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"ABSTRAK Severe gingival enlargement (GE) is one of the most commonly observed adverse effects in patients who have undergone renal transplants due to the use of cyclosporine A. Objectives: We aimed to gain more insight into the prevalence of GE in patients with renal transplants. Methods: We searched the PubMed and Web of Science databases for relevant studies from January 1990 to January 2018. Using random effects models, we calculated summary incidence rates and 95% confidence intervals (CIs). Results: A total of 595 patients from 10 studies were included. Patients using cyclosporine A with or without any other drugs had a 62.6% (95% CI, 41.9% until 79.5%) incidence of GE. Subgroup analysis according to diagnostic criteria showed that the incidence of GE was lower when using well defined diagnostic criteria or scoring system. The incidence of GE was 88.2% (95% CI, 80.9% until 93.0%) in patients using cyclosporine A with nifedipine. Cyclosporine A without nifedipine was associated with a significantly decreased risk of GE incidence when compared with the combination of cyclosporine A and nifedipine (odds ratio:0.198, 95% CI, 0.083 until 0.473, P < 0.001). Conclusions: It is important for all clinicians to know the effects of the aforementioned drugs and the treatment options. "

"PURPOSE: To clarify the risk factors for complications after diverting ileostomy closure in patients who have undergone rectal cancer surgery.METHODS: The study group comprised 240 patients who underwent a diverting ileostomy at the time of lower anterior resection or internal anal sphincter resection, in our department, between 2004 and 2015. Univariate and multivariate analyses of 18 variables were performed to establish which of these are risk factors for postoperative complications.RESULTS: The most common complications were intestinal obstruction and wound infection. Univariate analysis showed that an age of 72 years or older (p = 0.0028), an interval between surgery and closure of 6 months or longer (p = 0.0049), and an operation time of 145 min or longer (p = 0.0293) were significant risk factors for postoperative complications. Multivariate analysis showed that age (odds ratio, 3.4236; p = 0.0025), the interval between surgery and closure (odds ratio, 3.4780; p = 0.0039), and operation time (odds 2.5179; p = 0.0260) were independent risk factors.CONCLUSIONS: Age, interval between surgery and closure, and operation time were independent risk factors for postoperative complications after diverting ileostomy closure. Thus, temporary ileostomy closure should be performed within 6 months after surgery for rectal cancer."

"Strabismus merupakan suatu masalah kesehatan yang memiliki dampak negatif yang besar pada kualitas hidup seseorang. Strabimus tidak hanya menyebabkan terjadinya permasalahan dari aspek fungsi, tetapi juga permasalahan pada aspek psikososial. Studi ini bertujuan membandingkan kualitas hidup pada pasien strabismus dewasa yang belum dilakukan operasi koreksi strabismus dan pasien strabismus dewasa yang sudah dilakukan operasi koreksi strabismus menggunakan kuesioner AS-20 versi Indonesia. Studi ini merupakan studi potong lintang perbandingan Terdapat 84 subjek dalam penelitian ini dan dibagi menjadi 2 kelompok yaitu kelompok yang belum dilakukan operasi koreksi strabismus dan sudah dilakukan operasi koreksi strabismus dengan jumlah tiap kelompok sebanyak 42 subjek.  Setiap subjek dilakukan pemeriksaan mata menyeluruh dan pemeriksaan strabismus. Setelah itu pasien diminta mengisi kuesioner AS-20 versi Indonesia. Hasil studi menunjukan pada pasien strabismus dewasa yang belum dilakukan operasi koreksi strabismus mempunyai kualitas hidup yang lebih rendah secara fungsi dan psikososial dibandingkan pasien strabismus dewasa yang sudah dilakukan operasi koreksi strabismus (p<0,001). Selain itu terdapat faktor-faktor yang mempengaruhi penilaian kualitas hidup strabismus dewasa yaitu usia, diplopia dan deviasi.

