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"This book brings about important research in the field of oral cancer realting to its prognosis and treatment. Oral cancer is a crucial public health problem on a global scale."

"Oral lichen planus (OLP) is a rather common oral disease, mainly affecting adults, occurring more often in women than in men. The etiopathogenesis is still unclear. The diagnosis may be cumbersome, even in the presence of a biopsy. In addition, there are several lesions that may resemble lichen planus (lichenoid lesions) both clinicallyand histopathologically. Treatment of OLP can only be symptomatic and usually consists of topical application of corticosteroids. The disease is characterized by remissions and exacerbations and may persist in some patients lifelong. There is an ongoing debate in the literature as whether OLP is a potentially malignant disease. Because of this uncertainty, annual follow-up is advised."

"A manual that is designed to support the diagnosis and management of oral soft tissue diseases for busy dental practitioners. It depicts lesions with one or more color photographs that illustrate typical clinical features. It includes recommendations for patient management, sample prescriptions, and monographs for drugs commonly used in treatment."

"Penatalaksanaan kanker payudara mungkin merupakan suatu hal yang amat kontrovesial dan telah mengalami perubahan luarbiasa dengan berjalannya waktu."

"Nasopharyngeal carcinoma (NPC) is still a significant health problem due to its relatively high incidence. Rarely, NPC could extend and involve the oral cavity, and may present as an ulceration or exophytic mass. Objectives: To discuss the rare clinical appearance of NPC involving the oral cavity and the significant role of dentists in its diagnosis and management. Case Report: We reported 3 cases of NPC with oral cavity involvement. In the first two cases, the patients presented with persistent oral ulceration with bone exposure and perforation to the above structure. The third patient presented with an ulcerated exophytic mass with temporomandibular disorder. The ulceration occurred due to bone destruction by the expansion of NPC mass, which indicated advance stage of the disease. All patients were managed with twice a day 0.2% chlorhexidine gluconate rinsing in combination with placing a chlorhexidine-moistened gauze to inhibit bacterial overgrowth and prevent secondary infection. The use of chlorhexidine was substituted by saline solution during patients’ radiotherapy and chemotherapy cycles. Conclusion: Dentist’s awareness to recognize the oral cavity involvement of NPC as well as recognizing the symptoms of NPC is very important, in order to make appropriate diagnosis and oral management. The oral management will eventually affect treatment outcome and quality of life."

"The purposes of this study are to study the pathogenesis of oral cancer and to see the role play of oncogenes, onco-suppressor genes in cancer growth and their mutation type. There are many predisposing factors which may influence the development of cancer. The factors are divided intrinsic (hereditary) and extrinsic factors (bacteria, viruses, fungi, chemical, drugs, radiation, trauma, heat, cold and nutrition). These agents may act individually, in combination with other carcinogen (co-carcinogen) or in combination with other agents that do not in themselves causes cancer (promoters), but that help the carcinogens to mutate or depress cells, but in the mechanism still enigma. Oncogenes oncosuppressor genes are normal genes in human. Oncogenes functions are as growth factor (e.g. sis), growth factor receptor (e.g. erbB1), signal transducer (e.g. ras) or nuclear factor (e.g.myc, jun). Tumor (oral cancer) will be arises if oncogenes andonco-suppressor genes function are disturbed by some carcinogenand these genes have mutation, deletion, amplification or translocation. That was also related to the loss or inactivation of onco-suppressor genes such as p53, so that causes the loss of the normal growth regulation/strait control that associated with tumorigenesis."