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"Madu dikenal dengan aktivitas biologisnya yang beragam, salah satunya adalah sebagai imunomodulator, yakni agen yang dapat mempengaruhi respon sistem imun. Di Indonesia, salah satu jenis madu yang sudah mulai banyak diproduksi adalah madu dari nektar Acacia crassicarpa. Penelitian ini dilakukan dengan uji proliferasi sel limfosit dengan uji MTS untuk mengetahui efek penambahan madu dalam berbagai variasi konsentrasi terhadap respon sel imun, identifikasi senyawa polifenol menggunakan Liquid Chromatography Mass Spectometry (LCMS/MS), serta pengukuran kadar senyawa fenolik total dimana senyawa polifenol yang terkandung dalam madu turut diduga memiliki efek imunomodulasi bagi tubuh. Selain itu dilakukan uji fisikokimia berdasarkan standar SNI 8664:2018. Hasil pengujian menunjukkan bahwa madu Acacia crassicarpa dapat meningkatkan viabilitas sel limfosit yang terinduksi LPS hingga mencapai 90% pada variasi konsentrasi madu Acacia crassicarpa terbesar yakni 160 μg/ml. Hal ini didukung dengan temuan senyawa-senyawa fenolik dan metabolit dalam madu yang lebih banyak dibandingkan madu randu sehingga diduga dapat mempengaruhi aktivitas imunomodulasi tersebut. Madu Acacia crassicarpa asal Tanjung Jabung Barat, Jambi menunjukkan kandungan fenolik total tertinggi sebesar 494,03 ppm, yang berpotensi memiliki aktivitas biologis lebih tinggi dibandingkan madu serupa asal daerah lain. Hasil pengujian fisikokimia menunjukkan bahwa madu Acacia crassicarpa memiliki kualitas yang baik dan aman dikonsumsi, namun dengan catatan pada beberapa parameter dimana hasil uji melebihi standar yang ditetapkan yakni kadar air, kadar gula pereduksi, kadar sukrosa, dan keasaman.

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Honey is well-known for its various biological activities, one of which as an immunomodulator, which are substances that can affect the response of the immune system. In Indonesia, one type of honey that is widely cultivated recently is the Acacia crassicarpa honey. This research was conducted by testing lymphocyte cell proliferation with MTS assay to determine the effect of various concentrations on immune cell response, identification of polyphenolic compounds using Liquid Chromatography Mass Spectometry (LCMS/MS), as well as measurement of total phenolic content in which polyphenolic compounds in honey are suggested to have immunomodulation effect on human body. In addition, physicochemical tests were conducted based on the SNI 8664:2018 standard. The test results showed that Acacia crassicarpa honey able to increase the cell viability of LPS-induced lymphocytes up to 90% which is shown by honey concentration of 160 μg/ml. This result is supported by the findings of more phenolic and metabolic compounds compared to randu honey, therefore suggests these compounds may affect the immunomodulating activity. Acacia crassicarpa honey from West Tanjung Jabung, Jambi showed the highest total phenolic content of 494.03 ppm, and may have higher biological activity potential compared to similar honey from other regions. The results of physicochemical test showed that Acacia crassicarpa honey has good quality and safe for consumption, but with a note on several parameters where the test results exceeded the established standards; with those parameters being water content, reducing sugar content, sucrose content, and acidity."

"Daging Sapi Segar merupakan bahan pangan yang mudah mengalami kerusakan mikrobiologi dan pembusukan karena memiliki kadar air dan nilai gizi yang tinggi. Madu dapat dimanfaatkan sebagai pengawet alami tanpa membahayakan kesehatan manusia. Madu berpotensi untuk mengawetkan daging karena memiliki aktivitas antibakteri. Madu akasia 1 dari Tanjung Jabung Barat (Jambi), madu akasia 2 dari Sontang (Riau), madu akasia 3 dari Dumai (Riau), dan madu randu dilakukan uji SNI dan kadar total fenolik terlebih dahulu. Pada penelitian ini, daging sapi giling segar digunakan sebagai sampel yang diawetkan menggunakan madu dengan variasi konsentrasi dan waktu penyimpanan. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan madu terhadap karakteristik mikrobiologis dan fisik daging sapi giling segar. Empat parameter analisis yang diteliti dalam penelitian ini, yaitu pH, aktivitas air, Angka Lempeng Total (ALT), dan organoleptik. Pada penelitian ini digunakan 5 perlakuan dengan variasi penambahan konsentrasi madu, yaitu 0% sebagai kontrol, 5%, 10%, 15% dan 20% dan variasi waktu penyimpanan daging sapi, yaitu hari ke0, hari-1, hari ke-3, dam hari-ke 5. Data yang diperoleh dianalisis dengan ANOVA alfa 0,05. Hasil analisis menunjukkan bahwa variasi konsentrasi madu dan waktu penyimpanan daging sapi berpengaruh secara signifikan terhadap pH, aktivitas air, Angka Lempeng Total (ALT), organoleptik, serta diperoleh konsentrasi madu yang memberikan efek pengawetan yang baik adalah penggunaan madu dengan konsentrasi sebesar 10%.

