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"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 37-41Periodontal treatment by conventional way will result in healing repair, which easily cause recurrence. Modification of treatment should be done to get an effective result, that is the regeneration of alveolar bone and to reduce inflammation. The objective of this study is to determine the alveolar bone regeneration after using DFDBA (Demineralize Freeze Dried Allograft). Quasi experimental designs with pre and post test method was used in this study, From 13 patients, 26 defects got conventional or regenerative treatment. The indicator of alveolar bone regeneration in bone height in radiographic appearence and level of osteocalsin in gingival crevicular fluid (GCF) were checked before and after the treatment, then the changes that occure were analyzed. The result of the research showed that alveolar bone regeneration only occurred to the group of regenerative treatment by using DFDBA. The conclusion is the effective periodontal tissue regeneration occurred at regenerative treatment by using DFDBA, and the osteocalsin in GCF can be used as indicator of bone growth."

"In cases of advanced alveolar bone loss frequently associated with periodontal pockets that may not be accessible by conservative therapy, corrective surgery is often indicated as osseous resective and complete debridement therapy. Transplantation of osseous fill material is often necessary, as a surgical intervention may create an alveolar bone defect. In this reported case of surgery, a cortico-cancellous bone graft taken from the mandibular symphysis was transplanted in a mixture with human mineralized bone from the Dr. Soetomo Hospital Surabaya Bone Bank, expecting for osseous regeneration to reduce the bony defect. Six months after surgery the morphology of the reconstructed alveolar process was satisfactory and showing new growth of bone"

"Pendahuluan : Pasien maloklusi kelas III skeletal hiperdivergen memiliki tulang alveolar simfisis mandibula yang tipis. Perawatan ortodonti pada kasus maloklusi kelas III skeletal memiliki pergerakan gigi anterior yang terbatas. Retraksi anterior insisif bawah yang terbatas merupakan perawatan kamuflase untuk mengatasi maloklusi kelas III skeletal. Tujuan : Menganalisis perubahan ketinggian dan ketebalan tulang alveolar simfisis mandibula sebelum dan sesudah perawatan ortodonti cekat maloklusi kelas III hiperdivergen. Metode : Desain penelitian ini berupa observasional analitik dengan desain potong lintang. Sampel pasien ini terdiri dari 34 sefalometri lateral pasien maloklusi kelas III skeletal hiperdivergen yang telah selesai dirawat ortodonti cekat di Kinik Ortodonti RSKGM FKG UI. Pengukuran ketinggian dan ketebalan tulang alveolar simfisis mandibula menggunakan perangkat lunak Winceph versi 11 English Edition, Rise Coorporation 3-8-15 Sendai, Japan. Hasil : Ketinggian tulang alveolar simfisis mandibula sebelum dan sesudah perawatan ortodonti menunjukkan tidak ada perbedaan yang berbeda bermakna. Ketebalan tulang alveolar sebelum dan sesudah perawatan ortodonti menunjukkan perbedaan bermakna berupa penurunan pada 1/3 servikal tualng alveolar sisi labial dan 1/3 apikal tulang alveolar sisi lingual (p<0.05). Kesimpulan : Ketebalan tulang alveolar regio simfisis bagian labial dan lingual sebelum dan sesudah perawatan ortodonti cekat mengalami penurunan namun tidak menimbulkan efek samping yang tidak diinginkan yaitu dehisensi maupun fenestrasi.

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Introduction : Patient with Class III Skeletal Hiverdivergent have a thin alveolar bone thickness in symphisis region. Anterior teeth movement in orthodontic treatment in this Class III malocllusion case is limited. Retraction of lower incisors in orthodontic camouflage treatment in class III skeletal malocclusion become limited. Aim : Analyze alveolar bone height and thickness in symphisis region before and after fixed orthodontic treatment in Class III skeletal malocclusion Hyperdivergent. Methods : This research is analitic observasional study with cross sectional design. Sample are 34 cephalomatric lateral radiographs before and after fixed orthdootnics treatment in classs III hyperdivergent patients in RSGKM FKG UI. Alveolar bone height and thickness were measured using Winceph 11 English Edition Esoftware by Rise Coorp Rise Coorporation 3-8-15 Sendai, Japan. Results : There was no difference in alveolar bone height before and after orthodontic treatment. Significant decreased was found in the alveolar bone thickness in 1/3 servical on labial side and 1/3 apical on lingual side (p<0.05). Conclusion : Alveolar bone thickness was decreased before and after orthodontic treatment, however there was no undesireable effects, such as dehiscence or fenestration found."

