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Thia Juniaty Manik

Korelasi antara kadar vitamin d dengan fungsi kognitif pada siswa SMA di Depok, Jawa Barat = The correlation between vitamin d and cognitive function among high school students in Depok, West Java

"KORELASI ANTARA KADAR VITAMIN D DENGAN FUNGSI KOGNITIF PADA SISWA SMA DI DEPOK, JAWA BARATThia Juniaty Manik1, Novi Silvia Hardiany2, Erfi Prafiantini1 1. Departemen Ilmu Gizi, Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo, Fakultas Kedokteran Universitas Indonesia2. Departemen Biokimia dan Biologi Molekuler, Fakuktas Kedokteran Universitas IndonesiaE-mail :tjmanik@gmail.com AbstrakKeberhasilan dalam pendidikan tidak hanya ditentukan oleh sistem pendidikan, tetapi juga kemampuan kognitif para siswa. Siswa dengan kemampuan kognitif tinggi akan dapat menyerap pelajaran dengan baik. Nutrisi yang dikonsumsi merupakan faktor penting yang berkontribusi pada pengembangan daya kognitif. Penelitian-penelitian sebelumnya telah menghubungkan mikronutrien vitamin D dengan berbagai hasil yang berkaitan dengan kesehatan. Namun, hanya sedikit yang meneliti hubungan vitamin D dengan fungsi kognitif dan hasilnya masih belum konklusif terutama pada remaja. Penelitian ini mengeksplorasi hubungan vitamin D dengan fungsi kognitif pada siswa sekolah menengah atas di Kota Depok. Sebanyak 64 siswa dari 4 SMA di Kota Depok, menjalani tes fungsi kognitif. Hasil utama yang dinilai adalah tes kognisi untuk fleksibilitas kognitif BCST test , planning tower test , dan working memory digit span backward test . Hasil sekunder adalah status sosial ekonomi, asupan vitamin D, skor paparan sinar matahari, kadar haemoglobin, skor family assessment device, skor strenght and difficulties dan aktivitas fisik siswa. Tiga jenis tes yang digunakan adalah : BCST test, Tower Hanoi test, dan Digit backward test. Dari 64 subyek yang ikut penelitian ini 62,5 mengalami kekurangan vitamin D

Success in education is not only determined by the education system, but also the cognitive power of the students. The students with high cognitive abilities will be able to absorb the lessons well. Nutrition consumed is one of the important factors that contributes to cognitive power development. Previous studies have linked micronutrient vitamin D to various health related outcomes. However, only few examined the correlation of vitamin D to cognitive function, and the result is still inconclusive especially in adolescent. This study explores the correlation of vitamin D to cognitive function in high school students. A samples of 64 adolescents from 4 high schools in Depok City, underwent cognitive function tests. The main outcomes assessed were cognitive flexibility, planning, and working memory test. The secondary outcomes were social economic status, dietary intake of vitamin D, sun light exposure score, haemoglobin level, family assessment device, strenght and difficulties score and physical activity. Sixty four participants 62,5 were vitamin D deficiencies "

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018

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Yusi Deviana Nawawi

Korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda = Correlation between vitamin D serum levels with physical performance among elderly individuals in nursing homes

"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat 85% subjek memiliki asupan vitamin D yang kurang dan 94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).

Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019

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Audrey Haryanto

Korelasi antara kadar vitamin D serum dengan kadar hsCRP pada usia lanjut = Correlation between serum vitamin D level and hsCRP in elderly

"Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut (usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5 (0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi. Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan kadar hsCRP pada usila (r=0,168, p=0,162).