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Fresh beef is a foodstuff food ingredient that is susceptible to microbiological damage and spoilage because it has high water content and nutritional value. Honey can be used as a natural preservative without harming human health. Honey has the potential to preserve beef because of it has antibacterial activity. Acacia 1 honey from Tanjung Jabung Barat (Jambi), acacia 2 honey from Sontang (Riau), acacia 3 honey from Dumai (Riau), and randu honey from Pati (East Java) were tested for SNI and total phenolic content first. In this research, fresh grinding ground beef was used as a sample that was preserved using honey with variations OF concentration of honey and storage time. The objectives of this research were to know evaluate? the influence of addition OF honey to microbiological and physical characteristics of fresh grinding beef. This research used four kinds of analysis, there were such as pH, water activity, Total Plate Count (TPC), and organoleptic. In this research, five treatments were used with various concentration of honey; there were which were 0% as control, 5%, 10%, 15% and 20% and various storage time; there were day-0, day-1, day-3, and day-5. The data obtained were analyzed by ANOVA alpha 0.05. The result showed that variations in honey concentration and storage time of meat significantly affected the pH value, water activity, Total Plate Count (TPC), organoleptic. 10% honey showed the best preservation effect on the sample."

"ABSTRAKLatar Belakang: Propolis merupakan bahan herbal yang mengandung flavonoidsebagai antibakteri. Pengonsumsian propolis dapat menurunkan aktivitaslaktoperoksidase (LPO) sebagai sistem pertahanan tubuh. Permen propolis madumerupakan salah satu pemanfaatan propolis yang sedang dikembangkan. Tujuan:Menganalisis pengaruh konsumsi permen propolis madu terhadap aktivitas LPOpada saliva terstimulasi. Metode: Sampel saliva terstimulasi dikumpulkan darisubjek sebelum dan setelah pengonsumsian permen propolis madu 2 kali sehariselama 7 hari. Aktivitas LPO diukur dengan melihat nilai OD microplate reader.Hasil: Aktivitas LPO sebelum perlakuan 0.010 dan sesudah perlakuan 0.013.Kesimpulan: Aktivitas LPO meningkat setelah pengonsumsian permen propolismadu dengan perbedaan bermakna (uji Wilcoxon; p<0,05)

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ABSTRACTBackground: Propolis is natural product contained flavonoid as antibacterialproperty which decrease lactoperoxidase (LPO) activity as host defense system.Propolis honey candy is one of propolis product which is being developed.Objective: To analyze the effect of propolis honey candy consumption on theLPO activity in stimulated saliva. Method: Stimulated saliva samples collectedfrom subjects before and after propolis candy consumption twice a day for 7 daysthen measured by OD value using microplate reader. Result: The LPO activitybefore consumption 0.010 and after consumption 0.013. Conclusion: The LPOactivity increased after propolis honey candy consumption with significantdifference (Wilcoxon; p<0.05)."

