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Ramadianty
Peran riwayat atopi pada keluarga terhadap risiko alergi obat = Family history of atopy as a risk factor of drug allergy
"[ABSTRAK
Tujuan Menganalisis peran riwayat atopi pada keluarga terhadap risiko kejadian alergi obat Metode Penelitian kasus kontrol dengan menggunakan data retrospektif pasien rawat inap dan rawat jalan Divisi Alergi dan Imunologi Departemen Ilmu Kesehatan Anak dan Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit Cipto Mangunkusumo tahun 2012 hingga 2014 yang didiagnosis alergi obat Kelompok kontrol adalah anak yang berdasarkan anamnesis tidak pernah mengalami alergi obat dengan usia dan diagnosis utama yang sama dengan subjek Hasil Sebanyak 29 38 2 dari 76 subjek yang mengalami alergi obat memiliki riwayat atopi pada keluarga dan hanya terjadi pada 16 subjek 21 1 pada kelompok kontrol OR 2 3 IK 95 1 13 4 75 Lima dari 6 kasus 83 3 dengan alergi obat berat sindrom Steven Johson nekrolisis epidermal toksik dan syok anafilaksis memiliki riwayat atopi dalam keluarga Riwayat atopi pada ibu merupakan faktor risiko yang dapat berpengaruh pada kejadian alergi obat OR 2 25 IK 95 1 01 5 087 Jika faktor perancu human imunodeffciency virus sepsis dan keganasan dikeluarkan terdapat 20 dari 46 pasien 43 5 anak dengan alergi obat memiliki riwayat atopi dalam keluarga sehingga masih terdapat hubungan yang bermakna antara riwayat atopi pada keluarga dengan alergi obat walaupun dengan power penelitian yang lebih rendah Subjek yang memiliki penyakit atopi tidak memiliki risiko lebih tinggi terhadap kejadian alergi obat dibandingkan dengan subjek yang tidak memiliki penyakit atopi Simpulan Pada penelitian ini subjek dengan risiko atopi pada keluarga memiliki risiko lebih besar untuk terjadinya alergi obat dibandingkan dengan anak non atopi Subjek dengan riwayat atopi pada ibu memiliki risiko lebih tinggi untuk terjadinya alergi obat dibanding dengan riwayat atopi pada ayah dan saudara kandung Kata kunci alergi obat riwayat atopi keluarga faktor risiko ABSTRACT Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors;Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors;Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors, Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors]"
Fakultas Kedokteran Universitas Indonesia, 2015
TA-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Indah Dewi Lestari
Praktik Kerja di Puskesmas Kecamatan Pulogadung Periode 17 - 28 Oktober 2022, Pemanfaatan Google Spreadsheet untuk Mendeteksi Kesesuaian Dosis Obat Antialergi yang Tersedia di Puskesmas Kecamatan Pulogadung Menggunakan Rumus Clark = Work Practice at The Pulogadung Sub-district Health Center on The Period 17 - 28 October 2022, Utilization of Google Spreadsheet to Detect Appropriate of Antiallergic Drug Doses in Puskesmas Kecamatan Pulogadung Using Clark Formula
"Obat antialergi merupakan salah satu obat yang paling banyak diresepkan di Puskesmas Kecamatan Pulogadung. Klorfeniramin maleat adalah obat antialergi yang menempati urutan kedua obat paling banyak diresepkan di puskesmas tersebut dengan penggunaan selama bulan Oktober 2022 sebanyak 19.003 peresepan. Tingginya jumlah penggunaan obat tersebut perlu menjadi perhatian agar tidak terjadi permasalahan terkait obat (DRPs), seperti ketidaktepatan dosis resep. Penelitian ini bertujuan untuk memanfaatkan Google Spreadsheet sebagai sarana pendeteksi kesesuaian dosis pada obat antialergi pada resep sehingga proses pelayanan resep dapat lebih efisien dan meminimalisir terjadinya DRP. Penyesuaian dosis racikan menggunakan sistem ini dilakukan berdasarkan pedoman dosis yang berlaku serta menggunakan rumus Clark untuk pasien anak. Hasilnya, sistem yang berbasis Google Spreadsheet ini dapat digunakan sebagai sarana penyesuaian dosis obat racikan di Puskesmas Kecamatan Pulogadung dengan lebih efektif dan efisien.
