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Ana Lopez-Gimenez
"ABSTRACT
The objective of this study is to characterize and compare tooth agenesis codes and their prevalence in a population of Spanish patients with unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP), and to determine if the extent of the cleft (BCLP or UCLP) was associated with the number of absent teeth. This retrospective cross-sectional human study included 118 patients with complete BCLP (29) or UCLP (89) and permanent dentition from first molar to first molar. Congenitally missing teeth were identified on panoramic radiographs using the tooth agenesis code (TAC) to identify agenesis codes. Agenesis prevalence was 50.6 and 51.7% for UCLP and BCLP patients, respectively. The lateral upper incisor was the most frequently absent tooth, especially in the cleft quadrant. Numbers of absent teeth ranged from 1 to 6. This study represents a different approach from previous agenesis investigations in cleft patients. These Spanish patients showed a high number of ageneses, presenting nineteen different tooth agenesis codes. A total of five TACs were unique, in other words, observed in a single patient in the sample. No statistically significant relationship was found between the extent of the cleft and the number of absent teeth. The TAC system makes it possible to identify agenesis codes with simultaneous absence of teeth not detected in general prevalence studies."
Tokyo: Springer, 2018
ODO 106:3 (2018)
Artikel Jurnal  Universitas Indonesia Library
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Fory Fortuna
"Latar Belakang: Proses epitelisasi yang cepat dapat menurunkan kontraksi luka pada proses penyembuhan luka yang kemudian dapat menurunkan formasi skar. Untuk jangka panjang, diprediksi akan menjadi faktor penting untuk membantu pertumbuhan maksila. Madu yang diberikan sebagai terapi oral mempercepat proses epitelisasi 2.1 kali lebih cepat pada defek lateral palatum pasca two flap palatoplasty. Namun hasil jangka panjang dari terapi ini belum dievaluasi.
Tujuan Penelitian: Untuk mengevaluasi pertumbuhan maksila sebagai efek jangka panjang proses epitelisasi yang cepat pada palatum yang diberikan terapi oral madu pasca two flap palatoplasty.
Metode : Merupakan studi kasus kontrol yang terdiri atas 2 grup membandingkan pertumbuhan maksila pasien dengan celah bibir dan langit-langit komplit yang diberikan terapi madu dan yang tidak diberikan madu setelah two flap palatoplasty pada tahun 2011-2012. Hasil pengukuran cephalometri dicatat dan dibuat cetakan gigi untuk tiap pasien kemudian dikategorisasi menggunakan metode GOSLON yardstick. Data yang diperoleh dianalisis dengan SPSS versi 20.
Hasil :Follow up dilakukan pada 20 orang pasien. Sepuluh orang diantaranya merupakan group kontrol yang tidak mendapat terapi oral madu setelah palatoplasty. Median masing-masing umur populasi adalah 8.5 pada subjek kisaran 6 tahun - 10 tahun dan 11 tahun pada kontrol kisaran 9 tahun - 14 tahun . Body Mass Index BMI r 0.49, 95 , p 0.03 . dan faktor keluarga dengan hipoplasi maksila p 0.02 berpengaruh secara statistik dengan panjang palatum. Hasil GOSLON yardstick tipe 4 merupakan hasil terbanyak pada kedua grup 40 dengan reliabilitas antara examiner 1-2 dan 2-3 adalah sedang kappa; 0.583 dan 0.512 dan 1-3 adalah kuat kappa 0.716 . Terdapat 40 SNA normal pada grup madu, sedangkan hanya 20 SNA normal pada grup kontrol.
Kesimpulan: Pemberian madu sebagai terapi oral setelah two flap palatoplasty memberikan hasil sudut SNA yang baik pada hampir separuh total subjek terapi madu. Sebagaimana pertumbuhan maksila berakhir pada umur 20 tahun, maka hasil penelitian ini tidak dapat menyimpulkan hasil final pertumbuhan maksila. Usaha lain untuk memperbaiki pertumbuhan maksila pada pasien sumbing langit-langit perlu dipertimbangkan kembali. Penelitan dalam bentuk inovasi baru dalam teknik operasi dapat berkontribusi sebagai usaha mambantu pertumbuhan maksila.