The prevalence of cardiovascular disease (CVD) increases in the elderly. Atherosclerosis is a major cause of CVD which stimulate inflammation and followed by increase production of C-reactive protein (CRP). Vitamin D is a vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The aim of this cross sectional study was to find the correlation between serum vitamin D level and hsCRP in elderly. Data collection was conducted during December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling method. A total of 71 elderly subjects had met the study criteria. Data were collected through interviews including age, vitamin D intake and weekly score of sunlight exposure. Anthropometry measurements to assess the nutritional status and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the subjects were less than recommended dietary allowances (RDA). Majority of the subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels 38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects were at moderate and high risk of CVD. No significant correlation was found between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013

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Isa Rosalia Ruslim

Korelasi antara asupan vitamin D dan skor paparan sinar matahari dengan kadar kalsidiol serum pada ibu hamil trimester 1 di Jakarta = Correlation between vitamin d intake and sun exposure score with serum calcidiol on first trimester pregnant women in Jakarta

"Hipovitaminosis D selama masa kehamilan dapat menimbulkan komplikasi selama kehamilan dan pada janin. Selain itu data mengenai status vitamin D pada ibu hamil terutama trimester 1 di Indonesia masih terbatas. Oleh karena itu penelitian ini dilakukan untuk mengetahui kadar kalsidiol serum pada ibu hamil trimester 1 dan korelasinya dengan asupan vitamin D dan skor paparan sinar matahari.

Penelitian ini menggunakan metode studi potong lintang pada ibu hamil sehat usia 20-35 tahun dengan usia kehamilan <12 minggu. Hasil penelitian menunjukkan rerata usia subyek 27,36+3,91 tahun dengan median usia kehamilan 9 minggu. Sebagian besar subyek berpendidikan tinggi (68,1%), status bekerja (70,2%) dengan pendapatan >UMP (59,6%) dan rerata IMT 23,74+3,83 kg/m2. Asupan lemak, protein, dan kalsium subyek

Median skor paparan sinar matahari adalah 14 (0-42) dengan median lama paparan 17,41 (0-85,71) menit. Terdapat perbedaan bermakna antara kadar kalsidiol serum dengan kelompok lama paparan sinar matahari 5-30 menit dan >30 menit (p=0,033). Rerata kadar kalsidiol serum 39,26+10,25 nmol/mL (insufisiensi) dengan 100% subyek memiliki kadar kalsidiol serum < 80 nmol/L yang menggambarkan keadaan hipovitaminosis D.

Tidak terdapat korelasi antara kadar kalsidiol serum dengan skor paparan sinar matahari (r=0,087; p=0,562), dan asupan vitamin D (r=-0,049; p=0,745). Kesimpulan yang didapatkan dari penelitian adalah seluruh ibu hamil trimester 1 di Jakarta mengalami hipovitaminosis D sehingga perlu segera diatasi melalui konseling dan edukasi gizi.

Vitamin D deficiency could be related to several complications to pregnancy`s outcomes, both for mother and fetus. Besides, there is limited data regarding to vitamin D status among pregnant women in Indonesia especially during the first trimester. Therefore this study was performed to determine serum calcidiol on the first trimester of pregnancy and its correlation to vitamin D intake and sun exposure score.
The methode in this study was cross-sectional study among healthy pregnant women aged 20-35 years old on their first trimester of pregnancy. Average age of the subjects was 27.36±3.91 years old with median gestational age of 9 weeks. Most of the subjects was well educated (68.1%), working (70.2%) with monthly income equal and more than the province minimum salary (59.6%), and with BMI average of 23.74±3.83 kg/m2. Mostly the subjects had fat, protein, and calcium intake below its RDA with the average intake of 44.49±22.22 g/day; 45.07±19.35 g/day; 661.93±405.91 mg/day, respectively. Vitamin D intake was mostly below its RDA with a median of 2.9 mcg/day and ranged from 0.3 to 15.6 mcg/day.
The median score of sun exposure score was 14 that ranged from zerro to 42, with a median for its duration of 17.41 minutes that ranged from zerro to 85.71 minutes. In this study, there was significant differences between serum calcidiol and sun exposure duration in 5-30 minutes and more than 30 minutes groups (p=0,033). As the main finding, it reveals that the average of serum calcidiol was 39.26±10.25 nmoL/mL or classified as insufficient where all of the subjects (100%) had serum calcidiol less than 80 nmol/L (hypovitaminosis D).
However, there were no significant correlations between serum calcidiol with sun exposure score and vitamin D intake (r=0.087 and p=0.562; r=-0,049 and p=0.745, respectively). In conclusion, all of the pregnant women in Jakarta, especially in their first trimester had low vitamin D status. Therefore, intervention is needed, i.e. through prenatal counselling and nutrition education regarding to natural sources of vitamin D."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013

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Nita Nurul Rachman

Korelasi kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut = Correlation between visceral fat levels and vitamin D 25 (OH) levels in acute stroke patients

"Latar Belakang: Vitamin D memiliki efek non-skeletal dalam mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar lemak viseral dan kadar vitamin D serum pada pasien stroke akut.

