Hasil Pencarian  ::  Simpan CSV :: Kembali

"This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection."

"Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. This book discusses recent progress in innate immunity and Treg cells, and the regulation of innate immunity through Toll-like receptor (TLR) signalling."

"Latar belakang: Systemic Immune-inflammation Index adalah suatu indeks hasil perhitungan antara trombosit (T), neutrofil (N), dan limfosit (L) dengan rumus SII = T × N/L. Retinoblastoma risiko tinggi, diantaranya: Rb bilateral, trilateral, grup D-E pada klasifikasi tumor intraokular berdasarkan International Classification of Retinoblastoma (ICRB), stadium III-IV menurut klasifikasi tumor ekstraokular berdasarkan International Staging System for Retinoblastoma (ISSRB), dan gambaran histologi unfavorable. Tujuan: Mengetahui kemampuan SII sebagai prediktor kesintasan tiga tahun Rb risiko tinggi. Metode: Kohor retrospektif, Agustus – September 2024, di RS Dr. Cipto Mangunkusumo. Hasil: Analisis dilakukan terhadap 157 subjek Rb risiko tinggi antara 2016 – 2024. Titik potong berdasarkan kurva Receiver Operating Characteristic (ROC) dengan nilai maksimal indeks Youden berada pada SII 351,72. Overall survival (OS) dan Event free survival (EFS) Rb risiko tinggi pada 36 bulan, berturut-turut adalah 39,5% (SE±4,5%) dan 38,1% (SE±4,5%). Median OS dan EFS 36 bulan, berturut- turut adalah 17 bulan dan 16 bulan. Nilai SII ≥351,72 memiliki median OS 11 bulan dan adjusted HR (aHR) sebesar 1,98 (p=0,02; IK 95% 1,13 – 3,35). Kesimpulan: SII dapat memprediksi kesintasan Rb risiko tinggi.

---

Background: The Systemic Immune-Inflammation Index (SII) is an index calculated from platelets (T), neutrophils (N), and lymphocytes (L) using the formula SII = T × N/L. High-risk Rb includes bilateral Rb, trilateral Rb, group D-E in the intraocular tumor classification based on the International Classification of Retinoblastoma (ICRB), stage III-IV in the extraocular tumor classification based on the International Staging System for Retinoblastoma (ISSRB), and unfavorable histological features.

Objective: To determine the ability of SII as a predictor of three-year survival in high-risk Rb.

Methods: A retrospective cohort study, from August to September 2024 at Dr. Cipto Mangunkusumo Hospital.

Results: The analysis was conducted on 157 high-risk Rb subjects between 2016 and 2024. The cut-off point based on the Receiver Operating Characteristic (ROC) curve, with the maximum Youden index value, was identified at an SII of 351.72. The overall survival (OS) and event-free survival (EFS) rates at 36 months for high-risk Rb were 39,5% (SE±4,5%) dan 38,1% (SE±4,5%), respectively. The median OS and EFS were 17 months and 16 months, respectively. An SII value ≥351.72 was associated with a median OS of 11 months and adjusted HR (aHR) of 1,98 (p=0,02; 95% CI 1,13 – 3,35).

Conclusion: SII may predict survival in high-risk Rb."

"This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance."

"This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia."

"A patient is said to be immuno-compromised (1C) if one or more of his or her natural and adaptive defense mechanisms are unable to function normally. Thus, immuno-compromised patients are easily susceptible to infection. Aim of study; to determine the immune response in immuno-compromised patients that makes them easily susceptible to infection. Method: the study was designed as a cross-sectional analytic observational study using multi-variant statistical tests. The samples were classified into the 1C and Non-iC groups, consisting of 14 people, 10 men, and 4 women, who were examined far the following immunologi-cal variables: IL-10, IFN-y, TNF-a, IL-I& IgG, C3, and C4. The results demonstrated a significant difference in the immune response of subjects from the 1C and NIC groups (p<0.05), with a significantly higher TNF-Ct, IL-10 and IgG levels, and a lower C3 level in the 1C group. Conclusion: during 1C conditions, there is a disorder in the natural as well as adaptive C3 natural immune system, making patients more susceptible to infection."

