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Andika Dwiputra Djaja
Pengaruh pajanan extreme low frequency pulsed electromagnetic field dalam proses penyembuhan fraktur delayed union femur tikus sprague dawley kajian terhadap skor radiologi rust dan failure load dari pemberian gaya radiologi rust dan failure load dari pemberian gaya aksial = The effect of extreme low frequency pulsed electromagnetic field exposure in the healing process of sprague dawley mouse delayed union femur fracture study of rust radiology score and failure load of axial force
"Pendahuluan: Fraktur adalah salah satu penyakit yang menjadi permasalahan yang cukup besar dalam bidang kesehatan di dunia, terutama di negara berkembang. Secara umum fraktur dapat sembuh dengan normal. Pada beberapa kondisi, penyembuhan fraktur mengalami komplikasi seperti delayed union atau non union. Penyembuhan fraktur yang sukses merupakan suatu interaksi yang kompleks antara proses angiogenesis dan osteogenesis. Stimulus fisika berupa pajanan PEMF (pulsed electromagnetic fields) menunjukkan pengaruh proses osteogenesis baik dalam tahap perkembangan penulangan embrio dan tahap penyembuhan fraktur.
Tujuan: Penelitian ini bertujuan untuk mengetahui penyembuhan fraktur tulang delayed union pada hewan coba pada pemberian ELF-PEMF dengan melihat skor radiologi RUST dan Failure Load dari Pemberian Gaya Aksial.
Metode: Dilakukan uji eksperimental pada 56 hewan coba di Laboratorium Hewan Departemen Gizi, Fakultas Kedokteran Universitas Indonesia, dengan membandingkan nilai RUST Score dan Load Score pada kedua kelompok hewan coba.
Hasil: Penelitian dilakukan selama Agustus-September 2018. Tidak ada perbedaan karakteristik hewan coba pada penelitian. Didapati bahwa terdapat perbedaan bermakna Rust Score pada kelompok perlakuan dan kelompok kontrol pada setiap minggu pemeriksaan dan terdapat perbedaan bermakna Load Score pada minggu keempat dan kelima.
Kesimpulan: Penelitian ini menyimpulkan terdapat perbaikan penyembuhan fraktur delayed union pasca pemberian ELF-PEMF dilihat dari perbedaan nilai Rust score dan load score.
Background: Fracture is a major health problem in the world, especially in developing countries. Usually, fractures can heal normally. In some conditions, the healing process becomes delayed union or non union. Successful healing of fractures is a complex interaction between angiogenesis and osteogenesis. Physical stimuli such as exposure of PEMF (pulsed electromagnetic fields) influences the osteogenesis process both in the development stage of embryo reinforcement and the fracture healing stage.
Objective: The aim is to determine the healing of delayed union fractures in experimental animals after exposure to ELF-PEMF.
Methods: The experimental study was conducted at Department of Nutrition Animal Laboratory, Faculty of Medicine, Universitas Indonesia with 56 experimental rats. The study was conducted by comparing the RUST Score and Load Score values ​​in the two experimental animal groups
Result: The study was conducted during August-September 2018 There was no difference in animal characteristics in the study. There was significant difference in Rust Score in both groups in each examination week and there were significant differences in Load Score in the fourth and fifth weeks.
Conclusion: There was improvement in delayed union fracture healing after the administration of ELF-PEMF as seen from the difference in Rust score and load score."
Depok: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Tesis Membership  Universitas Indonesia Library
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Panjaitan, Troydimas
Efek inhibisi enzim konversi angiotensin pada proses penyembuhan fraktur model delayed union uji eksperimental pada tikus sprague dawley = Inhibition effect of angiotensin converting enzyme to fracture healing in delayed union model experimental study in sprague dawley rats
"Latar Belakang Hipertensi dan fraktur merupakan masalah kesehatan yang sering terjadi ACE inhibitor telah dilaporkan dapat mempromosikan diferensiasi osteoblas meningkatkan mineralisasi dan sekresi matriks tulang sehinga konsumsinya diharapkan mampu mempercepat penyembuhan Tujuan Penelitian bertujuan mengetahui efek pemberian ACE inhibitor terhadap proses penyembuhan fraktur model delayed union Metode Enam belas femur tikus yang dibuat sesuai model delayed union dibagi secara acak menjadi kelompok kontrol kelompok perlakuan Captopril dosis 4 mg kgBB kelompok perlakuan Captopril dosis 8 mg kgBB dan kelompok Captopril dosis 16 mg kgBB Evaluasi dilakukan pada minggu ke 4 secara radiologis foto polos dan histomorfometri Hasil Pada histomorfometri minggu ke 4 didapatkan peningkatan area penulangan yang bermakna terhadap kontrol p 0 033 terutama pada pemberian Captopril dosis 8 mg kgBB p 0 008 dan dosis 16 mg kgBB p 0 015 Penurunan area fibrosa yang bermakna terhadap kontrol p 0 042 terjadi pada Captopril dosis 4 mg kgBB p 0 020 dan dosis 8 mg kgBB p 0 012 Secara radiologis didapatkan peningkatan skor RUST semua kelompok perlakuan yang bermakna terhadap kontrol p 0 021 Kesimpulan Pemberian Captopril dapat menstimulasi proses penyembuhan fraktur pada model delayed union secara radiologis dan histomorfometri Captopril dosis 8 mg kgBB menunjukkan efek yang paling signifikan dalam proses penyembuhan fraktur."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Annas Sumeru
Analisis praktik residensi keperawatan medikal bedah pada pasien dengan multiple fraktur dan sindroma kompartemen dengan penerapan model teori adaptasi roy di Rumah Sakit Umum Pusat Fatmawati Jakarta dan Rumah Sakit Orthopedi Prof Soeharso Surakarta = Analysis of medical surgical nursing clinical practise of residency on patient with multiple fracture and compartment syndrome using roy adaptation model approach in RSUP Fatmawati Jakarta and RSOP Prof Soeharso Surakarta