Anti-allergy drugs are one of the most prescribed drugs at Pulogadung District Health Center. Chlorpheniramine Maleate is an antiallergic drug that ranks as the second most prescribed drug at Pulogadung District Health Center prescribed 19,003 prescriptions on October 2022. The high amount of this drug use must be a concern so that drug-related problems (DRPs) do not occur, such as inaccurate prescription dosages. This study aims to utilize Google Spreadsheet to detect the suitability of dosages for anti-allergic drugs on prescriptions so that the prescription service process can be more efficient and minimize the occurrence of DRP. Adjustments to the dosage of concoctions using this system are based on the applicable dosage guidelines and use the Clark formula for pediatric patients. As a result, this Google Spreadsheet-based system can be used as a means of adjusting the dosage of concoction drugs at the Pulogadung District Health Center more effectively and efficiently."
Depok: Fakultas Farmasi Universitas Indonesia, 2023
PR-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Anesia Tania
Sebaran obat penyebab dan polimorfisme gen hla-b pada erupsi obat alergik tipe sindrom stevens-johnson dan nekrolisis epidermal toksik : studi pada lima rumah sakit di Jakarta = Causative drugs and hla-b polymorphism in drug induced stevens johnson syndrome and toxic epidermal necrolysis cutaneous : a study in five hospital in Jakarta
"ABSTRAK
Latar belakang: Erupsi obat alergik EOA tipe sindrom Stevens-Johnson dan nekrolisis epidermal toksik SSJ/NET adalah EOA berat yang jarang terjadi namun dapat mengancam nyawa. Tata laksana utama EOA tipe SSJ/NET saat ini adalah menghentikan pajanan obat penyebab. Di beberapa negara Asia, polimorfisme gen HLA-B telah digunakan sebagai metode skrining pada pemberian obat berisiko tinggi. Tujuan: Mengetahui sebaran obat penyebab dan polimorfisme gen HLA-B pada pasien EOA tipe SSJ/NET di Jakarta. Metode: Studi potong lintang ini dilakukan pada bulan April ndash; Juni 2017 di RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, dan RSUD Tarakan. Pemilihan sampel dilakukan secara total sampling pada pasien EOA tipe SSJ/NET di 5 RS tersebut selama 2 tahun. Dilakukan anamnesis dan penentuan obat dengan algoritma ALDEN dan pemeriksaan typing gen HLA-B dengan metode PCR ndash;SSOP. Hasil: Didapatkan 22 subjek dengan median usia 45,5 tahun dan sebagian besar perempuan. Obat penyebab tersering yang ditemukan adalah karbamazepin. Pada subjek, alel HLA-B yang tersering adalah HLA-B 15:02 dan HLA-B 18:01. Alel HLA-B 15:02 ditemukan pada lima 72 dari tujuh SP dengan obat penyebab karbamazepin. Simpulan: Obat penyebab EOA tipe SSJ/NET yang paling sering ditemukan pada SP adalah karbamazepin, dengan 5 dari 7 SP memiliki gen HLA-B 15:02.
ABSTRACT
Background Stevens Johnson syndrome and toxic epidermal necrolysis is a very rare but life threatening type of cutaneous drug eruption. The principle management of SJS TEN is withdrawal of causative drug and preventing reexposure to said drug. In other countries in Asia, spesific HLA B allele has already been utilized as a screening method to prevent SJS TEN. Objective to acquire data regarding causative drugs and HLA B allele polymorphism in SJS TEN patient in Jakarta. Method This cross sectional study was performed in RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, and RSUD Tarakan from April to June 2017. The sampling method is total sampling of all patient in all five hospital from March 2015 to March 2017. Subject fulfilling the inclusion and exclusion criteria was interviewed and their blood sample was taken for DNA extraction. The DNA was examined with PCR SSOP and Luminex technology for high resolution HLA B typing. Results We studied 22 subjects. The median age was 45,4 years old 14 74 and female gender predominate. The most common causative drug in this study is carbamazepine. HLA B 15 02 and HLA B 18 01 were the most common allele in all subjects. HLA B 15 02 was found in five 72 out of seven subjects whose condition was caused by carbamazepine. Conclusion The most common causative drug of SJS TEN in five hospitals in Jakarta is carbamazepine, with five 72 out seven subjects had HLA B 15 02 allele. "
2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Iris Rengganis
Penatalaksaan alergi obat dan Anafilaksis (artikel Pertemuan llmiah Tahunan llmu Penyakit Dalam 2015)
2015
MK-Pdf
UI - Makalah dan Kertas Kerja  Universitas Indonesia Library
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Prasna Pramita
Faktor-faktor yang berpengaruh terhadap Cutaneous Adverse Drug Reaction (CADR) pada penggunaan Obat Anti Tuberkulosis (OAT) = Cutaneous Adverse Drug Reaction (CADR) due to anti tuberculosis drugs and its influencing factors
"Latar Belakang: Cutaneous Adverse Drug Reaction (CADR) dapat memengaruhi tatalaksana infeksi TB. Hal ini berdampak pada bukan hanya morbiditas dan mortalitas tapi juga resistensi kuman. Untuk itu, proporsi CADR dan faktor-faktor yang berhubungan pada penggunaan Obat Anti Tuberkulosis (OAT) perlu ditentukan demi tatalaksana pasien yang komprehensif.