"Latar Belakang dan Tujuan: Prevalensi pendek pada anak usia di bawah dua tahun (baduta) di Indonesia pada tahun 2018 sebesar 29,9%, sedangkan di Jakarta sebesar 27,2%. Kondisi pendek pada awal kehidupan berhubungan dengan peningkatan morbiditas dan mortalitas, serta dapat mengurangi kapasitas fisik dan peningkatan risiko penyakit metabolik pada usia dewasa. Tujuan penelitian adalah memahami peran inflamasi usus pada baduta terhadap kejadian pendek.Metode dan bahan: Studi dengan desain kasus kontrol yang dilakukan pada anak usia 6–23 bulan di Kelurahan Kampung Melayu, Jakarta. Penentuan subjek penelitian secara acak sederhana. Pendek ditetapkan berdasarkan nilai z-score panjang badan menurut­­­­­­ umur (PB/U). Pengukuran panjang dan tinggi badan menggunakan infantometer dan microtoise. Penilaian hormon pertumbuhan berdasarkan kadar TSH, sedangkan penilaian inflamasi usus berdasarkan pengukuran kadar Reg 1B. Fungsi absorbsi usus ditetapkan dengan pengukuran kadar xilosa darah. Infeksi parasit dideteksi dengan pemeriksaan feses secara makroskopis dan kultur Blastocystis. Penilaian asupan energi dan zat gizi makro dilakukan dengan metode recall 24 jam. Frekuensi pengukuran panjang dan tinggi badan, inflamasi usus dan penilaian asupan dilakukan 2 kali dengan selang waktu 6 bulan.Hasil: Pada penapisan 269 anak didapatkan 20,4% pendek dengan 55,8% laki-laki, 55,0% kelompok umur 12-23 bulan dan 47,3% memiliki kedua orang tua normal. Profil subjek penelitian adalah 61,1% laki-laki, 88,9% pada kelompok umur 12-23 bulan dan memiliki kadar TSH normal. Persentase rata-rata asupan energi dan zat gizi makro anak pendek lebih rendah daripada anak normal, tetapi tidak berbeda secara statistik. Pada subjek penelitian tidak ditemukan Soil Transmitted Helminths dan hanya 1 anak normal yang positif Blastocystis hominis. Untuk pemeriksaan Reg 1B tidak ditemukan perbedaan antara anak pendek dan normal, tetapi subjek penelitian yang mengalami peningkatan kadar Reg 1B sebagian besar terjadi penurunan nilai Z-score PB/U dan berbeda bermakna secara statistik. Pada pemeriksaan kadar xilosa darah tidak ditemukan perbedaan antara anak pendek dan normal. Dalam analisis korelasi, tidak diperoleh korelasi antara infeksi parasit usus dengan inflamasi usus dan malabsorbsi tetapi ada korelasi bermakna antara inflamasi usus dengan malabsorbsi.Kesimpulan: Inflamasi usus terjadi pada anak pendek dan normal serta secara signifikan menurunkan nilai Z-score PB/U dari kedua anak tersebut dan berkorelasi secara bermakna dengan malabsorbsi.

---

Background and Objective: The prevalence of stunting in children under two years in Indonesia in 2018 is 29.9%, while in Jakarta it is 27.2%. Stunted early in life is associated with increased morbidity and mortality, and can reduce physical capacity and increase the risk of metabolic diseases in adulthood. The aim of the study was to understand the role of intestinal inflammation in children under 2-yrs of age in stunted incidents.

Materials and Methods: A case-control study involving children aged 6-23 months in Kampung Melayu Village, Jakarta was done in 2018. Study sampling was determined by simple randomization. Stunting is determined based on the z-score of the body length by age (LZA). Length was measured using infantometer while height was measured by microtoise. Growth hormone was determined by TSH levels, while intestinal inflammation was determined with faecal Reg 1B levels. The function of intestinal absorption is determined by blood xylose levels. Parasitic infections are determined by macroscopic fecal examination and Blastocystis culture. Assessment of intake of energy and macro nutrients was analyzed by 24-hour recall method. The frequency of length and height measurements, intestinal inflammation and intake assessment were carried out twice with an interval of 6 months.

Results: Screening of 269 children found 20.4% of stunting with 55.8% of men, 55.0% of age group 12-23 months and 47.3% had both normal parents. The percentage of the average intake of energy and macro nutrients from stunting was lower than normal, but not statistically different. Soil Transmitted Helminths were not found and only one child for positive Blastocystis hominis. For the examination of Reg 1B there was no difference between stunted and normal children, but the study subjects who experienced an increase in Reg 1B levels were mostly accompanied by decreased Z-score values of LZA and were significantly different. On examination of blood D-xylose levels no differences were found between stunted and normal children. In correlation analysis, there was no correlation between intestinal parasitic infection and intestinal inflammation and malabsorption but there was a significant correlation between intestinal inflammation and malabsorption.