"Sistem muskuloskeletal memberikan perlindungan terhadap organ vital tubuh gangguan pada sistem tersebut memberikan dampak serius bagi kondisi kesehatan seseorang kualitas hidup keuangan kenyamanan fisik dan kesehatan psikologis Penyakit dan cidera di Indonesia paling banyak merupakan kejadian patah tulang Pada kondisi patah tulang dapat mengakibatkan insufisiensi vaskuler dan kompresi saraf serta sindroma kompartemen Perawat spesialis medikal bedah berperan penting dalam penatalaksanaan asuhan keperawatan melalui pendekatan Model Adaptasi Roy pada kasus multipel fraktur dan sindroma kompartemen penerapan pemberian edukasi singkat dan latihan relaksasi nafas dalam sebagai upaya menurunkan nyeri pada klien post operasi ORIF Open Reduction Intra Fixation serta peran sebagai inovator melalui pengembangan program SBAR Situation Background Assessment Recommendation dalam handover perawat ruangan Hasil analisis praktik menunjukkan bahwa Model Adaptasi Roy sesuai dalam pengelolaan asuhan keperawatan pada multipel fraktur dan sindroma kompartemen Pemberian edukasi singkat dan latihan relaksasi nafas dalam mampu menurunkan tingkat nyeri secara efektif hingga hari ke 7 setelah operasi pemasangan ORIF Pengembangan program SBAR dilakukan melalui pembuatan panduan berdasarkan kasus yang sering terjadi di ruangan bedah orthopedi RSUP Fatmawati sehingga melalui panduan tersebut perawat dapat melakukan timbang terima menggunakan SBAR khususnya pada pasien dengan gangguan muskuloskeletal Kata kunci Model Adaptasi Roy fraktur multipel Edukasi singkat dan nafas dalam SBAR Depok 21 Agustus 2015 Mengetahui Suvervisor Utama Mahasiswa Dr Debie Dahlia S Kp MHSM Annas Sumeru.
The musculoskeletal system provides protection against the body 39 s vital organs disturbances in the system create serious implications for a person 39 s health condition quality of life financial physical comfort and psychological health Disease and injury in Indonesia mostly caused by incidence of fractures Fractures could possibly lead to vascular insufficiency and nerve compression as well as compartment syndrome Medical surgical nurse specialist plays an important role in the management of nursing care by Roy Adaptation Model approach in the case of multiple fractures and compartment syndrome the application of brief educational and breathing relaxation exercises to reduce pain level of patient attempt ORIF Open Reduction Intra Fixation as well as a role as innovator through the development of SBAR Situation Background Assessment Recommendation programs for nurse handover The results of the analysis of practices shows that Roy Adaptation Model fit in the management of nursing care in multiple fractures and compartment syndrome Giving a brief educational and breathing relaxation exercises able to effectively reduce pain until the 7th day after ORIF surgery SBAR program development is done through the creation of guidelines based on the case that often occur in orthopedic ward of RSUP Fatmawati so that through the guidance of nurses can using SBAR particularly in patients with musculoskeletal disorders Keywords Roy Adaptation Model multiple fracture brief educational and breathing relaxation exercise SBAR Depok 21 Agustus 2015 Mengetahui Suvervisor Utama Mahasiswa Dr Debie Dahlia S Kp MHSM Annas Sumeru."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Grace Boaz
Hasil Fungsional Operasi ORIF pada Pasien Fraktur Midface di Divisi Bedah Plastik Rumah Sakit Cipto Mangunkusumo Tahun 2009-2014 = Functional Outcome of ORIF Surgery on Midface Fracture Patients in Plastic Surgery Division Cipto Mangunkusumo Hospital from 2009-2014
"[Pendahuluan:
Fraktur yang mengenai midface akan menyebabkan gangguan fungsi baik fungsi mata maupun oklusi. Walaupun angka kejadian fraktur midface cukup tinggi, terdapat gangguan fungsional, dan membutuhkan biaya yang besar untuk tatalaksana menggunakan mini plate dan screw, tidak ada informasi mengenai hasil fungsional setelah tatalaksana fraktur midface.
Metode:
Data mengenai status fungsional pasien dengan fraktur midface sebelum operasi ORIF didapatkan dari data rekam medis dan data setelah operasi ORIF didapatkan dari pemeriksaan objektif dan subjektif. Status fungsional meliputi diplopia, gerakan bola mata, maloklusi, dan gangguan nervus fasialis dan nervus infraorbita.
Hasil:
Semua pasien yang dievaluasi menunjukkan perbaikan status fungsional setelah operasi ORIF.
Kesimpulan:
Pasien dengan fraktur midface yang telah menjalani operasi ORIF di Divisi Bedah Plastik Rumah Sakit Cipto Mangunkusumo menunjukkan adanya perbaikan pada diplopia, gerakan bola mata, oklusi, dan fungsi nervus fasialis dan infraorbita pada evaluasi jangka panjang.;Background:
Fractures involving the midface present more challenges due to the impairment on function both occlusion and visual function. In spite of the high number of occurrence, high impact to the impairment on function, and high cost in the treatment due to relatively expensive hardware required (mini plate and screw), there is inadequate information about the outcome after treating midface fracture.
Methods:
Data on functional status of patients with midface fracture before ORIF surgery collected from medical records and data after ORIF surgery gathered objectively and subjectively. Functional status including diplopia, eye motility, cranial facial nerve impairment, infraorbita nerve impairment and malocclusion.
Results:
All of the patients that have been evaluated was showing improvement in total functional status after treatment with ORIF surgery.
Conclusion:
Midface fracture patients underwent ORIF surgery in Plastic Surgery Division, Cipto Mangunkusumo hospital, resulted in the recovery of eye motility function, diplopia, malocclusion and facial and infraorbital nerve impairment at longterm evaluation., Background:
Fractures involving the midface present more challenges due to the impairment on function both occlusion and visual function. In spite of the high number of occurrence, high impact to the impairment on function, and high cost in the treatment due to relatively expensive hardware required (mini plate and screw), there is inadequate information about the outcome after treating midface fracture.
Methods:
Data on functional status of patients with midface fracture before ORIF surgery collected from medical records and data after ORIF surgery gathered objectively and subjectively. Functional status including diplopia, eye motility, cranial facial nerve impairment, infraorbita nerve impairment and malocclusion.
Results:
All of the patients that have been evaluated was showing improvement in total functional status after treatment with ORIF surgery.
Conclusion:
Midface fracture patients underwent ORIF surgery in Plastic Surgery Division, Cipto Mangunkusumo hospital, resulted in the recovery of eye motility function, diplopia, malocclusion and facial and infraorbital nerve impairment at longterm evaluation.]"
Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Marpaung, Yanthi
Analisis praktik klinik Keperawatan Kesehatan Masyarakat Perkotaan (KKMP) pada pasien fraktur radius ulna di Rumah Sakit Cipto Mangunkusumo = The analysis of clinical practice of Urban Nursing on patient with radius ulna fracture at Cipto Mangunkusumo Hospital
"[ABSTRAK
Keperawatan kesehatan masyarakat perkotaan merupakan bagian keperawatan
komunitas yang memfokuskan pelayanan pada penyelesaian masalah kesehatan.
Masyarakat perkotaan memiliki karakteristik yaitu padat penduduk, tingginya angka
pertumbuhan kendaraan bermotor, dan mobilitas yang tinggi. Karakteristik ini
mempengaruhi pola aktivitas masyarakat, salah satunya penggunaan alat transportasi
untuk efektivitas waktu. Faktor mobilitas yang tinggi, tingginya angka pertumbuhan
kendaraan, dan ketidakdisiplinan pengemudi kendaraan menimbulkan risiko
kecelakaan yang berdampak pada masalah kesehatan salah satunya fraktur. Selama
praktik di ruang bedah RSUP Cipto Mangunkusumo penulis mengambil kasus klien
fraktur radius ulna dengan ansietas tinggi selama hospitalisasi. Penulis menganalisis
salah satu tindakan keperawatan untuk mengurangi ansietas klien.ABSTRACT Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety;Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety;Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety, Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Persepsi klien fraktur yang mengalami nyeri pada teknik relaksasi napas dalam yang diberikan untuk menurunkan nyeri
"Penelitian ini bertujuan untuk mengetahui persepsi klien fraktur yang mengalami nyeri pada teknik relaksasi napas dalam. Desain peneiitian yang digunakan adalah deskriptif sederhana. Responden di ambil di RSUPN Cipto Mangunkusumo IRNA A lantai H1 kiri dan lantai IV kanan dengan kriteria klien fraktur yang pemah melakukan napas dalam. Instrumen pengumpulan data berupa kuisioner dengan 4 data tentang demografi dan 17 pertanyaan tentang persepsi. Hasil penelitian menunjukkan 75% klien persepsinya positif dan 25% yang lain persepsinya negatif terhadap napas dalam. Keberhasilan napas dalam yang dilakukan oleh klien salah satunya dipengaruhi oleh keterlibatan perawat dalam memberikan penjelasan tentang cara melakukan napas dalam dengan tepat. Kondisi dilapangan menunjukkan. 42% perawat memberikan penjelasan kepada klien sedangkan 58% lainnya tidak. Penelitian ini akhirnya menyimpulkan bahwa persepsi klien fraktur pada napas dalam cukup positif."
Fakultas Ilmu Keperawatan Universitas Indonesia, 2001
TA5067
UI - Tugas Akhir  Universitas Indonesia Library
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Sahrudin
Analisis praktik keperawatan kesehatan masyarakat perkotaan pada pasien post Open Reduction Internal Fixation (ORIF) fraktur tibia fibula tertutup dengan intervensi ambulasi di Ruang Angrek tengah kanan RSUP Persahabatan. = Analysis of professional practice of urban health nursing in patients post Open Reduction Internal Fixation (ORIF) tibia fibula closed fracture with ambulation intervention in Anggrek tengah kanan ward At Persahabatan Hospital.
"[ABSTRAK
Mayoritas populasi masyarakat dunia menepati daerah perkotaan. Akibat dari
kepadatan penduduk di daerah perkotaan timbul masalah yang berkaitan dengan lalulintas
salah satunya adalah tingginya jumlah kecelakaan lalu-lintas. Fraktur
merupakan salah satu akibat dari kecelakaan lalu-lintas yang memerlukan
penanganan segera untuk mempertahankan anatomi dan fungsi tubuh seperti semula.
Pasien post ORIF tibia dan fibula memerlukan tindakan ambulasi untuk
memperlancar sistem peredaran darah pasien. Karya ilmiah ini bertujuan untuk
menganalisis intervensi keperawatan ambulasi yang diberikan pada pasien post ORIF
fraktur tibia dan fibula di Ruang Angrek tengah kanan RSUP Persahabatan. Pasien
yang dilakukan tindakan ambulasi secara bertahap adalah pasien dapat terhindar dari
komplikasi akibat vaskularisasi yang buruk, dapat mempercepat proses penyembuhan
serta memperpendek masa perawatan pasien di rumah sakit.ABSTRACT The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.;The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.;The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital., The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Indhina Reihannisha
Pemajanan Pulsed Electromagnetic Field Pada Penyembuhan Fraktur Femur Tikus Model Delayed Union: Tinjauan Ekspresi RANK, RANKL, dan OPG Pada Kalus = Exposure of Pulsed Electromagnetic Field on Rat Femoral Fracture Healing Process in Delayed Union Model: A Study on RANK, RANKL and OPG Expression in Callus
"

