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Tanji, Fumiya
"Running economy (RE) at an intensity above the lactate threshold (LT) is reported to be the most important aerobic capacity for estimating 1,500-m running performance. The reason that the RE at intensity better reflects the energy metabolism during a 1,500-m run, is that it is performed above the LT intensity running. This study clarified the relationship be¬tween an 800-m run, which is performed above the LT intensity, and aerobic capacities, includ¬ing the RE measured at intensities below and above the LT. This study included 12 well-trained j male middle-distance runners (800-m velocity: 25.5 ± 0.5 km-h"1, LT intensity: 79.7 ± 5.1%
maximal oxygen uptake [VC>2max]). Both the RE of below and above the LT intensity were cal¬culated at 65%V02max (RE6s) and 90%VO2max (RE9o). The 800-m velocity was not related to the VC^max or the LT intensity (r = -0.16 and -0.10, respectively). This velocity correlated with both RE90 and RE65, with the correlation coefficient being higher for RE90 (r = -0.80 vs -0.75). Furthermore, the coefficient of determination for the 800-m velocity determined from V02max, LT intensity and RE90 was higher than that determined from V02max, LT intensity and RE65 (R2 = 0.522 vs 0.428, P = 0.03 vs 0.06). Based on these results, we concluded that the RE at an intensity above the LT might be better than other aerobic capacities for estimating the 800-m running performance, and more than 50% of this performance can be explained by VC max, LT intensity and RE at an intensity above the LT."
Tokyo: The Japanese Society of Physical Fitness and Sports Medicine, 2017
610 JPFSM 6:5 (2017)
Artikel Jurnal  Universitas Indonesia Library
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Tanji, Fumiya
"The maximal accumulated oxygen deficit (MAOD), which is the gold standard for anaerobic energy metabolism capacity, requires multiple tests for evaluation that impose a heavy load on subjects. The maximal accumulated blood lactate (AbLa) concentration is also a measure of anaerobic energy metabolism capacity, and is related to the accumulated oxygen deficit (AOD). Thus, AOD has been estimated by using AbLa (3.0 mL02 * kg-1 * mM"1), but it is unclear if this coefficient is suitable for measurement of supramaximal running of athletes. The purpose of this study was to clarify the estimated expression of AOD by using AbLa from the relationship between MAOD and AbLa during supramaximal running in middle-distance run¬ners. Eleven male middle-distance runners (800m running velocity: 425.3 ± 7.3 m-min'1) took part in this study. They performed three running tests (maximal, submaximal and supramaximal running test) to evaluate MAOD and AbLa. MAOD and AbLa were 56.6 ± 6.0 mL02 * kg'1 and 9.9 ± 1.1 mmolL'1, respectively. We observed a significant positive relationship between MAOD and AbLa (r = 0.73); the regression line equation was y = 3.58x + 18.6. Results showed that the AOD per mM of the AbLa of athletes was 3.58 mL02*kg 1, which was 19% higher than the conventional coefficient value."
Tokyo: The Japanese Society of Physical Fitness and Sports Medicine, 2017
610 JPFSM 6:5 (2017)
Artikel Jurnal  Universitas Indonesia Library
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Aidi
"ABSTRAK
Ada dua persoalan pokok mengenai gizi nakerwan Indonesia yakni
ketidakseimbangan energi kerja dan anemia terutama anemia defisiensi besi.
Kedua jenis masalah gizi ini memberikan dampak menurunnya derajat kesehatan
pekerja yang berakhir pada menurunnya produktifitas/kapasitas kerja. Tujuan
penelitian ini adalah untuk menganalisis hubungan konsumsi energi dan zat besi
dengan status gizi nakerwan divisi pabrik di PT. Great Giant Pineapple tahun
2013. Jenis penelitian ini adalah deskriptif analitik dengan rancangan cross
sectional. Penelitian dilakukan pada nakerwan divisi pabrik di PT. Great Giant
Pineapple, Kecamatan Terbanggi Besar, Kabupaten Lampung Tengah, Propinsi
Lampung.
