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"Latar Belakang: Kebocoran anastomosis adalah komplikasi yang dapat terjadi pasca dilakukannya reduksi manual, reseksi dan anastomosis end-to-end pada kasus intususepsi. Faktor-faktor yang mempengaruhi kebocoran anastomosis antara lain teknik operator, kondisi lokal usus, kondisi umum pasien dan grading kolagen yang terbentuk pada proses penyembuhan luka. Tujuan: Mengetahui pengaruh perubahan grading kolagen usus pasca reseksi anastomosis terhadap kebocoran pada kasus intususepsi. Metode: Dua puluh satu tikus Sprague-dawley dilakukan laparatomi untuk dibuat model intususepsi (IN). Setelah 45 menit dilakukan destrangulasi selama 10 menit, dinilai adanya nekrosis dan dilanjutkan reseksi anastomosis. Tikus dibagi menjadi 3 kelompok, kelompok A : reseksi anastomosis pada batas usus yang nekrosis, kelompok B : reseksi anastomosis pada batas usus yang mengalami trombosis pembuluh darah mesenteriumnya, dan kelompok C : reseksi anastomosis pada batas usus yang sehat. Sampel usus yang direseksi diperiksa secara Histopatologi untuk menilai grading kolagen. Setelah 5 hari dilakukan laparatomi ulang, dinilai secara subjektif ada tidaknya kebocoran anastomosis, lalu diambil sampel segmen anastomosis usus untuk dinilai kembali grading kolagennya. Diharapkan jika terjadi kenaikan grading kolagen, anastomosis akan paten, sebaliknya jika terjadi penurunan akan terjadi perforasi. Hasil: Kelompok A: grading kolagen menurun dengan perforasi 6 (85,7%), grading kolagen tetap tanpa perforasi 1 (14,2%). Kelompok B: grading kolagen menurun dengan perforasi 2 (28,6%), tetap dengan perforasi 1 (14,3%), meningkat tanpa perforasi 4 (42,9%). Kelompok C: grading kolagen meningkat tanpa perforasi 5 (71,4%), menetap tanpa perforasi 2 (28,6%). Kesimpulan: Terdapat perubahan grading kolagen pasca reseksi anastomosis usus yang mempengaruhi tingkat kebocoran anastomosis pada kasus intususepsi.

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Background: Anastomosis leakage is a common complication following manual reduction, resection and end-to-end anastomosis in treating intussusceptions. Factors influencing the anastomosis leakage such as surgeon?s technique, local bowel condition, systemic condition of patients and the concentration of collagen in the bowel tissue during the anastomosis healing.

Aim: To study the effect of collagen concentration changes after resection and anastomosis procedure, in relation to the anastomosis leakages in intussusceptions case.

Methods: 21 Sprague-dawley rats were performed laparotomy to create the intussusception model (IN). The IN models were applied for 45 minute, after the bowel considered necrotic, destrangulation were performed for 10 minutes continued with resection and anastomosis on 3 group of resection margin: A on necrotic margin of bowel, B: on the thrombotic mesenterium vessel margin, C: on normal bowel margin. Resected bowels were sent for histopathology examination of collagen concentrations. After 5 days, another laparotomy was performed and the anastomosis leakages were subjectively assessed. The anastomosed segments were sampled for collagen concentration and grade.

Results: In study group A the collagen grading were found to be decreased with 6 leakages occurred (85.7%) and 1 subject (14.2%) with stable collagen grading and no leakages. From group B, subjects with decreased collagen and leakages were 2 (28.6%), and 1 subjects (14.3%) were stable in grading with leakages, and 4 subjects (42.9%) with increased collagen without leakages. In Group C, 5 rats (71.4%) had increased collagens without leakages, and 2 rats were at stable collagen grade without leakages.

Conclusion: There were collagen grade changes in bowel anastomosis that affect the extent of leakages in intussusceptions case."

