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"[ABSTRAKLatar Belakang: Penelitian mengenai dampak kesehatan dari pajanan asap rokok lingkungan dengan menggunakan kotinin, yaitu suatu hasil metabolisme nikotin yang terdeteksi dalam urin, telah direkomendasikan sebagai pengukuran kuantitatif nikotin dalam tubuh dan biomarker pajanan asap rokok lingkungan. Tujuan: Tujuan penelitian ini untuk melihat hubungan pajanan asap rokok di rumah pada perempuan dewasa bukan perokok, dengan mengukur kadar kotinin urin, CO ekspirasi dan melihat dampak kesehatannya.Metode: Penelitian ini berjenis potong lintang terhadap 60 orang perempuan dewasa bukan perokok terpajan dan 58 orang tidak terpajan asap rokok di rumahnya dalam wilayah Pasar Rebo, Jakarta. Kadar kotinin urin diukur menggunakan metode pemeriksaan ELISA. Sebagai informasi tambahan, kami mengumpulkan data kadar CO ekspirasi, kuesioner kebiasaan merokok anggota keluarga di rumah dan dampak kesehatan respirasi subyek penelitian.Hasil: Nilai median kadar kotinin urin yang didapat adalah 24,65 ng/ml pada kelompok terpajan dan 7,30 ng/ml pada kelompok tidak terpajan (p=0.000). Nilai median kadar CO ekspirasi adalah 5,00 ppm pada kelompok terpajan dan 3,00 ppm pada kelompok tidak terpajan (p=0.000). Durasi terpajan asap rokok (jumlah jam/hari) pada perempuan perokok pasif memiliki hubungan signifikan dengan tinggi rendahnya kadar kotinin urin(p=0.037). Gejala sesak napas yang muncul berhubungan signifikan dengan status pajanan asap rokok subjek (p=0.01). Faktor lama pajanan asap rokok terakhir memiliki hubungan signifikan dengan kadar CO ekspirasi (p=0,004). Nilai titik potong kotinin urin antara kelompok terpajan dan tidak terpajan asap rokok adalah 14,4 ng/ml (sensitifitas 75,0 %, spesifisitas 74,0 %, p=0.000). Nilai titik potong CO ekspirasi adalah 3,5 ppm (sensitifitas 75,0 %, spesifisitas 81,0 %, p=0.000).Terdapat korelasi yang cukup kuat dan signifikan antara kadar CO ekspirasi dan kotinin urin (r=0,641, p=0,000).Kesimpulan: Kadar kotinin urin dan CO ekspirasi pada perempuan dewasa yang terpajan asap rokok lebih tinggi dibandingkan perempuan yang tidak terpajan asap rokok di rumah. Pengukuran kotinin urin adalah metode pengukuran pajanan asap rokok lingkungan dalam tubuh yang sensitif, non-invasif dan efektif.;Introduction :Studies of environmental tobacco smoke (ETS) health effects using cotinine, a nicotine metabolite detected in urine, has been recommended as a quantitative measurement of nicotine intake and as biomarker for ETS exposure in humans.

