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"Development of novel vaccines gives an overview of the tasks in basic research leading to the final product, the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. The current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. "

"Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ?unit dose? and ?unit effect? with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics."

"This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma."

"Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed."

"Summary: For graduate-level courses in Knowledge Management and Decision Support Systems, this text presents a multi perspective approach to knowledge management: it spans electrical engineering, artificial intelligence, information systems, and business. It aims to provide students with the right combination of theory, technology and solutions"

"This book includes studies quantifying the role of energy in socioeconomic development, analysis of the interplay between supranational and national institutions in policy implementation, the energy implications of demographic trends such as urbanisation, and exploration of supply-side issues such as the potential role of nuclear energy and ‘cleaning’ fossil fuel energy generation through carbon capture."