Hasil Pencarian

Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 129159 dokumen yang sesuai dengan query
cover
Hasra Depiesa Dianika
Nilai diagnostik servikografi modifikasi dan inspeksi visual asam asetat (IVA) sebagai penapisan lesi pra kanker = Modified cervicography and visual acetoacid inspection as an alternative screening for cervical pre-cancer lesion
"ABSTRAK
Tujuan : Mengetahui nilai Akurasi Diagnostik berupa sensitivitas, spesifisitas,
nilai duga positif dan nilai duga negatif Servikografi Modifikasi dan IVA.
Metode : Penelitian yang akan dilakukan merupakan penelitian uji diagnostik
dengan membandingkan akurasi diagnostik Servikografi Modifikasi dengan IVA.
Didapatkan 185 sampel, semua sampel akan diperiksa di poliklinik Ginekologi
berturut-turut IVA, servikografi modifikasi dan kolposkopi pada Feberuari 2015 -
April 2015.
Hasil : Dari hasil pemeriksaan IVA, servikografi modifikasi dan kolposkopi
didapatkan hasil IVA positif sebanyak 7%, servikografi modifikasi dengan hasil
positif sebanyak 7.6% dan kolposkopi abnormal sebanyak 5.4%. Sehingga
didapatkan hasil sensitifitas IVA sebesar 96% dan servikografi modifikasi
sebesar 97.7%. Spesifisitas didapatkan hasil sensitifitas IVA sebesar 90.9% dan
servikografi modifikasi sebesar 90.9%.
Kesimpulan : Nilai akurasi diagnostik servikografi modifikasi dan IVA dapat
dinyatakan sebanding dan dapat digunakan bersama dengan pemeriksaan IVA
sebagai alternatif pemeriksaan lesi pra kanker.;ABSTRACT Objective : To know the difference of diagnostic accuration between acetoacetate
visual inspection and modified cervicography as an alternative screening of
cervical cancer lesion.
Methods : This was an cross-sectional study that was performed at RSUPN Dr.
Cipto Mangunkusumo from February 2015 until April 2015.
Results : 185 patients were admitted on this study. Sensitivity and specificity of
visual acetoacid inspection were 96% and 90,9%. Sensitivity and specificity of
modified cervicography were 97,7% and 90,9% compared to colposcopy as a gold
standard.
Conclusion : Modified cervicography and VIA are reliabe tools for cervical
cancer screening. Modified cervicography could be use as an alternative tool to
improve the documentation of VIA. "
Lengkap +
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Kiki Kurniati
Pengaruh penggunaan kontrasepsi terhadap kejadian lesi prakanker leher rahim pada wanita yang melakukan pemeriksaan inspeksi visual dengan asam asetat (IVA) di 3 Puskesmas di Jakarta Timur tahun 2011 = Effect of contraceptive use against the incindes of cervical lesions in women who conducting visual inspection with acetic acid in 3 Primary Health Care in East Jakarta District in 2011
"ABSTRAK
Skripsi ini menjelaskan mengenai pengaruh penggunaan kontrasepsi
terhadap kejadian lesi prakanker leher rahim. Penelitian dilakukan dengan menggunakan disain studi kasus-kontrol dan data sekunder yang berasal dari catatan medis deteksi dini kanker leher rahim di 3 puskesmas kecamatan di wilayah Jakarta Timur. Jumlah sampel yang diteliti adalah 86 orang untuk kelompok kasus dan 258 orang untuk kelompok kontrol. Hasil penelitian ini menemukan bahwa terdapat hubungan yang bermakna secara statistik antara penggunaan kontrasepsi non-hormonal dengan kejadian lesi prakanker (nilai-p <
α, dimana α = 0,05), dimana wanita yang menggunakan kontrasepsi non-hormonal memiliki risiko 4 kali lebih tinggi untuk mengalami kejadian lesi prakanker dibandingkan dengan wanita yang tidak pernah menggunakan metode kontrasepsi apapun, sedangkan risiko wanita yang menggunakan kontrasepsi hormonal tidak berbeda dengan wanita yang tidak pernah menggunakan metode kontrasepsi untuk mengalami kejadian lesi prakanker.
ABSTRACT
This thesis describes the effect of contraceptive use against the incidence of cervical lesions. This study uses a case-control study design with secondary data derived from medical records of early detection of cervical cancer in three health centers in East Jakarta district. The number of samples studied was 86 cases and 258 control. The results of this study found that there was a statistically significant association between contraceptive use and the incidence of cervical lesions (p-value <α, where α = 0.05), women who use non-hormonal contraception has 4 times higher risk to have cervical lesions compared with women who never used any contraceptive method, while the risk of women using
hormonal contraception are no different from women who never used a
contraceptive method to have cervical lesions."