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ABSTRACTObjective: The aim of this study is to correlate dailyindoor ETS exposure in non-smokers (adult women) by measuring urinary cotinine levels, CO expiration and it`s health effects.Method: We performed a cross-sectional study to 60 ETS-exposed and 58 non ETS exposed adult women in Pasar Rebo area, Jakarta. The urinary cotinine concentrations were measured and analyzed using ELISA method. In addition, CO expiration data and other information were collected through questionnaire regarding smoking habits of the subjects family members at home and respiratory health effects occured to subjects.Results: Significant median urinary cotinine concentrations were found; 24,65 ng/ml in ETS-exposed group and 7,30 ng/ml in non-exposed to ETS group(p=0,000). Significant median CO expirationalso were found; 5,00 ppm in ETS exposed group and 3,00 ppm in non-exposed to ETS group (p=0.000). Total ammount of time (hours/day) women exposed to ETS in their house was significantly correlated to urinary cotinine concentrations result (p=0,037). The respiratory symptoms (dyspnea) occured to subjects showed significant relation with ETS exposure status (p=0,01). Time duration of last exposed to ETS had significant relation with CO expiration (p=0.004).The urinary cotinine concentrations cut-off point to differentiate ETS exposed and non-ETS exposed group in adult women was 14,4 ng/ml (sensitivity 75%,specificity 74%,p=0.000). The CO expiration cut-off point was 3,5 ppm (sensitivity 75%, specificity 81%, p=0.000). Strong and significant correlation was found between CO expiration and urinary cotinine value (r=0,641, p=0,000).Conclusion: The urinary cotinine concentration and CO expiration are significantly higher in women exposed to tobacco smoke at home group than the non-exposed group. Urinary cotinine measurement is a sensitive, noninvasive and effective method to correlate with ETS exposure.;Introduction :Studies of environmental tobacco smoke (ETS) health effects using cotinine, a nicotine metabolite detected in urine, has been recommended as a quantitative measurement of nicotine intake and as biomarker for ETS exposure in humans.Objective:The aim of this study is to correlate dailyindoor ETS exposure in non-smokers (adult women) by measuring urinary cotinine levels, CO expiration and it`s health effects.Method :We performed a cross-sectional study to 60 ETS-exposed and 58 non ETS exposed adult women in Pasar Rebo area, Jakarta. The urinary cotinine concentrations were measured and analyzed using ELISA method. In addition, CO expiration data and other information were collected through questionnaire regarding smoking habits of the subjects family members at home and respiratory health effects occured to subjects.Results :. Significant median urinary cotinine concentrations were found; 24,65 ng/ml in ETS-exposed group and 7,30 ng/ml in non-exposed to ETS group(p=0,000). Significant median CO expirationalso were found; 5,00 ppm in ETS exposed group and 3,00 ppm in non-exposed to ETS group (p=0.000). Total ammount of time (hours/day) women exposed to ETS in their house was significantly correlated to urinary cotinine concentrations result (p=0,037). The respiratory symptoms (dyspnea) occured to subjects showed significant relation with ETS exposure status (p=0,01). Time duration of last exposed to ETS had significant relation with CO expiration (p=0.004).The urinary cotinine concentrations cut-off point to differentiate ETS exposed and non-ETS exposed group in adult women was 14,4 ng/ml (sensitivity 75%,specificity 74%,p=0.000). The CO expiration cut-off point was 3,5 ppm (sensitivity 75%, specificity 81%, p=0.000). Strong and significant correlation was found between CO expiration and urinary cotinine value (r=0,641, p=0,000)Conclusion :The urinary cotinine concentration and CO expiration are significantly higher in women exposed to tobacco smoke at home group than the non-exposed group. Urinary cotinine measurement is a sensitive, noninvasive and effective method to correlate with ETS exposure., Introduction :Studies of environmental tobacco smoke (ETS) health effects using cotinine, a nicotine metabolite detected in urine, has been recommended as a quantitative measurement of nicotine intake and as biomarker for ETS exposure in humans.Objective:The aim of this study is to correlate dailyindoor ETS exposure in non-smokers (adult women) by measuring urinary cotinine levels, CO expiration and it`s health effects.Method :We performed a cross-sectional study to 60 ETS-exposed and 58 non ETS exposed adult women in Pasar Rebo area, Jakarta. The urinary cotinine concentrations were measured and analyzed using ELISA method. In addition, CO expiration data and other information were collected through questionnaire regarding smoking habits of the subjects family members at home and respiratory health effects occured to subjects.Results :. Significant median urinary cotinine concentrations were found; 24,65 ng/ml in ETS-exposed group and 7,30 ng/ml in non-exposed to ETS group(p=0,000). Significant median CO expirationalso were found; 5,00 ppm in ETS exposed group and 3,00 ppm in non-exposed to ETS group (p=0.000). Total ammount of time (hours/day) women exposed to ETS in their house was significantly correlated to urinary cotinine concentrations result (p=0,037). The respiratory symptoms (dyspnea) occured to subjects showed significant relation with ETS exposure status (p=0,01). Time duration of last exposed to ETS had significant relation with CO expiration (p=0.004).The urinary cotinine concentrations cut-off point to differentiate ETS exposed and non-ETS exposed group in adult women was 14,4 ng/ml (sensitivity 75%,specificity 74%,p=0.000). The CO expiration cut-off point was 3,5 ppm (sensitivity 75%, specificity 81%, p=0.000). Strong and significant correlation was found between CO expiration and urinary cotinine value (r=0,641, p=0,000)Conclusion :The urinary cotinine concentration and CO expiration are significantly higher in women exposed to tobacco smoke at home group than the non-exposed group. Urinary cotinine measurement is a sensitive, noninvasive and effective method to correlate with ETS exposure.]"