Latar belakang : Fraktur tulang banyak terjadi pada kecelakaan lalu lintas, dan juga berasal dari osteoporosis. Penyembuhan fraktur tulang diperlukan untuk mengembalikan tulang secara normal. Prosesnya terdiri dari tiga tahap yaitu tahap inflamasi, perbaikan dan remodeling tulang. Keseimbangan remodeling tulang ini diatur oleh osteoblas dan osteoklas. Gen receptor activator of nuclear factor kappa-B (RANK) dengan receptor activator of nuclear factor kappa-B ligand (RANKL) adalah pengaktif osteoklas. receptor activator of nuclear factor kappa-B ligand RANKL dengan osteoprotegerin (OPG) adalah penghambat osteoklas. Pulsed electromagnetic field (PEMF) sebagai salah satu aplikasi alat medis dalam penyembuhan fraktur tulang.

Tujuan : Mengetahui efek pajanan PEMF pada ekspresi RANK, RANKL dan OPG dalam membantu proses penyembuhan fraktur tulang.

Metode : Penelitian ini merupakan penelitian eksperimental in vivo menggunakan sampel dari kalus fraktur tulang femur yang tersimpan. Sampel diambil dari jaringan tulang tikus yang telah terfraktur dengan model delayed union dan dibagi menjadi dua kelompok (tanpa pemajanan dengan pemajanan PEMF). Metode menggunakan qPCR dan analisis data menggunakan two way ANOVA dan korelasi Pearson.