"ABSTRAK Latar Belakang : Angka kejadian reseksi anastomosis pada kasus intususepsi masih sangat tinggi. Hal ini dikarenakan masih seringnya pasien datang terlambatsetelah 72 jam, kurangnya SDM untuk melakukan reduksi non operatif, dankurangnya penunjang seperti USG untuk menegakkan diagnosa. Penting untukmemperhatikan presisi, tehnik dan mempertimbangkan usus yang tersisa dalammelakukan reseksi anastomosis. Hingga saat ini belum ada standar operasi khususyang dapat menjadi panduan bagi para dokter bedah dalam melakukan reseksiakibat intususepsi. Karena itu, peneliti tertarik untuk mencari batas reseksi yangdiperlukan untuk menghasilkan suatu anastomosis end-to-end yang optimal danrendah tingkat kebocorannya. Penelitian akan dilakukan kepada tikus sebagai pilotstudy sebelum dilakukan penelitian lebih lanjut. Tujuan : Mengetahui batas reseksi usus yang optimal dinilai dari kebocorananastomosis berdasarkan grading kolagen pada batas reseksi tersebut. Metode : Penelitian ini merupakan penelitian eksperimental dengan hewan cobatikus putih Sprague Dawley. Tikus putih dilakukan intususepsi denganmenggunakan stylet, dari proksimal ke distal. Setelah 45 menit, intususepsi direduksi.Tikus putih dikelompokkan dalam tiga kelompok sesuai batas reseksianastomosis, yang kemudian batas reseksi ini dilakukan pemeriksaan gradingkolagen. Setelah 5 hari, dilakukan laparotomi untuk menilai kebocorananastomosis. Hasil : Pada perbandingan grading kolagen dengan reseksi usus didapatkangrading terbanyak pada batas 1 adalah grading 2 (57,1 %), pada batas 2 grading 2(71,4 %) ,batas 3 grading 3 (71,4%).Perforasi terbanyak ditemukan pada grading 2 sebanyak 5 sampel. Pada perbandingan batas reseksi dengan perforasi didapatkan perforasi terbanyak pada batas 1 (85,7 %)Simpulan : Terdapat perbedaaan grading kolagen pada batas reseksi usus dimana batas kelompok batas 3 memiliki grading kolagen yang lebih baik ( grade 3 dan 4)sehingga kelompok batas 3 lebih direkomendasikan secara histopatologis.Grading kolagen dapat dinilai untuk melihat kemungkinan perforasi hasilanastomosis. Terdapat faktor-faktor lain yang dapat mempengaruhi kejadian perforasi selain grading kolagen. ;Background ABSTRACT There is still high presentation of intussuseption cases with resection andanastomose, caused of multi factors as : patient delay more than 72 hours, less onprofesional expert to do non operative reduction and less of examination such as ultrasound to make a diagnose. That is important to take attention with pretition, tehniquesand less of intestine when do the resection. There is still no operative standard about theboundary of resection cause of intussuseption, thats why the author want to do theexperimental to find the optimal part of resection with minimal leakage. The experimental will do on rat as a pilot study. Aim : How to get the optimal part of resection compared with anastomotic leakege basedon collagen grading. Method : The experimental test using a Sprague Dawley rat. We make a intussuseptionon gut rat using a styleth from proximal to distal. The release do after 45 minutes. Therats then separated into three boundaries group, and did resection-anastomose with eachgut from groups were performed a histopatologic test to count collagen grading. Leakageof anastomose were examinated after 5 days Result : In comparison between collagen grading and the extent of resectionobtained the highest grading in group 1 is grade 2 (57,1%), group 2 is grade 2(71,4%), group 3 (71,4%). The highest Leakage can be found on grade 2 (5sample).in comparison the extent of resection and leakage,the highest is group 1(85,7%). Summary : There are differences about collagen gradingin the extent of bowelresection which is the third group of resection has higher collagen grading (3 and4 ) and then more recommended as histopatologic exam. Collagen grading couldbe marked to see possibilities of anastomotic leakage. There is some factors thataffect a leakage besides collagen grading. ;Background : There is still high presentation of intussuseption cases with resection andanastomose, caused of multi factors as : patient delay more than 72 hours, less onprofesional expert to do non operative reduction and less of examination such as ultrasound to make a diagnose. That is important to take attention with pretition, tehniquesand less of intestine when do the resection. There is still no operative standard about theboundary of resection cause of intussuseption, thats why the author want to do theexperimental to find the optimal part of resection with minimal leakage. The experimental will do on rat as a pilot study. Aim : How to get the optimal part of resection compared with anastomotic leakege basedon collagen grading. Method : The experimental test using a Sprague Dawley rat. We make a intussuseptionon gut rat using a styleth from proximal to distal. The release do after 45 minutes. Therats then separated into three boundaries group, and did resection-anastomose with eachgut from groups were performed a histopatologic test to count collagen grading. Leakageof anastomose were examinated after 5 days Result : In comparison between collagen grading and the extent of resectionobtained the highest grading in group 1 is grade 2 (57,1%), group 2 is grade 2(71,4%), group 3 (71,4%). The highest Leakage can be found on grade 2 (5sample).in comparison the extent of resection and leakage,the highest is group 1(85,7%). Summary : There are differences about collagen gradingin the extent of bowelresection which is the third group of resection has higher collagen grading (3 and4 ) and then more recommended as histopatologic exam. Collagen grading couldbe marked to see possibilities of anastomotic leakage. There is some factors thataffect a leakage besides collagen grading. ;Background : There is still high presentation of intussuseption cases with resection andanastomose, caused of multi factors as : patient delay more than 72 hours, less onprofesional expert to do non operative reduction and less of examination such as ultrasound to make a diagnose. That is important to take attention with pretition, tehniquesand less of intestine when do the resection. There is still no operative standard about theboundary of resection cause of intussuseption, thats why the author want to do theexperimental to find the optimal part of resection with minimal leakage. The experimental will do on rat as a pilot study. Aim : How to get the optimal part of resection compared with anastomotic leakege basedon collagen grading. Method : The experimental test using a Sprague Dawley rat. We make a intussuseptionon gut rat using a styleth from proximal to distal. The release do after 45 minutes. Therats then separated into three boundaries group, and did resection-anastomose with eachgut from groups were performed a histopatologic test to count collagen grading. Leakageof anastomose were examinated after 5 days Result : In comparison between collagen grading and the extent of resectionobtained the highest grading in group 1 is grade 2 (57,1%), group 2 is grade 2(71,4%), group 3 (71,4%). The highest Leakage can be found on grade 2 (5sample).in comparison the extent of resection and leakage,the highest is group 1(85,7%). Summary : There are differences about collagen gradingin the extent of bowelresection which is the third group of resection has higher collagen grading (3 and4 ) and then more recommended as histopatologic exam. Collagen grading couldbe marked to see possibilities of anastomotic leakage. There is some factors thataffect a leakage besides collagen grading. ;Background : There is still high presentation of intussuseption cases with resection andanastomose, caused of multi factors as : patient delay more than 72 hours, less onprofesional expert to do non operative reduction and less of examination such as ultrasound to make a diagnose. That is important to take attention with pretition, tehniquesand less of intestine when do the resection. There is still no operative standard about theboundary of resection cause of intussuseption, thats why the author want to do theexperimental to find the optimal part of resection with minimal leakage. The experimental will do on rat as a pilot study. Aim : How to get the optimal part of resection compared with anastomotic leakege basedon collagen grading. Method : The experimental test using a Sprague Dawley rat. We make a intussuseptionon gut rat using a styleth from proximal to distal. The release do after 45 minutes. Therats then separated into three boundaries group, and did resection-anastomose with eachgut from groups were performed a histopatologic test to count collagen grading. Leakageof anastomose were examinated after 5 days Result : In comparison between collagen grading and the extent of resectionobtained the highest grading in group 1 is grade 2 (57,1%), group 2 is grade 2(71,4%), group 3 (71,4%). The highest Leakage can be found on grade 2 (5sample).in comparison the extent of resection and leakage,the highest is group 1(85,7%). Summary : There are differences about collagen gradingin the extent of bowelresection which is the third group of resection has higher collagen grading (3 and4 ) and then more recommended as histopatologic exam. Collagen grading couldbe marked to see possibilities of anastomotic leakage. There is some factors thataffect a leakage besides collagen grading. "