"ABSTRAKLatar Belakang : Benzo(a)pyrene (BaP) adalah hidrokarbon aromatik polisiklik sangat karsinogenik yang terdapat dalam asap rokok. Tidak hanya perokok yang perlu menjadi perhatian, namun bahaya yang ditimbulkan akibat asap rokok pada orang yang tidak merokok juga perlu diperhatikan.Metode : Penelitian ini berjenis potong lintang pada 26 perempuan dewasa bukan perokok yang terpajan asap rokok dan 15 perempuan tidak terpajan asap rokok di rumahnya di kelurahan Palmeriam Kecamatan Matraman, Jakarta. Kadar BPDE-protein adducts diukur menggunakan metode ELISA. Kadar CO ekspirasi, informasi kebiasaan merokok anggota keluarga di rumah pada subjek penelitian dikumpulkan melalui kuesioner.Hasil : Nilai BPDE-protein adducts <40 ng/ml sebanyak 16 orang (61,5%) dan nilai BPDE-protein adducts >40 ng/ml sebanyak 10 orang (38,5%), sedangkan pada kelompok perempuan tidak terpajan asap rokok di rumah, nilai BPDE-protein adducts <40 ng/ml sebanyak 11 orang (73,3%) dan nilai BPDE-protein adducts >40 ng/ml sebanyak 4 orang (26,7%), hasil analisis menunjukkan perbedaan yang tidak bermakna (p=0,443). Pengukuran kadar CO ekspirasi pada penelitian ini memperoleh nilai tengah kadar CO ekspirasi pada kelompok perempuan yang terpajan asap rokok sebesar 5,5 ppm. Pada kelompok perempuan yang tidak terpajan asap rokok, rerata kadar CO ekspirasi sebesar 6 ppm, hasil analisis tidak menunjukkan adanya perbedaan yang bermakna (p=0,398). Lama pajanan, jenis rokok, banyaknya jumlah rokok yang dihisap serta banyaknya jumlah perokok aktif dirumah tidak mempengaruhi kadar BPDE-protein adducts.Kesimpulan : Nilai BPDE-protein adducts >40 ng/ml pada perempuan terpajan asap rokok lebih tinggi dibandingkan dengan perempuan yang tidak terpajan asap rokok di lingkungan rumah.

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ABSTRACTBackground: Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon contained in cigarette smoke. This highly carcinogenic substance is also found in Environmental Tobacco Smoke (ETS) which equally dangerous to the health of population and equally require attentions as much as cigarette smoke. This study observes level of BaP among those in risk of ETS exposure.Methods: A cross-sectional study was performed involving 26 women exposed to ETS and 15 women unexposed to ETS in Palmeriam Matraman area, Jakarta, Indonesia. The BPDE (Benzo(a)pyrene Diol Epoxide) protein levels of adducts were measured using ELISA method. In addition, exhaled carbon-monoxide (CO) level during expiration was measured and family members smoking habits at home was obtained using questionnaire.Results: The mean age of women exposed to ETS was 35.8 ± 6.5 years and women unexposed to ETS was 41.7±7.5 years. In the ETS exposed women, the BPDE level of <40 ng/mL was found in 16 people (61.5%) and the BPDE level of >40 ng/mL was found in 10 people (38.5%). In the ETS unexposed women, the BPDE level of <40 ng/mL was found in 11 people (73.3%) and the BPDE level of >40 ng/mL was found in 4 people (26.7%). None of these results were significantly different (p=0.443). The median exhaled CO level of ETS exposed women was 5.5 ppm and of ETS unexposed women was 6.0 ppm. None of these results were significantly different (p=0.398). No correlation was found between length of ETS exposure, types of cigarettes, number of cigarettes smoked and number of active smokers at home and BPDE-protein adducts level.Conclusion: The BPDE level of ETS exposed women was higher than of ETS unexposed women (>40 ng/mL and <40 ng/mL, respectively). The median exhaled CO level of ETS exposed women was lower than of ETS unexposed women (5.5 ppm and 6.0 ppm). However, none of these results were statistically significant."