Lengkap +
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2012
S-Pdf
UI - Skripsi Open  Universitas Indonesia Library
cover
Annisa Nursyifa Qolbi
Gambaran Pengetahuan tentang Kanker Serviks dan Inspeksi Visual Asam Asetat (IVA) Pada Wanita yang Sudah Menikah di Desa Cimandala = The Description about Cervical Cancer and Visual Inspection with Acetate Acid (VIA) Knowledges on Married Women in Cimandala Village
"Kanker serviks merupakan pertumbuhan abnormal pada sel serviks yang disebabkan oleh infeksi human papilloma virus (HPV). Kanker serviks dapat dicegah dengan pemeriksaan inspeksi visual asam asetat (IVA), sebagaimana yang tercantum dalam Permenkes No.34 Tahun 2015. Angka kematian dan insidens kanker serviks terus meningkat dan angka cakupan pemeriksaan IVA masih jauh dari target. Pengetahuan wanita tentang kanker serviks dan IVA merupakan salah satu penyebabnya. Penelitian ini bertujuan untuk melihat gambaran pengetahuan tentang kanker serviks dan pemeriksaan IVA. Metode penelitian yang digunakan berupa survei deskriptif dengan cluster sampling. Responden terdiri atas 112 wanita berusia 15-49 tahun di 10 RW Desa Cimandala yang diukur tingkat pengetahuannya menggunakan kuesioner. Hasil menunjukkan rerata usia responden 35,20 tahun, berpendidikan SMA (50,9%), tidak bekerja (90,2%), berpendapatan dibawah UMR (58,9%), dan tanpa riwayat keluarga dengan kanker (97,3%). Tingkat pengetahuan kanker serviks baik (54,4%). Tingkat pengetahuan pemeriksaan IVA baik (58,9%). Tingkat pengetahuan tentang kanker serviks dan pemeriksaan IVA berada dalam kategori baik. Persepsi terhadap kanker serviks dan pemeriksaan IVA perlu diteliti sebagai hambatan wanita untuk berpartisipasi pada pemeriksaan IVA.
Cervical cancer is abnormal growth in cervix’s cells caused by human papilloma virus (HPV). Cervical cancer can be prevented by visual inspection with acetic acid (VIA), as stated in Permenkes No.34 Tahun 2015. Mortality and incidence rate still are increasing and participation rate in VIA are unsatisfactory. Women’s knowledge on cervical cancer and VIA test associated with low rate of VIA test. This study aims to determine the description cervical cancer and VIA test knowledges on married women in Cimandala village. Descriptive survey with cluster sampling was used to collect data in this research. There were 112 women ages 15-49 years old in 10 RW Desa Cimandala. Knowledge was measured by questionaire. In conclusion, average age of participants 35,20 years old, high school graduate (50,9%), unoccupied (90,2%), have low income (58,9%), and no family history with cervical cancer (97,3%). Women’s knowledge on cervical cancer is considered as good (54,4%). Knowledge on VIA test also is considered as good (58,9%). Knowledge on cervical cancer and VIA test is classified as good. Women’s perception about cervical cancer and VIA test should be analysed as barrier for women to participate in VIA test.
"
Lengkap +
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2022
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Indi Susanti
Hubungan usia pertama kali berhubungan seksual dan jumlah pasangan seksual dengan kejadian lesi pra kanker leher rahim pada wanita yang melakukan deteksi dini menggunakan metode Inspeksi Visual dengan Asam Asetat (IVA) di Puskesmas Cikampek, Pedes dan Kota Baru Kabupaten Karawang Tahun 2009 - 2010 = Relationship of age at first intercourse and multisexual partners with cervical pre-cancerous lesions in women doing early detection using Visual Inspection with Acetic Acid (VIA) in Cikampek, Pedes and Kota Baru Public health center Karawang regency 2009-2010
"Kanker leher rahim merupakan kanker yang sering terjadi pada wanita, meliputi 12% dari seluruh kanker di dunia. Insiden yang tertinggi terjadi di Amerika Selatan dan Karibian, Sub Sahara Afrika, Asia Selatan dan Asia Tenggara. Di Indonesia menurut Kementerian Kesehatan RI, insiden kanker leher rahim di perkirakan 100 per 100.000. Ketahanan hidup 5 tahun penderita kanker leher rahim bila ditemukan pada stadium yang lebih awal, probabilitasnya semakin tinggi. Untuk stadium I (95,1-80,1%), II (66,3-63,5%), III (38,7-33,3%), IV (17,1-9,4%) dan pada masa pra invasif mencapai 100%. Di negara maju insidens dan kematian akibat kanker leher rahim turun 50-60% dalam 20 tahun karena 40-50% wanitanya pernah menjalani screening. Di negara berkembang sebaliknya terus naik karena hanya 5% wanitanya yang pernah menjalani screening.
Metode Inspeksi Visual dengan Asam Asetat (IVA) telah diakui WHO efektif digunakan di negara berkembang dengan alasan sederhana, murah, nyaman, praktis dan mudah. Mempunyai sensitifitas 66-96% dan spesifisitas (64-98%). Kabupaten Karawang terpilih sebagai lokasi penelitian karena merupakan salah satu daerah pilot proyek deteksi dini kanker leher rahim. Dari bulan Juli 2007 - Maret 2010 ditemukan 2,3% kasus IVA positif. Kasus kanker leher rahim di Kabupaten Karawang tergolong tinggi dimana pada tahun 2005 dilaporkan 217 kasus dan tahun 2006 sampai dengan bulan September ditemukan 180 kasus. Sesuai etiologinya dua faktor risiko utama terjadinya kanker leher rahim adalah usia pertama kali berhubungan seksual dan jumlah pasangan seksual.
