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Ria Veni Susanti
"ABSTRAK
Latar belakang: Anestesia obstetrik termasuk anestesia yang memiliki risiko tinggi dalam praktik anestesia. Perubahan fisiologi ibu selama kehamilan dan keberadaan janin merupakan tantangan yang unik untuk anestesia obstetrik. Baik kehamilan normal maupun obesitas, sama-sama mengalami perubahan anatomi dan fisiologi yang signifikan dan pengaruh anestesi yang hampir sama. Belum ada penelitian sebelumnya yang membandingkan tingkat keberhasilan insersi jarum spinal dalam posisi duduk bersila antara ibu hamil obes maupun ibu hamil bukan obes yang menjalani seksio sesarea. Penelitian ini dilakukan di RSCM dan RSU Tangerang antara bulan Juli sampai Agustus 2016.Tujuan: Penelitian ini bertujuan untuk membandingkan tingkat keberhasilan insersi jarum spinal pada posisi duduk bersila antara ibu hamil obes dan ibu hamil bukan obes yang menjalani seksio sesarea.Metode: Penelitian ini merupakan open label study yaitu uji klinis terbuka dimana perlakuan sama-sama diketahui oleh subjek maupun pelaku anestesia. Ibu hamil yang menjalani seksio sesarea dibagi menjadi dua kelompok yaitu obes O dan bukan obes NO . Pada keduanya dilakukan insersi jarum spinal dalam posisi duduk bersila. Pada penelitian ini dilakukan penilaian tingkat keberhasilan insersi jarum spinal, persentase keberhasilan insersi jarum spinal, banyaknya kontak jarum spinal dengan tulang, dan kekerapan tusukan pembuluh darah.Hasil: Dari136 subjek penelitian, tidak ada yang termasuk kriteria penolakan dan pengeluaran. Keberhasilan insersi jarum spinal pada kelompok NO adalah 47 subjek 69,12 dan pada kelompok O 45 subjek 66,18 . Secara statistik tidak berbeda bermakna antara kelompok NO dan kelompok O pada tingkat keberhasilan insersi jarum spinal p=0,714 , jumlah kontak jarum spinal dengan tulang p=0,591 , dan kekerapan tertusuknya pembuluh darah pada waktu insersi jarum spinal p=0,282 .Simpulan: Tingkat keberhasilan insersi jarum spinal yang dilakukan dalam posisi duduk bersila pada ibu hamil bukan obes tidak lebih baik jika dibandingkan pada ibu hamil obes.Kata Kunci: Insersi jarum spinal, posisi duduk bersila, ibu hamil obes dan bukan obes, kontak tulang, tusukan pembuluh darah

ABSTRACT
Background Obstetric anesthesia is high risk in practice. The physiological changes during pregnancy and fetal wellbeing are unique challenges posed for obstetric anesthesia. Significant changes in anatomy and physiology along with anesthesia considerations are similar in normal and obese pregnancy. Up to this day, there are no studies comparing successful spinal needle insertion rate in cross legged sitting position between obese and non obese parturient undergoing caesarean section. This study was done in RSCM and RSU Tangerang between July August 2016.Aim This study aims to compare successful rate of spinal needle insertion in cross legged sitting position between obese and non obese parturient undergoing caesarean section.Method This was an open label study, which was an open clinical trial where treatment was known by subjects and anesthesiologist. Parturient undergoing caesarean section were categorized into two groups, which were obese O and non obese NO . Both of the groups had spinal needle insertion in cross legged sitting position. In this study, the variables assessed were the rate of successful spinal needle insertion, the percentage of successful spinal needle insertion, the frequency of spinal needle contact with bone, and the frequency of vein puncture.Result All 136 subjects were included in the analysis. The rate of successful spinal needle insertion in the NO group was 47 subjects 69.12 and 45 subjects in the O group 66.18 . This result was not statistically significant p 0.714 , along with the frequency of spinal needle contact with bone p 0.591 , and the frequency of vein puncture during spinal needle insertion p 0.282 .Conclusion The rate of successful spinal needle insertion in cross legged sitting position on non obese parturient was not better than on obese parturient.Key Words Spinal needle insertion, cross legged sitting position, obese and non obese parturient, bone contact, vein puncture."
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2017
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UI - Tesis Membership  Universitas Indonesia Library
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Sidharta Kusuma Manggala
"[Latar Belakang: Posisi pasien selama tindakan anestesia spinal menentukan keberhasilan penempatan jarum spinal. Traditional sitting position (TSP) merupakan posisi standar untuk anestesia spinal, namun angka keberhasilannya masih cukup rendah. Crossed leg sitting position (CLSP) merupakan salah satu posisi alternatif dalam anestesia spinal yang memiliki kelebihan berupa derajat fleksi lumbal yang lebih besar. Penelitian ini bertujuan untuk membandingkan CLSP dan TSP terhadap keberhasilan penempatan jarum spinal pada pasien bedah urologi.