Background: It is expected that faster epithelialization decrease wound contraction and then reducing scar formation. For long term, it will be an important factor that will result in good maxillary growth.Honey given as oral drops significantly precipitates the epithelialization process of the lateral palatal defects post two flap palatoplasty 2.1 times faster. Long term result has not been evaluated.
Aim of Study: To evaluate maxillary growth as long term effect of fast epithelialization of the palates treated honey as oral drops after two flap palatoplasty.
Methods: This is a case control study consists of 2 groups. Comparing maxillary growth of the unilateral complete cleft lip and palate UCCLP patients who were given honey as oral drops and without oral drops after their two flap palatoplasty in 2011 2012. The cephalometric measurements were recorded and the dental cast for each patient are evaluated using GOSLON yardstick method. The collected data are analysed using SPSS version 20.
Result: Long term follow ups are done in 20 patients. Ten of them are control group who are not given honey oral drop after palatoplasty. The median age of each population are 8.5 years for subjects range 6 years 10 years and 11 years for control group range 9 years 14 years. Body Mass Index BMI r 0.49, 95 , p 0.03. and family history of maxillary hypoplasia p 0.02 are two significant factors. GOSLON yardstick type IV are the most frequent GOSLON on both group 40 with interratter reliability between examiner 1 2 and 2 3 were moderate kappa 0.583 and 0.512 and 1 3 is substantial kappa 0.716 . There is 40 normal SNA angle on honey group, while only 20 normal SNA angle is found on control group.
Conclusion: Honey oral drops after two flap palatoplasty result good SNA angle of children in almost half of the honey group at the phase of initiation skeletal growth. As the growth of maxilla end up to 20 years old, this result cannot be concluded as final result of maxillary growth. Other effort to make maxillary growth better for cleft palate patient should be reconsidered. New innovation for operative technique can be a major contributing factor in maxillary growth for further study.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
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UI - Tugas Akhir  Universitas Indonesia Library
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Dimas Maharddhika
"Latar Belakang: Labioplasti dan palatoplasti merupakan tindakan definitif dalam tatalaksana celah bibir dan langit-langit. Pasca tindakan pembedahan, rata-rata ditemukan konstriksi lengkung gigi dalam arah antero-posterior dan lateral. Tujuan: Mengevaluasi dimensi lengkung gigi pada pasien UCLP dan BCLP pasca labioplasti dan palatoplasti menggunakan model studi pada usia 5 tahun. Metode: Dilakukan pencetakan model studi rahang atas dan bawah pada pasien UCLP dan BCLP pasca labioplasti dan palatoplasti, kemudian dilakukan pengukuran lebar lengkung gigi anterior dan posterior serta panjang lengkung gigi rahang atas dan bawah. Hasil perbandingan antar kelompok dan dengan kelompok kontrol dilakukan menggunakan uji Mann-Whitney dan Kruskal-Wallis. Hasil: Terdapat perbedaan yang signifikan pada dimensi lengkung gigi rahang atas antara kelompok kontrol, UCLP dan BCLP. Kesimpulan: Gangguan tumbuh kembang lengkung gigi pada pasien UCLP dan BCLP pasca labioplasti dan palatoplasti tercermin pada model studi saat pasien berusia 5 tahun

Background: Labioplasty and palatoplasty has been becoming the mainstay of treatment in cleft patients. Dental arch constriction in lateral and antero-posterior direction was among the most frequently encountered feature in the operated cases. Purpose: To evaluate the dental arch dimension of operated UCLP and BCLP cases by using dental cast at five years of age Method: dental arch dimensions were measured from the dental cast of the operated UCLP and BCLP cases. The results were compared between both group and a control group consisted of normal subjects. The statistical analysis was performed with Mann-Whitney and Kruskall-Wallis test. Results: There were statistically significant differences on the upper dental arch dimensions between those groups. The differences were also observed at the lower dental arch but not statistically significant. Conclusion: Dental arch constriction of the operated cases of UCLP and BCLP could be observed from the dental cast at five years of age."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2012
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UI - Tugas Akhir  Universitas Indonesia Library
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Made Widya Utami
"Latar Belakang: Keseimbangan dan harmoni gambaran wajah merupakan tujuan utama dari penatalaksanaan bedah pada pasien dengan celah bibir. Berbagai metode operasi untuk celah bibir unilateral telah tersedia. Labioplasti metode Cronin pada pasien celah bibir dan langit-langit unilateral menghasilkan bibir yang simetris dengan jaringan parut seminimal mungkin.