Tujuan: Mengetahui gambaran kejadian CADR terkait pemberian OAT dalam bentuk proporsi, analisis peran faktor pejamu yang berkaitan dengan kejadian tersebut, dan OAT yang paling sering menimbulkan CADR. Metode: Desain penelitian ini adalah kohort retrospektif dengan menggunakan rekam medik pasien Rumah Sakit Cipto Mangunkusumo selama 1 Januari 2014
hingga 30 Juni 2015. Sampel diperoleh dengan metode konsekutif yang diseleksi berdasarkan kriteria penelitian. Data kemudian dianalisis untuk menilai hubungan antara CADR dengan usia, jenis kelamin, status HIV, status gizi, dan riwayatmlkojuujhjh Adverse Drug Reaction (ADR). Hasil: Proporsi CADR pada pemberian OAT mencapai angka 5,5%. Dari kelima variabel independen, variabel usia (RR=6,510; IK95% 2,036-20,819 p=0,008) dan riwayat ADR (RR=5,174; IK95% 1,500-17,838; p=0,009) berpengaruh terhadap kejadian CADR. OAT yang paling sering menyebabkan kejadian CADR adalah
rifampisin. Analisis Cochran Mantel-Haenszel menunjukkan bahwa risiko relatif terjadinya CADR untuk faktor usia adalah 7,267 (IK95% 2,093-25,235 p <0,001) dan risiko relatif terjadinya CADR untuk faktor riwayat ADR adalah 5,880 (IK95% 1,552-22,273 p=0,003). Simpulan: Proporsi kejadian CADR setelah pemberian OAT adalah 5,5%. Variabel usia dan riwayat ADR bermakna secara statistik dan klinis terhadap kejadian CADR. Rifampisin adalah OAT tersering yang menimbulkan CADR.
Background: Cutaneous Adverse Drug Reaction (CADR) affected the therapy of TB, which impacted not only its morbidity and mortality but also its resistance. Therefore, the incidence of CADR and the factors associated during the
administration of Anti Tuberculosis Drugs (ATDs) needed to be determined in order to achieve comprehensive treatment.
Objective: To know CADR events on ATD administration by finding the incidence, analyzing the host factors associated with those events, and searching the most common ATD that caused CADR. Methods: This study used retrospective cohort by accessing medical record registered in Cipto Mangunkusumo Hospital from January 1st 2014 until June 30th 2015. Samples were collected consecutively, selected by certain criteria. The data were then analyzed to determine the association between CADR and age, sex, HIV infection, nutritional status, and history of Adverse Drug Reaction (ADR). Results: The incidence of CADR after the administration of ATD was 5.5%. Among the five variables, age (RR=6.510; 95%CI 2.036-20.819, p=0.008) and past history of ADR (RR=5.174; 95%CI 1.500-17.838; p=0.009) were statistically and clinically correlated to CADR. The most frequent drug that triggered CADR was rifampicin. Cochran Mantel-Haenszel showed that the relative risk of CADR according to age was 7,267 (IK95% 2,093-25,235 p <0,001), while the relative
risk according to the past history of ADR was 5,880 (IK95% 1,552-22,273 p=0,003). Conclusions: The incidence of CADR after ATDs administration was 5.5%. Age and past history of ADR were significantly associated with CADR. The most common ATD causing CADR was rifampicin."