Hasil : Ekspresi RANK menunjukkan adanya perbedaan bermakna di hari ke 5,10,18 dan 28 pada kelompok tanpa pajanan PEMF sedangkan pada  kelompok  pajanan PEMF di hari ke 5,18 dan 28 (p<0,05). Perbedaan bermakna ekspresi RANKL di hari ke 5,10,18 dan 28 pada kelompok tanpa pajanan dengan pajanan PEMF di hari ke 18 dan 28 (p<0,05)  Perbedaan bermakna ekspresi OPG di hari ke 10 dan 28  pada tanpa pajanan dengan pada pajanan PEMF di hari ke 5,18 dan 28 (p<0,05). Hasil dari uji korelasi pearson tanpa pajanan memperlihatkan RANKL dengan OPG mempunyai korelasi positif yang bermakna dengan nilai r=0,60 , p=0,03 (p<0,05). Hasil uji korelasi pearson yang dipajan dengan PEMF menunjukkan korelasi positif yang bermakna pada RANK dengan OPG  dan mempunyai nilai r=0,73 , p=0,008 (p<0,05).

Kesimpulan : Ekspresi RANK, RANKL dan OPG yang tidak diberikan pajanan memperlihatkan proses delayed union. Pajanan PEMF mempengaruhi ekspresi RANK, RANKL dan OPG dengan memperlihatkan proses normal union. Korelasi RANKL dengan OPG terlihat pada kelompok tanpa pajanan. Korelasi RANK dengan OPG terlihat pada kelompok yang diberikan pajanan PEMF.