"Latar Belakang: Menurut Global Youth Tobacco Survey GYTS Indonesia 2014, 57,3 siswa terpajan asap rokok. Pajanan asap rokok menyebabkan inflamasi saluran nafas dan paru, serta penurunan fungsi paru. Kotinin sebagai metabolisme nikotin dapat digunakan sebagai biomarker pajanan asap rokok.Tujuan: Mengetahui efek pajanan asap rokok lingkungan terhadap kadar kotinin urin dan uji fungsi paru pada anak.Metode: Penelitian teknik potong lintang dengan subyek siswa berusia 11-16 tahun di Jakarta. Data didapat dari kuesioner, spirometri, dan penghitungan kadar kotinin urin dengan metode ELISA.Hasil: Terdapat 92 subyek, terdiri dari 46 kelompok kasus dan 46 kelompok kontrol. Kadar kotinin urin >10 ng/ml ditemukan pada 37,0 kelompok kasus dan 4,3 kelompok kontrol; p=0,000; OR=8,50 95 IK 2,08-34,71 . Terdapat perbedaan bermakna kadar kotinin urin terhadap jumlah perokok p=0,027 dan jumlah batang rokok per hari p=0,037 . Tidak ditemukan hubungan pajanan asap rokok dengan uji fungsi paru. Terdapat perbedaan bermakna absensi anak pada kelompok kasus dibandingkan kelompok kontrol; p=0,004; OR=6,00 95 IK 1,42-25,33 .Kesimpulan: Anak yang terpajan asap rokok memiliki kadar kotinin urin lebih tinggi dibandingkan yang tidak terpajan, yang dapat dipengaruhi oleh jumlah perokok dan jumlah batang rokok per hari.

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Background Global Youth Tobacco Survey GYTS 2014 in Indonesia showed that 57,3 of students are exposed to enviromental tobacco smoke, which causes inflammation of respiratory tracts and decrease of lung function. Urinary cotinine can be used as biomarker for cigarette smoke exposure.Objectives To examine effects of enviromental tobacco smoke exposure on urinary cotinine level and lung function test in children.Methods Subjects were students aged 11 16 years old in Jakarta. Data were obtained from questionnaire, spirometry, and urinary cotinine test using ELISA method.Results There were 92 subjects, consisted of 46 case group and 46 control group. Urinary cotinine level 10 ng ml was found in 37,0 of case group and 4,3 of control group p 0,000 OR 8,50 CI 95 2,08 34,71 . There were significant differences between urinary cotinine level with number of smokers p 0,027 and number of cigarettes per day p 0,037 . No association was found between cigarette smoke exposure and lung function test. There was a significant difference in school abscence between case group and control group p 0,004 OR 6,00 CI 95 1,42 25,33 .Conclusions Children exposed to enviromental tobacco smoke have higher urinary cotinine level than non exposed children. Factor such as number of smokers and number of cigarettes per day may affect urinary cotinine level. "

"Besarnya jumlah perokok aktif yang ada di Indonesia diikuti juga oleh besarnya jumlahperokok pasif. Penelitian telah membuktikan bahwa asap rokok dari perokok aktif dapatmenimbulkan masalah kesehatan yang berbahaya bagi perokok pasif. Pengetahuan perokok pasif tentang bahaya asap rokok bagi perokok pasif akan mempengaruhi perilaku mereka terhadap hal tersebut. Untuk menggambarkan pengetahuan perokok pasif tentang bahaya asap rokok bagi perokok pasif dilakukan penelitian dengan metode survei cross-sectional pada 60 sampel yang dipilih secara random cluster sampling di RW 05 Kelurahan Bidara Cina pada tanggal 22 dan 23 Desember 2003. Penelitian ini menggunakan kuesioner dengan pertanyaan tertutup. Dari hasilpenelitian ini didapatkan sebanyak 13,3% responden mempunyai pengetahuan sangat baik, 63,3% responden mempunyai pengetahuan baik, 23,3% resppnden mempunyai pengetahuan buruk, dan tidak ada responden yang mempunyai pengetahuan sangat buruk. Selain itu, tidak didapatkan perbedaan pengetahuan yang berarti diantara jenis pekerjaan dan tingkat pendidikan."