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Strabismus is a health issue that has a significant negative impact on a person's quality of life. Strabismus not only causes functional problems but also psychosocial issues. This study aims to compare the quality of life in adult strabismus patients who have not undergone corrective surgery and those who have undergone corrective surgery using the Indonesian version of the AS-20 questionnaire. This study is a cross-sectional comparative study. There were 84 subjects in this study, divided into 2 groups: the group that had not undergone strabismus correction surgery and the group that had undergone strabismus correction surgery, with each group consisting of 42 subjects. Each subject underwent a comprehensive eye examination and a strabismus examination. After that, the patients were asked to complete the Indonesian version of the AS-20 questionnaire. After that, the patients were asked to complete the Indonesian version of the AS-20 questionnaire. The study results showed that adult strabismus patients who had not undergone strabismus correction surgery had a lower quality of life regarding function and psychosocial aspects compared to adult strabismus patients who had undergone strabismus correction surgery (p<0.001). Additionally, factors influenced the quality of life assessment in adult strabismus: age, diplopia, and deviation."

"Latar Belakang: Perlemakan hati metabolik (PHM) merupakan salah satu penyakit hati kronik yang diduga mempengaruhi keparahan penyakit Corona virus disease 2019 (COVID-19). Beberapa studi observasional menilai hubungan antara luaran pasien PHM yang terinfeksi SARS-CoV-2 menunjukkan hasil yang beragam, sehingga dibutuhkan studi telaah sistematik. Tujuan: Mengetahui pengaruh PHM terhadap luaran pasien dengan COVID-19 dibandingkan tanpa PHMMetode: Penulusuran literatur dilakukan melalui berbagai basis data daring seperti: PUBMED, Cochrane Library, ProQuest, ScienceDirect, dan EBSCOhost. Penilaian risiko bias dilakukan dengan menggunakan perangkat Newcastle Ottawa Scale untuk studi NRSIs oleh dua orang tim peneliti dan jika terdapat perbedaan akan diselesaikan oleh anggota tim peneliti yang lain. Meta-analisis akan dilakukan dengan perangkat Revman 5.4.1. Hasil telaah sistematis disajikan dalam bentuk tinjauan naratif. Hasil meta-analisis disajikan dalam bentuk forrest plot dengan menghitung pooled OR atau mean difference antara kelompok PHM dan non-PHM dari studi- studi yang dinilai beserta IK 95%.Hasil: Hasil meta-analisis menggunakan fixed effect model dari 7 studi menunjukkan bahwa pasien COVID-19 dengan PHM berhubungan dengan mortalitas lebih tinggi dibandingkan pasien COVID-19 tanpa PHM dengan pooled OR 1,47 (IK95% 1,22–1,77, p = < 0,0001, I2 48%). Akan tetapi, analisis luaran lainnya menunjukkan bahwa PHM tidak berhubungan dengan derajat keparahan COVID-19 yang lebih berat dibandingkan tanpa PHM (OR 3,12, IK95% 0,89–11,03, p=0,08, I2 92%). Analisis terhadap luaran perbedaan durasi rawat inap antara kedua kelompok dengan MD 1,27 (IK95% 0,03–2,52) dengan p sebesar 0,04 dan I2 80%. Kesimpulan: Pasien PHM yang terinfeksi SARS-CoV-2 berhubungan dengan mortalitas yang lebih tinggi dibandingkan pada pasien non-PHM, akan tetapi tidak berhubungan dengan derajat keparahan COVID-19 yang lebih berat dan durasi rawat inap yang lebih lama.

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Background: Previous observational studies showed conflicting results regarding the effect of metabolic associated fatty liver disease (MAFLD) on severity, mortality and length of stay of patients infected with SARS-CoV-2.

Aim: To determine outcomes of MAFLD patients infected with SARS-CoV-2.

