vitamin D, sun light exposure score, haemoglobin level, family assessment device, strenght and difficulties score and physical activity. Sixty four participants 62,5 were vitamin D deficiencies "