Depok: Fakultas Kedokteran Universitas Indonesia, 2016
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Karnen Garna Baratawidjaja
Mengenal alergi
Jakarta: Badan Penerbit Fakultas Kedokteran Universitas Indonesia, 2013
616.97 KAR m
Buku Teks SO  Universitas Indonesia Library
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Budi Utama
Efek pemberian vitamin d terhadap kadar il-10, ifn-? dan histamin pada kultur pbmc pasien rinitis alergi = Effect of vitamin d on il 10 ifn and histamine levels on pbmc cultur of allergic rhinitis patients
"ABSTRAK
Latar belakang. Rinitis Alergi adalah penyakit inflamasi yang disebabkan oleh reaksi alergi pada pasien atopi. Tungau debu rumah TDR merupakan aeroalergen tersering yang mensensitisasi reaksi alergi. Pada tahun 1988 reseptor vitamin D VDR , berhasil di klon. Reseptor vitamin D berlokasi di beberapa jaringan dan sel tubuh manusia, termasuk di peripheral blood mononuclear cells PBMCs dan limfosit T yang telah teraktivasi. Riset yang lebih jauh memperlihatkan bahwa vitamin D mempunyai beberapa efek dari pengaturan sitokin terhadap beberapa sel yang berbeda dari sistem imun. Vitamin D dapat menekan respon Th1 dan Th2. Sel Th1 dan Th2 menghambat perkembangan satu sama lain.Tujuan. Melihat pengaruh pemberian Vitamin D terhadap kadar IL-10, IFN-? dan histamin pada kultur PBMC pasien rinitis alergiMetode. Sampel merupakan darah segar whole blood penderita rinitis alergi yang telah dilekukan prick test, serta diiisolasi dengan metode Ficoll. Bahan biologis tersimpan yang berupa supernatan kultur. Kultur sel limfosit sebelum perlakuan, diberi pendedahan tanpa atau dengan 1,25 OH 2D3 100 nM, waktu inkubasi 7 hari, dengan penambahan PHA dan alergen tungau pada hari ke-4. Kultur sel-sel PBMC dari pasien RA setelah perlakuan, dilakukan harvest pada hari ke-7, kemudian supernatanannya dialikuot untuk diukur kadar sitokin IFN-? dan IL-10, dan diuji secara statistik untuk melihat pola dari tiap parameter.Hasil: Pemberian alergen tungau tanpa vitamin D menyebabkan meningkatnya kadar histamin serta menurunkan kadar IL-10 dan IFN-?. Pemberian vitamin D pada kultur sel PBMC yang telah diberi alergen tungau menyebabkan peningkatan kadar IL-10 dan penurunan kadar IFN-? dan histamin.Simpulan: Menurunnya kadar histamin dan IFN-? terhadap stimulasi alergen tungau pasien rinitis alergi yang diberi vitamin D cenderung berhubungan dengan meningkatnya kiadar IL-10.
ABSTRACT
Background. Allergic rhinitis is an inflammatory disease caused by an allergic reaction in atopic patients. House dust mites TDR are the most common aeroalergens that sensitize allergic reactions. In 1988 vitamin D receptor VDR , successfully in clones. Vitamin D receptors are located in several tissues and human body cells, including peripheral blood mononuclear cells PBMCs and activated T lymphocytes. Further research has shown that vitamin D has some effects of cytokine regulation on several cells different from the immune system. Vitamin D can suppress Th1 and Th2 responses. Th1 and Th2 cells inhibit the development of each other. Aim.To identify the Effect of Vitamin D On IL 10 IFN and histamine levels on PBMC Cultur of Allergic Rhinitis PatientsMethod. The sample is fresh blood whole blood of allergic rhinitis patients who have been prick tested, and isolated by Ficoll method. Pre treated lymphocyte culture, treated with or without 1,25 OH 2D3 100 nM, and incubated for 7 days, with addition of PHA and allergen mites on day 4. Cultures of PBMC cells from RA patients after treatment were harvested on day 7, then the supernatant was dialyzed for measured levels of IFN and IL 10 cytokines using elisa kits and tested statistically to see patterns of each parameter.Result. Giving allergen mites without vitamin D causes increased levels of histamine and lowers levels of IL 10 and IFN . Provision of vitamin D in PBMC cell culture that has been given allergen mites causes increased levels of IL 10 and decreased levels of IFN and histamine.Conclusion. Reduced levels of histamine and IFN against allergen mite stimulation of allergic rhinitis patients given vitamin D tend to be associated with increased IL 10 levels."