Hasil: Secara statistik ada hubungan antara asupan energi dan karbohidrat dengan
IMT. Tetapi tidak ditemukan hubungan umur, asupan lemak, asupan protein dan
asupan serat dengan IMT. Secara statistik ada hubungan antara pola haid, asupan
energi, asupan lemak, asupan protein, asupan zat besi dan enhancer absorpsi zat
besi (asupan vitamin C) dengan anemia. Tetapi tidak ada hubungan umur, asupan
karbohidrat, asupan zink, asupan kalsium, asupan magnesium, dan inhibitor
absorpsi zat besi (asupan makanan mengandung fitat, asupan minuman
mengandung tanin dan asupan serat) dengan anemia.

ABSTRACT
There are two main issues regarding nutrition Indonesia female worker the energy
imbalance of work and anemia, especially iron deficiency anemia. Both types of
nutritional problems this gives the effect of the health status of workers ended in
decreased productivity/labor capacity. The purpose of this study was to analyze
the relationship between energy and iron consumption with nutritional status of
female worker factory division at PT. Great Giant Pineapple in 2013. This
research is a descriptive analytic with cross sectional design. The study was
conducted at the female worker factory division at PT. Great Giant Pineapple,
Terbanggi Besar, Lampung Tengah District, Lampung Province.
Results:
Statistically, there is a relationship between energy intake and carbohydrate with
bodi mass index. However, no relationship age, fat intake, intake of protein and
fiber intake with body mass index. Statistically, there is a relationship between
menstrual pattern, energy intake, fat intake, protein intake, iron intake and iron
absorption enhancers (vitamin C) with anemia. But there is no relationship of age,
carbohydrate intake, intake of zinc, calcium intake, magnesium intake, and
inhibitors of iron absorption (intake of foods containing phytate, intake of foods
containing tannin and fiber intake) with anemia."
Universitas Indonesia, 2013
T36039
UI - Tesis Membership  Universitas Indonesia Library
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Siregar, Elisabet Anggita
"Risiko kekurangan energi kronik (KEK) merupakan keadaan dimana remaja putri mempunyai kecenderungan untuk menderita KEK. Kategori risiko KEK di Indonesia didasarkan pada hasil ukur lingkar lengan atas (LILA) kurang dari atau sama dengan 23,5 cm. Apabila KEK terjadi pada remaja dapat menyebabkan menurunnya kemauan belajar dan kesehatan fisik pada remaja putri, mengingat dampak KEK pada remaja putri juga dapat berlanjut hingga dewasa dan dapat berdampak buruk pada masa kehamilan dan melahirkan bayi stunting. Penelitian ini bertujuan untuk mengetahui hubungan faktor asupan energi, asupan gizi makro, frekuensi makan, kebiasaan sarapan pagi, citra tubuh, uang saku, dan pekerjaan ibu dengan kejadian KEK pada siswi Sekolah Menengah Kejuruan Informatika Bina Generasi 3 Kabupaten Bogor tahun 2023. Penelitian ini menggunakan desain studi analitik deskriptif dengan menggunakan metode cross sectional dan metode pengambilan sampelnya dengan simple random sampling pada siswi Sekolah Menengah Kejuruan Informatika Bina Generasi 3 Bogor yaitu kelas 11 - 12 periode 2022/2023 pada Agustus 2023. Analisis data menggunakan statistik chi-square. Hasil penelitian ini menunjukkan sebanyak 53,3% siswi Sekolah Menengah Kejuruan Informatika Bina Generasi 3 berisiko KEK dan 47,8% tidak berisiko KEK. Terdapat hubungan yang bermakna antara asupan energi, asupan karbohidrat, asupan lemak, asupan protein, frekuensi makan, dan pengetahuan gizi dengan risiko kurang energi kronik (KEK) pada siswi. . Asupan energi (p-value= 0,002) dan karbohidrat (p-value= 0,003) merupakan faktor terbesar terjadinya risiko KEK pada siswi, yaitu dimana siswi yang mempunyai asupan energi yang kurang berpeluang 5,400 dan 5,789 kali lebih besar berisiko KEK dibandingkan dengan responden dengan asupan energi dan karbohidrat yang cukup.Diharapkan siswi dapat lebih meningkatkan asupan energi dan asupan zat gizi makro melalui melakukan pola makan yang baik yaitu dengan memperbaiki frekuensi makan dengan rutin yaitu 3 kali sehari dengan makan utama dan meningkatkan kualitas makan dengan mengkonsumsi makanan yang bergizi seimbang.