"Latar Belakang : Angka kejadian reseksi anastomosis pada kasus intususepsimasih sangat tinggi. Hal ini dikarenakan masih seringnya pasien datang terlambatsetelah 72 jam, kurangnya SDM untuk melakukan reduksi non operatif, dankurangnya penunjang seperti USG untuk menegakkan diagnosa. Penting untukmemperhatikan presisi, tehnik dan mempertimbangkan usus yang tersisa dalammelakukan reseksi anastomosis. Hingga saat ini belum ada standar operasi khususyang dapat menjadi panduan bagi para dokter bedah dalam melakukan reseksiakibat intususepsi. Karena itu, peneliti tertarik untuk mencari batas reseksi yangdiperlukan untuk menghasilkan suatu anastomosis end-to-end yang optimal danrendah tingkat kebocorannya. Penelitian akan dilakukan kepada tikus sebagai pilotstudy sebelum dilakukan penelitian lebih lanjut.Tujuan : Mengetahui batas reseksi usus yang optimal dinilai dari kebocorananastomosis berdasarkan grading kolagen pada batas reseksi tersebut.Metode : Penelitian ini merupakan penelitian eksperimental dengan hewan cobatikus putih Sprague Dawley. Tikus putih dilakukan intususepsi denganmenggunakan stylet, dari proksimal ke distal. Setelah 45 menit, intususepsi direduksi.Tikus putih dikelompokkan dalam tiga kelompok sesuai batas reseksianastomosis, yang kemudian batas reseksi ini dilakukan pemeriksaan gradingkolagen. Setelah 5 hari, dilakukan laparotomi untuk menilai kebocorananastomosis.Hasil : Pada perbandingan grading kolagen dengan reseksi usus didapatkangrading terbanyak pada batas 1 adalah grading 2 (57,1 %), pada batas 2 grading 2(71,4 %) ,batas 3 grading 3 (71,4%).Perforasi terbanyak ditemukan pada grading2 sebanyak 5 sampel. Pada perbandingan batas reseksi dengan perforasididapatkan perforasi terbanyak pada batas 1 (85,7 %)Simpulan : Terdapat perbedaaan grading kolagen pada batas reseksi usus dimanabatas kelompok batas 3 memiliki grading kolagen yang lebih baik ( grade 3 dan 4)sehingga kelompok batas 3 lebih direkomendasikan secara histopatologis.Grading kolagen dapat dinilai untuk melihat kemungkinan perforasi hasilanastomosis. Terdapat faktor-faktor lain yang dapat mempengaruhi kejadianperforasi selain grading kolagen.