"Pendahuluan: Wasting, underweight, dan stunting meningkatkan angka mortalitas dan morbiditas serta merupakan permasalahan yang masih ditemukan di Indonesia. Paparan asap rokok terhadap anak meningkatkan resiko wasting, underweight, dan stunting pada anak. Penelitian ini bertujuan untuk mengetahui asosiasi antara paparan asap rokok terhadap status gizi anak 0-59 bulan yang berdomisili di DKI Jakarta.Metode: Studi dengan pendekatan potong lintang dilakukan terhadap 121 orangtua dengan anak yang berusia 0-59 bulan pada Jakarta Pusat. Data mengenai paparan asap rokok diambil melalui kuesioner yang dibagikan kepada responded. Analisis data dilakukan dengan program SPSS. Status gizi anak dianlisa berdasarkan WHO Weight-for-Height, Weight-for-Age, and Height-for-Age Z-score.Hasil: Dalam riset ini, prevalensi wasting, underweight, and stunting masing-masing adalah 6.6%, 9.1% and 31.4%. Analisis statistik bivariat dilakukan menggunakan chi-square dan fisher’s exact test yang menunjukan tidak adanya asosiasi antara paparan asap rokok dari ayah dan ibu yang merokok dengan wasting, underweight, dan stunting pada anak. Ditemukan adanya asosiasi anatara paparan asap rokok terhadap ibu saat kehamilan terhadap stunting pada anak (p= 0.024; OR= 0.409; CI(95%)= 0.186-0.898). Melalui analisa logistic regression, ditemukan assosiasi anatara umur ibu (p=0.042; OR= 3.223) dan pendidikan ayah (p=0.011; OR= 4.082) terhadap terjadinya stunting pada anak. Terdapat pula asosiasi antara umur ibu dan underweight pada anak (p= 0.047; OR= 4.229).Kesimpulan: Tidak ditemukan asosiasi anatara paparan asap rokok terhadap anak dan wasting, underweight, dan stunting. Terdapat asosiasi anatara paparan asap rokok terhadap ibu saat hamil terhadap stunting pada anak.

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Introduction:Wasting, underweight, and stunting is associated with an increase morbidity and mortality in children and is still a problem in Indonesia. Environmental tobacco smoke exposure towards children has been associated with an increase risk of wasting, underweight, and stunting in children. In this research, we aim to investigate the association between tobacco smoke exposure in DKI Jakarta household and nutritional status of children <5 years old.Methods : Cross-sectional study with random sampling technique in 121 parents with children age 0-59 months in Central Jakarta. Tobacco smoke exposure is measured through questionnaire. The results are analyzed using SPPS statistic program. Nutritional status of children is analyzed through WHO Weight-for-Height, Weight-for-Age, and Height-for-Age Z-score.Results: In this research, the prevalence of wasting, underweight, and stunting are 6.6%, 9.1% and 31.4%, respectively. Bivariate statistical analysis using chi-square and Fisher’s Exact Test showed no association between tobacco smoke exposure with wasting, underweight, and stunting, while an association was found between tobacco smoke exposure during pregnancy with stunting in children aged 0-59 months (p= 0.024; OR= 0.409; CI(95%)= 0.186-0.898). Logistic regression analysis showed that Mother's age (p and paternal education (p=0.011; OR= 4.082) increases risk of stunting in children. Age of mother is associated with Underweight in children (p= 0.047; OR= 4.229).Conclusion: No association between paternal and maternal smoking with underweight, wasting, and stunting is found, while an association was found between tobacco smoke exposure during pregnancy with stunting in children."