Method: Literature searches were conducted through PUBMED, Cochrane Library, ProQuest, ScienceDirect, and EBSCOhost. The risk of bias assessment was performed using the Newcastle Ottawa Scale tool for NRSI studies. The meta-analysis was performed using the Revman 5.4.1 tool. The systematic review results were presented in the form of a narrative review. The meta-analysis results were presented in the form of a forest plot by calculating the pooled odds ratio or mean difference between the MAFLD and non-MAFLD groups from the evaluated studies with a 95% CI.

Results: Seven studies were included in the meta-analysis using fixed effect model and showed that COVID-19 patients with MAFLD was associated with higher mortality compared to without to non-MAFLD (OR=1.41, 95% CI 1.19–1.69, p=0.01, I2 48). However, there were no different in COVID-19 severity (OR 3.12, IK95% 0.89–11.03, p=0.08, I2 92) and length of hospital stay (MD 1.27, CI95% 0.03–2.52, p=0.04, I2 80) between the two groups. Conclusion: MAFLD patients infected with SARS-CoV-2 were associated with a higher mortality than non-MAFLD patients, but were not associated with a greater severity of COVID-19 and a longer duration of hospitalization."

"Latar Belakang: Disfungsi ereksi (DE) adalah salah satu penyakit sering ditemukan pada mereka yang menderita penyakit ginjal stadium akhir (ESRD). Meskipun transplantasi ginjal memperbaiki masalah ini pada beberapa pasien, sebanyak 20 hingga 50% penerimanya terus menderita DE. Sampai saat ini, literatur mengenai efek transplantasi ginjal terhadap DE masih kontroversial. Mayoritas penelitian menunjukkan bahwa pasien mendapatkan kembali fungsi ereksi setelah transplantasi ginjal, sedangkan penelitian lain menunjukkan efek minimal transplantasi terhadap status DE. Kami melakukan tinjauan sistematis untuk merangkum efek transplantasi ginjal terhadap status DE.Metode: Pencarian literatur sistematis di PubMed, Cochrane, dan Scopus, dilakukan pada bulan April 2020 dengan menggunakan kata bebas dan istilah MeSH. Kami memasukkan semua penelitian prospektif yang menyelidiki skor IIEF sebelum dan sesudah transplantasi pada penerima transplantasi ginjal dengan DE.Hasil: Pencarian database awal di PubMed dan Google Scholar menghasilkan 4.052 makalah. 42 makalah dipertimbangkan untuk analisis teks lengkap. Dari 42 teks lengkap yang dicari, empat diantaranya dimasukkan dalam tinjauan sistematis. Sebanyak 152 dari 230 subjek menunjukkan peningkatan fungsi ereksi melalui skor IIEF-5 setelah transplantasi ginjal. Meta-analisis yang dilakukan terhadap skor IIEF dan kadar Testosteron menunjukkan perbedaan yang signifikan sebelum dan sesudah transplantasi.Kesimpulan: Temuan kami telah mengkonfirmasi bahwa transplantasi ginjal meningkatkan fungsi ereksi. Dengan demikian, peningkatan signifikan dalam skor testosteron dan IIEF pasca transplantasi terbukti secara statistik dalam penelitian ini. Namun, karena jumlah penelitian yang ada terbatas, bukti yang ada pun terbatas. Penelitian lebih lanjut dengan metodologi yang lebih baik dan ukuran sampel yang lebih besar diperlukan untuk menyelidiki pengaruh transplantasi ginjal pada fungsi ereksi.

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Introduction: Erectile dysfunction (ED) is a major health burden worldwide frequently found in those with end-stage renal disease (ESRD) Although renal transplant improves the problem in some patients, as many as 20 to 50% of recipients continue to suffer ED. To this date, literature regarding the effect of kidney transplantation on ED has been contradictory. Majority of studies have shown that patients regain erectile function following renal transplant, whereas other studies showed minimal effect of transplantation on the status of ED.1,2 We did a systematic review to summarize the effects of kidney transplantation on the status of ED.