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Background : There is still high presentation of intussuseption cases with resection and

anastomose, caused of multi factors as : patient delay more than 72 hours, less on

profesional expert to do non operative reduction and less of examination such as ultra

sound to make a diagnose. That is important to take attention with pretition, tehniques

and less of intestine when do the resection. There is still no operative standard about the

boundary of resection cause of intussuseption, thats why the author want to do the

experimental to find the optimal part of resection with minimal leakage. The experimental

will do on rat as a pilot study.

Aim : How to get the optimal part of resection compared with anastomotic leakege based

on collagen grading.

Method : The experimental test using a Sprague Dawley rat. We make a intussuseption

on gut rat using a styleth from proximal to distal. The release do after 45 minutes. The

rats then separated into three boundaries group, and did resection-anastomose with each

gut from groups were performed a histopatologic test to count collagen grading. Leakage

of anastomose were examinated after 5 days

Result : In comparison between collagen grading and the extent of resection

obtained the highest grading in group 1 is grade 2 (57,1%), group 2 is grade 2

(71,4%), group 3 (71,4%). The highest Leakage can be found on grade 2 (5

sample).in comparison the extent of resection and leakage,the highest is group 1

(85,7%).

Summary : There are differences about collagen gradingin the extent of bowel

resection which is the third group of resection has higher collagen grading (3 and

4 ) and then more recommended as histopatologic exam. Collagen grading could

be marked to see possibilities of anastomotic leakage. There is some factors that

affect a leakage besides collagen grading."

"Pendahuluan. Kebocoran anastomosis merupakan komplikasi yang berat berhubungan dengan peningkatan morbiditas, dan mempengaruhi lama rawat di rumah sakit. Banyak peneliti yang telah meneliti faktor resiko terjadinya kebocoran usus, diantaranya sepsis, malnutrisi, ketegangan garis anastomosis, gangguan perfusi jaringan, obstruksi distal, dll. Usus adalah organ yang rentan terhadap cedera, cedera pada usus dapat menyebabkan edema, ileus, dan kegagalan mekanisme pertahanan usus. Kondisi ini dapat ditemukan pada gastroshizis, invaginasi, strangulasi, penyakit radang usus dan sirosis. Pemberian cairan berlebih dapat menyebabkan edema, peningkatan tekanan intra abdomen, menurunkan aliran darah mesenterik, berpengaruh terhadap penyembuhan dan meningkatkan kebocoran anastomosis. Studi ini bertujuan untuk mengetahui pengaruh edema terhadap anastomosis usus. Metode. Studi eksperimental pada tikus Sprague–Dawley untuk mengetahui pengaruh edema dan pemberian cairan yang berlebihan terhadap anastomosis usus. Hasil. Tidak terdapat perbedaan antara edema usus dan pemberian cairan berlebihan dengan peningkatan kebocoran anastomosis (p=0,178)  Kesimpulan. Edema usus tidak ada hubungan dengan kebocoran anastomosis.

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Introduction. Anastomotic leak is a severe complication associated with increased morbidity, and affects hospital stay. Many researchers have examined risk factors for intestinal leakage, including sepsis, malnutrition, anastomotic line tension, impaired tissue perfusion, distal obstruction, etc. The intestine is an organ that is prone to injury, injury to the intestine can cause edema, ileus, and failure of the intestinal defense mechanism. This condition can be found in gastroshizis, invagination, strangulation, inflammatory bowel disease and cirrhosis. Excessive fluid can cause edema, increase intra-abdominal pressure, decrease mesenteric blood flow, affect healing and increase anastomotic leakage. This study is to investigate intestinal edema on anastomosis. Method. This is an experimental study using Sprague-Dawley to determine the effect of edema and excessive fluid administration on intestinal anastomosis Results. There was no difference between intestinal edema and excessive fluid administration with increased anastomotic leak (p = 0.178). Conclusion. Intestinal edema is not associated with anastomotic leakage."

