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"Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-free technologies for drug discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis."

"Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process."

"This book is about structural, physical, and chemical properties of fluorous compounds, selective fluoroalkylation of organic compounds by tackling the “negative fluorine effect”, synthetic and biological applications of fluorous reagents as phase tags, chemical applications of fluorous reagents and scavengers, methods for the synthesis of peptides and oligonucleotides, fluorous organic hybrid solvents for non-fluorous organic synthesis, fluorous catalysis : from the origin to recent advances, fluorous organocatalysis, thiourea based fluorous organocatalyst, fluoroponytailed crown ethers and quaternary ammonium salts as solid–liquid phase transfer catalysts in organic synthesis, fluorous hydrogenation, fluorous hydrosilylation, fluorous hydroformylation, incorporation of fluorous glycosides to cell membrane and saccharide chain elongation teflon AF materials, ecotoxicology of organofluorous compounds, and biology of fluoro-organic compounds."

"Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development."

"The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability."

"This resource provides an integrated and comprehensive overview of modern approaches to drug lead discovery. Each chapter in this book reviews the theoretical background and application of a key technology in drug discovery, complemented by relevant case studies. The coverage includes the key approaches for drug design and discovery, high-throughput screening, fragment screening, multi-target drugs, de novo design, ADMET, natural products. This cutting-edge reference helps medicinal chemists in biotech, pharmaceutical, and other research contexts consider all possible avenues in starting their drug research programs."

"Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. The authors discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results."

"RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects."