Hasil Pencarian  ::  Simpan CSV :: Kembali

"This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection."

"Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. This book discusses recent progress in innate immunity and Treg cells, and the regulation of innate immunity through Toll-like receptor (TLR) signalling."

"This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance."

"This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia."

"A patient is said to be immuno-compromised (1C) if one or more of his or her natural and adaptive defense mechanisms are unable to function normally. Thus, immuno-compromised patients are easily susceptible to infection. Aim of study; to determine the immune response in immuno-compromised patients that makes them easily susceptible to infection. Method: the study was designed as a cross-sectional analytic observational study using multi-variant statistical tests. The samples were classified into the 1C and Non-iC groups, consisting of 14 people, 10 men, and 4 women, who were examined far the following immunologi-cal variables: IL-10, IFN-y, TNF-a, IL-I& IgG, C3, and C4. The results demonstrated a significant difference in the immune response of subjects from the 1C and NIC groups (p<0.05), with a significantly higher TNF-Ct, IL-10 and IgG levels, and a lower C3 level in the 1C group. Conclusion: during 1C conditions, there is a disorder in the natural as well as adaptive C3 natural immune system, making patients more susceptible to infection."

"Latar Belakang dan Tujuan: Prevalensi pendek pada anak usia di bawah dua tahun (baduta) di Indonesia pada tahun 2018 sebesar 29,9%, sedangkan di Jakarta sebesar 27,2%. Kondisi pendek pada awal kehidupan berhubungan dengan peningkatan morbiditas dan mortalitas, serta dapat mengurangi kapasitas fisik dan peningkatan risiko penyakit metabolik pada usia dewasa. Tujuan penelitian adalah memahami peran inflamasi usus pada baduta terhadap kejadian pendek.Metode dan bahan: Studi dengan desain kasus kontrol yang dilakukan pada anak usia 6–23 bulan di Kelurahan Kampung Melayu, Jakarta. Penentuan subjek penelitian secara acak sederhana. Pendek ditetapkan berdasarkan nilai z-score panjang badan menurut­­­­­­ umur (PB/U). Pengukuran panjang dan tinggi badan menggunakan infantometer dan microtoise. Penilaian hormon pertumbuhan berdasarkan kadar TSH, sedangkan penilaian inflamasi usus berdasarkan pengukuran kadar Reg 1B. Fungsi absorbsi usus ditetapkan dengan pengukuran kadar xilosa darah. Infeksi parasit dideteksi dengan pemeriksaan feses secara makroskopis dan kultur Blastocystis. Penilaian asupan energi dan zat gizi makro dilakukan dengan metode recall 24 jam. Frekuensi pengukuran panjang dan tinggi badan, inflamasi usus dan penilaian asupan dilakukan 2 kali dengan selang waktu 6 bulan.Hasil: Pada penapisan 269 anak didapatkan 20,4% pendek dengan 55,8% laki-laki, 55,0% kelompok umur 12-23 bulan dan 47,3% memiliki kedua orang tua normal. Profil subjek penelitian adalah 61,1% laki-laki, 88,9% pada kelompok umur 12-23 bulan dan memiliki kadar TSH normal. Persentase rata-rata asupan energi dan zat gizi makro anak pendek lebih rendah daripada anak normal, tetapi tidak berbeda secara statistik. Pada subjek penelitian tidak ditemukan Soil Transmitted Helminths dan hanya 1 anak normal yang positif Blastocystis hominis. Untuk pemeriksaan Reg 1B tidak ditemukan perbedaan antara anak pendek dan normal, tetapi subjek penelitian yang mengalami peningkatan kadar Reg 1B sebagian besar terjadi penurunan nilai Z-score PB/U dan berbeda bermakna secara statistik. Pada pemeriksaan kadar xilosa darah tidak ditemukan perbedaan antara anak pendek dan normal. Dalam analisis korelasi, tidak diperoleh korelasi antara infeksi parasit usus dengan inflamasi usus dan malabsorbsi tetapi ada korelasi bermakna antara inflamasi usus dengan malabsorbsi.Kesimpulan: Inflamasi usus terjadi pada anak pendek dan normal serta secara signifikan menurunkan nilai Z-score PB/U dari kedua anak tersebut dan berkorelasi secara bermakna dengan malabsorbsi.

---

Background and Objective: The prevalence of stunting in children under two years in Indonesia in 2018 is 29.9%, while in Jakarta it is 27.2%. Stunted early in life is associated with increased morbidity and mortality, and can reduce physical capacity and increase the risk of metabolic diseases in adulthood. The aim of the study was to understand the role of intestinal inflammation in children under 2-yrs of age in stunted incidents.

