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"Latar belakang: Interpretasi cairan peritoneum yang tepat secara sitopatologi sangat mempengaruhi tatalaksana dan prognosis pasien, padahal pemeriksaan sitopatologi cairan peritoneum masih memiliki nilai negatif palsu dan positif palsu yang cukup tinggi, dan hingga saat ini penelitian tentang arsitektur sitopatologi maupun penanda sitomorfologi yang mengarahkan pada adanya sel neoplasma di cairan peritoneum masih menunjukkan hasil yang beragam. Bahan dan cara kerja: Penelitian potong lintang dengan data sekunder berupa slaid dan formulir sediaan sitopatologi cairan peritoneum yang memiliki data berpasangan dengan diagnosis histopatologi. Diagnosis klinis berupa neoplasma epitelial ovarium. Slaid dan formulir diambil dari arsip Departemen Patologi Anatomik FKUI/RSCM tahun 2011 - 2012, dilakukan pembacaan ulang semua slaid sitopatologi dengan diagnosis akhir dikategorikan sebagai positif atau negatif, peneliti membaca pula sediaan histopatologi untuk mengetahui morfologi sel pada lesi, kemudiaan dilakukan penilaian terhadap arsitektur sitopatologi berupa: selularitas, sel berkelompok, struktur papiler, intercelular windows, group contours, jisim psamoma, dan penanda sitomorfologi berupa: atipia inti, inti bertumpuk, anak inti, rasio inti:sitoplasma, ukuran inti, dan ukuran sel.Hasil penelitian: Sampel penelitian sejumlah 47 sediaan sitopatologi dengan diagnosis sitopatologi akhir 34 kasus (72.3%) negatif, 13 kasus (27.7%) positif. Terdapat perbedaan bermakna arsitektur sitopatologi berupa: selularitas (p = 0.017), sel berkelompok (p = 0.001), intercellular windows (p = 0.00), group contours (p = 0.00), dan gambaran sitomorfologi berupa: atipia inti (p = 0.00), inti bertumpuk (p = 0.001), anak inti (p = 0.001), rasio inti:sitoplasma (p = 0.00), ukuran inti (p = 0.00), ukuran sel (p = 0.00) antara cairan peritoneum positif dan negatif. Melalui uji multivariat didapatkan penanda yang paling berpengaruh terhadap diagnosis sitopatologi positif atau negatif yaitu: intercellular windows, atipia inti, dan selularitas.Kesimpulan: Terdapat tiga penanda yang paling berpengaruh terhadap diagnosis positif ditemukannya sel neoplasma ganas dalam cairan peritoneum pada kasus dengan lesi ovarium, secara berturut - turut yaitu: tidak ditemukannya intercellular windows pada kelompokan sel, sel memiliki atipia inti sedang hingga berat, dan selularitas lebih dari 20 kelompok dari keseluruhan sediaan apus.

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Background : Peritoneal fluid cytopathology interpretation profoundly influences patients management and prognosis, however this practice still has high false positive and false negative value, and until now research concerning the architectural and cytomorphology features for detecting malignant cells in peritoneal fluid still has various result.Materials and Methods : Cross sectional study using secondary data of peritoneal fluid cytopathology and histopathology slides and form, from patients with clinical diagnosis of ovarian epithelial neoplasm. The data was taken from the archive of Anatomical Pathology Department Cipto Mangunkusumo Hospital 2011 - 2012. The researchers examined the cytopathology slides and also examined the histopatology slide for morphology comparison, and then make a final cytopathological diagnosis of positive peritoneal fluid containing neoplastic cells or negative. Architectural features including: cellularity, cells grouping, papillary structure, intercellular windows, group contours, psamoma bodies, and cytomorphology features including: nuclear atypia, overlapping nuclei, nucleoli, nuclei : cytoplasm ratio, the dimension of the nuclei and cells were also examined.Result : There were 47 samples with final cytopathology diagnosis: 34 cases (72.3%) negative for neoplastic cells in the peritoneal fluid and 13 cases (27.7%) positive. There were significant differences in cytopathology architectural including cellularity (p = 0.017), cells grouping (p = 0.001), intercellular windows (p = 0.00), group contours (p = 0.00) and cytomorphology features including nuclear atypia (p = 0.00), overlapping nuclei (p = 0.001), nucleoli (p =0.001), nuclei : cytoplasm ratio (p = 0.00), the dimension of nuclei (p = 0.00), the dimension of cell (p = 0.00) between the positive and negative peritoneal fluid cytopathology. Using multivariate analysis there were 3 cytological features that have the strongest association with positive or negative peritoneal cytopathology diagnosis, they were: intercellular windows, nuclear atypia, and cellularity.Conclusion: In peritoneal fluid cytopathology for examining ovarian lesion there were 3 cytological features that have the strongest association with finding neoplastic cells in peritoneal fluid, they were: the absent of intercellular windows, moderate to severe cytological atypia, and cellularity more than 20 groups in all smear preparation."