Metode: Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia selama bulan November -Desember 2023. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis (BIA) bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay (CMIA). Analisis bivariat dan multivariat digunakan untuk menilai korelasi dan hubungan antara variable bebas dan terikat, serta mengidentifikasi faktor perancu lain yang berhubungan dengan kadar vitamin D serum.

Hasil: Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan dengan regresi linear untuk faktor perancu lain, hanya didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) yang menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.

Kesimpulan: Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.

Background: Vitamin D has non-skeletal effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Until now, studies that discuss the correlation between these two factors are still inconsistent. This study aims to determine the correlation between visceral fat levels and serum vitamin D levels in acute stroke patients.
Methods: A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital during November - December 2023. Measurement of visceral fat levels using bioelectrical impedance analysis (BIA) bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay (CMIA) method. Bivariate and multivariate analyses were used to assess the correlation and relationship between independent and dependent variables, as well as identify other confounding factors associated with serum vitamin D levels.
Results: In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis with linear regression for other confounding factors, only visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels.
Conclusion: There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024

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UI - Tugas Akhir Universitas Indonesia Library

Nita Nurul Rachman

Korelasi Kadar Lemak Viseral dengan Kadar Vitamin D 25 (OH) pada Pasien Stroke Akut = Correlation Between Visceral Fat Levels and Vitamin D 25 (OH) Levels in Acute Stroke Patients

"Vitamin D memiliki efek mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay. Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan, didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.

Vitamin D has effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Studies that discuss the correlation between these two factors are still inconsistent. A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital. Measurement of visceral fat levels using bioelectrical impedance analysis bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay method. In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis, visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels. There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024

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UI - Tesis Membership Universitas Indonesia Library

Ade Gautama

Korelasi Antara Kadar Vitamin D dan Penanda Fungsi Ginjal pada Subjek Dewasa di Kawasan Urban Kampung Jakarta dan Tangerang = Correlation Between Vitamin D Serum Level and Kidney Function Parameter in Adult Subjects of Urban Kampung Area Around Jakarta and Tangerang

"Latar belakang: Masyarakat kawasan urban kampung di Indonesia memiliki risiko lingkungan berupa gorong-gorong yang gelap dan ventilasi yang tidak adekuat. Hal ini menjadi risiko kadar vitamin D yang tidak optimal (serum 25OHD <20 ng/mL dan >100 ng/mL). Kadar vitamin D yang tidak optimal juga bisa menjadi risiko penurunan fungsi ginjal. Oleh karena itu penelitian ini dilakukan untuk mengetahui korelasi antara kadar vitamin D dan penanda fungsi ginjal pada masyarakat kawasan urban kampung Jakarta dan Tangerang.

Metode: Studi potong lintang pada subjek dewasa kawasan urban kampung Jakarta dan Tangerang di tahun 2019-2020. Kemudian dilakukan penyesuaian dengan kriteria inklusi dan eksklusi. Lalu, dilakukan pengambilan darah untuk pengukuran kadar vitamin D juga nilai penanda fungsi ginjal.

Hasil: Pada 161 subjek dewasa di urban kampung Jakarta dan Tangerang diperoleh nilai median kadar vitamin D 24,46 ng/mL (10,04 – 52,55 ng/mL), kadar kreatinin serum 0,7 mg/dL (0,5 – 6,7 mg/dL), kadar ureum 20,6 mg/dL (11,9 – 50,5 mg/dL), dan nilai eGFR (CKD-EPI) 97,854 ml/min/1,73m2 (5,52 – 121,92 ml/min/1,73 m2). Hasil analisis menggunakan uji Spearman menunjukkan tidak terdapat korelasi antara kadar vitamin dengan kadar ureum, kreatinin, dan nilai eGFR.

