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"This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. "

"Penyakit ginjal kronis (PGK) merupakan salah satu penyakit dengan tingkat kematian terbanyak di dunia. Oleh karena itu, diperlukan metode diagnosis yang cekatan dan akurat agar dapat ditangani dalam waktu secepatnya. Magnetic Particle Imaging (MPI) adalah metode pencitraan non-invasif baru yang sedang berkembang. MPI bekerja dengan menggunakan medan magnet untuk memindai, mengeksitasi dan mendeteksi sinyal tracer, yang berupa superparamagnetic iron oxide nanoparticle (SPION), yang sebelumnya telah diinjeksikan ke dalam subjek. Dibandingkan dengan modalitas lain seperti Computed Tomography (CT), tracer MPI tidak radioaktif dan tidak diproses oleh ginjal, sehingga lebih aman untuk diagnosis atau pemantauan PGK. Tujuan dari penelitian tesis ini adalah untuk menyimulasikan alat MPI dengan bidang field-free point (FFP) dan mendemonstrasikan rekonstruksi citra MPI 1D dari sinyal output simulasi. Hal tersebut dilakukan dengan membuat model 3 dimensi sesuai dengan parameter yang telah ditentukan oleh hasil studi literatur dan melakukan simulasi dengan tracer pada lokasi-lokasi berbeda dalam field of view, lalu mengolah data menggunakan dua metode signal processing yaitu metode system matrix (SM) dan metode X-Space. Hasil dari penelitian adalah model 3D mampu menyimulasikan kinerja MPI dengan cukup baik, dengan hasil rekonstruksi dengan metode SM mempunyai error rata-rata 42,66% dan skor Structural Similarity Index Measure (SSIM) 0,346 karena jumlah sampel yang sedikit. Namun, sinyal output tidak dapat digunakan untuk rekonstruksi X-Space oleh karena bentuk FFP yang terlalu landai, meskipun berdasarkan pemodelan matematis, metode rekonstruksi X-Space memiliki tingkat akurasi yang sangat tinggi dengan waktu rekonstruksi yang cepat, dengan resolusi 2 mm dan skor SSIM 0,861. Melalui penelitian ini, didapat bahwa meskipun tidak dapat menggunakan metode X-Space, model MPI yang dibuat mampu digunakan untuk menyimulasikan kinerja MPI FFP 1D dengan akurasi yang cukup baik agar dapat menghasilkan citra melalui metode rekonstruksi system matrix.

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Chronic kidney disease (CKD) is one of the deadliest diseases in the world. Therefore, there is a constant search for an accurate and fast method to diagnose CKD so treatment can begin as fast as possible. Magnetic Particle Imaging (MPI) is an emerging non-invasive imaging method that is currently being developed for medical use. MPI uses a combination of varying magnetic fields to scan and detect magnetic signals from its tracers, named superparamagnetic iron oxide nanoparticles (SPIONs), which are injected into the subject beforehand. Compared to other imaging modalities like Computed Tomography (CT), MPI’s tracers are not radioactive and are not processed in the kidneys, making it a safer option for diagnosing CKD without worsening its condition. The aim of this thesis is to simulate the mechanisms of a field-free point (FFP) MPI and to reconstruct a 1D image based on the acquired simulated MPI data. This is done by making a 3-dimensional model of an MPI device based on parameters gathered via literature research and simulating MPI scans with tracers located in various points inside the field of view. The gathered data are then processed by two methods, the system matrix (SM)-based reconstruction and the X-Space reconstruction. The results of this research are that the 3D model can simulate the mechanisms of MPI properly, with an average error of 42.66% and a Structural Similarity Image Measure (SSIM) score of 0.346 using the SM-based reconstruction due to a very limited sample size and an inaccurate tracer model. However, the signals cannot be reconstructed using X-Space methods due to the low gradient of the FFP, despite the X-Space method being a very fast and accurate reconstruction method based on mathematical models, having a 2 mm resolution and an SSIM of 0.861. These findings conclude that despite being unable to use the X-Space reconstruction method, the 1-dimensional FFP MPI model can simulate the mechanics of MPI with enough accuracy to create an image using SM-based reconstruction."

"The idea of using the enormous potential of magnetic resonance imaging (MRI) not only for diagnostic but also for interventional purposes may seem obvious, but it took major efforts by engineers, physicists, and clinicians to come up with dedicated interventional techniques and scanners, and improvements are still ongoing. Since the inception of interventional MRI in the mid-1990s, the numbers of settings, techniques, and clinical applications have increased dramatically. This state of the art book covers all aspects of interventional MRI. The more technical contributions offer an overview of the fundamental ideas and concepts and present the available instrumentation. The richly illustrated clinical contributions, ranging from MRI-guided biopsies to completely MRI-controlled therapies in various body regions, provide detailed information on established and emerging applications and identify future trends and challenges."

"Principles of Computerized Tomographic Imaging provides a comprehensive, tutorial-style introduction to the algorithms for reconstructing cross-sectional images from projection data and contains a complete overview of the engineering and signal processing algorithms necessary for tomographic imaging. In addition to the purely mathematical and algorithmic aspects of these algorithms, the book also discusses the artifacts caused by the nature of the various forms of energy sources that can be used for generating the projection data. Kak and Slaney go beyond theory, emphasizing real-world applications and detailing the steps necessary for building a tomographic system.Since the fundamental aspects of tomographic reconstruction algorithms have remained virtually the same since this book was originally published, it is just as useful today as it was in 1987. It explains, among other things, what happens when there is excessive noise in the projection data; when images are formed from insufficient projection data; and when refracting or diffracting energy sources are used for imaging. Anyone interested in these explanations will find a wealth of useful information in this book."