"Kanker payudara merupakan kanker paling umum pada wanita di seluruh duniadengan insiden lebih dari dua juta orang setiap tahunnya. Kanker payudarastadium lanjut lokal adalah jenis kanker payudara invasif yang terbatas padapayudara regional dan kelenjar getah bening. Salah satu terapi adalah kemoterapineoadjuvan (KN) yang efikasinya dapat dievaluasi secara respons patologisdengan Miller Payne. Penting untuk mengidentifikasi biomarker sebagai prediktorrespons patologis setelah KN. Limfosit CD8+ diperiksa sebagai prediktorkeberhasilan KN lanjut lokal. Dengan menggunakan metode cross-sectional,penelitian ini dilakukan di laboratorium patologi anatomi dan divisi bedahonkologi RSUPN Dr. Cipto Mangunkusumo antara bulan Januari-Juni 2022.Subjek penelitian ini adalah pasien kanker payudara stadium lanjut lokal yangmenjalani operasi pengangkatan payudara dengan terapi KN dari bulan September2015- Februari 2022. Subjek penelitian ini didominasi luminal B, grade 2, ER+dan kemoterapi berbasis antrasiklin. Ekspresi limfosit CD8+ tinggi dan tidak adahubungan dengan faktor klinikopatologi. Sebagian besar pasien memberikanrespon patologis positif terhadap kemoterapi dan terdapat hubungan yangbermakna antara ekspresi limfosit T CD8+ dengan respon patologis Miller-Payne.Diperlukan penelitian lebih lanjut mengenai ekspresi limfosit CD8+ sebagai faktorprediktif dalam respon kemoterapi neoadjuvan.

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Breast cancer is the most common cancer in women worldwide with an incidence

of more than two million people annually. Locally advanced breast cancer is a

type of invasive breast cancer limited to the regional breast and lymph nodes. One

of the treatments is neoadjuvant chemotherapy (NC) whose efficacy can be

evaluated by the Miller Payne method. It is important to identify biomarkers to

predict pathological responses after NC. CD8+ lymphocyte was examined as a

predictor of advanced local NC successfulness. Using cross-sectional method, this

research was done in the laboratory of anatomical pathology and division

surgical oncology RSUPN Dr. Cipto Mangunkusumo between January-June 2022.

The subjects were locally advanced breast cancer patients who received

neoadjuvant breast removal surgery from September 2016- February 2022. 35 out

of 40 subjects had clinical stage T4 mostly NST, luminal B, grade 2, ER+ and

anthracycline-based chemotherapy. The expression of CD8+ lymphocytes was

high and there was no association with clinicopathological factors. Most of the

patients respond positively to chemotherapy and there is a significant relationship

between the expression of CD8+ T lymphocytes with Miller Payne pathological

response. Further research on CD8+ lymphocyte expression"

"The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases."

"Penelitian awal mengenai distribusi frekwensi kista dentigerous sebagai akibat gigi impaksi dilakukan pada penderita2 yang datang pada poliklinik bedah mulut FKG UI / RSCM selama periode Jan.'84 - Des.'84.Hal ini dianggap penting, karena berdasarkan pengalaman-pengalaman selama dasawarsa terakhir , cukup banyak dijumpai kasus-kasus baik kasus impaksi maupun kasus-kasus kista dentigerous.5edangkan data-data mengenai hal tersebut,terutama di Bagian Bedah Mulut FKGUI/ RSCM belum ada hingga saat ini.Memang harus diakui, bahwa dengan penelitian salama setahu pada pasien-pasien yang datang ke Poli Badah Mulut FKGUI/RSCM belum dapat menggambarkan atau mewakilimpopulasi sebenarnya. Tetapi penelitian ini dapat diperluas ke rumah; sakit wilayah dan juga Puskesmas-puskesmas bila keadaan memungkinkan.Pada hasil penelitian ini, akan diperoleh data mengenai frekwensi dan distribusi kista dentigerous sebagai akibat gigi impaksi nada tulang rahang."