Terkait faktor risiko berganti pasangan seksual, kasus kawin cerai di Karawang tinggi. Tahun 2008 tercatat 508 kawin, 259 cerai talak dan 424 cerai gugat. Tahun 2009 tercatat 270 talak dan 562 gugat. Terkait faktor risiko usia hubungan seksual, pernikahan muda di Karawang juga tinggi. Tahun 2007 42,8% pernikahan usia muda di Indonesia terjadi di pantai utara Jabar. Pernikahan di Jabar 35% dilakukan wanita dibawah usia 16 tahun.
Penelitian ini bertujuan mengetahui hubungan usia pertama kali berhubungan seksual dan jumlah pasangan seksual dengan kejadian lesi pra kanker leher rahim pada wanita yang melakukan deteksi dini menggunakan metode Inspeksi Visual dengan Asam Asetat (IVA) di Puskesmas Cikampek, Pedes dan Kota Baru Kabupaten Karawang tahun 2009 ? 2010. Metode penelitian yang digunakan adalah studi analitik observasional dengan desain kasus kontrol. Faktor yang diteliti didapat melalui wawancara terstruktur dengan kuesioner. Sedangkan data kasus kontrol diambil dari buku register dan catatan medik di Puskesmas Cikampek, Pedes dan Kota Baru dalam 2 tahun terakhir 2009 ? 2010. Total sampel yang diambil adalah 357 yang terdiri dari 119 kasus dan 238 kontrol.
Variabel independen yang diteliti adalah usia pertama kali berhubungan seksual dan jumlah pasangan seksual. Variabel kovariat terdiri dari umur, pendidikan, pekerjaan, pendapatan, riwayat kanker keluarga, jarak haid pertama kali dengan hubungan seksual pertama, kebiasaan merokok, jumlah batang rokok per hari, lama merokok, riwayat partus, riwayat abortus, penggunaan kontrasepsi, lama penggunaan kontrasepsi, riwayat deteksi dini sebelumnya, kebiasaan merokok pasangan, jumlah batang rokok per hari pasangan, lama merokok pasangan, riwayat perkawinan pasangan dan sirkumsisi. Analisis data dilakukan dengan soft ware SPSS versi 17.0 yang meliputi analisis univariat, bivariat, stratifikasi dan multivariat.
Hasil penelitian mendapatkan ada hubungan yang bermakna antara usia pertama kali berhubungan seksual dengan kejadian lesi pra kanker leher rahim setelah di kontrol dengan variabel lain dengan p value 0,001 dan OR 2,539 (CI 95% 1,444 - 4,464) sedangkan dampak potensialnya AR% 60,61%. Untuk jumlah pasangan dengan kejadian lesi pra kanker leher rahim setelah di kontrol dengan variabel umur juga memiliki hubungan yang bermakna dengan p value 0,002 dan OR 3,441 (CI 95% 1,598 ? 7,410) sedangkan dampak potensialnya AR% 70,94%.
Kesimpulan penelitian adalah risiko terkena lesi pra kanker leher rahim pada wanita yang memulai hubungan seksual pada usia < 17 tahun adalah 2,539 kali lebih tinggi dibanding mereka yang memulai hubungan seksual < 17 tahun dan kejadian lesi prakanker pada seorang wanita dapat dicegah 60,61% bila dia tidak melakukan hubungan seksual pertama < 17 tahun. Sedangkan untuk risiko terkena lesi pra kanker leher rahim pada wanita yang memiliki jumlah pasangan seksual > 1 orang adalah 3,441 kali lebih tinggi dibanding mereka yang mempunyai pasangan seksual 1 orang setelah di kontrol variabel umur dan kejadian lesi pra kanker pada seorang wanita dapat dicegah 70,94% bila dia tidak mempunyai jumlah pasangan seksual > 1.
Cervical cancer is the most common cancer in women, counting for 12% of all cancers in the world. The highest incidence occurred in South America and Karibian, Sub-Saharan Africa, South Asia and Southeast Asia. In Indonesia, according to the Ministry of Health, the incidence of cervical cancer is estimated occurred 100 per 100.000. The probability of 5-year survival of patients with cervical cancer when found at an earlier stage is higher. For stage I (95.1 to 80.1%), II (66.3 to 63.5%), III (38.7 to 33.3%), IV (17.1 to 9.4%) and in the pre-invasive reaches 100%. In developed countries the incidence and death from cervical cancer are decreased by 50-60% in the last 20 years since 40-50% women of those counties had undergone screening. In developing countries on the contrary, it continues to rise because only 5% women who had undergone screening.