"ABSTRAK Latar Belakang : Kotinin merupakan hasil metabolit utama nikotin dankadarnya pada urin merupakan indikator pajanan asap rokok. Penlitian ini untukmengetahui kadar kotinin urin pada anak yang terpajan dan tidak terpajan asaprokok di lingkungan rumah. Metode : Penelitian potong lintang pada anak usia sekolah dasar yang tidakmerokok. Subjek dikelompokkan menjadi kelompok terpajan dan tidak terpajanberdasarkan status pajanannya. Data yang diperoleh dari kuesioner dan sampelurin sewaktu yang diukur dengan metode ELISA. Hasil : Total subjek 128 anak usia 6-12 tahun yang terdiri dari 64 anak padakelompok terpajan dan 64 anak yang tidak terpajan. Kadar kotinin urin padakelompok terpajan lebih tinggi dibandingkan kelompok tidak terpajan (median30,1 vs 8,45 ng/ml; p<0.05). Terdapat perbedaan kadar kotinin pada anak yangterpajan asap rokok dengan jumlah batang rokok yang dihisap oleh perokok dirumah (p<0.05). Status pajanan asap rokok berhubungan dengan keluhan batuk,infeksi saluran napas atas dan rawat inap karena keluhan respirasi pada anak. Nilaititik potong optimal kadar kotinin urin pada anak untuk menilai pajanan asaprokok yaitu 17,95 ng/ml (sensitifitas 81%, spesifisitas 81%, AUC 91,2%, p<0.05).Kesimpulan: Kadar kotinin urin dapat digunakan sebagai biomarker yang tidak invasif untuk evaluasi pajanan asap rokok pada anak.ABSTRACT Introduction : The cotinine is major metabolite of nicotine and the level ofurinary cotinine is an indicator of tobacco smoke exposure. This study investigate role of urinary cotinine level in children exposed and unexposed to tobacco smokeat home.Method : A Cross sectional study that enrolled elementary school nonsmokerschildren classified into exposed group and unexposed group based on tobaccosmoke sexposure status. The questionnaire and spot urinary samples werecollected and urinary cotinine levels were measured by ELISA.Results : A total 128 nonsmokers children age 6-12 years divided into 64 childrenin exposed group and 64 children in unexposed group. The urinary cotinine levelsin exposed group significantly higher than unexposed group (median 30,1 ng/m;vs 8,45 ng/ml; p<0.05). There was significant difference of urinary cotinine levelin exposed group with number of cigarettes (p<0.05). Tobacco smoke exposurestatus associated with frequent cough symptom, upper respiratory infection andhospitalization because of respiratory symptoms in subjects. The optimal cut offpoint urinary cotinine in children to distinguish unexposed children with exposedto tobacco smoke at home was 17,95 ng/ml (sensitivity 81%, spesificity 81%,p<0.05).Conclusion : The urinary cotinine level is useful and noninvasive biomarker for evaluating tobacco smoke exposure in children. ;Introduction : The cotinine is major metabolite of nicotine and the level ofurinary cotinine is an indicator of tobacco smoke exposure. This study investigate role of urinary cotinine level in children exposed and unexposed to tobacco smokeat home.Method : A Cross sectional study that enrolled elementary school nonsmokerschildren classified into exposed group and unexposed group based on tobaccosmoke sexposure status. The questionnaire and spot urinary samples werecollected and urinary cotinine levels were measured by ELISA.Results : A total 128 nonsmokers children age 6-12 years divided into 64 childrenin exposed group and 64 children in unexposed group. The urinary cotinine levelsin exposed group significantly higher than unexposed group (median 30,1 ng/m;vs 8,45 ng/ml; p<0.05). There was significant difference of urinary cotinine levelin exposed group with number of cigarettes (p<0.05). Tobacco smoke exposurestatus associated with frequent cough symptom, upper respiratory infection andhospitalization because of respiratory symptoms in subjects. The optimal cut offpoint urinary cotinine in children to distinguish unexposed children with exposedto tobacco smoke at home was 17,95 ng/ml (sensitivity 81%, spesificity 81%,p<0.05).Conclusion : The urinary cotinine level is useful and noninvasive biomarker for evaluating tobacco smoke exposure in children. ;Introduction : The cotinine is major metabolite of nicotine and the level ofurinary cotinine is an indicator of tobacco smoke exposure. This study investigate role of urinary cotinine level in children exposed and unexposed to tobacco smokeat home.Method : A Cross sectional study that enrolled elementary school nonsmokerschildren classified into exposed group and unexposed group based on tobaccosmoke sexposure status. The questionnaire and spot urinary samples werecollected and urinary cotinine levels were measured by ELISA.Results : A total 128 nonsmokers children age 6-12 years divided into 64 childrenin exposed group and 64 children in unexposed group. The urinary cotinine levelsin exposed group significantly higher than unexposed group (median 30,1 ng/m;vs 8,45 ng/ml; p<0.05). There was significant difference of urinary cotinine levelin exposed group with number of cigarettes (p<0.05). Tobacco smoke exposurestatus associated with frequent cough symptom, upper respiratory infection andhospitalization because of respiratory symptoms in subjects. The optimal cut offpoint urinary cotinine in children to distinguish unexposed children with exposedto tobacco smoke at home was 17,95 ng/ml (sensitivity 81%, spesificity 81%,p<0.05).Conclusion : The urinary cotinine level is useful and noninvasive biomarker for evaluating tobacco smoke exposure in children. "