Metode: Penelitian ini adalah uji klinik acak tidak tersamar terhadap pasien yang menjalani anestesia spinal untuk prosedur urologi pada bulan Maret-April 2015 di RSUPN dr. Cipto Mangunkusumo. Setelah mendapatkan persetujuan izin etik dari Komite Etik Penelitian Kesehatan FKUI-RSCM, sebanyak 138 subjek dialokasikan ke dalam dua kelompok posisi penusukan jarum spinal yaitu kelompok CLSP dan TSP. Proporsi keberhasilan penempatan jarum spinal di rongga subarakhnoid, kemudahan perabaan landmark, dan jumlah needle-bone contact pada kedua kelompok kemudian dinilai.
Hasil: Enam subjek masuk kriteria pengeluaran berupa kegagalan penempatan jarum spinal setelah lebih dari sembilan kali percobaan. Tersisa 132 subjek, 67 subjek pada kelompok CLSP dan 65 subjek pada kelompok TSP, yang berhasil menyelesaikan penelitian. Keberhasilan penempatan jarum spinal secara one shot pada kelompok CLSP dan TSP tidak berbeda bermakna (64.2% vs 53.8%, p=0.227). Kemudahan perabaan landmark pada kelompok CLSP berbeda bermakna dengan TSP (94% vs 75%, p=0.003). Jumlah needle-bone contact pada kedua kelompok tidak berbeda bermakna (p=0.337).
Simpulan: Keberhasilan penempatan jarum spinal pada kelompok CLSP tidak berbeda bermakna dibandingkan dengan keberhasilan penempatan jarum spinal pada kelompok TSP pada pasien bedah urologi.;Background: Patient position during spinal anesthesia plays a major role in determining the success of spinal needle insertion to subarachnoid space. Traditional sitting position (TSP) is a standard position for spinal anesthesia, but the success rate for spinal anesthesia in TSP is still quite low. Crossed leg sitting position (CLSP) is one of the alternative positions in spinal anesthesia, which can increase the degree of lumbar flexion. This study aimed to compare CLSP and TSP to the successful insertion of spinal needle in urologic surgery patients.
Methods: This study was a non-blinded randomized controlled trial in patients undergoing spinal anesthesia for urologic procedures between March-April 2015 in RSUPN dr. Cipto Mangunkusumo. After obtaining approval from FKUI-RSCM Ethical Committee, 138 subjects were allocated into two groups, CLSP group and TSP group. The proportion of successful spinal needle insertion to the subarachnoid space, ease of landmark palpation, and the number of needle-bone contact in both groups were then analyzed and assessed.
Result: Six subjects met dropout criteria, which was failure of obtaining successful spinal needle insertion after nine consecutive redirections. The remaining 132 subjects, 67 subjects in the CLSP group and 65 subjects in TSP group, successfully completed the study. The proportion of successful spinal needle insertion in a one-time shot, was not significantly different between CLSP and TSP group (64.2% vs. 53.8%, p = 0227). Ease of landmark palpation in CLSP group was significantly different with TSP group (94% vs. 75%, p = 0.003). The number of needle-bone contact in both groups was not significantly different (p = 0337).
Conclusion: The proportion of successful spinal needle insertion in CLSP group was not significantly different compared to TSP group for urologic surgery patients.;Background: Patient position during spinal anesthesia plays a major role in determining the success of spinal needle insertion to subarachnoid space. Traditional sitting position (TSP) is a standard position for spinal anesthesia, but the success rate for spinal anesthesia in TSP is still quite low. Crossed leg sitting position (CLSP) is one of the alternative positions in spinal anesthesia, which can increase the degree of lumbar flexion. This study aimed to compare CLSP and TSP to the successful insertion of spinal needle in urologic surgery patients.
Methods: This study was a non-blinded randomized controlled trial in patients undergoing spinal anesthesia for urologic procedures between March-April 2015 in RSUPN dr. Cipto Mangunkusumo. After obtaining approval from FKUI-RSCM Ethical Committee, 138 subjects were allocated into two groups, CLSP group and TSP group. The proportion of successful spinal needle insertion to the subarachnoid space, ease of landmark palpation, and the number of needle-bone contact in both groups were then analyzed and assessed.
Result: Six subjects met dropout criteria, which was failure of obtaining successful spinal needle insertion after nine consecutive redirections. The remaining 132 subjects, 67 subjects in the CLSP group and 65 subjects in TSP group, successfully completed the study. The proportion of successful spinal needle insertion in a one-time shot, was not significantly different between CLSP and TSP group (64.2% vs. 53.8%, p = 0227). Ease of landmark palpation in CLSP group was significantly different with TSP group (94% vs. 75%, p = 0.003). The number of needle-bone contact in both groups was not significantly different (p = 0337).