 

Background : Many bone fractures occur in traffic accidents, and also come from osteoporosis. Healing of bone fractures is needed to restore bone normally. The process consists of three stages, namely the inflammatory, bone repair and remodeling. Bone remodeling balance is regulated by osteoblasts and osteoclasts. The receptor activator of nuclear factor kappa-B (RANK) gene with the receptor activator of nuclear factor kappa-B ligand (RANKL) is an osteoclast activator. The receptor activator of nuclear factor kappa-B ligand RANKL with osteoprotegerin (OPG) is an osteoclast inhibitor. Pulsed electromagnetic field (PEMF) as one of the applications of medical devices in healing bone fractures.

Purpose : To find out the effects of PEMF exposure on RANK, RANKL and OPG expression in helping the process of bone fracture healing.

Method : This research is an in vivo experimental study using samples from stored fracture of the femur bone callus. Samples were taken from bone tissue of rats that had been fractured with delayed union models and divided into two groups (without exposure and PEMF exposure). The method of using qPCR and data analysis using two way ANOVA and Pearson correlation.

Result : RANK expression showed a significant difference on days 5.10,18 and 28 in the group without exposure to PEMF while in the PEMF exposure group on days 5.18 and 28 (p <0.05). Significant differences in RANKL expression on days 5,10,18 and 28 in the group without exposure to PEMF exposure on days 18 and 28 (p <0,05) Significant differences in OPG expression on days 10 and 28 in non-exposure to exposure PEMF on days 5.18 and 28 (p <0.05). The results of the Pearson correlation test without exposure showed that RANKL with OPG had a significant positive correlation with a value of r = 0.60, p = 0.03 (p <0.05). Pearson correlation test results exposed with PEMF showed a significant positive correlation on RANK with OPG and had a value of r = 0.73, p = 0.008 (p <0.05).

Conclusion : RANK expression, RANKL and OPG that are not given exposure show delayed union processes. Exposure to PEMF affects the expression of RANK, RANKL and OPG by showing the normal union process. Correlation of RANKL with OPG was seen in groups without exposure. RANK correlation with OPG was seen in the group given PEMF exposure.

"
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
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UI - Tesis Membership  Universitas Indonesia Library
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Agus Maruli
Peran Vitamin C Oral Terhadap Percepatan Penyembuhan Fraktur pada Fraktur dengan periosteal stripping di Femur Tikus Putih Sprague Dawley = The Role of Vitamin C in Enhancement of fracture healing in Fracture with Periosteal Stripping at Sprague Dawley white rats Femur
"Penyembuhan fraktur masih merupakan masalah besar. Banyak hal dilakukan
untuk mempercepat penyembuhan fraktur dan menghindari komplikasi
penyembuhan fraktur. Pemberian vitamin C salah satunya. Penelitian ini bertujuan
untuk mengetahui peran vitamin C dalam mempercepat penyembuhan fraktur
pada fraktur dengan periosteal stripping di femur tikus putih Spague Dawley
Evaluasi percepatan penyembuhan fraktur dilakukan secara radiologis dengan
skor RUST dan histologis dengan histomorphometri. Penelitian ini adalah
penelitian eksperimental. Penilaian dilakukan terhadap 32 ekor tikus dengan
dosis vitamin C yang berbeda-beda dan dievaluasi pada minggu ke 2 dan minggu
ke 4. Terdapat percepatan penyembuhan fraktur pada kelompok dengan dosis
besar pada skor RUST di minggu ke-4. Secara histologis pada histomorphometri
didapatkan percepatan penyembuhan fraktur,tetapi secara statistik tidak bermakna.
Fracture Healing still became a problem. There are many things to do to enhance
and avoid the complication of fracture healing. Vitamin C is one of the way to
enhance the fracture healing.. The purpose of this study is to know the role of
vitamin C in enhancement the fracture healing in fracture with periosteal stripping
at white rats femur. The evaluation of enhancement of fracture healing used
radiograpic with RUST score and histologic with histomorphometry. This is an
experimental study. The study used 32 rats which were given vitamin C in
different dosage and was evaluated at the 2nd and 4th week. There is
enhancement of fracture healing in all dosage, especially the large dosage of
vitamin C in RUST score evaluation in the 4th week. In histomorphometry
evaluation there were enhancement of fracture healing but statistically no
significant"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tesis Membership  Universitas Indonesia Library
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Umiatin
Pengaruh Pajanan Pulsed Electromagnetic Field (PEMF) Terhadap Kecepatan Penyembuhan Fraktur Model Delayed Union Tikus Spraque-Dawley Melalui Jalur Sinyal Wnt = Effect of Pulsed Electromagnetic Field (PEMF) Exposure on the Healing Rates of Delayed Union Fracture Model Via Wnt Signaling Pathway gy and Alkaline Phosphatase Activity of Delayed Union Fracture Model on Rats
"