Method of Visual Inspection with Acetic Acid (VIA) has been recognized by WHO effectively used in developing countries by reason of simple, inexpensive, convenient, practical and easy. The specifity of VIA method is 64-98% and sensitivity is 66-96%. Karawang District was selected as research sites because it is one of the pilot projects for early detection of cervical cancer. From July 2007 - March 2010 found 2.3% positive VIA cases. The cases of cervical cancer in the Karawang regency is high, where in 2005 was reported 217 cases and as of September 2006 was found 180 cases.
According to the etiology of two major risk factors for cervical cancer is the age at first intercourse and multisexual partners. In relation to risk factors of sexual partner change, a divorce & marriage case in Karawang is high. In 2008 it was recorded 508 marriage, 259 divorces and 424 divorce claim. In 2009 there were 270 divorces and 562 divorce claim. Concerning to age-related risk factors for sexual intercourse, young marriages in Karawang are also high. In 2007 42.8% marriage of young age in Indonesia was occurred in the northern coast of West Java. Marriage in West Java which is done by women under the age of 16 years was counted as 35%.
This study is aimed to verify the relationship of age at first intercourse and multisexual partners with cervical pre-cancerous lesions in women doing early detection using Visual Inspection with Acetic Acid (VIA) in Cikampek, Pedes and Kota Baru Public Health Center of Karawang District in 2009 - 2010. The research method used was an observational analytic study with case control design. Factors studied were obtained through structured interviews with questionnaires. While the case-control data were taken from the book registers and medical records at Cikampek, Pedes and Kota Baru Public Health Center in the last two years from 2009 to 2010. Total samples taken was 357 consisting of 119 cases and 238 controls.
Independent variables studied were age at first intercourse and multisexual partners. Kovariat variables consisted of age, education, occupation, income, family history of cancer, distance of first menstruation to first intercourse, smoking habits, number of cigarettes per day, duration of smoking, history of parturition, and abortion history, contraceptive use, duration of use of contraception, previous history of early detection, smoking spouse, the number of cigarettes per day couples, duration of couples smoking, history of marriage partners and circumcision. Data analysis was performed with SPSS version 17.0 software which includes univariate, bivariate, and stratification and multivariate analysis.
The results of study find significant relationship between age at first sexual intercourse with cervical pre-cancerous lesions after being controlled with other variables with p value of 0.001 and OR 2.539 (95% CI 1.444 - 4.464), while the potential impact of AR% 60.61%. For the number of sexual pairs with cervical precancerous lesions after being controlled with variables of age also have a meaningful relationship with p value of 0.002 and OR 3.441 (95% CI 1.598 - 7.410) while the potential impact of AR%, 70.94%.
The conclusion is the risk of cervical pre-cancerous lesions in women who began sexual intercourse at age <17 years is 2.539 times higher than those who start a sexual intercourse at age < 17 years and the incidence of precancerous lesions in a woman could be prevented 60.61% if she does not have first sexual intercourse before 17 years. While for the risk of cervical pre-cancerous lesions in women who have a number of sexual partners more than 1 person is 3.441 times higher than those who have only one sexual partners after being controlled by variables of age and the incidence of precancerous lesions in a woman can be prevented 70.94 % if she does not have the number of sexual partners more than 1."
Lengkap +
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2010
T30824
UI - Tesis Open  Universitas Indonesia Library
cover
Sulaeman Daud
Kelainan lesi prakanker serviks melalui papsmear pada pemeriksaan IVA dengan tampilan sambungan skuamo-kolumnar tidak tampak = Cervical pre cancer lesion with diagnosed by papsmear examination and IVA in women with unvisible squamo-columnar junction
"ABSTRAK
Tujuan : Untuk mengetahui kelainan yang tersembunyi pada keadaan
Sambungan Skuamo-Kolumnar (SSK) tidak tampak melalui pemeriksaan
Papsmear.
Metode : Penelitian ini merupakan deskriptif potong lintang (Cross Sectional).
Penelitian dilakukan pada periode Agustus 2014 sampai Maret 2015 di beberapa
Puskesmas di Jakarta. Sebanyak 1682 subjek yang dilakukan pemeriksaan IVA
(Inspeksi Visual dengan Asam asetat). Setelah data dikumpukan, akan dilakukan
verifikasi data, editing dan coding. Analisis data statistik berupa deskriptif
variabel kategorik yaitu persentase letak Sambungan Skuamo-Kolumnar (SSK)
berdasarkan distribusi umur, persentase hasil pemeriksaan IVA berdasarkan SSK,
dan persentase hasil pemeriksaan Papsmear pada SSK yang tidak tampak dari
hasil pemeriksaan IVA negatif disajikan dalam bentuk n%.
