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"The paradigm of Evidence Based Medicine (EBM) is new in the world of medicine and is used in practice praxis and medical research through a systematic observation, standardized, and objective. The article brings to light whether EBM and the supportive apparatus are able to defend the theory of decision-making concept of Pellegrino and Thomasma and how it affects the attitude of the practitioners in making a well-thought decision to administer a rational, objective, and effective treatment for the patients."

"The paradigm of evidence based medicine (EBM) is new in the world of medicine and is used in practice praxis and medical research through a systematic observation, standardized, and objective. The article brings to light whether EBM and the supportive apparatus are able to defend the theory of decision-making concept of pallegrino and thomasma and how it affects the attitude of the practitioners in making a well-thought decision to administer a rational, objective, and effective treatment for the patients"

"Apoteker adalah profesi yang memberikan pelayanan farmasi klinik dengan berorientasi pada pasien, bertujuan untuk meningkatkan hasil terapi obat dan mengurangi risiko efek samping. Dalam praktiknya, apoteker sebagai decision maker pada konsep 10-star pharmacist, diharapkan untuk mengambil keputusan yang baik, dimana hal tersebut dapat dicapai dengan pendekatan pengobatan berbasis bukti atau evidence-based medicine (EBM). Penggunaan bukti yang dapat diandalkan sangat penting dalam membuat keputusan terhadap terapi untuk pasien. Contohnya adalah pasien dengan penyakit kardiovaskular di Indonesia yang semakin berkembang, sedangkan tiap pasien memiliki kondisi unik yang mungkin memerlukan penanganan yang berbeda-beda. Keputusan penggunaan obat selalu mempertimbangkan kemanan dan khasiat, sehingga dapat meningkatkan kualitas hidup pasien dengan risiko yang minimal. Dalam laporan ini, jurnal tentang efek obat kardiovaskular oleh Ma et al., (2021) ditelaah secara kritis berdasarkan EBM, dan jurnal oleh Adesuyan et al., (2022) dirangkum. Telaah kritis jurnal tentang efek obat kardiovaskular yang mengacu pada appraisal tools oleh Critical Appraisal Skills Programme (CASP). Hasil dari telaah kritis jurnal oleh Ma et al., (2021) menegaskan keandalan data studi, namun diperlukan penelusuran lebih lanjut untuk memastikan keamanan penggunaan 4-5 obat kombinasi untuk mengatasi stroke iskemik dan serangan iskemik transien pada populasi Indonesia. Ringkasan tinjauan sistematis dari Adesuyan et al., (2022) menunjukkan bahwa obat antihipertensi golongan angiotensin receptor blocker (ARB) dapat secara signifikan mengurangi risiko Alzheimer's disease, dengan analisis sensitivitas dan heterogenitas yang tinggi sebagai penegasnya.

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A pharmacist is a profession who provides patient-oriented clinical pharmacy services, aiming to improve the results of drug therapy and reduce the risk of side effects. In practice, pharmacists as decision-makers in the 10-star pharmacist concept, are expected to make good decisions, which can be achieved through an evidence-based medicine (EBM) approach. The use of reliable evidence is essential in making therapeutic decisions for patients. For example, with the increasing prevalence of cardiovascular disease in Indonesia, each patient may have unique conditions that require individualized treatment. Decisions regarding drug use always consider safety and efficacy to enhance the patient's quality of life with minimal risk. In this report, a journal about the effects of cardiovascular drugs by Ma et al., (2021) is critically appraised based on EBM, and a journal by Adesuyan et al., (2022) is summarized. Critical appraisal of journal on the effects of cardiovascular drugs referring to appraisal tools by the Critical Appraisal Skills Program (CASP). The results of a critical appraisal of the journal by Ma et al., (2021) confirm the reliability of the study data, but further investigation is needed to ensure the safety of using 4-5 combination drugs to treat ischemic stroke and transient ischemic attacks in Indonesian population. The systematic review journal summary from Adesuyan et al., (2022) shows that angiotensin receptor blocker (ARB) antihypertensive drugs can significantly reduce the risk of Alzheimer's disease, with high sensitivity and heterogeneity analysis as confirmation."

