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Elwood, Mark
"Summary:
Critical appraisal is now accepted as central to the development of rational health care and evidence-based medicine, by applying it to questions of aetiology, clinical therapy, and health care management. The reader will learn how to assess the strengths and weaknesses of new studies, and how to conduct their own studies"
New York: Oxford University Press, 2010
614.402 ELW c
Buku Teks SO  Universitas Indonesia Library
cover
Elwood, Mark
"This book presents a system of critical appraisal applicable to clinical, epidemiological and public health studies and to many other fields. It assumes no prior knowledge. The methods are relevant to students, practitioners and policymakers. The book shows how to assess if the results of one study or of many studies show a causal effect. The book discusses study designs: randomised and non-randomised trials, cohort studies, case-control studies, and surveys, showing the presentation of results including person-time and survival analysis, and issues in the selection of subjects. The system shows how to describe a study, how to detect and assess selection biases, observation bias, confounding, and chance variation, and how to assess internal validity and external validity (generalisability). Statistical methods are presented assuming no previous knowledge, and showing applications to each study design. Positive features of causation including strength, dose-response, and consistency are discussed. The book shows how to do systematic reviews and meta-analyses, and discusses publication bias. Systems of assessing all evidence are shown, leading to a general method of critical appraisal based on 20 key questions in five groups, which can be applied to any type of study or any topic. Six chapters show the application of this method to randomised trials, prospective and retrospective cohort studies, and case-control studies. An appendix summarises key statistical methods, each with a worked example. Each main chapter has self-test questions, with answers provided."
Oxford: Oxford University Press, 2017
e20511936
eBooks  Universitas Indonesia Library
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Elwood, Mark
Oxford: Oxford University Press, 2017
614.4 ELW c
Buku Teks SO  Universitas Indonesia Library
cover
Biran Affandi
"ABSTRACT
Pure water, a sanitary environment, and nutritious food have long been recognized as prerequisites of good health. In the last two decades, medical studies have revealed another essential component of health strategies: family planning. Uncontrolled fertility directly threatens the health of mother and other family members. Today no health program can be considered complete unless it can also offer all potential parents ready access to appropriate family planning measures for all potential parents.

It is an unfortunate evolutionary fact that women become fertile several years before what is, for mother and child, the safest time for birth; moreover, they usually remain fertile for ten to fifteen years beyond the period of lowest risk. While the onset of fertility ranges from age 10 to the mid-tens, pregnancy becomes safest from a biological point of view around the age of 20. The period of maximum safety lasts for about a decade; then, when a woman reaches the age of about 30, risks to mother and child begin to rise and they continue to escalate with each passing year.

The number of children a woman bears in her life affects her health significantly. Her first birth carries a slightly higher risk of complications or death for her and her child than second and third births do, primarily because the first birth reveals any physical weaknesses of genetic abnormalities in the mother or the father. A woman's second and third births are generally the safest but with the fourth birth, the incidences of maternal death, stillbirth, and infant and even childhood mortality begin to rise, jumping sharply with the birth of the fifth and every succeeding child. Beyond a certain point, then, practice does not make perfect in childbearing; quite the contrary, it entails escalating dangers. The actual level of risk involved in bearing large numbers of children depends, of course, on the mother's social milieu. But one pattern prevails in every country and in every social class: risks increase as the number of children passes 3. Contrary to the belief held by many people, including some doctors, that women with many children are apt to give birth easily and painlessly, such women are in fact particularly susceptible to the complications and diseases associated with pregnancy.

Some studies found that about 60 percent of all severely undernourished children were of the fourth or later birth order. It is calculated that even without any other improvements in income, food availability, or medical care, the "limitation of family size to 3 children would bring down the incidence of severe forms of protein calorie malnutrition by at least 60 percent". The ill effects of numerous births on both mothers and their children are more likely to occur when the intervals between these births are short. Studies have shown that infants born less than two years after the previous child are 50 percent more likely to die by age 1 than are infants born two to four years after the previous child. Considering the health of mother and children, the risks related to the reproductive process could be reduced to the lowest level possible if:

1. The birth of the first-born can be deferred until the mother is 20 years old
2. The space between children's births must be at least 2 years
3. No more than 2-3 children are to be born
4. No more births after the mother's age reaches 30 years or over should be expected.
"
1987
D7
UI - Disertasi Membership  Universitas Indonesia Library
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Oxford: Blackwell, 1977
615.19 CLI
Buku Teks SO  Universitas Indonesia Library
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Pocock, Stuart J.
New York: Wiley, 1983
615.707.24 POC c
Buku Teks SO  Universitas Indonesia Library
cover
New York: Springer, 2015
610.724 FUN
Buku Teks SO  Universitas Indonesia Library
cover
"This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing, and international trials.
This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.
The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives."
Switzerland: Springer International Publishing, 2015
e20509987
eBooks  Universitas Indonesia Library
cover
"The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically–relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published. Confidently apply gold standard treatment for 10 of the most critical areas of cardiology Written by an international team of experts, Cardiovascular clinical trials : putting the evidence into practice, provides a succinct overview of recent major clinical trials, the gold standard for all medical treatment, across all the major cardiovascular subspecialties, to ensure you’re up–to–date on the most critical findings Guides cardiology trainees and clinicians on how cardiovascular clinical trials are designed and conducted, including statistical methodology."
Chichester, West Sussex, U.K.: Blackwell , 2013
e20375781
eBooks  Universitas Indonesia Library
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"This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic of that chapter. As a collection, the chapters would be intended to serve as a guidance for statisticians designing trials."
New York: Springer, 2012
e20417633
eBooks  Universitas Indonesia Library
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