Fraktur delayed union dan union sampai saat ini masih menjadi tantangan para dokter orthopaedi. Berbagai terapi menggunakan metode biologi dan biofisika digunakan untuk mendorong penyembuhan fraktur nonunion. Penelitian ini bertujuan untuk mengevaluasi penggunaan stimulasi PEMF (Pulsed Electromagnetic Fields) untuk mempercepat penyembuhan fraktur model delayed union dengan menggunakan hewan coba. Sebanyak dua puluh empat tikus Spraque Dawley dikelompokan menjadi dua yaitu kelompok Kontrol dan kelompok PEMF. Kelompok PEMF mendapatkan pajanan medan magnet dinamik dengan intensitas 1.6 mT, frequency 50 Hz dan lama pajanan 4 jam /hari selama 7 hari / minggu. Kemajuan penyembuhan fraktur dinilai secara histopatologi dengan metode histomorfometri dan secara biokimia pada hari ke 5, 10, 18 dan 28 paska fraktur. Parameter histomorfometri yang dievaluasi adalah persentase area fibrosa, tulang rawan dan tulang. Penanda biokimia penyembuhan fraktur yang dievaluasi adalah Alkaline Phosphatase pada serum darah yang diperiksa menggunakan metode Elisa. Hasil pemeriksaan histomorfometri menunjukkan pada kelompok PEMF, jaringan fibrosa menurun secara signifikan pada tahap awal penyembuhan fraktur. Aktivitas Alkaline Phosphatase meningkat signifikan menunjukkan kenaikan aktivitas osteoblas dalam membentuk matrik tulang. Berdasarkan analisis statistic menunjukkan adanya korelasi yang bermakna antara aktivitas Alkaline Phosphatase dengan presentasi jaringan tulang pada hari ke 10 paska fraktur, hal ini menunjukkan bahwa ALP dapat digunakan sebagai penanda awal proses penyembuhan fraktur.

 

Delayed union and non-union fracture remain a major clinical challenge for the orthopedic surgeon. Many biophysical and biological modalities can be used to promote healing of non-union. The aim of this study was to evaluate the healing process of femoral delayed union fracture model after pulsed electromagnetic field (PEMF) stimulation. Twenty four rats were randomized into two groups; Control group and PEMF group, administration of PEMF stimulation (1.6 mT, frequency 50 Hz, 4 hours/day). The progression of healing was evaluated by histomorphometry and biochemical assessment at days 5, 10, 18 and 28 post fracture. The histomorphometry parameters were evaluated; percentages area of fibrous, cartilage and osseous tissue.  The serum biochemical marker of bone healing, Alkaline Phosphatase was determined using ELISA kit. Histomorphometry evaluation showed that in PEMF groups, fibrous tissue significantly decreased in the early phase of fracture healing. Alkaline phosphatase activity increased significantly in the PEMF group which indicated an increase in osteoblast activity in the bone matrices formation. The results of this study also showed a strong postitive correlation between ALP activity and bone formation on the 10th day after fracture, so that ALP can be used as a markers to assess fracture healing in the early stages.

 

"
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
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UI - Disertasi Membership  Universitas Indonesia Library
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