2017
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Arinda Putri Pitarini
Perubahan Kualitas Hidup, Jumlah Eosinofil Mukosa Hidung dan Kadar Interleukin 5 (IL 5) Serum Pada Pasien Rinitis Alergi Persisten Sedang Berat Sebelum dan Setelah Terapi Medikamentosa = Changes in Quality of Life, Eosinophil Number of Nasal Mucosa and Interleukin 5 (IL 5) Serum Level in Moderate-Severe Allergic Rhinitis Patient Before and After Medicamentosa Therapy
"Latar belakang: Rinitis alergi (RA) merupakan suatu kelainan hidung yang sering memengaruhi kualitas hidup penderitanya. Perubahan kualitas hidup pasien RA secara subjektif dapat diukur dengan kuesioner mini RQLQ dan secara objektif dengan hitung jumlah eosinofil pada mukosa hidung dan kadar IL 5 serum. Tujuan: Mengetahui karakteristik subjek RA dan mengetahui perubahan kualitas hidup, jumlah eosinofil mukosa hidung dan kadar interleukin 5 pada pasien rinitis alergi persisten sedang berat sebelum dan setelah terapi medikamentosa. Metode: Pre eksperimental yang bersifat analitik sebelum dan setelah terapi dengan jumlah subjek RA persisten sedang berat sebanyak 33 orang. Subjek diminta untuk mengisi kuesioner Mini RQLQ, dilakukan kerokan mukosa hidung dan pengambilan darah sebelum dan 2 minggu setelah terapi. Hasil: Didapatkan 14 subjek berjenis kelamin laki-laki dan 19 subjek perempuan dari 33 subjek penelitian dengan rerata usia 32,55 ± 11,67. Sebanyak 31 dari 33 subjek mengalami perubahan bermakna dari kualitas hidup, seluruh subjek mengalami perubahan jumlah eosinofil yang bermakna dan 30 dari 33 subjek mengalami perubahan kadar IL 5 yang responsif setelah terapi selama 2 minggu. Kesimpulan: Kualitas hidup pasien RA persisten sedang berat dapat diukur dengan menggunakan kuesioner mini RQLQ dan jumlah eosinofil mukosa hidung dan kadar IL 5 dapat digunakan untuk evaluasi terapi RA namun tidak untuk pemeriksaan penunjang rutin.
Background: Allergic rhinitis (AR) is a nasal disorders that frequently affects the quality of life. Changes in quality of life AR patient can be measured subjectively using mini RQLQ and objectively by eosinophil count of nasal mucosa and IL 5 level. Objectives: To find the subject characteristic of AR and quality of life, eosinophil count of nasal mucosa and IL 5 level changes of moderate-severe AR patient before and after medicamentosa therapy. Methods: Pre experimental analytic study before and after therapy with 33 subjects of moderate-severe AR. All subjects were asked to fill out Mini RQLQ, collect nasal scrapping and blood specimens before and 2 weeks after therapy. Result: Fourteen subjects were male and 19 were women out of 33 subjects, with mean age 32,55 ± 11,67 years. Thirty one out of 33 subjects had significant quality of life changes, all subjects had significant changes of eosinophil nasal scrapping and 30 out of 33 subjects had significant changes of IL 5 level after 2 weeks of medicamentosa therapy. Conclusion: Allergic rhintis patient quality of life can be measured by mini RQLQ and eosinophil nasal scrapping and IL 5 level can be used for therapy evaluation but not for routine examination."
2014
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Hardini Tri Indarti
Analisis riwayat alergi antibiotik terhadap kejadian penyakit lupus eritematosus sistemik di RSUP dr Hasan Sadikin Kota Bandung = Analysis of antibiotics allergy as risk factors of systemic lupus erythematosus in dr Hasan Sadikin Hospital Bandung / Hardini Tri Indarti
"ABSTRAK
Lupus Eritematosus Sistemik (LES) merupakan penyakit autoimun yang
mengakibatkan peradangan di banyak organ. Prevalensi LES terus meningkat dan
angka mortalitasnya pun tinggi. Etiologi LES sampai saat ini belum diketahui
secara pasti. Namun, beberapa faktor risiko yang diduga dapat mempengaruhi
kejadian LES. Salah satunya adalah riwayat alergi obat, terutama antibiotik.