"Intususepsi merupakan penyebab paling sering obstruksi usus pada bayi dan anak. Di beberapa negara berkembang, banyak anak dengan intususepsi datang terlambat untuk terapi definitif dan tindakan pembedahan masih rutin dilakukan. Pada penelitian ini menentukan durasi klinis sebagai predictor reseksi usus pada intususepsi. Analisis dilakukan pada 73 subjek dengan intususepsi yang ditangani dari bulan Juli 2008 ndash; Desember 2015 di RS Cipto Mangunkusumo. Didapatkan tujuh puluh tiga bayi dan anak dengan intususepsi. Median usia sebesar 7 bulan dengan rentang 3 ndash; 48 bulan. Median durasi klinis sekitar 81 jam dengan rentang 15-256 jam. Durasi klinis mempunyai hubungan yang signifikan dengan reseksi usus p 0,004. Area under curve AUC sebesar 73.7 dengan nilai p 0,001. Titik potong durasi klinis sebagai batas apakah diperlukan reseksi usus atau tidak sebesar 78,5 jam dengan sensitifitas 67,9 dan spesifisitas 71.1. Pada penelitian ini kami mencoba untuk menurunkan tindakan pembedahan di rumah sakit kami dengan mendapatkan titik potong durasi klinis terhadap reseksi usus sebesar 78,5 jam yang merupakan prediktor signifikan yang dapat digunakan untuk menentukan strategi tatalaksana dan sebagai panduan tenaga medis untuk lebih mempercepat penegakan diagnosis sehingga tatalaksana non-operatif dapat dilakukan.

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Intussusception is the commonest cause of bowel obstruction in infancy and childhood. In some developing countries, many children with intussusception are reported to present late for definitive therapy and operative treatment is still routinely performed for intussusceptions. This study determines the clinical duration as a predictor of bowel resection in intussusception. Comparative analysis of 73 consecutive children with intussusception managed from January 2008 to December 2015 at Ciptomangunkusumo Hospital was done. Seventy three infants and children with intussusception were identified. Median age was 7 months range 3 to 48 months. The median time from onset to definitive treatment was 81 hours range 15 hours to 256 hours. Clinical duration was significantly associated with the need for intestinal resection p 0.004. Area under curve AUC was 73.7 p 0.001. Cut off point clinical duration as prediction border needed or not bowel resection was 78.5 hours with sensitivity 67.9 and specificity 71.1. In this study, we try to decreasing regular surgical treatment in our hospital with find cut off point clinical duration and bowel resection is 78.5 hours, a significant predictor which can be used to determine treatment strategy for intussusception and as guidance healthcare provider to enhanced establishment diagnosis intussusception in order to can use as much as nonoperative management."

"Latar belakang : Tindakan diversi fekal sclama kurun waktu tertentu dapat menyebabkan hilangnya kekuatan dan kontraktilitas otot polos usus scrta atrofi villi mukosa usus segmen distal, yang secara makroskopis tampak scbagai perbedaan diameterantara puntung proksimal dengan puntung distal. Akhirnya, stoma tidak dapat dianastomosis langsung namun memerlukan prosedur Santulli terlebih dahulu, kemudianpenutupan stoma. Untuk mencegah morbiditas ini, anastomosis stoma harus sudah dilakukan sebelum puntung distal mengecil.Tujuan : Untuk mengetahui rentang waktu rata-rata antara diversi fekal dan anastomosis secara langsung, antara diversi fekal dan prosedur Santulli, scrta antara prosedur Santulli dan penutupan Santulli.Subyek & Cara Kerja : Subyek dari studi Kohort retrospektif ini adalah scmua pasien atresia ani dengan data rekam medis yang lengkap, yang telah dilakukan diversi fekal pada usia < 13 tahun dan sudah menjalani operasi PSARP, yang dirawat untuk dilakukanoperasi penutupan stoma di RSUPN-CM, antara bulan Juni 2006 dan bulan Pebruari 2010.Hasil : Didapatkan 50 pasien, terdiri dari 25 laki-laki (8 anastomosis langsung; 17Santulli) dan 25 perempuan (21 anastomosis langsung, 4 Santulli). Jenis atresia anidengan : fistel rektovestibuler (36%); fistel rektouretra (24%); tanpa fistel (18%); fistelrektoperineal (10%); fistel rektovesika dan anus anterior (masing-masing 4%); scrta fistelrektovagina dan kloaka (masing-masing 2%). Rentang waktu antara diversi fekal -anastomosis langsung : rata-rata 427 (SD 213) hari, median 358 hari; antara diversi fekal- prosedur Santulli: median 1267 (minimum 335, maksimum 6848) hari. Hasil ujistatistik non parametrik '2-independent samples' dengan Mann Whitney nilai p < 0.05.Rentang waktu antara prosedur Santulli - penutupan Santulli: rata-rata 245 (SD 112)hari.Kesimpulan : Rentang waktu rata-rata antara diversi fekal - anastomosis langsungdengan diversi fekal - proscdur Santulli berbeda Sebaiknya operasi penutupan stoma telah dilakukan sebelum waktu minimum perbedaan diameter puntung terjadi"