Kesimpulan: Tidak terdapat korelasi antara kadar vitamin D dan penanda fungsi ginjal baik dengan eGFR, kadar kreatinin serum, maupun kadar ureum pada masyarakat yang tinggal di kawasan urban kampung Jakarta dan Tangerang.

Background: Individuals who live in urban kampung have the environmental risk factors of dark alleyways and inadequate ventilations. These increase the risk of subjects in developing vitamin D deficiency and later may decrease the kidney function. Therefore, this study is performed to identify the correlation between vitamin D serum levels and kidney function markers in adults of urban kampung area around Jakarta and Tangerang.
Methods: Cross-sectional study performed in adults of urban kampung areas around Jakarta and Tangerang in 2019-2020. We recruited participants using predetermined inclusion and exclusion criteria. Afterward, blood sample were drawn to quantify vitamin D serum level and kidney function markers of the subjects.
Results: From 161 adult subjects in urban kampung around Jakarta and Tangerang, the vitamin D serum level median is 24,46 (10,04 – 52,55) ng/mL, the serum creatinine median is 0,7 (0,5 – 6,7) mg/dL, the urea serum level median is 20,6 (11,9 – 50,5) mg/dL, and the median of eGFR score (CKD-EPI), is 97,854 (5,52 – 121,92) ml/min/1,73 m2. Analysis using Spearman shows that there is no correlation between vitamin D serum level with urea serum level, serum creatinine, and eGFR score.
Conclusion: There are no correlation between vitamin D serum level and kidney function markers in individuals who live in urban kampung area around Jakarta and Tangerang."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021

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Napitupulu, Luther Holan Parasian

Korelasi antara asupan vitamin d dengan kadar vitamin D dalam darah pada ibu hamil trimester pertama di Jakarta = Corellation between vitamin d intake and value of vitamin D in blood on firs trimester pregnancy in Jakarta

"Vitamin D adalah salah satu mikronutrien yang penting bagi manusia terlebih lagi pada ibu hamil. Di beberapa Negara kekurangan vitamin D menjadi masalah yang terabaikan terutama di negara Asia Tenggara termasuk di Indonesia. Ibu hamil yang kekurangan vitamin D dapat berisiko lebih tinggi untuk mengalami pre eklampsia. Pada bayi yang lahir dari ibu yang mengalami kekurangan vitamin D dapat lahir dengan berat badan yang rendah dan kedepannya dapat mengalami gangguan pada organ penting seperti otak dan tulang. Oleh karena itu, pencegahan harus dilakukan sedini mungkin dari trsimester pertama. Namun terbatasnya fasilitas untuk mengukur tersebut mendorong untuk mencari tahu faktor yang berperan penting dalam kadar vitamin D seperti asupan harian.

Penelitian ini dilakukan dengan menggunakan desain studi cross-sectional. Data yang digunakan dalam penelitian ini merupakan data sekunder dari penelitian yang dilakukan oleh Fakultas Kedokteran Universitas Indonesia pada tahun 2013 sampai 2014 dengan subjek ibu hamil trimester pertama yang tinggal di Jakarta.

Metode penelitian menggunakan pengukuran 25-hidroxivitamin D terstandar untuk memperoleh kadar vitamin D dalam darah subjek serta food-frequency questionnaire (FFQ) untuk mengetahui asupan harian vitamin D subjek. Data yang diperoleh kemudian diolah menggunakan piranti lunak SPSS for Windows 20.0 lalu dianalisis dengan uji Spearman. Didapatkan bahwa persentase subjek hipovitaminosis vitamin D adalah sebesar 43,5% (27 orang, n = 62) dan seluruh subjek memiliki asupan vitamin D harian yang rendah.

Hasil penelitian menunjukkan bahwa tidak ditemukan adanya korelasi antara asupan harian vitamin D dengan kadar 25-hidroxivitamin D. Banyak faktor lain yang mempengaruhi misalnya adalah sinar matahari.