"This manual for diagnostic cytologists offers detailed guidance on diagnostic problems likely to be encountered in everyday practice. It encompasses exfoliative and aspiration cytology of all major nongynecologic body sites. Each chapter opens with an algorithm that presents the reader with the relevant microscopic findings, the most important additional findings, and the differential diagnostic possibilities and problems in a clear and easily remembered form. Another important feature is the wealth of high-quality color photomicrographs, which clearly document the visual appearances of the most important lesions and highlight the differential diagnostic difficulties. The accompanying text contains helpful general remarks and presents further relevant information on diagnostics, differential diagnostic procedures, and auxiliary methods. Besides established cytologists and pathologists, cytopathologists in training and cytotechnologists will find this book to be a valuable aid."

"Latar Belakang : Infeksi sering didapatkan pada pasien kenker nasofaring yang menjalani kemoterapi. Infeksi disebabkan oleh rusaknya barier fisik karena efek kemoterapi atau efek kemoterapi yang akan menurunkan imunitas tubuh,Infeksi pasca kemoterapi akan menunda kemoterapi berikutnya, akibatnya respon kemoterapi menjadi tidak optimal. Tujuan : Mendapatkan data status imunitas selular primer dan sekunder, pasca kemoterapi neoajuvan 3 siklus, data kekerapan infeksi dan perbandingan kekerapan infeksi pada pasien KNF stadium lanjut yang mendapatkan kemoterapi neoadjuvan 3 siklus pada pasien kanker nasofaring stadium lanjut, antara yang imunitas selular menurun dan yang tidak menurun. Metode : Penelitian one group before and after observasional, 1 kelompok tanpa kontrol selama 3 bulan di gedung A lantai 8 RSCM, juli ndash; september 2015.Penurunan rerata jumlah lekosit, netrofil, CD4 , CD8, kejadian infeksi dianalisis bivariat dengan uji T berpasangan atau uji Mann Whitney.Penelitian ini juga melihat kekerapan kejadian infejsi post kemoterapi neoadjuvan.Penelitian ini menggunakan tingkat kemaknaan 0,005, interval kepercayaan 95. Hasil : Tidak ada penurunan status imunitas selular primer, lekosit p=0,356 dan netrofil p=0,289.Terdapat penurunan status imunitas selular sekunder, CD 4 P=0,002, CD 8 P=0,001, dengan ratio CD 4 /CD 8 tidak berubah rerata CD 4 sudah rendah sejak sebelum kemoterapi.Mukositis oral dan pneumonia merupakan infeksi yang kerap didapatkan. CD4 yang rendah pada kelompok sebelum kemoterapi meningkatkan potensi infeksi selama dan sesudah kemoterapi neoadjuvan.Penurunan imunitas seluler sekunder nilai rerata jumlah CD4 berhubungan dengan peningkatan kejadian infeksi pasca siklus ke 2 p=0,016. Kesimpulan : Tidak terdapat penurunan imunitas selular primer dan didapatkan penurunan imunitas selular sekunder pada pasien karsinoma nasofaring stadium lanjut yang menjalani kemoterapi neoadjuvan 3 siklus.Pada pasien dengan penurunan imunitas selular sekunder terdapat peningkatan kejadian infeksi mukositis oral dan pneumonia CD 4 yang rendah merupakan prediktor kejadian infeksi. Penurunan imunitas selular sekunder hanya akan meningkatkan kejadian infeksi pasca siklus ke 2 kemoterapi neoadjuvan.

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Background: The infections especially in a the oropharynx often get on cancer patients nasopharyngeal .One of the causes of infection include breakdowns physical mucous barier because the tumor growth or because the effects of chemotherapy and radiation .Chemotherapy and radiation will result in side effects namely the inflammation and ulceration mouth and the oropharynx mucous called mukositis oral.selama endure chemotherapy, besides mukositis oral, infections of the also often found .Chemotherapy resulted in an emphasis on cell production immune response that result in the lekopenia with rob possibilities infection become larger.

The purpose: To asess of immunity cellular status on advanced stage nasaofaringeal patient to get 3 cycle neoadjuvan chemotherapy and assess the incident lung infection and tumor area after undergoing 3 cycle neoadjuvan chemotherapy.

The methode: Research one group before and after observational use 1 group without control. The research was done during the three months in the building a floor 8 Ciptomangunkusumo Hospital juli september 2015. The Data on the background respondents will be analyzed by a sort of descriptive set by using analysis univariat.hubungan between chemotherapy neoadjuvan and an immune response cellular will be analyzed bivariat by test wilcoxon sign rank test. In this research also be seen the proportion of the infection before pre and post chemotherapy neoadjuvan .This research using level evidence 0.05 to the interval trust 95.