Conclusion: The proportion of successful spinal needle insertion in CLSP group was not significantly different compared to TSP group for urologic surgery patients., Background: Patient position during spinal anesthesia plays a major role in determining the success of spinal needle insertion to subarachnoid space. Traditional sitting position (TSP) is a standard position for spinal anesthesia, but the success rate for spinal anesthesia in TSP is still quite low. Crossed leg sitting position (CLSP) is one of the alternative positions in spinal anesthesia, which can increase the degree of lumbar flexion. This study aimed to compare CLSP and TSP to the successful insertion of spinal needle in urologic surgery patients.
Methods: This study was a non-blinded randomized controlled trial in patients undergoing spinal anesthesia for urologic procedures between March-April 2015 in RSUPN dr. Cipto Mangunkusumo. After obtaining approval from FKUI-RSCM Ethical Committee, 138 subjects were allocated into two groups, CLSP group and TSP group. The proportion of successful spinal needle insertion to the subarachnoid space, ease of landmark palpation, and the number of needle-bone contact in both groups were then analyzed and assessed.
Result: Six subjects met dropout criteria, which was failure of obtaining successful spinal needle insertion after nine consecutive redirections. The remaining 132 subjects, 67 subjects in the CLSP group and 65 subjects in TSP group, successfully completed the study. The proportion of successful spinal needle insertion in a one-time shot, was not significantly different between CLSP and TSP group (64.2% vs. 53.8%, p = 0227). Ease of landmark palpation in CLSP group was significantly different with TSP group (94% vs. 75%, p = 0.003). The number of needle-bone contact in both groups was not significantly different (p = 0337).
Conclusion: The proportion of successful spinal needle insertion in CLSP group was not significantly different compared to TSP group for urologic surgery patients.]"
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Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Desy Januarrifianto
"[Latar Belakang: Anestesia spinal pada wanita hamil sangat dipengaruhi oleh posisi pasien. Pendant position merupakan posisi yang baru diperkenalkan pada laporan kasus. Penelitian ini bertujuan untuk membandingkan keberhasilan penempatan jarum spinal pada usaha pertama antara pendant position dengan traditional sitting position untuk pasien yang menjalani pembedahan Sesar.
Metode: Penelitian ini adalah uji klinik Randomized Controlled Trial (RCT), dilakukan secara terbuka (tidak tersamar). Subjek dilakukan randomisasi untuk menentukan perlakuan pendant position atau traditional sitting position. Keberhasilan penempatan jarum spinal dinilai dari jumlah usaha, jumlah kontak tulang dan lama waktu penempatan jarum spinal.
Hasil: Sebanyak 308 subjek penelitian, tidak ada yang termasuk kriteria
penolakan dan pengeluaran. Keberhasilan penempatan jarum spinal pada usaha pertama untuk pendant position lebih baik (142 subjek (92%) vs 121 subjek (78%), p 0,001), total jumlah kontak tulang lebih sedikit (185 vs 421, p<0,001) dan median lama waktu yang dibutuhkan untuk penempatan jarum spinal lebih cepat ( 9 (4-350) vs 12 (5-486) detik, p<0,001) jika dibandingkan dengan traditional sitting position.
Simpulan: Pendant position lebih baik dalam hal keberhasilan penempatan jarum spinal pada usaha pertama untuk pasien yang menjalani pembedahan Sesar jika dibandingkan traditional sitting position., Background: Spinal anesthesia in pregnant women is strongly influenced by the position of the patient. Pendant position is a new position introduced in the case report. This study aimed to compare the successful placement of spinal needle on the first attempt between pendant position and traditional sitting position for patients who underwent sectio Caesarean.
Methods: The study was a randomized controlled trial (RCT), conducted openly (not blind). Subject randomization to determine treatment pendant position or traditional sitting position. The successful placement of spinal needle judged from the number of first attempt, the amount of bone contact and the duration of the placement of spinal needle.
Results: A total of 308 subjects, none of which include criteria for exclusion and drop out. The successful placement of spinal needle on the first attempt of pendant position is better (142 subjects (92%) vs. 121 subjects (78%), p 0.001), the total amount of bone contact is less (185 vs. 421, p <0.001) and the median length of time required for placement of spinal needle is faster (9 (4-350) vs. 12 (5-486) seconds, p <0.001) when compared to the traditional sitting position.
Conclusion: Pendant position is better in terms of the successful placement of spinal needle on the first attempt for a patient who underwent sectio Caesarean compared to traditional sitting position.]"