"Pendahuluan: Bimaxillary protrusion merupakan kondisi gigi insisif atas dan bawah sangat maju sehingga perawatan umumnya memerlukan pencabutan diikuti dengan retraksi gigi anterior. Retraksi pada maloklusi hiperdivergen perlu memperhatikan kondisi simfisis mandibula yang memiliki tulang alveolar tipis untuk mencegah dehisensi atau fenestrasi. Tujuan: Menganalisis perbedaan ketinggian dan ketebalan tulang alveolar regio simfisis mandibula sebelum dan setelah perawatan ortodonti cekat dengan ekstraksi premolar pada maloklusi kelas I bimaxillary protrusion dan hiperdivergen. Metode Penelitian: Penelitian menggunakan data sekunder berupa 34 sefalogram lateral pasien kelas I bimaxillary protrusion dan hiperdivergen sebelum dan setelah perawatan di klinik Ortodonti RSKGM FKG UI. Desain penelitian berupa observasional analitik dengan desain potong lintang. Pengukuran ketinggian dan ketebalan tulang alveolar dilakukan menggunakan perangkat lunak Winceph versi 11 English edition, Rise Corporation 3-9-15 Sendai, Jepang. Hasil: Terjadi penurunan ketinggian tulang alveolar sisi lingual sebesar 0.498 mm (p=0.003), dan penurunan ketebalan tulang alveolar sisi labial 1/3 servikal sebesar 0.226 mm (p=0.038). Secara keseluruhan terjadi perbedaan pada ketinggian dan ketebalan tulang alveolar sisi labial dan lingual, dengan perbedaan bermakna ditemukan pada perbedaan ketinggian sisi lingual, dan perbedaan ketebalan sisi labial 1/3 servikal. Kesimpulan: Terdapat perbedaan ketinggian dan ketebalan tulang alveolar regio simfisis mandibula sebelum dan setelah perawatan ortodonti cekat dan tidak menunjukkan adanya dehisensi ataupun fenestrasi.

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ntroduction: Bimaxillary protrusion is characterized by protrusive incisors requiring first premolar extractions and retraction of anterior teeth as treatment plan. Precautions are needed when retracting aenterior teeth of hyperdivergent patients with thin alveolar bones in order to prevent dehiscence and fenestration. Aim: To Analyze the difference of alveolar bone thickness and alveolar bone height before and after orthodontic treatment in Class I hyperdivergent and bimaxillary protrusion with extraction. Methods: This research is an analytical observational cross-sectional study using 34 before and after lateral cephalograms of Class I hyperdivergent with bimaxillary protrusion cases treated in the Orthodontic Clinic at RSKGM FKG UI. Changes of alveolar bone height and thickness were measured with Winceph software 11th version English edition, Rise Corporation 3-9-15 Sendai, Japan. Results: Reduce of 0.498 mm was found in alveolar bone height on the lingual side (p=0.003), and reduce of 0.226 mm was found in alveolar bone thickness on the 1/3rd coronal part of the labial side (p=0.038). Overall changes occur in alveolar bone height and alveolar bone thickness at both labial and lingual sides, but significant changes were only found at the alveolar bone height on the lingual side, and at the alveolar bone thickness on the coronal part of labial side. Conclusion: Changes were found at the alveolar bone height and alveolar bone thickness after fixed orthodontic treatment and showed no sign of dehiscene or fenestration."

"Purpose of the study: This study is undertaken to investigate the prevalence of smoking among dental undergraduates students in the University of Malaya, and to study the effects of smoking on the interproximal bone heights. Materials and method: A smoking habits questionnaire was distributed to the 299 Dental Undergraduate students of Year 2 to Year 5. Students were divided into groups of smokers (history of smoking for at least 1 year), former smokers (history of smoking and stopped more than 1 year) and non smokers (no smoking history). Two bitewing radiographs (left and right) were taken from 14 smokers and 5 former smokers. In addition, 14 students were randomly picked as control group, and their previously taken bitewing radiographs were collected. Interproximal bone loss defined as the distance (mm) from CEJ to the alveolar crest (AC) was measured using caliper, magnifier and metal ruler. Results: The prevalence of smokers and former smokers among dental students was 5.57% and 1.99%, respectively. Mean ± SEM of the CEJ-AC distance for smokers and non smokers was 1.063 ± 0.066 mm and 0.849 ± 0.050 mm, respectively. The difference was statistically significant between the smokers and non smokers (p<0.05). Mean ± SEM of bone loss among the smoker was 0.204 ± 0.066 mm. There was no satistically significant difference between former smokers and non smokers (p>0.05). Premolar is the most affected tooth in smokers, with a mean ± SEM of the CEJ-AC distance of 1.350 ± 0.102 mm. Conclusions: Smoking prevalence among dental undergraduate students was very low. Smokers have more bone destruction than the non-smokers."