Penelitian ini bertujuan untuk mengetahui hubungan riwayat alergi antibiotik
dengan kejadian LES setelah dikontrol oleh variabel kovariat berupa riwayat
keluarga menderita LES, riwayat menderita penyakit autoimun lain, usia
menarche, dan perilaku merokok di RSUP Dr. Hasan Sadikin Kota Bandung.
Penelitian ini dilakukan bulan April-Juli 2014 dengan menggunakan desain kasus
kontrol. Kasus adalah pasien LES wanita yang berobat ke Poli Rematologi RSUP
Dr. Hasan Sadikin Kota Bandung. Kontrol merupakan pasien wanita yang berobat
ke Poli Penyakit Dalam dengan dilakukan individual matching dengan kasus pada
usia (rentang 3 tahun), dan asal daerah. Data dianalisis dengan analisis univariat,
bivariat, dan multivariat dengan uji regresi logistik conditional. Hasil penelitian
menunjukkan bahwa riwayat alergi antibiotik cenderung meningkatkan risiko
kejadian LES sebesar 2,34 kali (OR=2,34, 95% CI 0,66-8,22) setelah dikontrol
oleh riwayat keluarga LES, riwayat autoimun, dan perilaku merokok. Untuk kelas
antibiotik penisilin/sefalosporin, risiko meningkat menjadi 2,75 kali (OR=2,75,
95% CI 0,65-11,59).
ABSTRACT
Systemic Lupus Erythematosus ( SLE ) is an autoimmune disease that results in
inflammation in many organs. The prevalenceof SLE is increasing and the
mortality rate was high. Etiology of SLE has not known. However , several risk
factors could be expected to affect the incidence of SLE . One of them is a history
of drug allergies, especially antibiotics. This study aimed to determine the
relationship between antibiotic allergy history and SLE after controlled by family
history,other autoimmune disease, age of menarche, and smoking behavior in Dr.
Hasan Sadikin Hospital Bandung. This study was conducted from April to July
2014 using case-control design. Cases were women SLE patients who went to
Rheumatology Department Dr. Hasan Sadikin Hospital Bandung. Control were a
female patient who went to Internist Department with individually matched at the
age ( 3 years range ), and region. Data were analyzed with univariate, bivariate ,
and multivariate conditional logistic regression. The results showed that a history
of antibiotic allergy tends to increase the incidence of SLE for 2.34 times ( OR =
2.34 , 95 % CI 0.66 to 8.22 ) after controlled by SLE family history, history of
autoimmune, and smoking behavior. For the class of penicillin/cephalosporin, the
risk increased to 2.75 times ( OR = 2.75 , 95 % CI 0.65 to 11.59) ."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2014
T43364
UI - Tesis Membership  Universitas Indonesia Library
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Suzy Maria
Faktor yang memengaruhi sensitisasi terhadap alergen hirup dan manifestasi klinis penyakit alergi pada populasi dewasa muda di Indonesia = Factors affecting sensitization to inhalant allergens and clinical manifestation of allergic diseases in Indonesian young adults
"ABSTRAK
Latar Belakang: Atopi yang ditandai dengan sensitisasi (produksi IgE) terhadap alergen merupakan faktor risiko untuk terjadinya penyakit alergi. Karena komposisi genetik cenderung stabil, peningkatan prevalensi penyakit alergi diduga disebabkan oleh faktor lingkungan yang berubah.
Tujuan: Mengetahui faktor yang memengaruhi sensitisasi terhadap alergen hirup dan munculnya manifestasi penyakit alergi pada populasi dewasa muda di Indonesia.