"Salah satu unsur yang sangat penting untuk mempertahankan kehidupan umat manusia, hewan dan tumbuh-tumbuhan adalah udara, namun seiring dengan berkembangnya kehidupan manusia maka semakin banyak pencemaran yang dihasilkannya, salah satu hasil pencemaran yang umum terjadi dalam masyarakat adalah polutan dari asap rokok. Partikel dari asap rokok tersebut dapat menyebabkan berbagai gangguan kesehatan pada manusia.Salah satu cara untuk mengurangi pencemaran udara akibat asap rokok adalah dengan mendepositkan partikel-partikel dari asap rokok tersebut sehingga kebersihan udara sekitar dapat tetap terjaga.Oleh karena itu dibuatlah suatu alat uji untuk mendepositkan partikel-partikel tersebut menggunakan gaya thermophoresis. Gaya thermophoresis adalah gaya yang terjadi pada partikel yang disebabkan adanya gradien temperatur. Alat uji ini dinamakan thermal precipitator dimana partikel asap rokok yang melewati alat ini akan tersaring sehingga pencemaran udara yang diakibatkan oleh asap rokok ini dapat teratasi.

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One of the most important elements for maintaining the lives of human beings, animals and plants is air is an air, but within time, human life has change a lot and created more pollution, one of the pollution that is happening among the society is the pollutant from tobacco smoke. The particles from the smoke could cause so much distraction on human health.

In order to reduce air pollution caused by tobacco smoke, the particles from the tobacco smoke should be deposited so then the surround air quality can be keep clean and healthy.

Therefore, it needs to be built a device to deposits the particles using a thermophoretic force. Thermophoretic force is a force that applied on a particle because of a temperature gradient. This device called Thermal Precipitator where the particles from tobaccos smoke when passing through this device will be filtered so the pollution can be handled."

"Salah satu penyebab pencemaran udara adalah adanya polutan yang berupa aerosol smoke. Aerosol smoke itu sendiri ada bermacam-macam, tetapi yang dibahas dalam tugas akhir ini adalah tobacco smoke berukuran 0,01 ∝m ~ 1 ∝m dengan thermal precipitator sebagai alat pembersihnya yang paling efektif.Dalam melakukan penelitian ini, dibuatlah suatu alat uji coba thermal precipitator yang terdiri dari box penampung, test section, exhaust fan, dan rangka. Kegiatan yang dilakukan adalah dengan mempelajari dan menganalisa arah pergerakan smoke partikel yang kecenderungannya selalu menuju ke pelat yang lebih dingin, baik ketika posisi heater di atas maupun di bawah. Fenomena ini dinamakan thermophoresis, yaitu pergerakan partikel dalam suatu fluida yang diakibatkan adanya gradien temperatur dalam sistem tersebut.Dari hasil eksperimen dan analisa dapat diambil kesimpulan bahwa alat uji thermal precipitator dapat digunakan sebagai smoke collector dengan memanfaatkan gaya thermophoresis. Hal ini dibuktikan dengan terlihatnya pergerakan partikel ke arah pelat yang lebih dingin. Arah pergerakan juga dapat diambil visualisasinya dengan menggunakan kamera digital.