The risk of chronic energy deficiency (CED) is a condition in which young women tend to suffer from CED. The CED risk category in Indonesia is based on the results of measuring the upper arm circumference (MUAC) which is less than or equal to 23.5 cm. If CED occurs in adolescents it can cause a decrease in the willingness to learn and physical health in young women, considering that the impact of CED on young women can also continue into adulthood and can have a negative impact during pregnancy and childbirth. retarded baby. This study aims to determine the relationship between energy intake, macronutrient intake, meal frequency, breakfast habits, body image, pocket money, and mother's occupation with the incidence of CED in female students at SMK Informatics Bina Generasi 3, Bogor Regency, in 2023. This study used a research design descriptive analysis using the cross-sectional method and the sampling method using simple random sampling in female students of SMK Informatics Bina Generasi 3 Bogor, namely class 11 – 12 for the 2022/2023 period in August 2023. Data analysis used chi-square statistics. The results showed that 53.3% of female students at SMK Informatika Bina Bata 3 were at risk of KEK and 47.8% were not at risk of CED. There is a significant relationship between energy intake, carbohydrate intake, fat intake, protein intake, meal frequency, and nutritional knowledge with the risk of chronic energy deficiency (CED) in female students. Energy intake (p-value = 0.002) and carbohydrates (p-value = 0.003) are the biggest risk factors for CED in female students, namely students who have less energy intake are 5,400 and 5,789 times more likely to be at risk of CED compared to respondents with low energy intake. sufficient energy and carbohydrates. It is hoped that female students can further increase their energy intake and macronutrient intake by adopting a good diet, namely by improving the frequency of eating regularly, namely 3 times a day with main meals, and improving the quality of eating by consuming nutritionally balanced foods."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2023
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UI - Skripsi Membership  Universitas Indonesia Library
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Nadra Anniswah
"Latar Belakang: Kurang Energi Kronis (KEK) pada ibu hamil dapat menyebabkan mortalitas dan morbiditas baik bagi ibu maupun anak yang dilahirkan. Faktor-faktor yang berhubungan dengan status KEK perlu diketahui agar dapat ditentukan intervensi dalam penurunan prevalensi KEK. Tujuan: Menganalisis faktor-faktor yang berhubungan dengan KEK pada ibu hamil di Kabupaten Buol Tahun 2021. Metode: Penelitian ini menggunakan desain studi cross-sectional yang dilakukan di Kabupaten Buol. Jumlah sampel dalam penelitian ini adalah sebanyak 239 ibu hamil. Variabel terikat berupa status KEK sedangkan variabel bebas berupa karakteristik ibu, pendapatan keluarga, umur pertama menikah, jarak kehamilan, pengetahuan gizi ibu hamil, frekuensi dan asupan makanan (karbohidrat, energi, protein), akses layanan kesehatan (ANC, K1, dan PMT). Analisis yang dilakukan berupa uji univariat, bivariat dengan menggunakan uji Chi square, dan multivariat menggunakan regresi logistik. Hasil: Prevalensi KEK dalam penelitian ini adalah sebesar 23.4%. Variabel yang berhubungan dengan status KEK (p<0.05) dalam penelitian ini adalah jarak kehamilan, umur pertama menikah, dan PMT. Simpulan dan saran: faktor yang paling mempengaruhi KEK adalah usia pertama menikah. Diperlukan pendidikan gizi untuk meningkatkan pengetahuan ibu hamil megenai pentingnya nutrisi saat kehamilan serta terkait sumber dan cara yang tepat mengolah pangan lokal alami untuk mencukupi asupan nutrisi. Selain itu dibutuhkan edukasi untuk menunda usia pernikahan dan kehamilan agar mencapai usia ideal, serta mengatur jarak kelahiran ideal untuk meminimalisasi risiko KEK serta komplikasi kehamilan dan persalinan. Peningkatan pengetauan juga perlu didampingi dengan perubahan sikap, intensi dan ketersediaan akses untuk dapat mencapai perubahan perilaku masyarakat.

