Hasil Pencarian  ::  Simpan CSV :: Kembali

"Administration of a renal dose of dopamine in acute renal failure still attracts a lot of controversy, store there has not been a study that found a significant protective effect on the kidneys.Nevertheless, according to its ability to increase renal blood flow in laboratory animals and normal subjects, several parties still maintain its use, even though the required dose is very much individualized.The side effect of dopamine, such as tachycardia, arrhythmia, miocardiac ischemia, and intestinal ischemia due to precapilary vasoconstriction causing bacterial translo-caiionfrom the intestinal lumen to the systemic bloodstream, even though relatively rare, should receive adequate attention."

"The prevalence of chronic renal failure in Indonesia tends to increase in the lower age group (45–54 years). Chronic renal failure may lead to impaired sexual function. A descriptive phenomenology study with in-depth interviews was carried out with 12 participants, and thematic content analysis was applied. Six themes were revealed, as follows: 1) adaptation process to sexual dysfunction experienced, 2) sexual dysfunction experience, 3) importance of fulfilling sexuality needs, 4) behavior in dealing with sexual dysfunction, 5) perception of the cause of sexual dysfunction, and 6) participants’ expectation of health service related to sexual function. The experience of adapting to sexual dysfunction became a meaningful process through partner involvement. Similar research involving more heterogeneous samples would benefit further discourse.

---

Prevalensi gagal ginjal kronis di Indonesia cenderung meningkat pada kelompok usia lebih muda (45–54 tahun). Gagal ginjal kronis sering menyebabkan gangguan fungsi seksualitas (disfungsi seksual). Penelitian ini bertujuan mendapatkan gambaran mendalam tentang pengalaman proses adaptasi pasien gagal ginjal kronis yang mengalami disfungsi seksual. Desain penelitian menggunakan deskriptif fenomenologi dengan wawancara mendalam. Dua belas partisipan diperoleh dengan teknik purposive sampling. Hasil penelitian ini teridentifikasi enam tema yaitu 1) proses adaptasi terhadap disfungsi seksual yang dialami partisipan, 2) disfungsi seksual yang dialami, 3) makna pentingnya pemenuhan kebutuhan seksualitas, 4) perilaku dalam menghadapi disfungsi seksual, 5) persepsi tentang penyebab disfungsi seksual, dan 6) harapan partisipan terhadap pelayanan kesehatan terkait fungsi seksualitas. Proses adaptasi yang dialami partisipan merupakan pengalaman yang sangat bermakna karena melibatkan dirinya sendiri dan hubungan interpersonal dengan pasangannya. Penelitian sejenis dengan sampel lebih heterogen diperlukan untuk memperkaya keilmuan."

"The aim of this study was to investigate the effect of ant (hypertensive agents with different degrees of renal excretion lisinopril (L) eliminated in the kidney and fosinopril (F), only 50% of which is eliminated through the kidney on renal function in hypertension patients with mild to moderate renal failure.Materials and methods: Patients were divided into two groups. The first group was given F 10 mg/day and the second group was given L 10 mg/day. Groups were divided randomly, and drugs were given for 6 weeks each night at 8.00p.m. The hypertension status of each subject was determined from systolic blood pressureJ140 mmHg or diastolic blood pressure -f 90 mg/dl. Subjects were both male and female, with an age range of 18- 65 years old.Results: The results from the creatinine examination of the 10 mgF group was (3.06 ±0.97) mg/dl after drug use, which showed no decrease in renal function. The difference was insignificant (p=0.17). The 10 mgL group the creatinine level was (3.22 ±0.17), where as in the 10 mg L group the creatinine level was (3.22 ± 0.75) mg/dl before the use of the drug and (4.11 ± 2.14) mg/dl after the use of the drug respectively. There was no worsening of the renal function, which did not differ significantly (p=0.11). There was a significant difference (p < 0.05) in the creatinine level of the 10 mg F and 10 mg L groups. The serum creatinine level before and after treatment did show any significant changes at. 6 week. However, the serum creatinine profile over 6 week was more significant in the F group than in the L groups."