Materials and Methods: A case-control study involving children aged 6-23 months in Kampung Melayu Village, Jakarta was done in 2018. Study sampling was determined by simple randomization. Stunting is determined based on the z-score of the body length by age (LZA). Length was measured using infantometer while height was measured by microtoise. Growth hormone was determined by TSH levels, while intestinal inflammation was determined with faecal Reg 1B levels. The function of intestinal absorption is determined by blood xylose levels. Parasitic infections are determined by macroscopic fecal examination and Blastocystis culture. Assessment of intake of energy and macro nutrients was analyzed by 24-hour recall method. The frequency of length and height measurements, intestinal inflammation and intake assessment were carried out twice with an interval of 6 months.

Results: Screening of 269 children found 20.4% of stunting with 55.8% of men, 55.0% of age group 12-23 months and 47.3% had both normal parents. The percentage of the average intake of energy and macro nutrients from stunting was lower than normal, but not statistically different. Soil Transmitted Helminths were not found and only one child for positive Blastocystis hominis. For the examination of Reg 1B there was no difference between stunted and normal children, but the study subjects who experienced an increase in Reg 1B levels were mostly accompanied by decreased Z-score values of LZA and were significantly different. On examination of blood D-xylose levels no differences were found between stunted and normal children. In correlation analysis, there was no correlation between intestinal parasitic infection and intestinal inflammation and malabsorption but there was a significant correlation between intestinal inflammation and malabsorption.

Conclusion: Intestinal inflammation occurs in stunted and normal children and significantly decreases the Z-score of LZA from these two children and correlates significantly with malabsorption.

"

"Latar belakang: masyrakat Indonesia sangat terpajan oleh radiasi UV. Efek toksik radiasi UV yang terdapat di sinar matahari merupakan masalah kesehatan yang serius yang dapat berupa inflamasi (eritema), tanning, dan imunosupresi lokal ataupun sistemik. Kunyit merupakan salah satu tanaman rempah yang terkenal di Indonesia. Kurkumin merupakan suatu zat yang terdapat pada kunyit. Penelitian secara in vitro dan in vivo menunjukkan bahwa kurkumin mempunyai efek antiinflamasi yang kuat. Sediaan kurkumin yang saat ini dipasarkan di Indonesia hanya dalam bentuk sediaan oral.Tujuan: Untuk membuktikan bahwa kurkumin dalam vehikulum salep dan krim mampu memberikan efek antiinflamasi pada kulit mencit yang telah diberi sinar UV. Metode: Penelitian ini merupakan penelitian eksperimental untuk mengetahui manfaat pemberian kurkumin secara topikal terhadap kulit mencit yang telah disinari UV. Dalam penelitian ini, peneliti mengelompokkan perlakuan pada mencit menjadi tiga kelompok, yaitu mencit yang diberi salep kurkumin 1%, kri kurkumin 1%, dan yang tidak diberi perlakuan. Hasil pengamatan dinilai secara histopatologi berdasarkan lima parameter, yaitu adanya blister, jumlah neutrofil, jumlah limfosit, jumlah fibroblast, dan morfologi kapiler.Hasil: Dengan menggunakan uji nonparametrik Kruskal-Wallis, diperoleh nilai probabilitas 0,047 (p=0,047) dilanjutkan dengan uji analisis Post Hoc dan didapatkan: kontrol dibandingkan dengan salep kurkumin 1% diperoleh nilai probabilitas 0,046 (p=0,046); kontrol dibandingkan dengan krim kurkumin 1% diperoleh nilai probabilitas 0,046 (p=0,046); krimkurkumin % dibandingkan dengan salep kurkumin 1% diperoleh nilai probabilitas 0,2 (p=0,2)Kesimpulan: terdapat perbedaan efek antiinflamasi antara salep kurkumin 1%, krim kurkumin 1%, dan yang tidak diberi perlakuan pada kulit mencit yang telah disinari sinar UV selama 5 jam; perbedaan vehikulum tidak mempengaruhi efekantiinflamasi yang diberikan oleh kurkumin.

---

Introduction: Indonesians are very exposed to UV irradiation. Toxic effect from the sun is a major health problem which include inflamation (erythema), tanning, and local or systemic immunosuppression. Curcuma is one of spices that is famous in Indonesia. Curcumin is the most important constituent in this plant. In vitro and in vivo researches had approved that curcumin has an antiinflammatory properties. Nowadays, curcumin that sold in Indonesia was an oral medicine.