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One of the caused of Air pollution is pollutant on aerosol smoke. Aerosol smoke itself, has many kinds of type, but in this final project, we will discuss about tobacco smoke sized 0,01 ∝ m ~ 1 ∝m. And thermal precipitator as the most effective gas cleaner.

In our analyzing, made an equipment called thermal precipitator which is consists of smoke box, test section, exhaust fan and frame. Analyzing that has been done is to know smoke particle direction movement that has tendency to move to lower temperature plate, even heater on top or under the plate. This phenomena is called thermophoretic, particle movement in the fluid system that caused by temperature gradient in that system itself.

The experimental and analysation result can conclude that thermal precipitation can used for smoke collector, that utilized thermophoretic force. Proven by particle movement can be seen goes to the lower temperature plate. And also movement direction can be captured by digital camera."

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Rute pulmonal merupakan rute penghantaran zat aktif yang menjanjikan untuk pengobatan lokal dan sistemik, karena memungkinkan untuk mengadministrasikan obat dengan dosis minimum dan konsentrasi tinggi langsung pada situs terapi, non-invasif, dan tidak melalui metabolisme lintas pertama. Pemilihan eksipien yang tepat dapat menghasilkan sediaan inhalasi dengan karakteristik yang sesuai untuk penghantaran zat aktif sesuai dengan tujuan penggunaannya. Bahan alam Indonesia yang berasal dari laut (seperti kitosan, alginat, gelatin ikan) dan bahan nabati (modifikasi pati, gum alam dan xyloglucan) telah dikembangkan sebagai eksipien pada sejumlah sediaan farmasi. Namun bahan alam tersebut belum banyak dimanfaatkan sebagai eksipien sediaan inhalasi. Oleh karena itu, penulisan artikel ini bertujuan untuk mengidentifikasi karakteristik bahan alam Indonesia yang prospektif untuk dikembangkan sebagai eksipien untuk sediaan inhalasi, serta menganalisa tantangan dalam proses pengembangannya. Metode yang digunakan adalah literature review dengan pencarian artikel penelitian di sciencedirect, PubMed dan google scholar dengan kata kunci natural, excipient dan inhalation. Bahan alam Indonesia yang berasal dari laut (seperti kitosan, alginat, gelatin ikan) dan bahan nabati (modifikasi pati, gum alam dan xyloglucan) menunjukkan karakteristik yang prospektif untuk penghantaran zat aktif ke paru-paru. Pengembangan bahan alam untuk sediaan inhalasi perlu dilakukan dengan mempertimbangkan sifat fungsional eksipien yang sesuai untuk tujuan pengobatan yang diinginkan dan proses produksi yang efisien, serta kompatibilitas dan keamanan eksipien tersebut terhadap sel dan jaringan paru-paru.

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Pulmonary route is a prospective delivery route for active substances for local and systemic therapy due to its possibility to administer drugs with minimum doses and high concentrations directly at the therapeutic site, non-invasive method, and avoid the first-pass metabolism. Selecting suitable excipients can produce inhalation dosage forms with appropriate characteristic to deliver API according to their intended use. Natural excipients from Indonesia which are derived from the sea (such as chitosan, alginate, fish gelatin) and from plants (modified starch, natural gum and xyloglucan) have been developed as excipients in several pharmaceutical dosage forms. However, this natural material has not been widely used as excipient in inhalation dosage form. Therefore, this article aimed to identify characteristics of natural resources which are prospective to be developed as excipients for inhalation dosage form, as well as analyze the challenges in its development. The literature review has been performed to explore research articles in sciencedirect, PubMed and google scholar with key words of natural, excipient dan inhalation. Natural excipients from Indonesia which are derived from the sea (such as chitosan, alginate, fish gelatin) and from plants (modified starch, natural gum and xyloglucan) exhibit prospective characteristics for delivering API to the lungs. Furthermore, several considerations should be performed in developing these natural materials for inhalation dosages form, including the functional properties of the excipient required for targeted therapy and efficient production processes, as well as the compatibility and safety of the excipient toward cells and lung tissue.

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