"ABSTRAKAbstrak. Inovasi terbaru untuk mendapatkan regenerasi jaringan periodontal adalah dengan bahan platelet rich fibrin (PRF) dan cangkok tulang. Penelitian ini merupakan penelitian eksperimental klinis. Tujuan: Mengevaluasi perbedaan tinggi tulang alveolar pada terapi bedah flep poket infraboni menggunakan Platelet rich fibrin dan kombinasi dengan cangkok tulang. Metode penelitian: Evaluasi radiografis periapikal sebelum dan sesudah perawatan menggunakan PRF dan kombinasi dengan cangkok tulang Hasil: secara statistik, terdapat perbedaan tinggi tulang yang bermakna pada terapi bedah poket infraboni dengan PRF dan kombinasi dengan cangkok tulang. Kesimpulan: Platelet rich fibrin dan kombinasi dengan cangkok tulang memiliki hasil yang sama pada evaluasi radiografis ketinggian tulang secara statistik

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ABSTRACTAbstract. The new innovation to enhance periodontal tissue regeneration are using PRF and bone graft material. The study was clinical experimental. Purpose:To evaluate the difference of alveolar bone heigh on periodontitis therapy using PRF and combination with bone graft.Research methods: periapical radiograph evaluation before and after periodontitis therapy using PRF compare to combination with bone graft. by assessing alveolar bone height. Results: Statistically, there were no significant difference between alveolar bone height on periodontitis therapy PRF compare to combination with bone graft. Conclusion: PRF and combination with bone graft has the same result statictically in radiographic evaluation of alveolar bone height."

"[ABSTRAKLatar Belakang: Penggunaan biomaterial berupa bahan tandur tulang dan membran untuk prosedur Guided Bone Regeneration (GBR) sangat diperlukan di bidang bedah maksilofasial dan, untuk mengatasi defek tulang yang dapat terjadi oleh berbagai sebab. Penelitian ini bertujuan untuk mengetahui efek pemakaian bahan tandur tulang DFDBX dengan membran perikardium (MPK) bovine pada defek tulang kalvaria tikus.Bahan dan Metode: Studi eksperimental ini menggunakan 45 ekor tikus Sprague Dawley sebagai hewan coba dibagi dalam 3 kelompok secara acak. Ciritical size defect sebesar diameter 5 mm dibuat pada tulang kalvaria seluruh hewan coba. Kelompok I merupakan kelompok kontrol, tidak diberikan perlakuan dan defek dibiarkan sembuh dengan sendirinya, kelompok II yang diberi DFDBX, dan pada kelompok III defek diisi dengan DFDBX dan ditutup dengan MPK (DFDBX+MPK). Setelah 1,4 dan 8 minggu dilakukan dilakukan pengorbanan pada kelompok hewan coba, dilanjutkan dengan evaluasi secara radiologik, histopatologik untuk reaksi radang, pertumbuhan tulang dan pemeriksaan imunohistokimia dengan osteokalsin. Data dianalisis secara statistik dengan menggunakan uji ANOVA.Hasil: Penilaian radiografik diperoleh perbedaan bermakna pada rerata densitas area defek minggu ke 8 antara kelompok kontrol dengan DFDBX+MPK (p<0,001) dan antara kelompok DFDBX dengan DFDBX+MPK (p=0,03).Pertumbuhan tulang baru pada minggu ke 8 tertinggi adalah pada kelompok DFDBX+MPK dengan perbedaan bermakna dengan kelompok kontrol (p=0,016) dan dengan kelompok DFDBX nilai p=0,048. Ekspresi osteokalsin minggu ke-8 menunjukkan perbedaan bermakna antara kelompok kontrol dengan kelompok DFDBX (p<0,001) maupun dengan kelompok DFDBX+MPK (p=0,0013), namun tidak terdapat perbedaan bermakna antara kelompok DFDBX dengan kelompok MPK (p=1,000).Kesimpulan: Penggunaan DFDBX dengan kombinasi MPK terbukti secara radiologik, histopatologik dan imunohistokimia dapat meningkatkan regenerasi tulang pada defek tulang kalvaria.