"[ABSTRAKLatar Belakang. Perburukan fungsi ginjal berkaitan dengan luaran klinis yang lebih buruk pada pasien gagal jantung dekompensasi akut. Karakteristik klinis pada saat pasien masuk ke unit gawat darurat (UGD) dapat menolong untuk identifikasi pasien yang berisiko terhadap kejadian perburukan fungsi ginjal. Tujuan penelitian ini adalah membuat sistem skor untuk mempermudah identifikasi pasien yang berisiko terhadap perburukan fungsi ginjal pada gagal jantung dekompensasi akut.Metode. Studi kohort retrospektif dilakukan terhadap 614 pasien yang menjalani perawatan karenan gagal jantung dekompensasi akut. Perburukan fungsi ginjal didefinisikan sebagai peningkatan nilai kreatinin serum ≥ 0.3 mg/dL kapanpun selama perawatan atau ≥ 25% dari awal masuk perawatan.Hasil. Perburukan fungsi ginjal terjadi pada hampir 26% pasien. Prediktor independen terhadap kejadian perburukan fungsi ginjal yang didapat melalui analisis dengan logistik regresi backward selection adalah usia > 75 tahun (p < 0.0001); perempuan (p = 0.034); riwayat hipertensi (p = 0.001); anemia (p = 0.005); dan serum Creatinin saat masuk di UGD > 2.5 mg/dL (p = 0.013). Sistem skor dibuat dari model akhir tersebut. Dilakukan validasi internal dengan metode bootstrap didapatkan hasil optimisme yang baik (0.01088808).Kesimpulan. Sistem skor baru dapat memprediksi kejadian perburukan fungsi ginjal pada pasien gagal jantung dekompensasi akut yang menjalani rawat inap.

---

ABSTRACTBackground. Worsening renal function (WRF) is associated with worse outcomes among patients who are hospitalized with acute decompensated heart failure (ADHF). Clinical characteristics at admission may help identify patients at increased risk of WRF. The aim of this study was to create in admission scoring system to simplify identification patients at risk of WRF in ADHF setting.Methods. A retrospective data of 614 patients admitted with ADHF was analyzed. By the definition WRF occurred when serum Creatinin increased at anytime during hospitalization by ≥ 0.3 mg/dL or by ≥ 25% from admission.Results. Worsening renal function developed in near 26% patients. The independent predictors of WRF analyzed with backward selection logistic regression were: age > 75 years old (p < 0.0001), female (p = 0.034); history of hypertension (p = 0.001); anemia (p = 0.005); and in admission serum Creatinin (p = 0.013). A scoring system was generated from this final model. An internal validation with bootstrap method showed good optimism (0.01088808).Conclusion. A new scoring system could predict in-hospital worsening renal function among patients hospitalized with acute decompensated heart failure., Background. Worsening renal function (WRF) is associated with worse outcomesamong patients who are hospitalized with acute decompensated heart failure(ADHF). Clinical characteristics at admission may help identify patients at incresedrisk of WRF. The aim of this study was to create in admission scoring system tosimplify identification patients at risk of WRF in ADHF setting.Methods. A retrospective data of 614 patients admitted with ADHF was analyzed.By the definition WRF occurred when serum Creatinin increased at anytime duringhospitalization by ≥ 0.3 mg/dL or by ≥ 25% from admission.Results. Worsening renal function developed in near 26% patients. Theindependent predictors of WRF analyzed with backward selection logisticregression were: age > 75 years old (p < 0.0001), female (p = 0.034); history ofhypertension (p = 0.001); anemia (p = 0.005); and in admission serum Creatinin (p= 0.013). A scoring system was generated from this final model. An internalvalidation with bootstrap method showed good optimism (0.01088808).Conclusion. A new scoring system could predict in-hospital worsening renal function among patients hospitalized with acute decompensated heart failure.]"