"Madu memiliki berbagai efek positif bagi tubuh manusia dan telah digunakan sebagai obat selama berabad-abad. Madu Manuka dan MedihoneyTM di Indonesia masih sulit dilakukan karena harganya yang mahal dan ketersediaannya. Penelitian sebelumnya telah mengevaluasi aktivitas fisika kimia antara madu Nusantara (madu lokal) dan Madu Manuka. Namun dalam penelitian ini kami menambahkan lebih banyak variasi madu lokal dan komponen kimiawi yang bermanfaat untuk aktivitas antimikroba, antara madu lokal dibandingkan dengan madu Manuka. Namun dalam penelitian ini kami menambahkan lebih banyak variasi madu lokal dan komponen pemeriksaan kimia yang bermanfaat sebagai indikator untuk melihat aktivitas antimikroba terhadap bakteri K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853 dan S. aureus ATCC 25923, E. cloacae ATCC 23355, E. coli ATCC 25922 pada setiap sampel. Hasil penelitian menunjukkan bahwa madu manuka memiliki pH lebih rendah, keasaman lebih tinggi, viskositas lebih tinggi dan kadar gula lebih tinggi dibandingkan madu lokal Indonesia, madu manuka memiliki kandungan MGO dan NPA lebih tinggi dibandingkan madu lokal Indonesia, tetapi madu nusantara memiliki tingkat MGO yang lebih tinggi dibandingkan dengan madu Jawa. Madu Manuka memiliki aktivitas antibakteri yang sebanding pada bakteri P. aeruginosa ATCC 27853, S. aureus ATCC 25923, K. pneumonia ATCC 13883, E. coli ATCC 25922, and E. cloacae ATCC 23355 dibandingkan dengan madu lokal Indonesia.

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Honey has various positive effect human body, and has been used as medicine for centuries Manuka honey and Medihoney™ has been accepted widely used by medical honey. Research has been conducted for these honeys and shown to have in vivo activity and are suitable for the treatment of ulcers, infected wounds and burns. But using Manuka honey and MediHoney™ in Indonesia is still difficult due to its high cost and availability. The previous study had evaluated in physiochemical activity between Nusantara honey (local honey) and Manuka Honey. However, in this study we added more variety of local honey and chemical components that was beneficial for antimicrobial activity, between the local honey compared Manuka Honey. More extensive research was needed especially the physicochemical and antibacterial effect of Indonesian local honey, The purpose of this study is as a baseline data to produce our own medical grade honey that was equal compared to the international medical grade honey. This is a descriptive analytical study using samples of Indonesian local honey and Manuka honey, and check each samples for physical chemical characteristic, Unique Manuka Factor, and antimicrobial effect for K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25923, E. cloacae ATCC 23355, E. coli ATCC 25922 in every honey samples. The results of the study shows that New Zealand manuka honey has lower pH, higher acidity, higher viscosity, and higher sugar content compared to Indonesian local honey, New Zealand manuka honey has higher MGO content and NPA compared to Indonesian local honey, but Nusantara honey shows has higher MGO level, compared to Java honey. New Zealand manuka honey has lower pH, higher acidity, higher viscosity, and higher sugar content compared to Indonesian local honey. New Zealand manuka honey showed comparable antibacterial effect for P. aeruginosa ATCC 27853, S. aureus ATCC 25923, K. pneumoniaATCC 13883, E. coli ATCC 25922, and E. cloacae ATCC 23355 compared with Indonesian local honey."

"[Diare merupakan penyebab ke-13 mortalitas di dunia. Salah satu jenis diare yang merupakan sebuah kegawatdaruratan adalah disentri dengan manifestasi klinis diare yang disertai mukus dan darah. Pengobatan menggunakan siprofloksasin diperkirakan masih memiliki keterbatasan dalam kecepatan penyembuhan pasien dan tatalaksana dari komplikasi disentri. Madu manuka dan madu tualang memiliki efek antiinflamasi secara in vitro sehingga ingin diketahui apakah madu manuka dan madu tualang memiliki efek antiinflamasi pada vili usus akibat Shigelosis. Penelitian eksperimental pararel ini dilakukan pemberian madu sebagai terapi adjuvan berupa madu tualang dan madu manuka secara in vivo pada tikus Sprague Dawley. Jumlah bakteri pada feses (CFU/g) tikus Shigella dysenteriae dihitung dengan menggunakan metode total plate count pada hari ke 1,3, dan 7. Analisis data dilakukan dengan uji Kruskal-Wallis dan Spearman melalui program SPSS 20.0 for Windows. Hasil penelitian menunjukkan tidak ada perbedaan bermakna secara statistik antara pemeberian madu tualang, madu manuka, serta kontrol positif pada penyembuhan penyakit disentri pada tikus, Diarrhea is the 13th most common cause of mortality in the world. One form of diarrhea which posed as a medical emergency is dysentery presenting with clinical manifestations of diarrhea accompanied by mucus and blood. Treatment using ciprofloxacin is limited in the rate of patient's recovery and management of dysentery's complication. Manuka honey and Tualang honey are known to have anti-inflammatory effect in vitro, however, their anti-inflammatory effect to intestinal villi in Shigellosis have yet to be proven. In this pararel experimental research, both types of honey are administered as the adjuvant therapy in vivo in Sprague Dawley rat. Bacteria count in feces (CFU/g) of mice infected with Shigella dysenteriae was calculated using total plate count method on day 1, 3, and 7. Data analysis was performed with Kruskal-Wallis and Spearman test using SPSS 20.0 for Windows. The result showed no significant statistical difference between the groups administered with manuka honey, tualang honey, and positive control in rat suffering from dysentery.]"