Hasil : Perempuan dengan Sambungan Skuamo-Kolumnar (SSK) yang tampak
1484 (88,2%), yang tidak tampak 198 (11,8%). Sambungan Skuamo-Kolumnar
(SSK) yang tidak tampak pada perempuan yang sudah menopause 122 (61,6%),
sedangkan pada perempuan yang belum menopause 76 (38,4%). Hampir
setengahnya proporsi SSK yang tampak didapatkan pada kelompok perempuan
yang sudah menopause 45,78% (103/225). Hasil pemeriksaan IVA positif
didapatkan 4(7,1%) pada kelompok perempuan menopause dan 52(92,9%) pada
kelompok perempuan yang belum menopause. Pada pemeriksaan Papsmear
dengan SSK yang tidak tampak, persentase kelainan lesi prakanker yaitu sebesar
0(0,0%) ASCUS, 0(0,0%) LSIL, 0(0,0%) HSIL, dan 197(100%) normal.
Kesimpulan : Hampir setengahnya Sambungan Skuamo-Kolumnar (SSK) yang
tampak ditemukan pada kelompok perempuan menopause. Sebagian besar IVA
positif ditemukan pada kelompok perempuan yang belum menopause. Seluruh perempuan dengan SSK yang tidak tampak memiliki hasil pemeriksaan Papsmear normal. ABSTRACT Objective: To know is there any concealed precancer lesion in women with
unvisible Squamo-Columnar Junction (SCJ) by Papsmear examination.
Methods : This study was a descriptive cross-sectional design starting from
August 2014 to March 2015 at several Public Health Care in Jakarta. A total of
1682 subjects were screening by Acetoacetate Visual Inspection (AVI)
examination. After the data was collected, and continued by verification, editing
and coding. The analysis from the data by variable categoric descriptive like
percentage of SCJ in age distribution, percentage the result of AVI examination
based on SCJ and percentage the result of Papsmear examination in unvisible
SCJ from negative AVI result. All the result would be present in n%.
Results : Women with the visible SCJ were 1484(88,2%) and women with
unvisible SCJ were 198(11,8). The percentage of unvisible SCJ in the menopausal
women group were 122(61,6%), However, in the non-menopausal women group
were 76(38,4%). Almost a half of the percentage of visible SCJ found in
menopausal women group 45,78%(103/225). The positive AVI result was 4(7,1%)
in the menopausal women group and 52(92,9%) in non-menopausal women grup.
The result of papsmear examination with unvisible SCJ were 0(0,0%) ASCUS,
0(0,0%) LSIL, 0(0,0%) HSIL, and 197(100%) normal..
Conclusion : Almost a half of visible SCJ found in menopausal women group.
Most of positive AVI result was found in the non-menopausal women group. All
woman with the unvisible SCJ have a normal papsmear result.
;Objective: To know is there any concealed precancer lesion in women with
unvisible Squamo-Columnar Junction (SCJ) by Papsmear examination.
Methods : This study was a descriptive cross-sectional design starting from
August 2014 to March 2015 at several Public Health Care in Jakarta. A total of
1682 subjects were screening by Acetoacetate Visual Inspection (AVI)
examination. After the data was collected, and continued by verification, editing
and coding. The analysis from the data by variable categoric descriptive like
percentage of SCJ in age distribution, percentage the result of AVI examination
based on SCJ and percentage the result of Papsmear examination in unvisible
SCJ from negative AVI result. All the result would be present in n%.
Results : Women with the visible SCJ were 1484(88,2%) and women with
unvisible SCJ were 198(11,8). The percentage of unvisible SCJ in the menopausal
women group were 122(61,6%), However, in the non-menopausal women group
were 76(38,4%). Almost a half of the percentage of visible SCJ found in
menopausal women group 45,78%(103/225). The positive AVI result was 4(7,1%)
in the menopausal women group and 52(92,9%) in non-menopausal women grup.
The result of papsmear examination with unvisible SCJ were 0(0,0%) ASCUS,
0(0,0%) LSIL, 0(0,0%) HSIL, and 197(100%) normal..
Conclusion : Almost a half of visible SCJ found in menopausal women group.
Most of positive AVI result was found in the non-menopausal women group. All
woman with the unvisible SCJ have a normal papsmear result.