Conclusion: Intestinal inflammation occurs in stunted and normal children and significantly decreases the Z-score of LZA from these two children and correlates significantly with malabsorption.

"

"Latar belakang: masyrakat Indonesia sangat terpajan oleh radiasi UV. Efek toksik radiasi UV yang terdapat di sinar matahari merupakan masalah kesehatan yang serius yang dapat berupa inflamasi (eritema), tanning, dan imunosupresi lokal ataupun sistemik. Kunyit merupakan salah satu tanaman rempah yang terkenal di Indonesia. Kurkumin merupakan suatu zat yang terdapat pada kunyit. Penelitian secara in vitro dan in vivo menunjukkan bahwa kurkumin mempunyai efek antiinflamasi yang kuat. Sediaan kurkumin yang saat ini dipasarkan di Indonesia hanya dalam bentuk sediaan oral.Tujuan: Untuk membuktikan bahwa kurkumin dalam vehikulum salep dan krim mampu memberikan efek antiinflamasi pada kulit mencit yang telah diberi sinar UV. Metode: Penelitian ini merupakan penelitian eksperimental untuk mengetahui manfaat pemberian kurkumin secara topikal terhadap kulit mencit yang telah disinari UV. Dalam penelitian ini, peneliti mengelompokkan perlakuan pada mencit menjadi tiga kelompok, yaitu mencit yang diberi salep kurkumin 1%, kri kurkumin 1%, dan yang tidak diberi perlakuan. Hasil pengamatan dinilai secara histopatologi berdasarkan lima parameter, yaitu adanya blister, jumlah neutrofil, jumlah limfosit, jumlah fibroblast, dan morfologi kapiler.Hasil: Dengan menggunakan uji nonparametrik Kruskal-Wallis, diperoleh nilai probabilitas 0,047 (p=0,047) dilanjutkan dengan uji analisis Post Hoc dan didapatkan: kontrol dibandingkan dengan salep kurkumin 1% diperoleh nilai probabilitas 0,046 (p=0,046); kontrol dibandingkan dengan krim kurkumin 1% diperoleh nilai probabilitas 0,046 (p=0,046); krimkurkumin % dibandingkan dengan salep kurkumin 1% diperoleh nilai probabilitas 0,2 (p=0,2)Kesimpulan: terdapat perbedaan efek antiinflamasi antara salep kurkumin 1%, krim kurkumin 1%, dan yang tidak diberi perlakuan pada kulit mencit yang telah disinari sinar UV selama 5 jam; perbedaan vehikulum tidak mempengaruhi efekantiinflamasi yang diberikan oleh kurkumin.

---

Introduction: Indonesians are very exposed to UV irradiation. Toxic effect from the sun is a major health problem which include inflamation (erythema), tanning, and local or systemic immunosuppression. Curcuma is one of spices that is famous in Indonesia. Curcumin is the most important constituent in this plant. In vitro and in vivo researches had approved that curcumin has an antiinflammatory properties. Nowadays, curcumin that sold in Indonesia was an oral medicine.

Aim: To prove that curcumin in vehicle such as ointment and vanishing cream has an antiinflammatory propesties in mice?s skin that was radiated with UV lamp. Methods: This research was an experiment in order to know the benefits of applying topical curcumin on mice?s skin that was radiated from UV lamp. In this research, the researcher devide the mice into three subgroups, which are mice given curcumin ointment 1%, vanishing 1%, and without intervention. All results were assessed by histopathology examination based on five parameters which are blisters, neutrofils, lymphocytes, morfology of dermis capiler, and fibroblast.

Results: By using Kruskal-Wallis non parametric test, the probability value was 0,047. Continued with Mann_whitney test, the obtained probability values were: control compare with curcumin ointment 1% 0,046 (p=0,046), control compare curcumin vanishing cream 1% 0,046 (p=0,046), curcumin vanishing cream 1% and curcumin ointment 1% 0,2 (p=0,2)

Conclusion: Curcumin ointment 1% and curcumin vanishing cream 1% exerted an antiinflammatory properties on mice?s skin that was radiated for five hours. Vehicles were not influenced the antiinflammatory properties of curcumin."