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ABSTRACTBackground: Reconstruction of cranial and maxillofacial defects is a challenging task. The standard method has included bone grafting and using membrane in guided bone regeneration procedure. Using biomaterial such as bone grafting and membrane for Guided Bone Regeneration (GBR) procedures is an essential issue in maxillofacial and dental reconstruction surgery to overcome bone defects caused by various etiologies. Our study was aimed to identify the effect of using Demineralized Freeze-Dried Bone Xenograft (DFDBX) with (or without) bovine pericardium membrane (PCM) on the treatment of rats calvarial bone defects.Materials and Method: The experimental study used 45 Sprague-Dawley rats as the experimental animals, which were categorized randomly into three groups, i.e. the control group, DFDBX group, and DFDBX+PCM group. The 5-mm-critical-sized calvarial defects were created in all experimental animals. The first group was a control group, which did not receive any treatment with self-limiting defects; while subjects in the second group received DFDBX (DFDBX group) and in the third group, the defects were filled with DFDBX and PCM (DFDBX + PCM group). Animals were sacrified at the 1st, 4th, and 8th weeks following the surgery. Subsequently, an evaluation was carried out using radiological analysis, histopathological assay to observe inflammatory reaction and bone growth, as well as immunohistochemical analysis of osteocalcin. Data were analyzed statistically using ANOVA test. The specimens were embedded ini paraffin, serially cut, and stained with hematoxylin and eosin for analysis under light microscope. The inflammation reaction, new bone formation, and the rest of DFDBX and PCM were histomorphometrically evaluated. Immunohistochemical analysis of osteocalcin expression was performed.Results: Radiological analysis demonstrated a significant difference of mean bone density in the defect area at the 8th week between subjects in the control group and those in DFDBX+PCM group (p < 0.001), as well as between subjects in the DFDBX group and those in DFDBX+PCM group (p = 0.03). The highest rate of bone healing at the 8th week was found in DFDBX+PCM group, which showed significant difference compared to the control group (p=0.016) and to DFDBX group (p=0.048). There was a significant difference of osteocalcin expression between the control group and DFDBX group (p < 0.001), as well as between the control group and DFDBX + PCM group (p=0,0013). However, there was no significant difference between the DFDBX group and the DFDBX+PCM group (p = 1.000). Conclusion: Our radiological, histopahtological and immunohistochemical evaluation has demonstrated that DFDBX combined with PCM increases bone regeneration in the treatment of bone calvarial defect. ;Background :Reconstruction of cranial and maxillofacial defects is a challenging task. The standard method has been bone grafting and using membrane in guided boneregeneration procedure.The aim of this study was to analyze the effect of Demineralized Freeze Dried BoneXenograft (DFDBX) with (or without)bovine pericardium membrane (PCM) on boneregeneration, in surgically created critical-size defects in rat calvaria, radiographically,histopathologically and immunohistochemically.Material and Methods :Surgical critical-size bone defects were created in 45 animalsthat randomly divided into three groups : control group, DFDBX group, andDFDBX+PCM group. Animals were sacrified at 1, 4 and 8 weeks post surgery.Radiological analysis was done. The specimens were embedded ini paraffin, serially cut,and stained with hematoxylin and eosin for analysis under light microscope. Theinflammation reaction, new bone formation, and the rest of DFDBX and PCM werehistomorphometrically evaluated. Immunohistochemical analysis of osteocalcinexpression was performed. Result : DFDBX and DFDBX+PCM groups demonstrated superior bone healingcompared with control group. Group DFDBX+PCM showmore advanced healing at 8weeks post surgery and show the highest density radiographically as compared with theother group DFDBX and control.Immunohistochemistry revealed the presence ofosteocalcin in osteoblast and matrix extracellular and show significant differences werenoted between DFDBX and DFDBX+PCM to control groups.Conclusion : Application of DFDBX combined with bovine PCM gave the best result in bone regeneration of critical size defects in rat calvaria. , Background :Reconstruction of cranial and maxillofacial defects is a challenging task. The standard method has been bone grafting and using membrane in guided boneregeneration procedure.The aim of this study was to analyze the effect of Demineralized Freeze Dried BoneXenograft (DFDBX) with (or without)bovine pericardium membrane (PCM) on boneregeneration, in surgically created critical-size defects in rat calvaria, radiographically,histopathologically and immunohistochemically.Material and Methods :Surgical critical-size bone defects were created in 45 animalsthat randomly divided into three groups : control group, DFDBX group, andDFDBX+PCM group. Animals were sacrified at 1, 4 and 8 weeks post surgery.Radiological analysis was done. The specimens were embedded ini paraffin, serially cut,and stained with hematoxylin and eosin for analysis under light microscope. Theinflammation reaction, new bone formation, and the rest of DFDBX and PCM werehistomorphometrically evaluated. Immunohistochemical analysis of osteocalcinexpression was performed. Result : DFDBX and DFDBX+PCM groups demonstrated superior bone healingcompared with control group. Group DFDBX+PCM showmore advanced healing at 8weeks post surgery and show the highest density radiographically as compared with theother group DFDBX and control.Immunohistochemistry revealed the presence ofosteocalcin in osteoblast and matrix extracellular and show significant differences werenoted between DFDBX and DFDBX+PCM to control groups.Conclusion : Application of DFDBX combined with bovine PCM gave the best result in bone regeneration of critical size defects in rat calvaria. ]"