"
Lengkap +
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Septi Ayu
Analisis Pemeriksaan Inspeksi Visual Asam Asetat (IVA) pada Wanita Usia Subur di Kelurahan Cilodong Kota Depok Tahun 2024 = Analysis of Visual Inspection with Acetic Acid (VIA) Screening among Women of Reproductive Age in Cilodong Subdistrict, Depok City, in 2024
"Pada tahun 2023 cakupan pemeriksaan IVA pada Wanita usia subur di Kelurahan Cilodong masih rendah hanya mencapai 2,2%. Penelitian ini bertujuan untuk menganalisis cakupan pemeriksaan IVA dan faktor apa saja yang berhubungan dengan pemeriksaan IVA di Kelurahan Cilodong, Depok. Penelitian ini menggunakan desain cross sectional. Data dikumpulkan melalui wawancara menggunakan kuesioner pada sampel sebanyak 130 WUS di Kelurahan Cilodong, Kota Depok, yang dipilih secara random dari 8 RW yang ada. Data dianalisis menggunakan uji chi-square dan regresi logistik ganda. Hasil penelitian menunjukkan hanya 6,2% WUS yang melakukan pemeriksaan IVA. Penelitian ini membuktikan pendidikan dan tingkat pengetahuan berhubungan dengan pemeriksaan IVA. Faktor yang paling dominan adalah tingkat pengetahuan (POR=38,96, 95% CI= 4,23 – 358,66), WUS dengan tingkat pengetahuan tinggi berpeluang hampir 39 kali untuk melakukan pemeriksaan IVA dibandingkan dengan WUS tingkat pengetahuan rendah, setelah dikontrol oleh pendidikannya. Atas dasar tersebut maka instansi terkait perlu melakukan peningkatan pengetahuan dengan mengembangkan program edukasi kesehatan mengenai kanker leher rahim dan pemeriksaan IVA, baik untuk WUS maupun suami/keluarganya, sehingga cakupan pemeriksaan IVA meningkat
In 2023, the coverage of visual inspection of acetic acid (VIA) examinations in women of childbearing age in Cilodong Village is still low, only reaching 2.2%. This study aims to analyze the coverage of VIA examinations and factors related to VIA examinations in Cilodong Village, Depok. This study used a cross-sectional design. Data were collected through interviews using questionnaires on a sample of 130 women of childbearing age in Cilodong Village, Depok City, who were randomly selected from 8 existing neighborhood associations. Data were analyzed using the chi-square test and multiple logistic regression. The results showed that only 6.2% of women of childbearing age underwent VIA examinations. This study proves that education and level of knowledge are related to VIA examinations. The most dominant factor is the level of knowledge (POR = 38.96, 95% CI = 4.23 - 358.66); women of childbearing age with a high level of knowledge are almost 39 times more likely to undergo VIA examinations compared to women of childbearing age with low levels of knowledge, after being controlled by their education. Based on these reasons, related agencies need to increase knowledge by developing health education programs regarding cervical cancer and IVA examinations, both for WUS and their husbands/families, so that the coverage of IVA examinations increases."
Lengkap +
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2024
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Maya Sarita Dewi
Gambaran Implementasi Program Deteksi Dini Kanker Serviks dengan Metode Inspeksi Visual Asam Asetat (IVA) di Puskesmas Kecamatan Pancoran Mas, Kota Depok Tahun 2022 = Description of the Implementation of Cervical Cancer Early Detection Program using Visual Inspection with Acetic Acid Method (VIA) at Public Health Center in Pancoran Mas District, Depok City in 2022
"Latar Belakang: Tingginya angka prevalensi kanker serviks di Indonesia membuat pemerintah Indonesia berupaya untuk menurunkan angka kasus kanker serviks melalui program Deteksi Dini Kanker Serviks. Inspeksi Visual Asam Asetat (IVA) merupakan suatu metode pemeriksaan visual seluruh permukaan leher rahim menggunakan asam asetat yang diencerkan dengan tujuan untuk mengetahui dini adanya kanker serviks.
Tujuan: Melihat gambaran implementasi dari program deteksi dini kanker serviks menggunakan metode Inspeksi Visual Asam Asetat (IVA) yang ada di Puskesmas Kecamatan Pancoran Mas.
Metode: Penelitian ini menggunakan metode kualitatif dengan wawancara mendalam melalui pendekatan rapid assessment procedures. Teori yang digunakan adalah teori logic model. Informan dalam penelitian berjumlah 19 orang yang terdiri dari 4 informan kunci dan 15 informan utama. Peneliti mengambil data secara langsung dengan menerapkan protocol Covid-19.
Hasil: Sebagian besar pelaksanaan program IVA telah berjalan sesuai alur yang ditetapkan oleh Kementerian Kesehatan. Namun terdapat beberapa hambatan dalam pelaksanaannya yaitu terdapat tenaga pelaksana yang belum terlatih tetapi dapat memberikan IVA, kurangnya kesadaran masyarakat untuk melakukan IVA serta pemberian penyuluhan terkait IVA di Puskesmas Kecamatan Pancoran Mas masih sedikit.
Kesimpulan: Pemberian penyuluhan terkait IVA di Puskesmas Kecamatan Pancoran Mas perlu ditingkatkan lagi untuk meningkatkan kesadaran masyarakat melakukan IVA agar tercapainya cakupan IVA sesuai target.
Background: High prevalence of cervical cancer in Indonesia makes Indonesian Government strive to reduce the number of cervical cancer cases through the cervical cancer early detection program. Visual inspection with acetic acid (IVA) is a method of visual inspection of the entire surface of the cervix using diluted acetic acid with the aim to detecting cervical cancer early.
Aim: Describing the implementation of Cervical Cancer Early Detection Program using Visual Inspection with Acetic Acid Method (VIA) at Public Health Center in Pancoran Mas District.
Methods: This study used a qualitative method with indepth interviews through a rapid assessment procedure approach with. There were 19 informants consisting of 4 key informants, 3 main informants, and 12 supporting informants. Researchers took data directly by applying the Covid-19 health protocol.