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Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Henry Agus
"LATAR BELAKANG : Kombinasi anestetik lokal dosis rendah dengan opioid yaitu bupivakain 0,5% hiperbarik 7,5 mg dan 5 mg ditambah fentanil 25 mcg diharapkan keefektifannya untuk memfasilitasi bedah Caesar, yaitu dengan cara menurunkan angka kejadian hipotensi dan kualitas analgesia serta blok motorik yang adekuat.
METODE : 112 pasien hamil usia 18-40 tahun yang akan menjalani bedah Caesar baik cito maupun elektif ASA I-III yang sesuai dengan kriteria inklusi. Randomisasi menjadi 2 kelompok; kelompok I mendapatkan bupivakain 0,5% hiperbarik 7,5 mg ditambah fentanil 25 mcg dan kelompok II mendapatkan bupivakain 0,5% hiperbarik 5 mg ditambah fentanil 25 mcg. Posisi pasien kedua kelompok yaitu posisi duduk dengan pungsi lumbal setinggi L3-4/L4-5.Total volume 2 cc disuntikkan dengan kecepatan 0,2 cc/detik.Kemudian telentang dengan posisi left lateral tilt. Dilakukan pencatatan tekanan darah pada menit ke-3, 6, 9, 12, 15, 20, 30, 40, 50, 60 atau sampai bayi lahir setelah disuntikkannya obat anestetik lokal ke ruang subaraknoid. Dilakukan pencatatan tercapai blok motorik dan sensorik sampai operasi selesai.
HASIL : Keefektifan pada kelompok I 89,3 % dan kelompok II 76,8 %.
KESIMPULAN : Tidak terdapat perbedaan yang bermakna mengenai keefektifan pada kedua kelompok subyek penelitian.

BACKGROUND : the combination of low doses local anesthetics with opioid is 0,5 % hyperbaric bupivacaine 7,5 and 5 mg plus fentanyl 25 mcg is expected to facilitate the effectiveness cesarean that is by way of reducing the incidence of hypotension and the quality of analgesia and motor block adequate.
METHOD : 112 pregnant patients aged 18-40 years who underwent emergency surgery or elective cesarean both ASA I-III corresponding inclusion criteria. Randomization into 2 groups: group 1 receive hyperbaric bupivacaine 0,5 % 7,5 mg plus fentanyl 25 mcg and group 2 get hyperbaric bupivacaine 0,5 % 5 mg plus fentanyl 25 mcg. The position of the two groups are seated position with lumbar puncture as high as L3-4/L4-5. The total volume of 2 ml injected with a speed of 0,2 ml/sec. then supine with left lateral tilt position. Did recording of blood pressure in minute-3, 6, 9, 12, 15, 20, 30, 40, 50, 60 or until the baby was born after injection of local anesthetics into subarachnoid space. Did recording of motor and sensory block achieved until the operation was complete.
RESULT : The effectiveness of the group I was 89,3 % and group II was 76,8 %.
CONCLUSION : There were no significant differences between the two groups regarding the effectiveness of the study subjects.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Laras Lembahmanah
"Latar Belakang: Penyuntikan obat anestesia spinal dosis tunggal diketahui menyebabkan hipotensi yang lebih besar dibandingkan dosis terbagi pada pasien obstetrik sehat, namun belum ada penelitian yang dilakukan pada pasien obsterik dengan penyulit hipertensi, khususnya di Indonesia. Hipotensi akibat anestesia spinal, khususnya pada pasien obstetrik dengan penyulit hipertensi, akan mengganggu kesejahteraan ibu dan janin.
Tujuan: Membandingkan penurunan MAP dan kebutuhan efedrin, serta mengetahui level ketinggian blok antara teknik anestesia spinal dosis terbagi dengan dosis tunggal untuk bedah Sesar dengan penyulit hipertensi.
Metode. Uji klinis acak tersamar tunggal terhadap 42 pasien di RSU Kabupaten Tangerang yang memenuhi kriteria dibagi menjadi dua kelompok. Kelompok dosis terbagi (TB) dilakukan dengan menyuntikkan 2/3 dosis (1,5 ml), dilanjutkan 1/3 dosis sisanya (1 ml) setelah jeda 90 detik. Kelompok dosis tunggal (TU) dilakukan dengan menyuntikkan seluruh dosis dalam sekali bolus. Keduanya dilakukan dalam posisi duduk, menggunakan kombinasi obat anestesia spinal bupivakain 0,5% hiperbarik 10 mg dan fentanil 25 mcg (volume total 2,5 ml), kecepatan 0,2 ml/detik, barbotase £0,1 ml sebelum penyuntikan, serta pemberian coloading cairan kristaloid 5-10 ml/KgBB. MAP diukur sebanyak 7 kali, dan kebutuhan efedrin serta ketinggian blok dicatat. Analisis hasil menggunakan uji General Linear Model (GLM) untuk pengukuran berulang, uji Fisher dan Mann-Whitney U.