Aim: To prove that curcumin in vehicle such as ointment and vanishing cream has an antiinflammatory propesties in mice?s skin that was radiated with UV lamp. Methods: This research was an experiment in order to know the benefits of applying topical curcumin on mice?s skin that was radiated from UV lamp. In this research, the researcher devide the mice into three subgroups, which are mice given curcumin ointment 1%, vanishing 1%, and without intervention. All results were assessed by histopathology examination based on five parameters which are blisters, neutrofils, lymphocytes, morfology of dermis capiler, and fibroblast.

Results: By using Kruskal-Wallis non parametric test, the probability value was 0,047. Continued with Mann_whitney test, the obtained probability values were: control compare with curcumin ointment 1% 0,046 (p=0,046), control compare curcumin vanishing cream 1% 0,046 (p=0,046), curcumin vanishing cream 1% and curcumin ointment 1% 0,2 (p=0,2)

Conclusion: Curcumin ointment 1% and curcumin vanishing cream 1% exerted an antiinflammatory properties on mice?s skin that was radiated for five hours. Vehicles were not influenced the antiinflammatory properties of curcumin."

"Inflamasi derajat rendah diduga terlibat dalam patogenesis penyakit kronis yangterjadi secara global. Salah satu penanda inflamasi yang kerap digunakan adalahhigh sensitivity C-reactive protein (hsCRP). Asupan serat pangan yang lebih rendahdiduga berperan terhadap kadar hsCRP serum, akan tetapi hasil penelitiansebelumnya masih bervariasi. Studi ini bertujuan untuk mengetahui korelasi antaraasupan serat pangan dengan kadar hsCRP serum pada pekerja sedentari usia 19-49tahun di Jakarta Timur, Indonesia. Studi ini merupakan studi potong lintang pada58 pekerja sedentari yang dilaksanakan pada Bulan Agustus hingga Oktober 2020.Data dasar dikumpulkan memakai kuesioner. Asupan makanan dicatat dengan 3-day food record dan dilakukan pengukuran antropometri untuk mengetahui indeksmassa tubuh (IMT) dan ukuran lingkar pinggang. Pemeriksaan hsCRP serummemakai metode imunoturbidimetri. Analisis untuk menilai korelasi antara asupanserat pangan dan kadar hsCRP serum dilakukan menggunakan uji Spearman jikanilai p<0,05 dianggap bermakna. Mayoritas subjek adalah perempuan, tidakmerokok, dengan aktivitas fisik kurang dan memiliki status gizi normal serta tidakobesitas abdominal. Berdasarkan data asupan makanan didapatkan asupan energi,karbohidrat total, dan serat pangan total berada dibawah rekomendasi AKG. Hanyaasupan lemak total yang sesuai dengan rekomendasi AKG. Asupan serat pangantotal didapatkan sebesar 7,45 g/hari. Nilai hsCRP serum masih dalam batasannormal, yaitu sebesar 0,4 mg/L. Pada analisis bivariat tidak didapatkan korelasiantara asupan serat pangan dengan kadar hsCRP serum (r=0,003, p=0,981). Hasilpenelitian ini tidak mendapatkan adanya korelasi antara asupan serat pangandengan kadar hsCRP serum, namun diketahui asupan serat pangan masih sangatrendah sehingga perlu dilakukan promosi kesehatan untuk meningkatkan asupanserat pangan pada pekerja sedentari.

---

Low grade inflammation has previously been linked to the global development of

chronic disease. High sensitivity C-reactive protein (hsCRP) is commonly used to

detect inflammation. Low dietary fiber intake was hypothesized to have an effect

on serum hsCRP concentration. To this day, studies on the relationship between

dietary fiber and serum hsCRP have shown inconclusive result. In this study, we

aimed to find a correlation between dietary fiber intake and serum hsCRP on

sedentary worker age 19-49 years old at East Jakarta, Indonesia. This was a cross

sectional study on 58 sedentary workers. This study was conducted in August-

October 2020. Subject’s characteristics was obtained using a questionnaire. Dietary

assessment was conducted using 3-day food record. Anthropometic measurements

included body mass index (BMI) and waist circumference. Serum hsCRP

concentrations were measured using immune turbidimetry. Spearman test was used

to determine correlation between dietary fiber intake and serum hsCRP, with

p<0,05 being significant. Subjects were mostly female, non-smoker, with

inadequate physical activity. A majority of subjects had normal BMI and waist

circumference. Dietary assessment showed subject has inadequate intake of energy,

carbohydrate, and dietary fiber. Only fat intake was adequate in the present study.

Total dietary fiber intake was 7,45 g/day. Median value of serum hsCRP was 0,4

mg/L. There was no correlation between dietary fiber intake and serum hsCRP

(r=0,003, p=0,981). However, this study found that dietary fiber intake was very

low. Thus, education on increasing dietary fiber intake is necessary for sedentary

workers."