Methods: A systematic literature search on PubMed, Cochrane, and Scopus, were carried out in April 2020 by using both free words and MeSH terms. We included all prospective studies investigating the pre- and post-transplant IIEF scores of renal transplant recipients with ED.

Results: The initial database search on PubMed and Google Scholar produced 4,052 papers. 42 papers were considered for full-text analysis. Out of 42 full texts sought, four were included in the systematic review. A total of 152 out of 230 subjects showed improvement of erectile function by means of IIEF-5 score after renal transplantation. Meta-analysis performed on IIEF score and Testosterone level show significant differences pre and post-transplantation.

Conclusion: Our findings have confirmed that renal transplantation improves erectile function. Thus, significant improvement in testosterone and IIEF score post- transplantation were proven statistically in this study. However, as there were only a limited number of studies, the evidence is limited. Further studies with better methodology and larger sample size are needed to investigate the effect of renal transplantation on erectile function."

"Pendahuluan: Dalam memberikan panduan pencitraan pada nefrolitotomi perkutan (PCNL), ultrasonografi telah menjadi alternatif panduan dalam PCNL bebas sinar-x yang akan mengurangi radiasi baik pada pasien maupun operator. Meta-analisis ini menilai literatur secara kritis dengan membandingkan keamanan dan kemanjuran PCNL bebas sinar-x dan PCNL yang dipandu fluoroskopi dengan sub-analisis dalam posisi terlentang dan tengkurap. Metode: Pencarian literatur secara sistematis dilakukan menggunakan Wiley Library, Clinicalkey, dan Pubmed. Studi yang membandingkan fluoroskopi dan PCNL bebas sinar-x hingga Agustus 2020 disertakan. Hasil yang diukur termasuk tingkat bebas batu, waktu operasi, perdarahan, komplikasi, dan lama rawat rumah sakit. Meta-analisis dilakukan pada setiap hasil. Hasil: Dari 283 artikel yang teridentifikasi dari skrining, tujuh artikel dimasukkan ke dalam analisis kuantitatif dan kualitatif. Tingkat bebas batu (p=0,50), waktu operasi (p=0,83), perdarahan (p=0,41), komplikasi (p=0,20), dan lama rawat inap (p=0,27) pada kedua kelompok secara statistik tidak berbeda. Dalam sub-analisis, ditemukan bahwa komplikasi dan perdarahan signifikan secara statistik pada kelompok rawan, p=0,05 dengan OR 0,17 (95%CI 0,03-1,00) dan p=0,02 dengan OR 0,52 (95%CI 0,30-0,92) masing-masing. Kesimpulan: Bukti yang mendukung pendekatan pencitraan yang lebih baik masih terbatas saat ini. Namun, sebagai pendekatan alternatif untuk PCNL dengan ultrasonografi bebas x-ray, hal ini menawarkan keamanan yang lebih baik pada posisi tengkurap dan keamanan yang sebanding pada kelompok terlentang. Efikasi antara kedua kelompok ditemukan sebanding baik dalam sub-analisis terlentang dan tengkurap.

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Introduction: There are imaging guidances used for percutaneous nephrolithotomy (PCNL), Ultrasonography has been an alternative for guidance in x-ray free PCNL that would reduce radiation both in patients and operators. This meta-analysis critically appraises the literature comparing the safety and efficacy of x-ray free and fluoroscopy-guided PCNL with sub-analysis in supine and prone position.

Method: A systematic literature search using Wiley Library, Clinicalkey, and Pubmed. Studies comparing fluoroscopy and x-ray free PCNL up to August, 2020 were included. The outcome measured included the stone-free rate, operative time, bleeding, complication, and hospital length. Meta-analysis was conducted for each of the outcomes.

Result: Of 283 articles identified from screening, seven were included in quantitative and qualitative analysis. The stone-free rate (p=0.50), operative time (p=0.83), bleeding (p=0.41), complication (p=0.20), and hospital length of stay (p=0.27) in both groups statistically indifferent. In sub-analysis, we found that complication and bleeding statistically significant in prone group, p=0.05 with OR 0.17 (95%CI 0.03-1.00) and p=0.02 with OR 0.52 (95%CI 0.30-0.92) respectively.