Hasil: Uji GLM menunjukkan tidak ada perbedaan bermakna antar waktu pengukuran antar kelompok (P >0,05), namun grafik garis menunjukkan trend MAP kelompok TB lebih tinggi pada 3 menit pertama dibandingkan kelompok TU. Penurunan MAP >20% terjadi lebih cepat pada kelompok TU (menit ke-3). Ketinggian blok sensorik keduanya terbanyak pada level T4 sebesar 11 subjek (52,4%) pada kelompok TB dan 9 subjek (42,9%) pada kelompok TU (P=0,59). Perbandingan dosis total pemakaian efedrin mendapat nilai median (range) kelompok TB sebesar 10 (0-25) mg dan kelompok TU sebesar 15 (0-30) mg (P=0,30).
Simpulan: Penurunan MAP dan kebutuhan efedrin pada dosis terbagi tidak lebih kecil secara signifikan dibanding dosis tunggal, namun trend penurunan MAP >20% terjadi lebih lambat dan pemakaian efedrin lebih sedikit pada 3 menit pertama, dengan level ketinggian blok keduanya serupa.

Background: Injection of a single bolus of local anesthetics in spinal anesthesia is known to cause greater hypotension than a fractionated dose in healthy obstetric patients, but no studies have been performed on obstetric patients with hypertensive complications, especially in Indonesia. Spinal hypotension will interfere to maternal and fetal well-being, particularly to mother with pregnancyinduced hypertension.
Objective: Compare the decrease in mean arterial pressure (MAP) and ephedrin requirements, as well as to determine the level of sensory blockade between fractionated dose and single dose technique in spinal anesthesia for Cesarean section in pregnancy-induced hypertension.
Methods: Single blinded randomized clinical trials of 42 patients at Tangerang District General Hospital who met the criteria were divided into two groups. The fractionated dose group (TB) was administered by injecting 2/3 of the total doses (1,5 ml) initially, followed by 1/3 of the remaining dose (1 ml) after 90 s. A Single dose group (TU) was performed by injecting all doses in one bolus. Both were performed in a sitting position, using a combination of 0,5% hyperbaric bupivacaine 10 mg and fentanyl 25 mcg (total volume of 2,5 ml), with velocities 0,2 ml/sec, £0,1 ml barbotage before injection, and administration of 5-10 ml/KgBW crystalloids for co-loading. MAP was measured 7 times, as well as ephedrine requirement and level of sensory blockade were recorded. Analysis was performed using a General Linear Model (GLM) test for repeated measurements, Fisher exact and Mann-Whitney U test.
Results: The GLM test showed no significant differences between the time measurements between groups (P>0,05), but the line chart showed the TB group's trend of MAP was higher in the first 3 minutes than TU group. MAP decline >20% occured faster in TU group (minute-3). The level of sensory block was mostly at the T4 level of 11 subjects (52,4%) in TB group and 9 subjects (42,9%) in TU group (P = 0,59). The total dose of ephedrine requirement was in median (range) value of 10 (0-25) mg in TB group and 15 (0-30) mg in TU group (P = 0,30).
Conclusion: MAP decline and ephedrine requirement in fractionated dose were not significantly smaller than single dose, but >20% decrease in MAP's trend occured more slowly and ephedrine requirement was less in the first 3 minutes, with similar level of sensory block in both groups."
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Tugas Akhir  Universitas Indonesia Library
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Emi Setyaningsih
"Insersi jarum spinal dapat menimbulkan nyeri sehingga perlu dilakukan teknik stimulasi kompres dingin guna menurunkan intensitas nyeri yang dialami. Penelitian ini bertujuan untuk mengidentifikasi efektivitas kompres dingin dalam menurunkan intensitas nyeri insersi jarum spinal pada prosedur spinal anestesi. Desain yang digunakan adalah quasy experimental dengan pendekatan post test only design non equivalent control group. Sampel terdiri dari 72 pasien dewasa yang terbagi atas 36 orang kelompok intervensi dan 36 orang kelompok kontrol.
Analisis data untuk mengetahui perbedaan rerata kelompok perlakuan (kompres dingin) dan kelompok kontrol (standar prosedur) dengan intensitas nyeri dan menganalisis hubungan variabel jenis kelamin dan pengalaman nyeri insersi spinal dengan intensitas nyeri menggunakan uji Mann Whitney. Analisis data untuk mengetahui hubungan variabel usia, ukuran jarum spinal dan kecemasan dilakukan uji Kruskal Wallis.
Hasil analisis menunjukkan terdapat perbedaan bermakna antara kelompok perlakuan (kompres dingin) dan kelompok kontrol (standar prosedur) dan hubungan bermakna antara variabel kecemasan dengan intensitas nyeri (p<0,05). Hasil analisis menunjukkan tidak terdapat hubungan bermakna pada variabel usia, jenis kelamin, pengalaman nyeri insersi dan ukuran jarum spinal (p>0,05). Dapat disimpulkan kompres dingin merupakan intervensi yang terbukti efektif untuk menurunkan intensitas nyeri insersi jarum spinal pada prosedur spinal anestesi.

