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"This book is intended as a text for a one-semester course on mathematicaland computational neuroscience for upper-level undergraduate and first-year graduatestudents of mathematics, the natural sciences, engineering, or computer science.An undergraduate introduction to differential equations is more than enoughmathematical background. Only a slim, high school-level background in physics isassumed and none in biology"

"This book presents a concise treatment of stochastic calculus and its applications. It gives a simple but rigorous treatment of the subject including a range of advanced topics, it is useful for practitioners who use advanced theoretical results. It covers advanced applications, such as models in mathematical finance, biology and engineering."

""This book offers a practical, concise introduction to regression analysis for upper-level undergraduate students of diverse disciplines including, but not limited to statistics, the social and behavioral sciences, MBA, and vocational studies. The book’s overall approach is strongly based on an abundant use of illustrations, examples, case studies, and graphics. It emphasizes major statistical software packages, including SPSS(r), Minitab(r), SAS(r), R, and R/S-PLUS(r). Detailed instructions for use of these packages, as well as for Microsoft Office Excel(r), are provided on a specially prepared and maintained author web site. Select software output appears throughout the text. To help readers understand, analyze, and interpret data and make informed decisions in uncertain settings, many of the examples and problems use real-life situations and settings. The book introduces modeling extensions that illustrate more advanced regression techniques, including logistic regression, Poisson regression, discrete choice models, multilevel models, Bayesian modeling, and time series and forecasting. New to this edition are more exercises, simplification of tedious topics (such as checking regression assumptions and model building), elimination of repetition, and inclusion of additional topics (such as variable selection methods, further regression diagnostic tests, and autocorrelation tests)"-- Provided by publisher."

"Latar Belakang : Neuronal ceroid lipofuscinoses (NCL) tipe 2 adalah kelompok penyakit langka yang diturunkan, bersifat autosomal resesif, dan progresif neurodegeneratif. Penyakit NCL tipe 2 disebabkan oleh mutasi pada gen TPP1 dengan prognosis buruk. Penyakit ini dapat diterapi dengan terapi sulih enzim yang mahal. Dengan melakukan carrier testing kita dapat melihat pembawa sifat dalam keluarga. Informasi tersebut berguna dalam mencegah keturunan berikut menjadi sakit dengan preimplantation genetic diagnosis (PGD). Salah satu teknik PGD adalah preimplantation genetic testing for monogenic disorder (PGT-M) dengan validasi analisis linkage dari short tandem repeat (STR). Tujuan penelitian ini untuk mendapatkan profil STR pada keluarga pasien NCL tipe 2 di Indonesia untuk persiapan PGD.

Metode : Penelitian ini merupakan suatu studi observasional analitik pada keluarga pasien dengan NCL tipe 2 yang sudah terkonfirmasi secara enzimatik dan genetik. Carrier testing dilakukan pada kedua orang tua dan saudara kandung subjek, dilanjutkan pencarian STR pada area  ± 1 Mb dari gen TPP1. Pada setiap kandidat STR dilakukan fragment analysis pada subjek, kedua orang tua dan saudara kandung, serta dilakukan linkage analysis untuk menilai penanda STR bersegregasi dalam keluarga dan dapat digunakan sebagai kandidat dalam PGT.

Hasil Penelitian : Terdapat 4 pasien dari 4 kota di Indonesia. Terdiri dari satu lelaki dan tiga perempuan. Keempat subjek menunjukkan gejala NCL tipe 2 klasik dengan awitan gejala usia 31-42 bulan. Ditemukan 3 varian patologis yaitu 1 varian frame-shift (c.583_584insTACA), 1 varian in-frame (c.1222_1224delAGT), dan 1 varian missense (c.679T>C). Hasil carrier testing menunjukkan semua orang tua sebagai carrier varian patogenik. Hasil fragment analysis dari dua buah STR D11S1996 dan D11S1338 menunjukkan segregasi dalam linkage analysis dalam keluarga subjek.

Kesimpulan : Pada keempat pasien NCL tipe 2 di Indonesia ditemukan 3 varian patogenik. Carrier testing menunjukkan semua orang tua adalah pembawa sifat. Kedua STR D11S1996 dan D11S1338 dapat dipakai dalam program PGD pada pasien NCL tipe 2 di Indonesia.

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Background : Type 2 Neuronal Ceroid Lipofuscinoses (NCL) is a type of autosomal recessively inherited and progressive neurogenerative rare disease. This disease is due to TPP1 gene mutation, which have poor prognosis. Enzyme replacement therapy is available but with high cost. Carrier trait individual can be detected by carrier testing procedure, such as pre-implantation genetic diagnosis (PGD). These information can be useful to prevent disease occurence on subsequent generation. One PGD technique currently used is pre-implantation genetic testing for monogenic disorder (PGT-M) with linkage validation analysis of short tandem repeat (STR). The aim of this study was to search for STR marker in the type 2 NCL family in Indonesia for the preparation of PGD.

Methods : This is an analytical observational study on patient's family with enzymatic and genetically confirmed case of type 2 NCL. Carrier testing were done on both parents and sibling of case patients. STR sequence testing were done on ± 1 Mb area of TPP1 gene, with fragment analysis on each STR candidate. Linkage analysis were also performed to look for segregated STR pattern on the family, which can be used as a candidate in PGD.

Result : There were four case patients from 4 cities in Indonesia, 1 male and 3 female cases. These four cases manifested classic symptoms of type 2 NCL with onset age ranging from 31-42 months. Three pathological variants were found: 1 frame-shift variant (c.583_584insTACA), 1 in-frame variant (c.1222_1224delAGT), and 1 missense variant (c.679T>C). Carrier testing results showed all parents as pathogenic variant carrier. Fragment analysis from 2 STR (D11S1996 and D11S1338) showed segregation in linkage analysis on subject's family.

Conclusion : From 4 type 2 NCL cases in Indonesia, 3 pathogenic variants were found, with carrier testing showed both of their parents as carriers. Both D11S1996 and D11S1338 STR can be utilized as PGD diagnostic of type 2 NCL patients in Indonesia."