"Latar Belakang: Alveolar bone loss dapat terjadi karena ketidakseimbangan remodeling tulang. Selain kehilangan tinggi, tulang alveolar juga mengalami penurunan volume tulang trabekula. Sudah banyak studi yang menilai densitas tulang dengan status periodontal, namun masih sangat sedikit yang melakukannya pada subjek dengan metabolisme tulang yang sehat. Tujuan: Memperoleh hasil evaluasi densitas radiografik interproksimal individu laki-laki dan perempuan usia 25-40 tahun dengan kondisi kehilangan tinggi alveolar sampai dengan setengah akar. Metode: Studi cross-sectional dengan 160 sampel (80 tinggi alveolar normal dan 80 kehilangan tinggi alveolar) radiograf panoramik digital individu laki-laki dan perempuan usia 25-40 tahun dari data sekunder di RSKGM FKG UI. Evaluasi densitas radiografik menggunakan metode pixel intensity dari hasil pengukuran nilai rerata graylevel menggunakan aplikasi I-Dixel Morita di interproksimal alveolar regio premolar dua mandibula. Selanjutnya, evaluasi kesepakatan pengukuran intraobserver dan interobserver dilakukan dengan uji reliabilitas interclass correlation coefficient (ICC). Analisis deskriptif dan uji komparatif dilakukan antar kategori kondisi tinggi alveolar dan jenis kelamin. Hasil: Hasil analisis rerata densitas berdasarkan kondisi tinggi alveolar, didapati terdapat perbedaan bermakna secara statistik antara kondisi tinggi alveolar normal dan kehilangan tinggi alveolar. Evaluasi densitas interproksimal kondisi kehilangan tinggi alveolar lebih rendah (120.61 ± 1,92) dibandingkan kondisi tinggi alveolar normal (135.71 ± 1,57). Pada analisis rerata densitas antar jenis kelamin, terdapat perbedaan bermakna antar jenis kelamin dengan kondisi tinggi alveolar berbeda, tetapi antar jenis kelamin dengan kondisi tinggi alveolar yang sama tidak ditemukan perbedaan yang bermakna. Densitas interproksimal pada kondisi tinggi alveolar normal kelompok subjek perempuan (135,10 ± 1,90) memiliki rata-rata densitas lebih rendah dibandingkan kelompok subjek laki-laki (137,80 ± 2,41). Kesimpulan: Terdapat perbedaan bermakna densitas interproksimal alveolar antara kelompok kondisi tinggi alveolar normal dan kehilangan tinggi alveolar, serta tidak ditemukan perbedaan bermakna antar jenis kelamin pada kondisi tinggi alveolar yang sama.