Tujuan: Evaluasi kesimetrisan bibir pada pasien celah bibir dan langit-langit unilateral pasca labioplasti metode Cronin sesuai protap yang berlaku di Unit Celah Bibir dan Langit-langit Rumah Sakit Anak dan Bunda Harapan Kita Jakarta.
Metode: Pasien celah bibir dan langit-langit unilateral 2 minggu, 1 bulan, 3 bulan, 6 bulan, dan 1 tahun pasca labioplasti dengan metode Cronin sebanyak 36 orang dinilai kesimetrisan bibir secara antropometri dengan fotograf yang telah terstandarisasi dari 2 aspek, yaitu anterior dan lateral. Bibir pada sisi celah diukur dan dibandingkan dengan sisi non celah.
Hasil: Tidak terdapat perbedaan bermakna pada jarak ac ke komisura ipsilateral (p = 0.387) dan jarak puncak cupid?s bow ke komisura ipsilateral (p = 0.933) pada sisi celah dan non celah. Terdapat perbedaan bermakna jarak sbal ke puncak cupid?s bow (p = 0.007) antara sisi celah dan non celah pada 2 minggu, 1 bulan, 3 bulan, dan 6 bulan pasca labioplasti.
Kesimpulan: Kesimetrisan bibir pada sisi celah dan non celah pasca labioplasti dengan metode Cronin berdasarkan rasio pengukuran antropometri dengan fotograf yang telah terstandarisasi dapat dicapai sempurna pada 1 tahun pasca labioplasti.

Background: Balance and harmony of facial features are the goal of surgical treatment for patients with cleft lip. Various methods of surgery for unilateral cleft lip had been provided. Labioplasty Cronin method in patients with unilateral cleft lip and palate produce symmetrical lips with minimal scarring.
Objective: Evaluation lip symmetry post labioplasty Cronin method in patients with unilateral cleft lip and palate based on standard operating procedure in Cleft Center Harapan Kita General Hospital.
Material and Methods: Thirty-six patients with unilateral cleft lip and palate after performing labioplasty Cronin method were photographed on anterior and lateral side by a standardized method 2 weeks, 1 month, 3 months, 6 months, and 1 year after surgery. Lips on the cleft side were measured and compared with the opposite side.
Results: There were no significant differences the length of ac to ipsilateral commissure (p = 0.387) and the distance of the peak cupid's bow to the ipsilateral commissure (p = 0.933) on cleft and norm side. There are significant differences the length of sbal to the Cupid's bow peak (p = 0.007) between cleft and norm side at 2 weeks, 1 month, 3 months, and 6 months post labioplasty.
Conclusion: Symmetrical lip post labioplasty with Cronin method at cleft and non cleft side based on the ratio of anthropometric measurements with standardized photographs can be accomplished perfectly in 1 year after labioplasty.
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Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2016
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UI - Tesis Membership  Universitas Indonesia Library
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Muslita Rizky Wahyuni
"Studi mengenai pengukuran dental cast telah beberapa kali dilakukan namun sedikit sekali yang terkait dengan Celah Bibir dan Langit-langit Bilateral karena jumlah kasus yang sangat jarang. Tujuan dari studi ini untuk mengevaluasi pertumbuhan maksila pasien Celah Bibir dan Langit-langit Bilateral menggunakan beberapa perlengkapan alat dan software menggunakan landmark yang sama dengan studi pengukuran lengkung maksila dan sudut palatal shelves. Penelitian Retrospektif ini diselenggarakan di RS Harapan Kita Cleft Center Jakarta, Indonesia. 35 dental cast sebelum labioplasti dan 35 dental cast setelah labioplasti dari pasienyang sama didigitisasi menggunakan scanner desktop 3D E4 dari 3shape. Lebar lengkung maksila dengan pengukuran linear dan palatal shelve dilakukan pada penelitian ini. Pengukuran dilakukan sebanyak dua kali oleh orang yang sama (intra observer) dan measurement error dihitung menggunakan dahlberg test. Laju pertumbuhan linear pada pasien ini baik, 45,1% pasien mengalami laju pertumbuhan positif setelah pembedahan, 34,3% laju pertumbuhan positif antar kaninus, dan 14,3% pasien mengalami laju pertumbuhan negatif pada interkaninus maksila dan intertuberositas. Laju pertumbuhan angular 22,9% mengalami hasil negatif dan 5,7% mengalami laju pertumbuhan positif. Laju pertumbuhan relatif normal pada penelitian ini. Palatal shelve mengalami pendangkalan pada penelitian ini namun pada tuber maksila kiri ada peninggian.