Background: Chronic energy deficiency in pregnancy can cause mortality and morbidity in both maternal and her children. Factors associated with chronic energy deficiency to be known to determine an intervention for decreasing prevalence chronic energy deficiency. Objectives: To analyze the factors associated with chronic energy deficiency in Buol Regency. Methods: Design study was cross-sectional conducted in Buol Regency. Total sample was 239 pregnant women. The dependent variables was chronic energy deficiency status while the independent variable were subject characteristic, family income, age of first marriage, pregnancy distance, antenatal care, supplementary feeding, maternal nutrition knowledge, eating behavior, carbohydrate, energy, and protein intake . Statistical analysis were univariate, bivariate analysis using Chi Square, and multivariate analysis using logistic regression. Results: The prevalence of chronic energy deficiency in this study was 23.4%. Variables associated with chronic energy deficiency (p<0.05) was pregnancy distance, age of first marriage, and supplementary feeding. Conclusions and suggestions: age of first marriage is the strongest associated factor to CED. Nutritional education is needed to increase the knowledge of pregnant women to meet the importance of nutrition during pregnancy, related sources and ways to properly process natural local food to meet nutritional intake. In addition, education is needed to delay the age of marriage and pregnancy in order to reach the ideal age, and set the ideal birth distance to minimize the risk of CED and complications of pregnancy and childbirth. Increasing knowledge also needs to be accompanied by changes in attitudes, intentions and availability of access to be able to achieve changes in people's behavior."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2021
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Astri Mentari
"Latar Belakang : Perempuan pascamenopause memiliki risiko tinggi mengalami penurunan massa tulang akibat bekurangnya hormon estrogen dan asupan kalsium. Penting bagi perempuan pascamenopause untuk menjaga residual ridge dari resorpsi yang berlebihan.
Tujuan : Mengetahui hubungan asupan kalsium terhadap derajat resorpsi residual ridge pada perempuan pascamenopause.
Material dan Metode : Penelitian dengan metode potong lintang dilakukan di Pos Binaan Terpadu Lanjut Usia Perhimpunan Gerontologi Indonesia, Depok RW 02 yang melibatkan 99 perempuan pascamenopause. Subjek diwawancara menggunakan kuesioner asupan kalsium beserta model makanan dan porsinya dengan metode semiquantitative food frequency questionnaire selanjutnya dilakukan pemeriksaan derajat resorpsi residual ridge dengan mengukur tinggi residual ridge. Data dihitung dan dianalisis menggunakan piranti lunak statistik.
Hasil : Hasil analisis chi square menunjukkan bahwa terdapat hubungan yang bermakna secara statistik antara jumlah asupan kalsium terhadap derajat resorpsi residual ridge (p=0,035) pada perempuan pascamenopause.
Kesimpulan : Perempuan pascamenopause berasupan kalsium tercukupi memiliki derajat resorpsi residual ridge rendah.

Background : Postmenopausal women have a high risk to decreasing bone mass because of estrogen and calcium intake deficiency. It is important for postmenopausal women to keep the residual ridge from excessive resorption.