Results: From 17 subject of research , 12 subjects 70,6 is laki laki , women made up subjects 29,4 .Median age patient is 46,7 , 10 patients 58,8 less than median age , 7 patients 42,2 more of age median.stadium 4a obtained on 4 patients 23,5 patients , while stadium 4 b obtained on 13 patients 76,5 .Seen from the infection after chemotherapy neoadjuvan 9 subjects 52,8 never would have experienced infection , 8 subjects 47,2 experienced infection. Looks the relationship between chemotherapy neoadjuvan 3 cycle in immunity cellular p 0,007 on cds 4 and p 0,005 on cds 8 , the immunity cellular decline in the infection look after chemotherapy neoadjuvan cycle to 2 p 0,016 on cds 4 while after cycle to 3 not seen the relationship between chemotherapy neoadjuvan 3 cycle in the infection .Count of leukosit and lymphocytes cannot be used to predict a decrease in an immune response cellular after undergoing 3 cycle neoadjuvan chemotherapy.

Conclusions: Immune response decreased on advanced stage nasopharynx carcinoma patient are undergoing 3 cycle neoadjuvan chemotherapy neoadjuvan 3 . The Decreased of cellular immune response has played of increased infection in the lung and tumor area post 2 cycle neoadjuvan chemotherapy. "

"Pendahuluan: Kanker payudara kanker dengan prevalensi, morbiditas dan mortalitas terbanyak di dunia. Kemoterapi neoadjuvan merupakan terapi sistemik pada kanker yang ditujukan untuk meningkatkan prognosis pasien. Proses imunologi dan inflamasi berperan dalam prognosis tumor. Beberapa indikator inflamasi antara lain neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), dan platelet-lymphocyte ratio (PLR). Penelitian ini ditujukan untuk menganalisa NLR, PLR, dan LMR terhadap respons klinis kanker payudara stadium lokal lanjut.Metode: Desain penelitian ini adalah cross-sectional yang ditujukan untuk menilai hubungan NLR, LMR, dan PLR terhadap respons klinis dengan metode WHO. Penelitian ini akan dilakukan di RSCM pada wanita dengan kanker payudara stadium lokal lanjut yang menjalani kemoterapi neoajuvan RSCM tahun 2016-2021. Pengumpulan data akan dilakukan secara konsekutif (consecutive sampling) pada rekam medis.Hasil: Pada penelitian ini didapatkan 84 subjek penelitian dengan usia rerata 50 tahun dan stadium klinis T4. Pada penelitian ini didapatkan nilai median NLR sebesar 2,62, PLR sebesar 186,9 dan LMR sebesar 3,78 pada populasi sampel. Analisis bivariat antara NLR, LMR, dan PLR dengan respons klinis didapatkan tidak bermakna secara statistik (p>0,05) dengan nilai OR 1,3 (CI95% 0,7-2,2), 0,81 (CI95% 0,04-1,4), dan 1,06 (CI95% 0,5-1,9) secara berurutan. Terdapat hubungan yang bermakna antara NLR dengan kejadian mortalitas 1 tahun (p<0,05) dengan nilai OR 2,27 (CI95% 1,1-4,5).Kesimpulan: Penelitian ini tidak mendapatkan adanya hubungan antara NLR, LMR, dan PLR dengan respons klinis pada kanker payudara lokal lanjut pasca KNA di RSCM.

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Introduction: Breast cancer is one of the most prevalent cancer around the globe with significant morbidity and mortality. Neoadjuvant chemotherapy is a systemic therapy with the aim of reducing the size of tumor, including breast cancer. The role of immunologic and inflammatory process has been reported as a prognostic factors in breast cancer including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR). We aimed to analyze the role NLR, PLR, and LMR to the clinical response of locally advanced breast cancer after neoadjuvant chemotherapy regimen.

Methods: We used cross-sectional research design for this study with the aim of observe the relation between NLR, LMR, and PLR and clinical response of neoadjuvant chemotherapy. We conducted this study in Cipto Mangunkusumo General Hospital. Our subjects include women with locally advanced breast cancer that has been treated with neoadjuvant chemotherapy between 2016-2021. We collected the subject consecutively using medical record as the primary data source.

Result: We obtained 84 subjects with the mean age of 50 years and clinical stage of T4. The median of NLR, LMR, and PLR were 2.62, 186.9, and 3.78 consecutively. Bivariate analysis of NLR, LMR, dan PLR with clinical response showed no significant association with the odd ratio of 1,3 (CI95% 0,7-2,2), 0,81 (CI95% 0,04-1,4), and 1,06 (CI95% 0,5-1,9) consecutively. We found significant association between NLR and 1 year mortality rate with the odd ratio of 2,27 (CI95% 1,1-4,5).

Conclusion: We found no correlation between NLR, LMR, and PLR with clinical response after neoadjuvant chemotherapy in locally advanced breast cancer."