"Pendapat ahli yang disampaikan dalam proses hukum harus dapat dipertanggungjawabkan secara ilmiah, yang dikenal dengan evidence-based practice (EBP). Dalam kedokteran forensik, EBP belum diterapkan secara eksplisit, termasuk di Indonesia. Salah satu pendekatan potensial untuk merumuskan pendapat ahli berbasis bukti disebut dengan INFERENCE (INtegration of Forensic Epidemiology and the Rigorous EvaluatioN of Causation Elements). Selain itu, belum ada pedoman universal untuk membuat laporan patologi forensik. Salah satu pedoman yang potensial bernama PERFORM-P (Principles of evidence-based Reporting in FORensic Medicine-Pathology version). Penelitian ini menggunakan metode campuran (mixed-methods) melalui lima tahapan yang saling terkait yaitu (1) survei potong lintang untuk mengetahui karakteristik dokter forensik Indonesia dan praktiknya saat ini, (2) proses adaptasi dan validasi kedua alat tersebut melalui review oleh Kolegium Ilmu Kedokteran Forensik Indonesia, (3) studi pre-post intervention satu kelompok untuk menilai validitas dan reliabilitas pendapat ahli kedokteran forensik yang diformulasikan menggunakan i-INFERENCE (Indonesian-INFERENCE) dan dilaporkan menggunakan i-PERFORM-P (Indonesian-PERFORM-P), (4) studi kasus analitik menggunakan i-INFERENCE, dan (5) diskusi kelompok terfokus untuk mengeksplorasi kepuasan pelanggan terhadap i-INFERENCE dan i-PERFORM-P. Seluruh penelitian ini dilaksanakan di Jakarta (secara luring dan daring) sejak bulan Desember 2017 sampai Juli 2022. i-INFERENCE dan i-PERFORM-P dapat meningkatkan validitas pendapat ahli kedokteran forensik. Kedua alat tersebut berpotensi untuk digunakan dalam setting Indonesia dengan beberapa tambahan/klarifikasi dalam pedoman pengguna. Keduanya juga mendapat sambutan yang umumnya positif, baik dari pengguna potensial (dokter forensik Indonesia) maupun oleh konsumen (jaksa dan hakim) meskipun diperlukan upaya lebih dalam menggunakannya. Peserta membayangkan bahwa kedua alat tersebut akan sangat berguna dalam kasus yang rumit. Dengan adanya i-INFERENCE dan i-PERFORM-P dokter forensik Indonesia diharapkan lebih siap dalam menganalisis dan melaporkan kasus yang kompleks, serta implementasi EBP dapat ditingkatkan.

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Expert opinions presented in legal proceedings should be scientifically accountable, which is known as evidence-based practice (EBP). In forensic medicine, EBP has not been explicitly applied, including in Indonesia. One potential approach to formulate evidence-based expert opinions is called INFERENCE (INtegration of Forensic Epidemiology and the Rigorous EvaluatioN of Causation Elements). Additionally, there is also no universal guideline for making forensic pathological reports. One prospective guideline is the PERFORM-P (Principles of Evidencebased Reporting in FORensic Medicine-Pathology version). This study uses a mixed-method through five interrelated phases, i.e., (1) a cross-sectional survey to determine the characteristics of Indonesian forensic doctors and their current practice, (2) the adaptation and validation process of the two tools through a review by the Indonesian College of Forensic Medicine, (3) a one-group pre-post intervention study to assess the validity and reliability of forensic medical expert opinions formulated using i-INFERENCE (Indonesian-INFERENCE) and reported using i-PERFORM-P (Indonesian-PERFORM-P), (4) an analytic case study using i-INFERENCE, and (5) a focused group discussion to explore customer satisfaction towards i-INFERENCE and i-PERFORM-P. This study was conducted in Jakarta (online and offline) from December 2017 until July 2022. i-INFERENCE and iPERFORM-P can increase the validity of forensic medical expert opinions. Both tools can potentially be used in the Indonesian setting with some additions/clarifications in the user manuals. They also received a generally positive reception, both by potensial user (Indonesian forensic medical doctors) and by consumers (public prosecutors and judges) albeit the extra effort that is needed in using them. Participants envision that both tools will be most useful in complex cases. By obtaining the i-INFERENCE and the i-PERFORM-P, Indonesian forensic medical doctors are better equipped in analyzing and reporting complex cases, and the implementation of EBP can be improved."