Objective : Determine the relationship calcium intake and degree of residual ridge resorption in postmenopausal women.
Material and Method : the cross sectional study was performed at Pos Binaan Terpadu Lanjut Usia Perhimpunan Gerontologi Indonesia, Depok RW 02 involving 99 postmenopausal women. Subjects were submitted to interview using calcium intake questionnaire (semiquantitative food frequency questionnaire method ) with food model and the size and then examining the degree of residual ridge resorption through measuring residual ridge height. Data obtained was tabulated and analyzed using statistical software.
Result : The results of chi square analysis showed a statistically significant relationship between the amount of calcium intake and the degree of residual ridge resorption (p = 0.035) in postmenopausal women.
Conclusion : Postmenopausal women that have adequate calcium intake show the low degree of residual ridge resorption.
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2013
S45186
UI - Skripsi Membership  Universitas Indonesia Library
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Haloho, Andreas S
"Acanthamoeba dikenal sebagai organisme penginfeksi baru yang mulai banyak mendapatkan perhatian dalam dunia kedokteran. Organisme ini merupakan sejenis parasit yang diketahui cukup sering menginfeksi pengguna lensa kontak dan bermanifestasi di mata sebagai Acanthamoeba Keratitis (AK). Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar tingkat pengetahuan mahasiswa kedokteran mengenai etiologi dan patofisiologi infeksi yang dapat ditimbulkan oleh Acanthamoeba. Responden adalah mahasiswa kedokteran FKUI tingkat I, II, dan III yang menggunakan lensa kontak. Tingkat pengetahuan responden dinilai berdasarkan jawaban mereka terhadap kuesioner penelitian yang sebelumnya telah dilakukan uji validitas dan realibilitas. Hasil penelitian menunjukkan 18,6% responden memiliki tingkat pengetahuan baik, 41,2% cukup, dan 40,2% kurang. Analisis data menunjukkan bahwa jenis kelamin tidak berpengaruh terhadap tingkat pengetahuan responden (chi square, p=0,902; p>0,05), namun tingkat pendidikan memiliki hubungan yang bermakna dengan tingkat pengetahuan (chi square, p=0,000; p<0,05). Faktor yang mempengaruhi hasil ini adalah tidak ditemukannya diskriminasi gender pada responden dan sistem kurikulum yang membuat responden dengan tingkat pendidikan yang lebih tinggi mempunyai tingkat pengetahuan yang lebih baik.

Acanthamoeba is known as the new infectious agent which begin to get much more attention in medicine. This organism is a kind of parasite which is known to infect the contact lens user frequently and has manifestation in the eyes as Acanthamoeba Keratitis (AK). The aim of this research is to get the information about the medicine students? level of knowledge about the etiology and pathophysiology of Acanthamoeba Infection. Respondents is the students in first, second, and third degree in FMUI who use the contact lens. The level of knowledge is measured based on the the answers of the respondents to the questionnaire which has been done validation and realibility testing. The results show 18,6% respondents have the good level of knowledge, 41,2% fair, and 40,2% poor. After these data have been analyzed, we got the conclusion that the gender has no differences to the level of knowledge (chi-square, p=0,902; p>0,05), but the level of education is proven to influence the level of knowledge (chi square, p=0,000; p<0,05). These results are caused by no gender discrimination between respondents and the curriculum which makes the higher degree respondents have the better level of knowledge.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Skripsi Membership  Universitas Indonesia Library
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Mohammad Akita Indianto
"Kebutuhan akan industri mikro semakin meningkat setiap tahunnya sehingga membutuhkan pengembangan dalam teknologi fabrikasinya,dengan biomachining menjadi salah satu alternatif yang low cost dan ramah lingkungan. Oksigen sangat berpengaruh terhadap metabolisme dari bakteri Acidithiobacillus ferrooxidans sebagai cutting tool Biomachining. Pengaruhnya terlihat dari adanya perbedaan nilai material removal rate dalam setiap komposisi oksigen di setiap ketinggian penempatan sampel.