There were several studies regarding to measure the growth from dental cast, but it is severely limited study which is related to Bilateral Cleft Lip and Palate (BCLP) since the case is quite rare. The aim of this study is to evaluate the maxillary growth of BCLP patients using different tools and software with the same landmark to the previous methods for dental arch width and palatal shelves angle. This retrospective study was held in Children and Maternal Cleft Center Harapan Kita Hospital, Jakarta, Indonesia. 35 dental casts before labioplasty and 35 dental casts before palatoplasty from the same patients were digitized using 3D desktop scanner E4 from 3shape. Dental arch width of BCLP maxillary growth rate with linear measurement and palatal shelf angle were conducted in this study. The measurements were performing twice by same person (intra observer) and the measurement error was calculated by Dahlberg test. The growth rate linear in this patients results are good, 45.1% of patients experiencing positive growth rate post surgery, 34.3% positive growth surgery intercanine, but negative growth rate on intertuberosity, 14.3% patients have negative maxillary intercanine results and positive intertuberosity growth rate, and finally 14,3% patients experiencing negative growth rate in both maxillary intercanine and intertuberosity . Angular growth rate 22.9% have negative results and 5.7% have positive growth rate results. The dental arch linear growth rate relatively normal in this research. The palatal shelves were elevated in this research but in left tuber maxillary the degree is increasing."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2021
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UI - Tugas Akhir  Universitas Indonesia Library
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Ahdadiansyah
"Latar belakang: Palatoplasti merupakan tindakan operasi untuk merekonstruksi celah langit-langit, sehingga fungsi bicara maupun fungsi mastikasi dapat lebih baik. Pada proses penyembuhan pasca palatoplasti, akan terjadi gaya tarik dari flap mukoperiosteal yang disatukan. Gaya tarikan pada mukoperiosteal itu diduga dapat menyebabkan kontraksi jaringan dan menyebabkan terjadinya jaringan parut. Adanya pembentukan jaringan parut tersebut dapat menyebabkan gangguan pertumbuhan maksila baik ke arah antero-posterior maupun ke arah lateral. MMP-9 merupakan protein yang berperan penting dalam penyembuhan luka pada fase remodelling. Ekspresi MMP-9 ditemukan tinggi pada jaringan yang lebih sedikit terjadinya jaringan parut. Tujuan: Studi ini bertujuan untuk melihat ekspresi MMP-9 pada pasien pasca palatoplasti primer celah langit-langit unilateral komplit non sindromik. Metode: Studi dilakukan dengan pemeriksaan imunohistokimia pada sampel jaringan mukoperisoteal palatum pasien celah langit-langit pasca palatoplasti primer. Hasil: Pada pemeriksaan imunohistokimia didapatkan hasil intensitas ekspresi MMP-9 pada kelompok favorable berkisar 26,62 % hingga 41,30 %, sedangkan skor intensitas ekspresi MMP-9 kelompok unfavorable berkisar 8,78 % hingga 24,91 %. Kesimpulan: Intensitas ekspresi MMP-9 pada kelompok favorable lebih tinggi (rata-rata 41,30 %) daripada intensitas ekspresi MMP-9 kelompok unfavorable (rata-rata 16,50 %).