"ABSTRAKLatar BelakangSurgicel (Oxidized Regenerated Celulose) telah digunakan secara luas di bidangBedah Plastik untuk mengatasi perdarahan saat operasi. Dalam penyembuhanluka, madu mempunyai banyak sekali manfaat. Madu terbukti mempercepatepitelisasi dan penyembuhan luka. Untuk mendapatkan keuntungan-keuntunganyang dimiliki madu sekaligus di saat mengatasi perdarahan, beberapa konsulensenior merendam agen hemostasis local (ORC) dalam madu. Tetapi sampai saatini belum ada laporan mengenai pengaruh madu terhadap ORC. Penelitian inidiharapkan mampu mengetahui interaksi antara madu dan ORC.MetodeDibuat penelitian pada hewan coba untuk menilai kemampuan hemostsasis ORCsetelah direndam dalam madu. Sebanyak 27 tikus dibagi dalam 3 kelompok dandibuat laserasi hepar pada setiap klompok, dan masing-masing laserasi pada tiapkelompok dirawat dengan ORC saja, ORC yang direndam dalam madu dankontrol. Banyaknya perdarahan dari laserasi hepar dan waktu perdarahan dinilai.HasilKemampuan hemostasis ORC saat direndam dalam madu tidak berubah. Waktuperdarahan pada kelompok ORC adalah 57,2 + 18,5 detik pada kelompok ORCmadu adalah 56 + 25,3 detik, nilai P 0,997 (> 0,05). Jumlah perdarahan padakelompok ORC madu adalah 126,9 + 87,5 miligram, 124 + 80,1 miligram padakelompok ORC saja dan 543,7 + 333,5 miligram pada kelompok control. Nilai Padalah 1,000 (>0,05).KesimpulanEfek hemostasis ORC tidak mengalami perubahan saat direndam dalam madu

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ABSTRACTBackgroundSurgicel (oxidized regenerated cellulose/ ORC) widely use as local hemostaticagent to minimise surgical bleeding in plastic surgery. Honey has numerousadvantage in wound healing. It has been proven to accelerate epithelialisation andpromote wound healing. In order to adopt this numerous advantages of honeywhile control surgical bleeding, some of our senior consultant soak localhemostatic agent (ORC) with honey. But there isn?t any information regardinginteraction between honey and ORC. This research aimed to asses thisinteraction.MethodsAn animal study design to asses hemostatic performance of ORC after beensoaked with honey. 27 rats were divided into 3 groups, where each group oflacerated liver treated with ORC alone, honey soaked ORC and control. Amountof blood exanguinated from liver laceration and the bleeding time wererecorded.ResultHoney soaked ORC has no difference in term of haemostatic property comparedwith ORC alone. Bleeding time ORC group was 57,2 + 18,5 second, and inhoney soaked ORC group was 56 + 25,3 second, P value 0,997 (> 0,05). Amountbleeding in honey soaked ORC is 126,9 + 87,5 miligram, ORC alone 124,9 +80,1 miligram and control 543,7 + 333,5 miligram. P value of Post Hoc test1,000 (> 0,05),ConclussionBeen soaked with honey, ORC doesn?t change it?s hemostatic properties."