"Pendahuluan dan tujuan: Hiperplasia prostat jinak merupakan penyakit yang melemahkan yang menyebabkan 90% pria berusia 80 tahun menderita sindrom saluran kemih bagian bawah. Dalam studi ini, kami mencoba untuk mengevaluasi hasil dari reseksi transurethral prostat pada pasien hiperplasia prostat jinak untuk menguraikan manfaatnya. Metode: Penelitian ini dilakukan secara retrospektif. Subjek dalam penelitian ini adalah pasien yang didiagnosis BPH. Pasien dibagi menjadi dua kelompok (<80gr dan> 80gr). Data yang diperoleh dalam penelitian ini dianalisis secara statistik menggunakan Independent T-Test dan Mann-Whitney. Hasil: Kami tidak menemukan perbedaan yang signifikan pada skor IPSS dan QoL pada kedua kelompok. Skor IPSS dan kualitas hidup pasca operasi juga menunjukkan tidak ada perbedaan yang signifikan antara pasien kelompok 1 dan 2. Kesimpulan: Kami menemukan bahwa volume prostat tidak berhubungan dengan kualitas hidup pasien, yang diilustrasikan oleh indeks IPSS dan QoL setelah TURP. Selain itu, TURP dapat dilakukan pada semua pasien terlepas dari ukuran prostatnya. Lebih lanjut, TURP memiliki keuntungan komplikasi yang lebih rendah untuk pasien dengan ukuran prostat> 80 gr.

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Introduction and objectives: Benign prostatic hyperplasia is a debilitating disease which causes 90% of 80 years old male suffers from lower urinary tract syndrome. In this study, we tried to evaluate the outcome of transurethral resection of the prostate in benign prostatic hyperplasia patients to elaborate its benefit.

Methods: This study is conducted retrospectively. Subject in this study are patients who are diagnosed with BPH. Patients is divided into two groups (<80gr and >80gr). Data obtained in this study is statistically analyzed using Independent T-Test and Mann-Whitney.

Results: We found no significant differences in the IPSS and QoL score in both groups. Postoperative IPSS and QoL score also showed no significant differences between group 1 and 2 patients.

Conclusion: We found that prostate volume is not correlated with patient quality of life, which illustrated by IPSS and QoL index after TURP. In addition, TURP can be conducted in any patients regardless of their prostate size. Furthermore, TURP has the advantage of lower complication for patients with prostate size >80 gr."

"Penyakit ginjal tahap akhir (PGTA) merupakan masalah kesehatan masyarakat yang memerlukan terapi pengganti ginjal (TPG) seperti Hemodialisis. Fistula Arteriovenosa (FAV) merupakan pilihan akses vaskular terbaik bagi penderita yang menjalani hemodialisis. Akan tetapi, kegagalan maturasi FAV relatif tinggi akibat gangguan dari înflow dan/atau outflow. Pengukuran peningkatan Blood Flow Rate (BFR) pada arteri brakialis proksimal anastomosis, distal anastomosis dan vena outflow dapat mengidentifikasi penyebab kegagalan maturasi FAV. Penelitian dilakukan di RSCM, RS Hermina Depok dan RS Hermina Bekasi pada periode Februari 2024 – Mei 2024. Desain penelitian kohort prospektif menggunakan data primer meliputi: usia, jenis kelamin, hipertensi, merokok, diabetes melitus, aterosklerosis, riwayat pemasangan catheter double lumen (CDL) dan hasil pengukuran USG doppler berupa diameter arteri brakialis, vena sefalika dan BFR arteri brakialis preoperasi serta BFR arteri brakialis proksimal anastomosis, distal anastomosis dan vena outflow (OV) segera setelah tindakan AVF, hari ke 7, hari ke 14 sampai minggu ke 6. Dari total 45 subjek yang memenuhi kriteria inklusi dan eksklusi, terdapat 36 subjek yang mengalami maturasi dalam 6 minggu pascaoperasi. Dengan analisis multivariat uji t-tidak berpasangan, didapatkan diameter arteri brakialis dan vena sefalika nilai rerata >2,5 mm serta nilai BFR arteri brakialis preoperasi 66,22 ± 22,60 (p<0,001). Didapatkan batasan nilai persentase peningkatan BFR arteri brakialis proksimal 167,23% pada hari ke-7 yang memprediksi  keberhasilan maturitas FAV brakiosefalika setelah 6 minggu pascaoperasi dengan sensitivitas 58,3%, spesifisitas 87,5%, interval kepercayaan 97,3%. Nilai persentase peningkatan OV diatas 186,92% pada hari ke-7 dan diatas 468,0% pada hari ke-14 dapat memprediksi keberhasilan maturitas FAV pada minggu ke-6 dengan sensitifitas dan spesifisistas sebesar 61,1% dan 100% untuk hari ke-7 dan 80,6% dan 100% untuk hari ke-14. Sebagai kesimpulan Peningkatan persentase BFR arteri brakialis proksimal anastomosis dan vein outflow hari ke-7 pasca tindakan FAV dapat dipakai sebagai prediktor maturitas FAV brakiosefalika.