Conclusion: Evidence supporting a better imaging approach remains limited at present. However, as an alternative approach for x-ray free ultrasound-guided PCNL, it offers better safety in prone positio and comparable safety in supine group. The efficacy between both groups found comparable both in supine and prone sub-analysis."

"Latar Belakang. Penyalahgunaan zat merupakan masalah global yang berkembang dengan angka kekambuhan yang cukup tinggi. Undang undang no 35 tahun 2009 mewajibkan semua penyalahguna zat untuk mengikuti rehabilitasi, namun terdapat perbedaan pendapat terkait efektifitas terapi berdasarkan keinginan untuk mengikuti rehabilitasi. Faktor yang turut berperan dalam keberhasilan rehabilitasi adalah tingkat kesiapan untuk berubah yang terlihat dari motivasinya. Implikasi UU no 35 dapat dilihat melalui perbedaan tingkat motivasi dan hubungannya dengan karakteristik serta mekanisme koping dari individu yang telah menjalani rehabilitasi berdasarkan keinginannya. Metode. Potong lintang melibatkan 100 orang penyalahguna zat yang telah mengikuti rehabilitasi selama periode bulan Juli-September 2014 di Balai Besar Rehabilitasi BNN. Pengukuran tingkat motivasi dengan instrumen University of Rhode Island Change Assessment Scale (URICA) dan mekanisme koping diukur dengan instrumen Brief-Coping Orientation to Problem Experienced (Brief-COPE). Hasil. Tidak terdapat perbedaan yang bermakna pada tingkat motivasi antara penyalahguna zat yang mengikuti rehabilitasi secara sukarela dengan yang tidak sukarela setelah mengikuti proses terapi rehabilitasi. Terdapat hubungan antara tingkat motivasi dengan mekanisme koping (nilai p 0.001). Mekanisme koping yang digunakan pada subyek dalam penelitian berupa emotion-focus koping dan skor mekanisme koping yang terbanyak pada tingkat sedang. Simpulan. Tidak terdapat perbedaan tingkat motivasi pada penyalahguna zat yang telah menjalani rehabilitasi berdasarkan keinginan.

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Background. Substance abuse is a growing global problem at a fairly high recurrence rate. Indonesia narcotics law no 35 in 2009 requires compulsory treatment for people with drug dependence, nevertheless there are many differences in opinions regarding the effectiveness of therapy based on the willingness to participate. Factors that contribute to the outcomes of rehabilitation s the readiness to change seen by motivation. The implications of the Law No. 35 can be seen through motivational level differences and its relationship with the characteristics and coping mechanisms of substance abusers who have undergone a rehabilitation based on the willingness to be rehabilitated. Method. A crosssectional involving 100 substance abusers who have undergone a rehabilitation program during the period July-September 2014 at BNN rehabilitation center. Motivation level measurement by University of Rhode Island Change Assessment Scale (URICA) instrument and coping mechanism by Brief-Coping Orientation to Problems Experienced (Brief-COPE) instrument. Result. There is no significant differences of motivational level between voluntary and compulsary substance abuser. There is a relationship between the level of motivation with coping mechanisms (p-value 0.001). Coping mechanisms used by the subject is emotionfocused coping with the highest score is at moderate level. Conclusion.There is no difference of motivational level among substance abusers who have undergone a rehabilitation program based on the willingness."