Result: Most of the implementation of IVA program had run according to the law set by the Ministry of Health. However, there are several obstacles in its implementation as there were untrained health workers who already gave an IVA test, lack of public awareness to do IVA test, and the provision of socialization related to IVA at Public Health Center in Pancoran Mas District was still small.
Conclusion: The provision of socialization related to IVA at Public Health Center in Pancoran Mas District needs to be increased again to increase awareness in public also the scope of IVA so the target can be achieved."
Lengkap +
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2022
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Linggih Saputro
Penapisan inhibitor tankirase-2 untuk terapi kanker serviks = Screening of tankyrase 2 inhibitors for cervical cancer therapy
"Kanker serviks merupakan kanker kedua yang umum terjadi pada wanita yang da- pat menjadi ganas. Keganasan dapat disebabkan oleh deregulasi jalur sinyal Wnt/β- katenin. Inhibisi TNKS2 dengan ligan inhibitor dapat menjadi salah satu cara un- tuk menghentikan deregulasi ini. Ligan-ligan inhibitor yang berhasil terbentuk dari fragmen-fragmen akan ditapiskan secara in silico untuk mendapatkan ligan kandi- dat obat terbaik yang lebih baik dari ligan inhibitor standar. Ligan dengan kode 1-69 merupakan ligan inhibitor yang lebih baik jika dilihat dari energi pengikatan, kelarutan, total polar surface area.
Cervical cancer is the second most common cancer in women which can be ma- lignant. Malignancy can be caused by deregulation oleh Wnt/β-catenin signaling pathway. Inhibition of TNKS2 with ligand inhibitor can be an alternative way to stop this deregulation. All of the inhibitors which assembled from fragments were screened in silico to get the best hit which is better than standard inhibitor. Ligand with codename 1-69 is a better inhibitor than the standard in the term of binding energy, solubility and total polar surface area."
Lengkap +
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2014
S55827
UI - Skripsi Membership  Universitas Indonesia Library
cover
Budiyanto Abdul Rohim
Uji diagnostik pemeriksaan ultrasonografi dibandingkan pemeriksaan klinis dalam mengukur ukuran lesi primer kanker serviks = Diagnostic performance of ultrasound compare to clinical examination in measuring the size of primary tumor of cervical cancer
"[ABSTRAK
Tujuan. Penelitian ini membahas perbandingan performa diagnostik antara pemeriksaan ultrasonografi dengan pemeriksaan klinis dalam mengukur ukuran lesi primer kanker serviks.
Metode. Dilakukan uji diagnostik potong-lintang secara retrospektif terhadap pasien kanker serviks stadium IB di RSUPN Dr. Ciptomangunkusumo dari tahun 2009 hingga tahun 2014. Nilai diagnostik dari kedua pemeriksaan dihitung dengan luaran: sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi. Uji kesesuaian dari kedua pemeriksaan juga dihitung dengan ukuran makroskopik sebagai standar baku emas.
Hasil. Dari periode tahun 2009 hingga tahun 2014, didapatkan 92 subjek yang memenuhi kriteria inklusi dengan komposisi yaitu 65 kasus (70%) kanker serviks stadium IB1 dan 27 kasus (30%) kanker serviks stadium IB2. Ultrasonografi didapatkan memiliki nilai diagnostik yaitu sensitivitas 92%, spesifisitas 96%, nilai prediksi positif 92%, nilai prediksi negatif 96%, dan akurasi 95%. Sementara itu, pemeriksaan klinis didapatkan memiliki nilai diagnostik yaitu sensitivitas 51%, spesifisitas 92%, nilai prediksi positif 73%, nilai prediksi negatif 82%, dan akurasi 80%. Dari perhitungan kesesuaian antara ukuran pemeriksaan ultrasonografi dan ukuran makroskopik, didapatkan perbedaan rata-rata 0,56 cm. Sementara itu, dari perhitungan kesesuaian antara ukuran pemeriksaan klinis dan ukuran makroskopik, didapatkan perbedaan rata-rata 0,97 cm.
Kesimpulan. Penelitian ini menyimpulkan bahwa pemeriksaan ultrasonografi memiliki performa diagnostik yang lebih baik dibandingkan pemeriksaan klinis dalam mengukur ukuran lesi primer kanker serviks.
ABSTRACT
Objective. The purpose of this study is to compare the diagnostic value of ultrasound and clinical examination in measuring the size of primary tumor of cervical cancer.
Methods. It is a retrospective cross sectional study for patients with cervical cancer stage IB in Cipto Mangunkusumo hospital from 2009 to 2014. Diagnostic value of both examinations were calculated with outcome: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Resemblance test of both examinations were also calculated with macroscopic size as the gold standart.
Result. From period 2009 until 2014, there were 92 subject which fulfilled the inclusion criteria, consisted of 65 cases (70%) cervical cancer stage IB1 and 27 cases (30%) cervical cancer stage IB2. Ultrasonografi was found to have diagnostic values as follow: sensitivity 92%, specificity 96%, positive predictive value 92%, negative predictive value 96%, and accuracy 95%. Meanwhile, clinical examination was found to have diagnostic values as follow: sensitivity 51%, specificity 92%, positive predictive value 73%, negative predictive value 82%, and accuracy 80%. From the calculation of resemblance between ultrasound and macroscopic size, there was an average difference approximately 0.56 cm. Meanwhile, from the calculation of resemblance between clinical examination and macroscopic size, there was an average difference approximately 0.97 cm.