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End-stage kidney disease (ESKD) is a public health problem that requires kEnd-stage kidney disease (ESKD) is a public health problem that requires Kidney replacement therapy (KRT) such as hemodialysis. Arteriovenosa fistula (AVF) is the best vascular access option for patients undergoing hemodialysis. However, AVF maturation failure is relatively high due to interruption of inflow and/or outflow. Measurement of increased Blood Flow Rate (BFR) in the brachial arteries of the proximal anastomosis, distal anastomosis and venous outflow can identify the cause of AVF maturation failure. The study was conducted at Ciptomangunkusumo Hospital, Hermina Depok Hospital and Hermina Bekasi Hospital in the period February 2024 – May 2024. The design of the prospective cohort study using primary data includes: age, gender, hypertension, smoking, diabetes mellitus, atherosclerosis, a history of installation of a double lumen catheter and doppler ultrasound measurements of the diameter brachial artery, cephalic vein and BFR of the preoperative brachialis artery as well as BFR proximal anastomosis, distal anastomosis and outflow vein immediately after the AVF operation, day 7, day 14 to week 6. A total of 45 subjects met the inclusion and exclusion criteria. Of these, 36 had matured within six weeks of the operation. A multivariate analysis of the non-pairing t-test revealed that a percentage increase of 167.23% in brachial artery BFR on the 7th day can predict the successful maturation of brachiocephalic AVF after 6 weeks of postoperative treatment. This model demonstrated a sensitivity of 58.3% and a specificity of 87.5%, with a confidence interval of 97.3%. The percentage value of OV increase above 186.92% on day 7 and above 468.0% on the 14th day can be used to predict the success of AVF maturity on week 6. This approach has a sensitivity and specificity of 61.1% and 100% for day 7th and 806% and 100% for day 14th. As a conclusion Increased percentage of BFR of proximal brachial artery anastomosis and venous outflow on day 7 after AVF can be used as a predictor of brachiocephalic FAV maturity."

"Komplikasi kebocoran anastomosis dan panjangnya reseksi usus non vital pada kasus intususepsi masih menjadi permasalahan. Tujuan: Mengetahui pengaruh NaCl 0.9 dan papaverin terhadap derajat kolagen serta kejadian komplikasi kebocoran anastomosis usus yang mengalami intususepsi pada model tikus putih. Metode: Dilakukan laparotomi pada 21 tikus Sprague-dawley untuk membuat model intususepsi. Setelah 45 menit, dilakukan relaparotomi dan reduksi manual intususepsi. Tikus dibagi 3 kelompok secara random: kelompok A tanpa perlakuan, kelompok B aplikasi NaCl 0,9 hangat, kelompok C aplikasi papaverin di daerah usus yang mengalami strangulasi. Kemudian dilakukan reseksi dan anastomosis pada zona usus yang votalitasnya meragukan. Setelah hari ke-5 dilakukan laparatomi ulang, dinilai secara subjektif ada tidaknya kebocoran anastomosis, dan diambil sampel untuk dinilai grade kolagennya secara mikroskopik dengan parameter Philips. Hasil: Kadar kolagen tertinggi pada kelompok C dan tidak ada kebocoran anastomosis pada kelompok ini. Lima ekor tikus dengan kolagen terendah pada kelompok A dan B, seluruhnya mengalami perforasi. Tikus dengan kolagen grade 3 dan 4 tidak ada yang mengalami perforasi. Perlakuan aplikasi NaCl 0.9 dan papaverin tidak bermakna secara statistik terhadap kejadian perforasi namun bermakna terhadap kadar kolagen. Kesimpulan: NaCl 0.9% dan papaverin memiliki hubungan dengan tingginya derajat kolagen. Tingginya derajat kolagen berhubungan dengan rendahnya kejadian perforasi anastomosis pada model intususepsi tikus.

