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"Medicinal chemistry of bioactive natural products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.Enhanced by examples with updated research results, the discussion covers such topics as :* The chemistry and biology of epothilones* Vancomycin and other glycopeptide antibiotic derivates* Antitumor and other related activities of Taxol and its analogs* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)* Huperzine A: A natural drug for the treatment of Alzheimer's disease* The medicinal chemistry of ginkgolides from Ginkgo biloba* Recent progress in Calophyllum coumarins as potent anti-HIV agents* Plant-derived anti-HIV agents and analogs* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics"

"The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: * Discovery and development of fluorine containing drugs and drug candidates.* New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates.* Structural and chemical biology of fluorinated amino acids and peptides.* Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis.* Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research."

"This edition places emphasis on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems"

"From the very beginning, the series focused on topical volumes covering hot concepts and technologies, and the reader will not miss any important topic in the field. The range of topics is as diverse as are the challenges facing modern drug developers, spanning the fields of organic chemistry, pharmacology, toxicology, life science, and analytics, the latter also including bioinformatics, chemoinformatics and proteomics."

"Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms have made quantum chemistry a valuable tool in the search for active substances.Written by a team of leading international quantum chemists, this book is aimed at both beginners as well as experienced users of quantum chemical methods. All commonly used quantum chemical methods are treated here, including Density Functional Theory, quantum and molecular mechanical approaches. Numerous examples illustrate the use of these methods for dealing with problems in pharmaceutical practice, whether the study of inhibitor binding, identifying the surface load of active substances or deriving molecular descriptors using quantum chemical tools."

"Wiart presents evidence that natural products are not only able to protect neurons and boost their activities, but also to induce neuritogenesis, raising the possibility that flowering plants helped apes evolve into Homo sapiens during the Tertiary period. In the near future, he says, they may also allow complete victory over neurodegenerative diseases."--ProtoView.com, April 2014"