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Background: Alveolar bone loss occur because of the imbalance of bone remodeling process. In addition to decrease of alveolar height, it reduce trabecular volume as well. Several studies have already address the assessment of bone density with periodontal status, but there is little knowledge to assess it with healthy subjects. Objective: The aim of this study was to obtain results of interproximal radiographic density evaluation of male and female individuals aged 25-40 years old with the condition og losing alveolar height up to half of the root. Method: Cross-sectional study with 160 samples (80 normal alveolar height and 80 loss of alveolar height) digital panoramic of male and female individuals 25-40 years old using secondary data at RSKGM FKG UI. Evaluation of radiographic density used the pixel intensity method from the result of measuring mean graylevel value with I-Dixel Morita application in the alveolar interproximal region of the mandibular second premolar. Furthermore, the reliability evaluation of intraobserver and interobserver measurement was carried out by testing interclass correlation (ICC). Descriptive and comparative tests were permorfed between categories of alveolar height conditions and gender. Result: The analysis of average density between different alveolar height showed there was a statistically significant difference between normal alveolar height and decreased alveolar height. Evaluation of interproximal density in condition loss of alveolar height was lower (120,61 ± 1,92) than in condition normal alveolar height (135.71 ± 1,57). In average density between genders analysis showed statistically significant differences were found between genders with different alveolar height conditions, but there is no significant difference were found between gender with same alveolar height conditions. The interproximal density in normal alveolar height of the female subject group (135,10 ± 1,90) had an average density lower than the male subject group (137,80 ± 2,41). Conclusion: There was significant difference of interproximal density between normal alveolar height group and loss of alveolar height, and there was no significant difference between genders on same alveolat height condition"

"This book that addresses the modern aspects of bone healing and repair. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones."

"ABSTRAKPendahuluan: Penyakit periodontitis masih menjadi masalah kesehatan utama di bidang kedokteran gigi. Menurut WHO 2012 , 15-20 penduduk dunia mengalami penyakit periodontal yang parah. Penelitian mengenai perawatan penyakit periodontitis sampai saat ini masih terus dikembangkan untuk mencari teknik terapi atau obat pilihan yang terbaik. Oleh karena itu, diperlukan sebuah model kerusakan tulang alveolar yang terkendali, sederhana, dan memiliki kesamaan kondisi kerusakan dengan penyakit periodontal pada manusia untuk dijadikan model referensi yang terstandar. Tujuan: Membuat model kerusakan tulang alveolar periodontitis terstandar pada regio maksila anterior tikus Rattus norvegicus Wistar dengan komprehensif dan terkendali. Bahan dan metode: Injeksi LPS E.coli dengan konsentrasi 200mg, 500mg, 750mg dalam 200?l larutan saline pada regio maksila anterior tikus Wistar. Setelah hari ke-7 dikorbankan, rahang maksila didiseksi. Sampel difoto dengan stereomikroskop dan dilakukan analisis tinggi penurunan tulang dengan aplikasi ImageJ. Hasil: Kerusakan tulang alveolar terbesar terjadi pada konsentrasi 200mg, dengan rata-rata tinggi penurunan tulang adalah 1.48mm. Pada konsentrasi 500mg dan 750mg, masing-masing terdapat tikus yang mati pada hari pertama dan kedua pasca injeksi LPS. Kesimpulan: Konsentrasi LPS 200mg dalam 200?l saline merupakan anjuran dosis optimal yang dapat diinjeksikan pada tulang rahang anterior maksila tikus Wistar untuk menghasilkan kerusakan tulang alveolar.

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ABSTRACT<>br>Introduction Periodontitis still remains as a major oral health problem. According to WHO 2012 , 15 20 of the world rsquo s population experience severe periodontal disease. Research about periodontitis treatment is still being developed to find the best drug of choice. Therefore, a controlled and simple model of periodontitis, that reiterates the features of human rsquo s disease, is required to be a standarized reference model..Aim To establish a standarized model of bone destruction in maxillary anterior Rattus norvegicus induced by lipopolysaccharide Method Bone destruction periodontitis was induced by injection of 200mg, 500mg, and 750mg LPS E.coli in 200 l saline into maxillary anterior region. Animals were sacrificed after 7 days, and the maxillary jaw were dissected. Samples were photographed with stereomicroscope and bone loss were examined by ImageJ. Results The highest bone loss occured at 200mg LPS injection, with an average height of bone loss was 1.48mm. Where as in 500mg and 750mg, there were 3 Wistar rats died on the first and second day after LPS injection. Conclusion Injection of 200mg LPS in 200 l saline into maxillary anterior region Wistar rat is an optimal dose recommendation to induced alveolar bone loss."