Vitamin D is one of the important micronutrients for humans especially pregnant women. In some countries, deficiency of vitamin D is one of neglected health problem, especially in South-East countries including Indonesia. Pregnancy women with deficiency vitamin D may be higher risk for having preeclampsia. In infants born from mother who have deficiency vitamin D may be born with low birth weight. Some important organs development will interference such as brain and bone. Therefore, prevention from deficiency vitamin D should be conducted as early as possible from first trimester pregnancy. But there are limitation in vitamin D measurement facilities so these research purpose is to elaborate the others factor that influencing vitamin D in blood and the most important factor is diet vitamin D. These research aims to determine whether a correlation between vitamin D intake and value of vitamin D in blood.
Running a cross-sectional study design, this research uses secondary data from a former research by Faculty Medicine of University Indonesia conducted in 2013 ? 2014 with pregnant women living in Jakarta.
The research method comprised a 25-hydroxyvitamin D measurement and the usage of food-frequency questionnaire (FFQ) to obtain subject's vitamin D in blood and vitamin D intake respectively. Using SPSS for Windows 20.0 software, data is then analyzed by Spearman, resulting 43.5% (n = 62) of subjects being hypovitaminosis D (<10 ng/mL) and the whole subjects receiving under the boundary value of vitamin D (12 mcg/day).
This research shows that no correlation could be found between vitamin d intake and value of vitamin D in blood."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015

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Rizka Farah Hilma

Hubungan Antara Kadar Serum Vitamin D (25-Hydroxyvitamin D) dan Kadar Plasma Reseptor Vitamin D Dengan Indeks Bakteri Pada Pasien Kusta = Association between Serum Level of Vitamin D (25-Hydroxyvitamin D) and Plasma Level of Vitamin D Receptor with Bacteriological Index in Leprosy Patients

"Salah satu peran sistem imunitas terhadap infeksi M.leprae adalah respons makrofag melalui interaksinya dengan vitamin D dan reseptor vitamin D (RVD). Interaksi vitamin D dengan RVD pada berbagai sel imun akan menstimulasi ekspresi katelisidin. Penelitian ini bertujuan untuk menganalisis kadar serum 25-hydroxyvitamin D (25(OH)D) dan kadar plasma RVD serta hubungannya dengan IB pada pasien kusta. Penelitian ini berupa observasional-analitik dengan desain potong lintang. Sebanyak 28 subjek penelitian (SP) menjalani pemeriksaan slit-skin smear kemudian diagnosis kusta ditegakkan berdasarkan tanda kardinal kusta. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan. Kadar serum 25(OH)D diperiksa dengan metode chemiluminescent immunoassay (CLIA) dan kadar plasma RVD dilakukan dengan metode enzyme linked immunosorbent assay (ELISA). Median kadar serum 25(OH)D adalah 12,68 ng/ml (4,88 – 44,74). Median kadar plasma RVD adalah 1,36 ng/ml (0,26 – 8,04). Berdasarkan analisis regresi multivariat, tidak terdapat hubungan antara IB dengan kadar serum 25(OH)D dan kadar plasma RVD (R square = 0,055). Tedapat korelasi positif kuat antara kadar serum 25(OH)D dengan skor pajanan sinar matahari (r = 0,863; p < 0,001).

One of many immunity system’s roles against M. leprae infection is macrophage response through its interaction with vitamin D and vitamin D receptor (VDR). The interaction between vitamin D and VDR in various immune cells will stimulate the expression of cathelicidin. The objective is to analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with IB in leprosy patients. This observational analytic study was performed with cross-sectional design. A total of 28 subjects underwent a slit-skin smear examination and then the diagnosis of leprosy was made based on the cardinal signs. This study also assessed the patient’s sun exposure with weekly sun exposure questionnaire. Serum 25(OH)D level was assessed with chemiluminescent immunoassay (CLIA) method and RVD plasma level was measured by enzyme linked immunosorbent assay (ELISA). Median serum level of 25(OH)D was 12.68 ng/ml (4.88 – 44.74). Median plasma level of VDR was 1.36 ng/ml (0.26 – 8.04). Based on multivariate regression analysis, there was no significant association between BI and serum level of 25(OH)D and plasma level of VDR (R square = 0.055). There was strong positive correlation between serum level of 25(OH)D and sun exposure score (r = 0.863; p < 0.001)."