"Pasien yang telah menjalani Intervensi Koroner Perkutan (IKP) masih ada yang mengalami keluhan baik klinis maupun mental. Hal tersebut disebabkan oleh kurangnya pemahaman terkait literasi kesehatan pada PJK. Pada pasien PJK penting untuk meningkatkan kemampuan literasi kesehatan yang dapat dilihat dari kemampuan manajemen diri agar dapat meningkatkan kualitas hidup. Perawat memegang peranan penting dalam penyampaian literasi kesehatan. Penelitian ini bertujuan untuk mengidentifikasi korelasi antara literasi kesehatan, manajemen diri dengan kualitas hidup pasien PJK, merupakan penelitian kuantitatif dengan desain deskriptif analitik korelasi dan pendekatan cross sectional dengan beberapa kriteria inklusi pada 127 reponden. Analisis data menggunakan analisis deskriptif, uji korelasi Spearman Rank dan regresi linier berganda. Hasil penelitian didapatkan Sebagian besar responden berjenis kelamin pria, berkisar pada usia 59 tahun, memiliki pendidikan rendah, berpenghasilan di bawah UMR Kotamadya Surakarta, mayoritas tidak memiliki kecemasan, memiliki cardiac self efficacy yang baik. Terdapat hubungan yang bermakna antara literasi kesehatan dan kualitas hidup, terdapat hubungan yang bermakna antara manajemen diri dengan kualitas hidup. Masih diperlukan penelitian lain untuk mengeksplorasi variabel lain yang mempengaruhi kualitas hidup pada pasien penyakit jantung koroner yang telah menjalani Intervensi Koroner Perkutan

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Patients who have undergone Percutaneous Coronary Intervention (CCI) still experience both clinical and mental complaints. This is due to a lack of understanding regarding health literacy in CHD. In CHD patients it is important to improve health literacy skills which can be seen from self-management skills in order to improve quality of life. Nurses play an important role in the delivery of health literacy. This study aims to identify the correlation between health literacy, self-management and the quality of life of CHD patients, is a quantitative study with a descriptive analytic correlation design and a cross sectional approach with several inclusion criteria in 127 respondents. Data analysis using descriptive analysis, Spearman Rank correlation test and multiple linear regression. The results showed that most of the respondents were male, around 59 years old, had low education, earned below the minimum wage of Surakarta Municipality, the majority did not have anxiety, had good cardiac self-efficacy. There is a significant relationship between health literacy and quality of life, there is a significant relationship between self-management and quality of life. Other studies are needed to explore other variables that affect quality of life in coronary heart disease patients who have undergone Percutaneous Coronary Intervention."

"The subject of the book is advanced statistical analyses for quantitative research synthesis (meta-analysis), and selected practical issues relating to research synthesis. Specifically the book describes multivariate analyses for several indices commonly used in meta-analysis (e.g., correlations, effect sizes, proportions and/or odds ratios), will outline how to do power analysis for meta-analysis (again for each of the different kinds of study outcome indices), and examines issues around research quality and research design and their roles in synthesis. For each of the statistical topics we will examine the different possible statistical models (i.e., fixed, random, and mixed models) that could be adopted by a researcher. "

"Modern meta-analyses do more than combine the effect sizes of a series of similar studies. Meta-analyses are currently increasingly applied for any analysis beyond the primary analysis of studies, and for the analysis of big data. This 26-chapter book was written for nonmathematical professionals of medical and health care, in the first place, but, in addition, for anyone involved in any field involving scientific research. The authors have published over twenty innovative meta-analyses from the turn of the century till now. This edition will review the current state of the art, and will use for that purpose the methodological aspects of the authors' own publications, in addition to other relevant methodological issues from the literature.Are there alternative works in the field? Yes, there are, particularly in the field of psychology. Psychologists have invented meta-analyses in 1970, and have continuously updated methodologies. Although very interesting, their work, just like the whole discipline of psychology, is rather explorative in nature, and so is their focus to meta-analysis. Then, there is the field of epidemiologists. Many of them are from the school of angry young men, who publish shocking news all the time, and JAMA and other publishers are happy to publish it. The reality is, of course, that things are usually not as bad as they seem. Finally, some textbooks, written by professional statisticians, tend to use software programs with miserable menu programs and requiring lots of syntax to be learnt. This is prohibitive to clinical and other health professionals."