Background: Palatoplasty is an operation procedure to reconstruct a cleft palate, so that both speech and mastication functions can be better. In the post palatoplasty healing process, there will be a attraction of the mucoperiosteal flap unity. The attraction force on mucoperiosteal can make a tissue contraction and scarring. The formation of scar tissue can cause interference with the growth of the maxilla both antero-posterior and lateral. MMP-9 is a protein that plays an important role in wound healing at the remodeling phase. MMP-9 expression was high in tissue with less scarring. Objective: This study aims to observe the expression of MMP-9 in post primary palatoplasty non-syndromic complete unilateral cleft-palate patients. Methods: The study uses immunohistochemical examination of mucoperisoteal tissue samples of the palate of patients with cleft palate post primary palatoplasty. Results: In the immunohistochemical examination the results of MMP-9 expression intensity in the favorable group ranged from 26.62% to 41.30%, while the MMP-9 expression intensity score of the unfavorable group ranged from 8.78% to 24.91%. Conclusion: The intensity of MMP-9 expression in favorable groups was higher (on average 41.30%) than the intensity of MMP-9 expression in unfavorable groups (average of 16.50%)."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2020
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UI - Tugas Akhir  Universitas Indonesia Library
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New York, NY: Springer, 2013
617.522 5 CLE
Buku Teks SO  Universitas Indonesia Library
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Devina Yastani
"Pendahuluan: mengetahui perbedaan ukuran angular dentokraniofasial antara anak dengan celah bibir dan langit-langit unilateral dan bilateral komplit pasca labiopalatoplasti dibandingkan dengan anak tanpa celah bibir dan langit-langit. Material dan metode: Subyek penelitian terdiri dari 16 anak dengan celah bibir dan langit-langit unilateral komplit pasca labiopalatoplasti, 16 anak dengan celah bibir dan langit-langit bilateral komplit pasca labiopalatoplasti, 16 anak tanpa celah bibir dan langit-langit yang berada pada status maturasi vertebra servikalis I dan II. Tahap maturasi vertebra servikalis ditentukan dengan metode oleh Baccetti dkk (2002). Uji statistik yang dilakukan meliputi uji untuk distribusi data yang normal, uji t berpasangan, dan anova dengan tingkat signifikansi p < 0,5. Hasil: Terdapat perbedaan bermakna pada sudut insisif atas – bidang maksila antara kelompok unilateral dan normal; terdapat perbedaan bermakna pada sudut ANB, sudut SN/MP, dan sudut insisif atas – bidang maksila antara kelompok bilateral dan normal; terdapat perbedaan bermakna pada sudut SNA, sudut insisif atas – bidang maksila antara kelompok unilateral dan bilateral. Kesimpulan: Inklinasi insisif atas paling terpengaruh oleh celah bibir dan langit-langit. Inklinasi maksila ditemukan sedikit retrusif untuk kelompok celah bibir dan langit-langit unilateral komplit, sedangkat sedikit protrusif untuk kelompok celah bibir dan langit-langit bilateral komplit. Hubungan sagital kelompok bilateral ditemukan paling protrusif, diikuti kelompok normal, dan selanjutnya kelompok unilateral. Kecuraman bidang mandibula ditemukan pada kelompok bilateral

Introduction: To evaluate dentocraniofacial morphology of children with complete unilateral and bilateral cleft lip and palate following labioplasty and palatoplasty. Analysis was made when the children were at first and second stages of cervical vertebral maturation stage, before the peak of maxillary growth. Materials and methods: Sixteen digital cephalometric images of subjects with complete unilateral and bilateral cleft lip and palate following labioplasty and palatoplasty were compared with 16 normal stage-matched controls. Cervical vertebral maturation stage was determined by Method of Baccetti et al (2002). Statistics included tests for normal distribution, paired t test, and anova with the significance level p < .05. Results: There were significant cephalometric differences in UI/MxPl angle between unilateral and normal group; ANB angle, SN/MP angle, UI/MxPl angle between bilateral and normal group; SNA angle, UI/MxPl angle between unilateral and bilateral group. Conclusion: The inclination of upper incisor was most affected by cleft lip and palate. The maxilla inclination was found a little retrusive for unilateral cleft lip and palate, while a little protrusive for bilateral. Sagittal relationship of bilateral was found the most protrusive followed by normal and unilateral group. Mandibular steepness was found for bilateral cleft lip and palate."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2016
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UI - Tesis Membership  Universitas Indonesia Library
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"Indonesian Journal of Dentistry 2006. Edisi Khusus KPPIKG XIV: 412-415
The purpose of this study was to analyze the effect of hotz plate appliance to maxillary arch development of complete unilateral cleft lip and palate patient. The subjects were divided into two groups. The first group consisted of 6 patients, aged under two years with hotz appliance, recruited from Hasan Sadikin Hospital Bandung, and the second group, as control group, consisted of 6 patients, aged under two years, without hotz appliance, recruited from Haji Hospital Makassar. It was showed that in group with hotz plate appliance, no difference found on the size of anterior maxillary arch and minor maxillary arch. On the other hand, in the control group, minor maxillary arch was longer than mayor maxillary arch. It was concluded that hotz plate appliances affected the palatal development of patient with complete unilateral cleft lip and palate."