Spinal needle insertion may cause pain hence cold compress stimulation technique to reduce the intensity of the pain is required. This study aims to identify the effectiveness of cold compress in reducing the intensity of spinal needle insertion pain in spinal anesthesia procedures. The design used was quasy experimental with post test only design non equivalent control group approach. The sample consisted of 72 adult patients divided into 36 intervention groups and 36 control groups.
Data analysis is to obtain the difference average of treatment group (cold compress) and control group (standard procedure) with pain intensity and analyze the connection of gender and spinal insertion pain variables and the intensity of pain using Mann Whitney test. Data analysis to obtain the correlation of age, spinal needle size and anxiety variables was conducted using Kruskal Wallis test.
Analysis results show that there are significant differences between treatment group (cold compress) and control group (standard procedure) and significant relationship between anxiety variables with pain intensity (p <0.05). The results show no significant association in age, sex, insertion pain experience and spinal needle size (p> 0.05). It can be concluded that cold compress is an effective intervention to decrease the intensity of spinal needle insertion pain in spinal anesthesia procedure."
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Depok: Universitas Indonesia, 2018
T49253
UI - Tesis Membership  Universitas Indonesia Library
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Dewata Aprilia Marilyn
"Latar belakang. Tingginya angka bedah sesar menunjukkan tingginya anestesia spinal, komplikasi yang disebabkan oleh anestesia spinal yang berhubungan dengan morbiditas ibu dan janin adalah hipotensi. Penelitian ini bertujuan untuk mengetahui apakah posisi reverse Trendelenburg (RT) dapat mencegah atau menurunkan angka kejadian hipotensi pada operasi bedah sesar yang menggunakan teknik anestesia spinal dengan bupivakain dosis 10 mg dengan fentanil 25 mcg.
Metode. Penelitian ini merupakan uji klinis, acak, tidak tersamar pada pasien yang menjalani bedah sesar dengan anestesia spinal di RSIA Budi Kemuliaan pada bulan Oktober sampai November 2018. Sebanyak 108 subjek diambil setelah memenuhi kriteria inklusi. Analisis data menggunakan uji komparatif non-parametris Chi Square.
Hasil. Angka kejadian hipotensi pada kelompok reverse Trendelenburg 10 derajat sebesar 15/54 (27,8%) sedangkan kelompok posisi netral sebesar 31/54 (57,4%). Posisi RT menurunkan risiko hipotensi sebesar 2.08 kali dibandingkan posisi netral (Risk ratio 0,48) dengan Interval Kepercayaan 95% berada pada rentang 0,3 – 0,8. Secara statistik dengan uji Chi square didapatkan perbedaan yang bermakna antara kelompok posisi RT dan netral dalam menyebabkan terjadinya hipotensi dengan nilai p 0,004.
Simpulan. Posisi reverse Trendelenburg 10 derajat menurunkan angka kejadian hipotensi dua kali lipat dibandingkan posisi netral.

Background. The high number of caesarean section procedure describes amount of spinal anesthesia method. Complication caused by spinal anesthesia which related to maternal and fetal comorbidities is hypotension. The main aim of this research is to study reverse Trendelenburg 10 degree position to prevent or lowering incidence of hypotension for patient undergo caesarean section with spinal anesthesia using bupivacaine 10 mg and fentanyl 25 mcg.
Method. This research is randomized but not blinded clinical trial to patient undergo caesarean section with spinal anesthesia at Budi Kemuliaan hospital during October to November 2018. Total 108 subjects were selected after fulfilling the inclusion criteria. Data were analyzed using nonparametric and comparative test with Chi Square.
Results.The incidence of hypotension in reverse Trendelenburg (RT) group is 15/54 (27.8%) while the incidence of hypotension in neutral group is 31/54 (57.4%). RT position lowering the incidence of hypotension in the amount of 2.08 times compared with neutral position (risk ratio 0.48), confidence interval 95% within 0.3-0.8. There is significant difference between groups with p 0.004.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Astria Yuliastri Permana
"Latar belakang. Kombinasi anestesi spinal bupivakain dan fentanil dengan penambahan klonidin dosis tinggi diketahui dapat memperpanjang durasi blok sensorik dan motorik, namun prevalensi timbulnya efek samping cukup tinggi. Dalam studi ini, kami menggunakan klonidin dosis rendah secara intratekal (30 mcg) sebagai adjuvan  bupivakain dan fentanil. 
Tujuan. Penelitian dilakukan untuk membandingkan efektifitas serta efek samping pada kombinasi anestesi spinal bupivakain fentanil dengan dan tanpa klonidin 30 mcg.