Depok: Fakultas Kedokteran Universitas Indonesia, 2022

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Reni Ratnawati

Korelasi antara kadar vitamin D dengan indikator Z-skor BB/TB pada anak usia 6 sampai 59 bulan di Indonesia = correlation between vitamin D level and weight/height Zscore for children age 6-59 month in Indonesia

"Latar belakang: Status gizi dan kadar vitamin D adalah dua masalah yang menjadi sorotan di dunia karena masih banyak negara dengan kejadian status gizi yang buruk dan defisiensi kadar vitamin D pada anak termasuk negara Indonesia. Anak dengan usia dibawah lima tahun dengan berat badan normal dan pendek dapat mengalami berat badan berlebih di kemudian hari. Kadar vitamin D yang menurun pada BMI lebih tinggi menjadi kemungkinan adanya pengaruh antara kadar vitamin D dengan status gizi.

Tujuan: Mengetahui korelasi antara kadar vitamin D dengan status gizi anak Metode: Penelitian ini merupakan penelitian potong lintang. Menggunakan data dari SEANUTS II bulan September 2019 – Maret 2020. Digunakan 132 sampel pada anak usia 6-59 bulan di Indonesia yang memenuhi kriteria penelitian dengan random sampling. Hasil kadar vitamin D dari hasil pemeriksaan lab, asupan vitamin D menggunakan food recall 24 jam, dan status gizi diukur dengan Z-skor BB/TB. Kemudian dilakukan uji normalitas Kolmogorov- Smirnov dan uji korelasi Spearman.

Hasil: Status gizi anak usia 6-59 bulan di Indonesia 89,4% memiliki status gizi normal.Sebanyak 88,6% anak kurang mendapatkan asupan vitamin D sesuai dengan rekomendasi AKG. Didapatkan 90,2% anak mengalami defisiensi vitamin D. Ditemukan korelasi bermakna antara asupan vitamin D dan kadar. Vitamin D (r= 0,234, nilai p=0,007). Tidak ada korelasi bermakna antara kadar vitamin D dengan Z skor BB/ TB ( r= -0,016, p=0,854).

Simpulan: Tidak terdapat korelasi antara kadar vitamin D dengan Z-skor BB/TB pada anak usia 6-59 bulan di Indonesia.

Background: Nutritional status and vitamin D levels are two highlighted global problem because there are still many countries with incidence of poor nutritional status and deficiency of vitamin D in children, including Indonesia. Children under five years of age with normal weight and short can develop to overweight later in life if not treated. A decreased vitamin D level at a higher BMI is a possible influence between vitamin D levels and nutritional status.
Objective: To determine the correlation between vitamin D levels and children's nutritional status Methods: This research is a cross sectional study. Using data from SEANUTS II collected from September 2019 until March 2020. A total of 132 samples children aged 6-59 months in Indonesia who met the research criteria chosen by random sampling. Vitamin D levels data from lab tests, vitamin D intake record with 24- hour food recall, and nutritional status was measured based on Z-score BW / TB. Then, performed normality test with Kolmogorov- Smirnov and correlation test with Spearman.
Results: The nutritional status of children aged 6-59 months in Indonesia 89,4% had normal nutritional status. Most of the children ( 88.6% ) did not get enough vitamin D intake according to the RDA recommendation. It was found that 90.2% of children had vitamin D deficiency. There was a significant correlation between vitamin D intake and levels. Vitamin D (r = 0.234, p value = 0.007). There was no significant correlation between vitamin D levels and Z score BW / TB (r = -0.016, p = 0.854).
Conclusion: There was no correlation between vitamin D levels and Z-score Weight/Height in children aged 6-59 months in Indonesia."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020

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