Conclusion. It can be concluded that the ultrasound has better diagnostic value compare to clinical examaination in examining the size of primary tumor of cervical cancer., Objective. The purpose of this study is to compare the diagnostic value of ultrasound and clinical examination in measuring the size of primary tumor of cervical cancer.
Methods. It is a retrospective cross sectional study for patients with cervical cancer
stage IB in Cipto Mangunkusumo hospital from 2009 to 2014. Diagnostic value of both
examinations were calculated with outcome: sensitivity, specificity, positive predictive value,
negative predictive value, and accuracy. Resemblance test of both examinations were also
calculated with macroscopic size as the gold standart.
Result. From period 2009 until 2014, there were 92 subject which fulfilled the inclusion
criteria, consisted of 65 cases (70%) cervical cancer stage IB1 and 27 cases (30%) cervical
cancer stage IB2. Ultrasonografi was found to have diagnostic values as follow: sensitivity
92%, specificity 96%, positive predictive value 92%, negative predictive value 96%, and
accuracy 95%. Meanwhile, clinical examination was found to have diagnostic values as follow:
sensitivity 51%, specificity 92%, positive predictive value 73%, negative predictive value 82%,
and accuracy 80%. From the calculation of resemblance between ultrasound and macroscopic
size, there was an average difference approximately 0.56 cm. Meanwhile, from the calculation
of resemblance between clinical examination and macroscopic size, there was an average
difference approximately 0.97 cm.
Conclusion. It can be concluded that the ultrasound has better diagnostic value compare to clinical examaination in examining the size of primary tumor of cervical cancer.]"
Lengkap +
Fakultas Kedokteran Universitas Indonesia, 2014
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Niken Widiyanti
Stusi in silico senyawa modifikasi largazol sebagai inhibitor potensial histone deacetylase HDAC kelas I homo sapiens pada kanker serviks = In silico study of modified largazole as potent inhibitor of histone deacetylase HSAC class i homo sapiens on cervical cancer
"Kanker serviks merupakan penyebab kematian kedua terbanyak pada wanita diseluruh dunia. Kanker serviks umumnya disebabkan oleh human pappilomavirus (HPV) onkogenik. Inhibisi aktivitas enzim histone deacetylase (HDAC) merupakan salah satu strategi potensial untuk terapi kanker. Largazol dilaporkan memiliki aktivitas inhibisi lebih besar dibandingkan romidepsin, senyawa peptida siklik dalam obat komersil, Istodax. Pada penelitian ini dilakukan modifikasi largazol pada bagian penghubung, zinc binding group dan hydrophobic cap bertujuan untuk meningkatkan selektivitas dan kemampuan inhibisi. Penambatan molekul terhadap 3429 ligan modifikasi dan standar dilakukan sebagai penapisan virtual dengan hasil 10 ligan terbaik dengan nilai ΔGbinding terendah untuk semua tipe HDAC kelas I Homo sapiens dibandingkan standar. Simulasi dinamika dilakukan pada ligan terbaik dengan nilai ΔGbinding terendah dan drug scan terhadap prediksi sifat farmakologi dan toksisitas terbaik, yaitu ligan Be2L1. Simulasi dinamika dilakukan dalam kondisi dipengaruhi oleh pelarut. Penambatan molekul dan simulasi dinamika dilakukan dengan menggunakan MOE 2008.10. Studi simulasi dinamika menunjukkan bahwa kompleks enzim-ligan ini stabil pada suhu 310 K dengan urutan kestabilan dari yang terbaik berturut-turut adalah HDAC 1, 2, 8 dan 3.
Cervical cancer is the second largest cause of death in women worldwide. Cervical cancer is generally caused by oncogenic human pappilomavirus (HPV). Inhibition of histone deacetylase (HDAC) activity is one of a potential strategy for cervical cancer therapy. Largazole reported to have greater inhibition activity than rhomidepsin, cyclic peptide compounds in commercial drugs named Istodax. In this research, the modifications of largazole on the linker, zinc binding group and hydrophobic cap aim to improve the selectivity and inhibition activity. The docking of 3429 modification ligands and standards performed as virtual screening and the results are 10 best ligands with the lowest ΔGbinding values for all types of HDAC class I Homo sapiens than standards. Molecular dynamics simulation was performed on the ligand with the lowest ΔGbinding value and the best drug scan results of pharmacological properties and toxicity prediction is Be2L1 ligand. Dynamics simulation conducted in hydrated conditions. Molecular docking and dynamics simulation were performed using MOE 2008.10. Dynamics simulation study showed that enzyme-ligand co."
Lengkap +
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2014
T43261
UI - Tesis Membership  Universitas Indonesia Library
<<   1 2 3 4 5 6 7 8 9 10   >>