Hasil Pencarian  ::  Simpan CSV :: Kembali

"This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia."

"Topically applied products and medications can profoundly affect skin's barrier function and overall health. Bursting with suggestions to assist research and development, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview on the innate immune system and its relevance to pharmaceutics, cosmetic chemistry, and personal care products. The book allows pharmaceutical and medical professionals to assess accumulated knowledge and develop an understanding that will pave the way for next generation treatment avenues, preventative approaches, and drug development. Part I of this book presents an overview emphasizing mechanisms for control of bacteria at the skin surface. This includes historical and ethical aspects of skin cleaning products.Part II of the book includes chapters discussing antimicrobial peptides and lipids in innate immunity of skin and mucosa. Part III deals with cellular components of innate immunity and the link between innate and adaptive immunity. Part IV deals with stressors that can influence innate immunity. These include radiation and oxidative stress, cosmetic formulations, and aging. Finally, microbial challenges are discussed in Part V."

"This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance."

"This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection."

"Tuberkulosis (TB) disebabkan oleh infeksi kuman Mycobacterium tuberculosis merupakan satu dari sepuluh penyebab kematian tertinggi di dunia yang dapat dicegah melalui vaksinasi. Vaksin BCG sebagai satu-satunya vaksin TB, memiliki beberapa kekurangan, diantaranya tingkat proteksi yang tidak merata di populasi orang dewasa dan kekhawatiran aplikasinya pada populasi imunokompromais, hal ini mendorong dikembangkannya vaksin TB alternatif. PE11 merupakan protein yang bertanggung jawab dalam rekonstruksi komponen lipid dinding sel M. tuberculosis dan berdasarkan analisis in-siliko diketahui memiliki domain pengenalan terhadap antibodi dan MHC-II. Dalam studi ini, gen pe11 dari M. tuberculosis strain Beijing diinsersikan ke dalam plasmid pcDNA3.1, pcDNA3.1-pe11, yang kemudian diuji kemampuannya dalam menginduksi respon imun humoral dan mediator seluler pada mencit Balb/c sebagai bentuk DNA vaksin. Berdasarkan uji western blot, respon imun humoral berupa IgG spesifik terhadap protein rekombinan PE11-His berhasil dikonfirmasi. Selain itu, mediator imun seluler dari splenosit mencit pasca vaksinasi dan pajanan antigen secara in-vitro menunjukkan adanya peningkatan produksi IL-12, IFN-γ dan IL-4 dibandingkan dengan kelompok kontrol, namun tidak terhadap sitokin IL-10.

---

Tuberculosis (TB) caused by infection bacteria Mycobacterium tuberculosis, one of ten causes of death in the world that can be prevented through vaccination. The BCG vaccine, as the only TB vaccine, has several drawbacks, including an uneven level of protection in adult population and risk application in immunocompromised population, this has led to the development of an alternative TB vaccine. PE11 is a protein that is responsible for the reconstruction of the lipid component of the cell wall of M. tuberculosis and based on in-silico analysis is known to have the recognition domain for antibodies and MHC-II. In this study, the pe11 gene from the Beijing strain of M. tuberculosis was inserted into the plasmid pcDNA3.1, pcDNA3.1-pe11, then tested for its ability to induce humoral immune responses and cellular mediators in Balb/c mice as a form of vaccine DNA. Based on the western blot test, the specific IgG humoral immune response to the recombinant protein PE11-His was confirmed. In addition, cellular immune mediators from post-vaccination mice splenocytes and in-vitro antigen exposure showed increased production of IL-12, IFN-γ and IL-4 compared to the control group, but not to the IL-10 cytokine."