Dengan demikian penelitian ini dilakukan untuk melihat signifikansi pengaruh tersebut dengan menyuplai udara dengan oksigen di dalamnya ke dalam proses dan melakukan karakterisasi terhadap proses biomachining dengan dan tanpa penambahan udara untuk melihat perbandingan pengaruhnya. Percobaan dilakukan dengan tiga ketinggian benda kerja yang berbeda dengan temperatur ruangan 23-25°C.
Hasil penelitian menunjukkan adanya pengaruh penambahan udara terhadap nilai MRR dengan kenaikan sebesar 350-400%. Selain itu ditemukan bahwa perbedaan ketinggian tidak memberikan pengaruh signifikan terhadap perbedaan nilai MRR. Nilai Ra yang terukur dalam percobaan dengan penambahan udara memiliki nilai yang lebih tinggi dari nilai Ra tanpa penambahan udara dengan kecenderungan yang menurun seiring bertambahnya waktu pemesinan.

Needs of micro product industry is increasing every year so the fabrication technology will need to be increased too with biomachining is one of the alternative that is low cost and environtmentally friendly. Oxygen has a big effect for metabolism of Acidithiobacillus ferrooxidans as biomachining cutting tool. The effect is seen in the difference value of Material Removal Rate in the difference composition of oxygen within the height of work piece's placement.
So this research is done to see how significant that effect by supplying air, with oxygen as its composition, to the process and do the characterization of biomachining process with and without the added air to see the comparison of the effect. The experiment is done with three different heights of work piece's placement and in the room temperature of 23-25°C.
The result shows that there is an effect of adding air to the value of material removal rate with the rise of 350- 400%. The difference of the height of work piece's effect has shown unsignificant effect to the performance of the bacteria. The measured Ra number of added air biomachining has a higher value than the Ra number of non added air with the trend of decreasing along with the increasing of machining time.
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Depok: Fakultas Teknik Universitas Indonesia, 2013
S52535
UI - Skripsi Membership  Universitas Indonesia Library
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Mohammad Yunus
"Biomachining merupakan proses alternatif dalam fabrikasi mikro yang tergolong ramah lingkungan karena menggunakan bakteri sebagai cutting tool. Proses biomachining menghasilkan kualitas permukaan yang lebih baik karena tidak menghasilkan panas pada permukaan benda kerja dan berpotensi menghasilkan produk dengan skala mikro yang lebih kompleks. Dalam penelitian ini, proses biomachining mulai dikembangkan variasi teknologi pemakanan, yang bertujuan untuk membuktikan seberapa besar pengaruh pemberian potensial listrik DC terhadap kinerja bakteri Acidithiobacillus ferrooxidans NBRC 14262 yang bisa dilihat dari nilai material removal rate (MRR) dan dibandingkan dengan proses biomachining normal (tanpa perlakuan khusus). Hasil pengujian menunjukan bahwa MRR pada penambahan potensial listrik meningkat 15% pada waktu pemakanan 12 dan 24 jam, sedangkan pada waktu pemakanan 18 jam turun 15-20%.

Biomachining is an alternative process in the micro-fabrication categorized as environmental friendly because it uses bacteria as a cutting tool. Biomachining process produces a better surface quality because it does not generate heat on the surface of the workpiece thatpotentially developedto producemore complex microproducts.In this study, the process was developed variations biomachining technology of material removal rate (MRR), which aims to prove how much of the effect of DC electric potential on the performance of the bacteria Acidithiobacillus ferrooxidans NBRC 14262 which can be seen from the value of material removal rate (MRR) and compared with normal biomachining process (without special treatment). The test results showed that the MRR on the potential addition of electricity increased by 15% at the time of removal 12 and 24 hours, while the removal at 18 hours down 15-20%."