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Background: In operative management of intussusception case, the most common complication is anastomosis leakage. Many factors influenced the anastomosis leakage and we concern the collagen factor which important in anastomosis wound healing process. We performed experimental study using topical 0.9 warm saline and papaverine at the released intussusceptum bowel.

Aim: To study the effect of topical saline and papaverin application in collagen grading and anastomosis leakage incident in rats intussusception model.

Methods: laparotomy was performed in 21 Sprague dawley rats to create the intussusception model. After the bowel considered ischemic, destrangulation with retrograde milking technique were performed. Rats were randomly divided in 3 groups A, control group B, saline group and C, papaverine group. We gave topical saline or papaverine at the mesenterium of the released intussusceptum bowel then resected and anastomosed the questionable vitality of bowel. After 5 days, the anastomosis leakage were subjectively assessed. The anastomose segment were sampled for measuring the collagen grading Phillips.

Results: Collagen grade of the group C was the highest among other groups and no anastomosis leakage in this group. There were 5 rats with collagen grade 1 and 2 in group A and B, and all 5 anastomosis site were perforated. There is no statistically relation between saline or papaverine application and the leakage events, but the application were significantly effect the collagen grading.

Conclusion: Findings suggest that saline and papaverine increase the collagen grading and the grading decrease the anastomosis leakage incidents."

"Tujuan penelitian ini adalah untuk melihat efek temperatur cairan irigasi terhadap perubahan temperatur inti badan selama prosedur Transurethral Resection of the Prostate (TURP). Suatu uji klinis acak terkontrol dilakukan terhadap 32 penderita pembesaran prostat jinak (Benign Prostatic Hyperplasia = BPH) yang menjalani prosedur TURP di RSUPNCM Jakarta, antara bulan September 2003 dan Januari 2004. Secara acak berselang-seling, penderita penelitian dimasukkan ke dalam kelompok standar (menggunakan cairan irigasi setara temperatur kamar + 23.60C) dan kelompok isotermik (menggunakan cairan irigasi yang dihangatkan sampai setara dengan temperatur badan + 37.20C). Jenis cairan irigasi yang digunakan oleh kedua kelompok adalah aquabidest. Kemudian dilakukan pencatatan terhadap usia penderita, lama reseksi, berat jaringan prostat yang direseksi, volume total cairan irigasi yang digunakan, temperatur kamar operasi serta temperatur inti badan sebelum dan sesudah prosedur TURP. Uji hipotesis untuk kedua kelompok menggunakan uji t, dengan nilai p < 0,05 dianggap bermakna. Hasil penelitian menunjukkan bahwa terdapat penurunan temperatur inti badan selama prosedur TURP, baik pada kelompok standar maupun pada kelompok isotermik (keduanya p = 0,000), tetapi tidak satupun penderita dari kedua kelompok tersebut yang masuk dalam kriteria hipotermi. Rerata penurunan temperatur inti badan pada kelompok standar (0,990C) lebih besar dibandingkan dengan kelompok isotermik (0,750C), tetapi secara statistik tidak berbeda bermakna (p > 0,05). Dari penelitian ini dapat disimpulkan bahwa penggunaan cairan irigasi selama prosedur TURP baik dengan temperatur yang setara dengan temperatur badan maupun yang setara dengan temperatur kamar, sama-sama menyebabkan penurunan temperatur inti badan pada tingkat yang kurang lebih sama. (Med J Indones 2005; 14: 152-6)

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The objective of this study was to determine the effect of irrigating fluid temperature on core body temperature changes in patients undergoing transurethral resection of the prostate (TURP). A cross sectional study was conducted on 32 patients with Benign Prostatic Hyperplasia (BPH) who underwent TURP at our institution between September 2003 and January 2004. Patients were randomized to one of two groups. Standard group consisted of 16 patients who received room temperature irrigating fluid (± 23.6 0C) throughout TURP. Isothermic group consisted of 16 patients whose procedure was performed using warmed irrigating fluid (± 37.2 0C). The irrigating fluid used for both groups was aquabidest. The age, resection time, weight of resected prostate, amount of irrigating fluid used, temperature in the operating theatre, core body temperature at beginning and at conclusion of TURP were recorded for each patient. The t test was used for comparison between both groups and a p value of 0.05 or less was considered significant. The result of this study showed a decrease of core body temperature during TURP, using either room temperature or warmed irrigating fluid (both p = 0.000). None of the patients in either group demonstrated any criteria of hypothermia. The average decrease of core body temperature in standard group (0.99 0C) was greater than in isothermic group (0.75 0C), but it was not significantly different (p > 0.05). In conclusion, our study revealed that using either room temperature irrigating fluid or warmed irrigating fluid during TURP could decrease core body temperature at approximately similar level, with no incidence of hypothermia. (Med J Indones 2005; 14: 152-6)"