Metode. Penelitian studi potong lintang yang dilakukan pada 70 pasien seksio sesarea terbagi kedalam dua kelompok masing-masing 35 pasien yang mendapatkan kombinasi anestesi spinal dengan penambahan klonidin 30 mcg dan tanpa klonidin 30 mcg. Penelitian ini mengevaluasi kualitas blok sensorik dan motorik. Efek samping yang terjadi diamati selama 24 jam paska tindakan seksio sesarea meliputi pruritus, mual muntah, nyeri tungkai, nyeri punggung dan mata merah. 
Hasil Penelitian. Median durasi blok sensorik kelompok kombinasi anestesi bupivakain fentanil dengan klonidin 30 mcg dibandingkan tanpa klonidin 30 mcg (330 menit vs 220 menit), Median durasi blok motorik (193 menit vs 188 menit). Efek samping tertinggi adalah mual muntah terdapat pada kelompok kombinasi tanpa klonidin 30 mcg (42.85%). Perbedaan bermakna (p-value < 0.05) terdapat pada durasi blok sensorik, blok motorik dan efek samping mual muntah.
Kesimpulan. Penambahan klonidin 30 mcg pada kombinasi anestesi spinal bupivakain fentanil dapat memperpanjang durasi blok sensorik dan motorik serta meminimalisir efek samping dibandingkan dengan tanpa klonidin 30 mcg.

Background. The combination of the spinal anesthesia bupivacaine and fentanyl with the addition of high doses of clonidine are known to prolong the duration of sensory and motor blocks, but the prevalence of side effects is high. In this study, we used an intrathecally low dose of clonidine (30 mcg) as an adjuvant to bupivacaine and fentanyl.
Aim. This study was conducted to compare the effectiveness and side effects of the combination spinal anesthesia bupivacaine fentanyl with and without clonidine 30 mcg.
Method. Cross-sectional study conducted on 70 patients with cesarean section divided into two groups of 35 patients each who received a combination of spinal anesthesia with the addition of clonidine 30 mcg and without clonidine 30 mcg. This study evaluates the quality of the sensory and motor blocks. Side effects observed for 24 hours after cesarean section included pruritus, nausea, vomiting, leg pain, back pain and red eyes.
Result. Median sensory block duration in the combination group of the anesthetic bupivacaine fentanyl with clonidine 30 mcg compared without clonidine 30 mcg (330 min vs 220 min), Median motor block duration (193 min vs 188 min). The highest side effect was nausea and vomiting in the combination group without clonidine 30 mcg (42.85%). Significant differences (p-value <0.05) were found in the duration of sensory blocks, motor blocks and side effects of nausea and vomiting.
Conclusion. The addition of clonidine 30 mcg to the combination of spinal anesthesia bupivacaine fentanyl can prolong the duration of sensory and motor blocks and minimize side effects compared to 30 mcg without clonidine.
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Lengkap +
Depok: Fakultas Farmasi Universitas Indonesia, 2020
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Gunawan Sukoco
"Latar belakang: Kecemasan prabedah timbul dari aspek pembedahan maupun aspek anestesi. Pencegahan kecemasan prabedah dengan pendekatan non farmakologis misalnya edukasi, dapat mengurangi efek samping dari penggunaan obat-obatan pada intervensi farmakologis. Penelitian ini membandingkan metode audiovisual dan penjelasan secara verbal sebagai medium edukasi untuk menurunkan kecemasan pasien yang akan menjalani operasi dengan anestesia spinal.
Metode: Penelitian ini merupakan uji klinis acak tersamar tunggal yang mengikutsertakan 74 pasien dewasa di Poli Perioperatif RSCM. Sampel dibagi 2 kelompok dengan metode acak, 37 sampel di tiap kelompok audiovisual dan kelompok verbal. Penilaian kecemasan dilakukan sebelum dan sesudah edukasi menggunakan kuesioner Amsterdam Preoperative Anxiety and Information Scale (APAIS).
Hasil: Sebanyak 74 subjek penelitian yang masuk dalam kriteria inklusi dibagi dalam dua kelompok, kelompok audiovisual dan kelompok penjelasan verbal. Tingkat kecemasan seluruh pasien sebelum edukasi 11 (4–20). Tingkat kecemasan pascaedukasi di kelompok verbal adalah 8 (4–18), dikelompok audiovisual 8 (4–18). Perubahan tingkat kecemasan pascaedukasi berbeda bermakna pada kelompok audiovisual dibandingkan kelompok verbal, (2 (-3 – 14) vs 1 (-3 – 8); p=0,046).
Simpulan: Metode audiovisual dengan videoedukasi sebagai medium edukasi lebih baik dalam menurunkan tingkat kecemasan pasien yang akan menjalani anestesia spinal dibandingkan penjelasan verbal.