Depok: Fakultas Teknik Universitas Indonesia, 2013
S52536
UI - Skripsi Membership  Universitas Indonesia Library
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A. Makbul Aman
"Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects.
Methods: this was a cross sectional study comparing the metabolic profile, risk of metabolic syndrome and insulin resistance in non-diabetic male adolescents (17-24 years old) whose one or both parents were with type-2 diabetes. We performed anamnesis, physical examination, fasting plasma glucose, lipid profile, fasting insulin level and insulin resistance based on HOMA-IR.
Results: metabolic abnormalities were more prevalent in subjects whose parents were with history of type-2 diabetes, especially their waist circumference, fasting plasma glucose, triglyceride, fasting insulin and HOMA-IR (p=0.000). There was increased risk of developing central obesity in adolescents with parental history of 19.3 fold (95%CI 2.46-151.07) and insulin resistance of 10.3 fold (95%CI 3.89-27.23). Parental history of type-2 diabetes together with metabolic syndrome component ie. waist circumference >90 cm and triglyceride ≥150 mg/dl were strong determinat factors for insulin resistance (R2=50.7%).
Conclusion: the early multiple metabolic defect can be detected in non-diabetes adolescents with parental history of type-2 diabetes. Cluster of metabolic syndrome component in these subject become a powerful determinat factor for insulin resistance.

Latar belakang: sifat kekeluargaan diabetes tipe 2 dimanifestasi oleh adanya resistensi insulin pada keturunan pertama keluarga non-diabetes. Sebagian besar penelitian ini telah dilakukan pada usia menengah dan hanya beberapa penelitian yang dilakukan pada usia muda dan remaja. Penelitian ini bertujuan untuk menganalis hubungan antara riwayat orang tua yang memiliki diabetes melitus (DM) tipe 2 dengan komponen sindroma metabolik dan kejadian resistensi insulin pada subyek dewasa muda non-diabetes.
Metode: studi ini merupakan penelitian potong lintang pada pria dewasa muda non-diabetes (usia 16-24 tahun) dengan riwayat satu atau kedua orang tua DM tipe 2. Sebagai pembanding adalah subyek yang tidak mempunyai riwayat orang tua DM tipe 2. Dilakukan pemeriksaan anamnesis, pemeriksaan fisis, dan pemeriksaan laboratorium glukosa darah puasa, profil lipid, insulin puasa dan resistensi insulin dengan menggunakan rumus HOMA-IR.
Hasil: profil metabolik yang abnormal lebih banyak ditemukan pada subyek dengan riwayat orang tua menderita DM tipe 2, khususnya dalam hal lingkar pinggang, glukosa darah puasa, trigliserida, insulin puasa dan HOMA-IR (p=0.000). Subyek dewasa muda non-diabetes dengan riwayat orang tua DM tipe 2 beresiko untuk menglami obesitas sentral sebesar 19.3 kali (95%CI 2.46-151.07) dan juga beresiko terhadap terjadinya resistensi insulin sebesar 10.3 kali (95%CI 3.89-27.23). Hasil uji regresi logistik menunjukkan bahwa faktor orang tua menderita DM tipe 2 bersama–sama dengan komponen sindroma metabolik yaitu lingkar pinggang >90 cm dan kadar trigliserida ≥150 mg/dl merupakan faktor determinan kuat untuk terjadinya resistensi insulin (R2=50.7%).
Kesimpulan: pada Subyek dewasa muda non-diabetes dengan riwayat orang tua menderita DM tipe 2 sudah dapat ditemukan abnormalitas metabolik yang multipel. Kluster dari komponen sindoma metabolik pada populasi tersebut merupakan faktor determinan kuat untuk terjadinya resistensi insulin.
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Jakarta: University of Indonesia. Faculty of Medicine, 2018
610 UI-IJIM 50:4 (2018)
Artikel Jurnal  Universitas Indonesia Library
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