Metode: Penelitian potong lintang dilakukan pada mahasiswa baru Universitas Indonesia tahun 2019. Mahasiswa diminta mengisi kuesioner berisi data demografi, kuesioner International Study of Asthma and Allergies in Childhood (ISAAC), menjalani pemeriksaan fisik dan uji cukil kulit terhadap lima alergen hirup (kecoa, Dermatophagoides farinae, Dermatophagoides pteronyssinus, bulu kucing, epitel anjing). Sensitisasi ditandai dengan terdapat setidaknya satu hasil positif pada uji cukil kulit. Jika terdapat hasil positif pada dua atau lebih alergen, subyek disebut mengalami polisensitisasi. Manifestasi alergi yang dinilai berupa asma, rinitis alergi, dan dermatitis atopi.
Hasil: Proporsi sensitisasi adalah 44,8% (128 dari 286 subyek), sedangkan proporsi manifestasi penyakit alergi adalah 57,7% (165 dari 258 subyek). Manifestasi penyakit alergi didapatkan pada 84 (65,6%) subyek dari subkelompok yang tersensitisasi. Sensitisasi ditemukan lebih banyak pada laki-laki (OR 2,25; IK95% 1,38-3,71; p=0,001) dan subyek yang lahir secara caesar (OR 2,46; IK95% 1,22-5,06; p=0,013), sebaliknya lebih sedikit pada subyek yang berasal dari urban (OR 0,54; IK95% 0,32-0,90; p=0,019). Subyek yang tersensitisasi cenderung untuk memiliki manifestasi penyakit alergi (OR 1,79; IK95% 1,10-2,95; p=0,020). Pada subkelompok yang tersensitisasi, manifestasi penyakit alergi ditemukan lebih banyak pada subyek yang tinggal di urban (OR 2,58; IK95% 1,15-6,01; p=0,024), obese (OR 5,25; IK95% 1,35-34,92; p=0,036), dan mengalami polisensitisasi (OR 2,26; IK95% 1,01-5,10; p=0,046).
Simpulan: Sensitisasi terhadap alergen hirup dipengaruhi oleh jenis kelamin lakilaki, status urban, dan riwayat persalinan caesar. Munculnya manifestasi penyakit alergi dipengaruhi oleh adanya sensitisasi. Pada subkelompok yang tersensitisasi, munculnya manifestasi penyakit alergi dipengaruhi oleh status urban, obesitas, dan polisensitisasi.
ABSTRACT
Background: Atopy marked by allergen sensitization (IgE production) is a risk factor for allergic diseases. Since genetic composition tends to be stable, the increase of allergic diseases prevalence is suspected due to changing environment factors.
Purpose: To identify the factors affecting sensitization to inhalant allergen and allergic diseases manifestation in Indonesian young adults.
Methods: Cross-sectional study done on Universitas Indonesia 2019 new students. Students were asked to fill in a demographic questionnaire, an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, undergo physical examination and skin prick tests for five inhalant allergens (cockroach, Dermatophagoides farinae, Dermatophagoides pteronyssinus, cat hair, dog epithelium). Sensitization was marked by at least one positive result on the skin prick test. If there were two or more positive allergen results, subject was deemed as being polysensitized. Evaluated allergic manifestations were asthma, allergic rhinitis, dan atopic dermatitis.
Result: Sensitization was found in 44.8% (128 out of 286 subjects), while allergic diseases clinical manifestation was found in 57.7% (165 out of 258 subjects). The manifestation was found in 84 (65.6%) subjects from the sensitized subgroup. Sensitization was found more on male (OR 2.25; 95%CI 1.38-3.71; p=0.001) and subjects born by caesarean section (OR 2.46; 95%CI 1.22-5.06; p=0.013), whereas fewer on subjects from urban (OR 0.54; 95%CI 0.32-0.90; p=0.019). Sensitized subjects tended to demonstrate allergic diseases manifestation (OR 1.79; 95%CI 1.10-2.95; p=0.020). In the sensitized subgroup, allergic diseases manifestation was found more on subjects living in urban (OR 2.58; 95%CI 1.15-6.01; p=0.024), are obese (OR 5.25; 95%CI 1.35-34.92; p=0.036), and are polysensitized (OR 2.26;
95%CI 1.01-5.10; p=0.046).
Conclusion: Sensitization to inhalant allergens was affected by male sex, urbanstatus, and caesarean section birth. Allergic diseases manifestation was affected by presence of sensitization. In the sensitized subgroup, allergic diseases manifestation was affected by urban status, obesity, and polysensitization."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
T55537
UI - Tesis Membership  Universitas Indonesia Library
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