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"This book seeks to promote an integrated approach among the various specialists involved in the management of rectal cancer with a view to ensuring that treatment is tailored appropriately to the individual patient. For ease of use, a question and answer format is employed. The focus is on those issues typically confronted during daily clinical practice in relation to risk factors, imaging, surgery, radiotherapy, and chemotherapy. The services of an outstanding panel of authors representative of the major European oncological societies have been acquired in order to formulate the questions and provide the answers. All who need assistance in addressing concerns that arise from the need for multidisciplinary management of rectal cancer will find the book to be an ideal source of helpful information."

"This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included."

"This book analyzes the process-oriented and organizational changes related to the digital transformation of multidisciplinary design firms. Based on this it proposes a systematic analysis-based methodology for change management, which consists of two distinct, but complementary components: a framework and a set of analysis methods. It particularly focuses on the relationship between the new paradigms, perspectives, and context of change related to digital transformation. The proposed framework combines these three elements in order to identify and address areas of investigation concerning process-oriented and organizational changes in the context of digital transformation, and also quantitatively and qualitatively assesses these changes in practice.This book offers the first comprehensive review of change management and digital practice, and includes case studies to enhance readers’ understanding of change management in the context of the digitalization. As such it is of interest to both industry practitioners and researchers."

"Tujuan: Menghitung Tingkat Utilisasi Radioterapi aktual (TURa) dan optimal (TURo) untuk kanker kolon dan rektum di Indonesia. Metodologi: Penelitian ini menggunakan desain potong lintang terhadap data sekunder registrasi/rekam medis kanker di rumah sakit (RS) dengan pusat radioterapi di Indonesia tahun 2019. Data dikumpulkan secara total sampling untuk menghitung TURo, TURa, dan persentase yang tidak terpenuhi. Hasil: Terdapat 32 RS yang datanya dapat diolah (1.211 dan 1.762 pasien kanker kolon dan rektum). Rata-rata pasien berusia sekitar 52-54 tahun (10-94 tahun), jenis kelamin laki-laki (51,1%) dan berasal dari Sumatera Utara atau Jawa Tengah. Sebagian besar datang dengan stadium lokal lanjut dan lanjut (III dan IV), tidak diradiasi (76,9%). TURa kolon 14 RS adalah 5,3% (0-33,3%), sedangkan TURo kolon 3,3 (3-3,7%) dengan persentase yang tidak terpenuhi -60,6% (-76,7 sampai -43,2%). Untuk TURa dan TURo rektum adalah 22,8% (0-100%) dan 41% (28-66%). Persentase yang tidak terpenuhi kanker rektum adalah 44,4% (18,6-65,5%). Kesimpulan: TURa kanker kolon terkesan sudah memenuhi TURo, tetapi ketika disesuaikan dengan data dalam lingkup yang lebih besar, masih terdapat celah yang belum terpenuhi. Untuk kanker rektum, masih diperlukan peningkatan utilisasi. Diperlukan penelitian lebih lanjut pada indikasi radiasi yang belum terlalu jelas. Selain itu, peningkatan TUR perlu mempertimbangkan faktor pasien, klinisi ataupun birokrasi.

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Aims: To calculate the actual and optimal Radiotherapy Utilization Rate (RTUa and RTUo) of colon and rectal cancer in Indonesia. Methodology: This cross-sectional study used secondary cancer registry/medical records from hospitals with radiotherapy centers in Indonesia in 2019. Total sampling was used for data collection to calculate RTUa, RTUo and percentage of unmet needs. Results: Out of 32 hospitals (1,211 and 1,762 colon and rectal cancer patients), the mean age was 52-54 years old (10-94), male (51.1%), from North Sumatra or Central Java province. Most patients came with locally advanced and advanced stages (III and IV), not irradiated (76.9%). RTUa of colon in 14 hospitals was 5.3% (0-33.3%), whereas RTUo was 3.3 (3-3.7%). The unmet needs was -60.6% (-76.7 to -43.2%). For rectal, the RTUa and RTUo were 22.8% (0-100%) and 41% (28-66%). The unmet needs for rectal was 44.4% (18.6-65.5%). Conclusion: Despite the impression of fulfilling the RTUo of colon cancer, gaps are to be filled when adjusted with a broader scope of data. Moreover, for rectal cancer, there was still an unmet need for utilization. Further research is needed, especially in cancer with obscure radiotherapy indications. The increase in RTU should also consider patient, clinician and bureaucratic factors."