Fakultas Kedokteran Gigi Universitas Indonesia, 2006
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Artikel Jurnal  Universitas Indonesia Library
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Angelina Debora Theresa
"Latar Belakang: Epigenetik lingkungan merupakan faktor yang masih dapat dikontrol dalam kejadian celah bibir dan lelangit. Masyarakat diharapkan dapat mengetahui apa saja epigenetik lingkungan yang berpengaruh terhadap kejadian celah bibir dan lelangit sehingga masyarakat sadar akan pentingnya tata laksana yang baik pada penderita celah bibir dan lelangit. Tujuan: Mengetahui gambaran epigenetik lingkungan pada penderita celah bibir dan lelangit. Metode: Penelitian deskriptif dengan desain potong lintang dengan sampel 184 rekam medis pasien celah bibir dan lelangit di RSAB Harapan Kita. Data menunjukkan gambaran epigenetik lingkungan pada anak dengan celah bibir dan lelangit yang sudah selesai menjalani perawatan bedah primer di RSAB Harapan Kita. Hasil: Nilai rerata usia ibu saat hamil adalah 30,5 tahun. Terdapat riwayat konsumsi obat pada 77,7 persen subjek. Tidak diketahui adanya kebiasaan merokok pada ibu. Tingkat pendidikan ibu sedang (SMP, SMA, Diploma 1–3) dan tingkat pendidikan ayah tinggi (Sarjana 1–2) memiliki persentase terbesar. Mayoritas ibu pasien berdomisili di Jabodetabek. Nilai rerata berat badan lahir, lingkar kepala lahir, dan panjang badan lahir sebagai parameter dari nutrisi ibu termasuk dalam kategori normal. Sebanyak 79,9% subjek menjalani recall pasca perawatan primer. Kesimpulan: Epigenetik lingkungan menunjukkan gambaran yang normal pada pasien celah bibir dan lelangit di RSAB Harapan Kita.

Background: Environmental epigenetics are controllable elements in the occurrence of cleft lip and palate. The community is expected to understand the environmental epigenetics that influence the incidence of cleft lip and palate, raising awareness of the importance of proper management in cleft lip and palate. Objective: This study aims to understand the overview of environmental in epigenetics individuals with cleft lip and palate. Methods: Descriptive research with a cross-sectional design involving a sample of 184 medical records of cleft lip and palate patients at RSAB Harapan Kita. The data illustrates the overview of environmental epigenetics in children with cleft lip and palate who have completed primary surgical treatment at RSAB Harapan Kita. Results: The average maternal age during pregnancy is 30,5 years. About 77,7% of subjects have a history of drug consumption, and smoking habits are unknown. Mothers typically have a moderate education level, while fathers have a higher education level. Most mothers reside in Jabodetabek. Birth weight, head circumference, and birth length fall within normal ranges. A recall after primary care was conducted for 79,9% of the subjects. Conclusion: The environmental epigenetics indicate a normal overview in patients with cleft lip and palate at RSAB Harapan Kita."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2024
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UI - Skripsi Membership  Universitas Indonesia Library
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