"Eruption of Mount Merapi in 2010 caused a dense cover of Acacia decurrens Willd., which is an Invasive Alien Plant Species (IAPS). The dense cover happened in all areas of Mount Merapi National Park (MMNP) in Java, Indonesia. This study was aimed to describe the relationship between major natural disturbance from volcanic eruption in triggering the invasion of A.decurrens in Mount Merapi National Park. Vegetation data were collected using line transect in two different sites. The first site was Cangkringan which was affected by pyroclastic flow and the second site was Selo which was not affected by pyroclastic flow. Distribution patterns and association of A.decurrens with other species in each location was analyzed using ordination analysis of the Non-Metric Multidimensional Scaling (NMDS). Microclimate such as temperature, humidity, light density and soil humidity was recorded in each location. Correlation between species abundance and microclimate data was assessed using Canonical Correspondence Analysis (CCA). The results showed that the population of A. decurrens was more dominant in Cangkringan than in Selo site. Cangkringan site was impacted with pyroclastic flow during Mount Merapi eruption in 2010, while Selo site was not affected. In Cangkringan, A.decurrens was distributed in clump, while in Selo the plant was randomly distributed. Ordination analysis using NMDS showed that there was positive association between A.decurrens and herbaceous plant. Negative association was observed between A.decurrens and other tree species. CCA analysis showed that temperature and light density was positively correlated with A. decurrens abundance. This study showed that the IAPS invasion in MMNP was correlated with the eruption of Mount Merapi."

"Meningkatnya pengetahuan masyarakat akan pentingnya kesehatan menyebabkan tingginya permintaan alternatif pemanis selain gula. Salah satu alternatif yang paling banyak diminati adalah madu. Madu dipercaya dapat membantu meningkatkan sistem imun dan mencegah berbagai penyakit. Disebabkan khasiatnya, tren permintaan masyarakat terhadap madu meningkat sehingga menjadi perhatian bisnis untuk memanfaatkan potensi tersebut. Agar dapat memenangkan pasar, maka bisnis harus membentuk consumer-brand relationships dengan menghadirkan perasaan cinta konsumen terhadap brand madu tersebut (brand love), dimana selanjutnya brand love akan membentuk intensi konsumen muslim untuk membeli madu murni kembali (repurchase intention). Penelitian ini menganalisis faktor yang dapat mendorong intensi pembelian kembali terhadap produk madu pada segmen konsumen muslim, selain karena jumlahnya yang besar, madu banyak disebutkan dalam Al-Quran sehingga memiliki nilai lebih di mata segmen konsumen muslim. Data dianalisis dengan metode Covariance Based Square Structural Equation Model (CB-SEM) dan dibantu oleh perangkat lunak AMOS 26. Hasil dari penelitian ini yaitu Health Consciousness, Reasons For, Attitude berkontribusi dalam memengaruhi Brand Love yang selanjutnya memengaruhi secara positif Repurchase Intention. Serta tidak ditemukannya pengaruh variabel Reasons For dan Environmental Concern dalam penelitian ini. Hasil penelitian ini dapat bermanfaat bagi pelaku usaha madu murni untuk membentuk branding baru dalam memasarkan produk mereka.

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The increasing public knowledge of the importance of health has led to a high demand for alternative sweeteners other than sugar. One of the most popular alternatives is honey. Honey is believed to help boost the immune system and prevent various diseases. Due to its benefits, the trend of public demand for honey is increasing so that it is a business concern to take advantage of this potential. In order to win the market, businesses must establish consumer-brand relationships by presenting consumers' feelings of love for the honey brand (brand love), which in turn will shape the intention of Muslim consumers to buy pure honey again (repurchase intention). This study analyzes the factors that can encourage repurchase intentions for honey products in the Muslim consumer segment, apart from the large amount, honey is mentioned a lot in the Quran so that it has more value in the eyes of the Muslim consumer segment. Data were analyzed using Covariance Based Square Structural Equation Model (CB-SEM) assisted by AMOS 26 software. The results of this study are Health Consciousness, Reasons For, Attitude contribute to influence Brand Love which in turn positively affects Repurchase Intention. And there is no prove that Reasons For and Environmental Concern affecting variables in this study. The results of this study can be useful for natural honey strakeholders to form new branding in marketing their products."