Background: Anesthesia and surgery can induce preoperative anxiety. Non-pharmacological approaches like education have been used to alleviate preoperative anxiety and pharmacological interventions. One form of preoperative education is audiovisual method. This study compares preoperative education methods using audiovisual vs standard verbal explanations in reducing preoperative anxiety prior to surgery under spinal anesthesia.
Methods: This research is a single-blind randomized clinical trial including 74 patients at the Perioperative Clinic of RSCM. Subjects randomly divided into audiovisual and verbal explanation group. Preoperative anxiety was assessed before and after education using Amsterdam Preoperative Anxiety and Information Scale (APAIS) questionnaire.
Results: A total of 74 subjects were included in this study. Subjects randomly allocated into two groups: audiovisual (n=37) and verbal explanation (n=37). Median for the level of anxiety for all patients before education was 11 (4–20). Median for post-education anxiety level in the verbal group was 8 (4–18), vs 8 (4–18) in the audiovisual group. Change in anxiety levels was significantly different in audiovisual compared to verbal (2 (-3 – 14) vs 1 (-3 – 8); p=0.046).
Conclusion: Preoperative education using audiovisual method through video is more effective in reducing anxiety level of patients undergoing spinal anesthesia compared to verbal explanations.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Fahmi Agnesha
"Latar Belakang : Brakhiterapi intrakaviter merupakan terapi keganasan pada stadium lanjut yang sering digunakan pada bidang ginekologi. Pasien brakhiterapi pada umumnya dilakukan dengan pelayanan rawat jalan sehingga anestesia yang menjadi pilihan selama ini adalah anestesia spinal.Pemilihan obat yang memiliki waktu pulih anestesia spinal yang lebih cepat membuat pasien dapat pulang kerumah lebih cepat. Penelitian ini mencoba mengetahui waktu pulih anestesia spinal levobupivakain 5 mg hiperbarik + fentanil 25 mcg dibandingkan dengan bupivakain 5 mg hiperbarik + fentanil 25 mcg pada brakhiterapi intrakaviter rawat jalan.
Metode : Penelitian ini merupakan penelitian eksperimental dan uji klinik acak tersamar ganda yang akan dilaksanakan di unit radioterapi RSCM pada bulan Oktober 2015. Sebanyak 60 orang subyek penelitian akan dibagi menjadi dua kelompok perlakuan yaitu levobupivakain 5 mg hiperbarik + fentanil 25 mcg (LV) dan bupivakain 5 mg hiperbarik + fentanil 25 mcg (BV) untuk menilai waktu pulih anestesia spinal antara kedua kelompok perlakuan tersebut.
Hasil : Pengukuran waktu pulih dilakukan dengan menilai waktu kesiapan pulang pasien, waktu ambulasi dan waktu pasien dapat miksi spontan. Pada variabel waktu ambulasi, miksi spontan, dan waktu kesiapan pulang didapatkan hasil berbeda bermakna (p < 0,05).
Simpulan : Waktu pulih anestesia spinal, waktu ambulasi dan waktu miksi pada kelompok levobupivakain 5 mg hiperbarik + fentanil 25 mcg lebih cepat jika dibandingkan dengan bupivakain 5 mg hiperbarik + fentanil 25 mcg pada brakhiterapi intrakaviter rawat jalan.

Introduction : Intracavitary brachytherapy is one of advanced stage cervical cancer modality treatment. These patients were treated as outpatient clinic fashion and the chosen anesthesia was spinal anesthesia. The regimens of spinal anesthesia will influenced the recovery time. The aim of the study is to compare the recovery time between two spinal anesthesia regimens Levobupivacaine + 25 mcg Fentanyl and 5 mgs Hyperbaric Bupivacaine+ 25 mcg Fentanyl for brachytherapy outpatient clinic patient.
Method: This is a double blind randomized control trial study. The study was taken place at radiotherapy unit RSCM at October 2015. There were 60 patients that divided into two groups Levobupivacaine + 25 mcg Fentanyl group and 5 mgs Hyperbaric Bupivacaine+ 25 mcg Fentanyl group. These two groups will be measured for spinal anesthesia recovery time.
Result : The spinal anesthesia recovery time measured by discharged readiness time, ambulation time, spontaneous micturition time. From the result of the study all of these three variables were significantly different between these two group regimens (P< 0,05).
Conclusion : spinal anesthesia recovery time, ambulation time, spontaneous micturition time of Levobupivacaine + 25 mcg Fentanyl group were faster than 5 mgs Hyperbaric Bupivacaine+ 25 mcg Fentanyl group at intracavitary brachytherapy outpatient clinic.
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Lengkap +
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
T55725
UI - Tugas Akhir  Universitas Indonesia Library
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