"ABSTRAKLatar Belakang : Meskipun manajemen gagal jantung (GJ) semakin maju, prognosis pasien tetap belum membaik. Hal ini disebabkan karena adanya komorbid, terutama perburukan fungsi ginjal yang juga memainkan peran utama dalam patofisiologi GJ. Pada tahun 2015, Putri dkktelah mengembangkan sistim skor VKPP untuk memprediksi perburukan fungsi ginjal pada pasien dengan Gagal Jantung Dekompensasi Akut (GJDA), yang variabelnya terdiri atas jenis kelamin perempuan, Hb < 12,5 mg/dl, kreatinin awal > 2,5 mg/dl, riwayat hipertensi, dan usia > 75 tahun. Nilai diskriminasi sistim skor tersebut 0,682 (95% IK; 0,630 - 0,734). Sampai saat ini, belum ada validasi eksternal pada sistim skor VKPP tersebut, sehingga perlu dilakukan agar dapat diimplementasikan secara klinis.Tujuan : Melakukan validasi eksternal sistim skor Kardio-Renal VKPP pada pasien dengan GJDA yang menjalani rawat inap.Metode : Penelitian merupakan studi kohort retrospektif dengan metode validasi eksternal temporal yang dilakukan di Departemen Kardiologi dan Kedokteran Vaskular Universitas Indonesia/Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita, menggunakan data sekunder September 2015 hingga April 2016, yang diambil secara consecutive sampling. Analisis data ditujukan untuk mendapatkan nilai kalibrasi dan diskriminasi.Hasil : Sampel akhir berjumlah 418, dengan kejadian perburukan fungsi ginjal sebesar 20,3%. Odds Ratio (OR) semua variabel sesuai dengan OR pada studi VKPP, kecuali variabel jenis kelamin perempuan yang justru tidak menjadi faktor risiko (OR 0,78; 95% IK 0,43-1,45).Setelah dilakukan penghitungan skor VKPP pada semua sampel studi, didapatkan nilai kalibrasi 0,594 dan diskriminasi/AUC sebesar 0,568 (95% IK; 0,502 - 0,634). Pada studi Validasi, kejadian perburukan fungsi ginjal pada kelompok risiko rendah, sedang, dan tinggi yang dihitung menggunakan skor VKPP berurutan sebesar 18,6%, 21,9%, dan 29,6%. Dengan demikian, hanya kelompok risiko rendah yang berada pada rentang probabilitas prediksi perburukan fungsi ginjal yakni 11-26% (pada risiko sedang dan tinggi sebesar 27-49,5% dan 50-80%).Kesimpulan : Sistim skor VKPP secara eksternal valid untuk memprediksi kelompok risiko rendah, namun masih perlu kajian lebih lanjut pada kelompok risiko sedang dan tinggi.

---

ABSTRACT

Background : Although the management of Heart Failure (HF) has developed, prognosis of patients still not significantly improved. It is due to comorbidities, especially worsening kidney function, which also plays a major role in the pathophysiology of HF. In 2015, Putri et al have developed a scoring system (VKPP score) to predict worsening of renal function in patients with

Acute Decompensated Heart Failure (ADHF), in which predictors are female, Hb < 12.5 mg/dl, admission creatinine > 2.5 mg/dl, history of hypertension, and age > 75 years . This scoring system yields discrimination value of 0.682 (95% CI; 0.630 to 0.734). Until now, there has been no external validation on the VKPP scoring system, therefore it is needed in order to implement

them clinically.

Objective : To validate externally the VKPP Cardio-Renal scoring system in patients who are hospitalized with ADHF.

Methods : This is a retrospective cohort study with temporal external validation method that performed at the Department of Cardiology and Vascular Medicine, Universitas

Indonesia/National Cardiovascular Center Harapan Kita, using secondary data from September 2015 until April 2016, which taken by consecutive sampling method. The data analysis is intended to develop the value of calibration and discrimination.

Results : The final samples are 418, with 20.3 % incidence of kidney function deterioration. Odds Ratio of all predictors is similar with the result in VKPP study, except female variable which is not a risk factor (OR 0.78; 95% CI; 0,43-1,45). As final, the calibration and

discrimination values are 0.594 and 0.568 (95% CI; 0.502-0.634). In the validation study, the incidence of worsening renal function in the low, moderate, and high risk group which are calculated using VKPP consecutively valued 18.6 % , 21.9 % and 29.6 %. However, only the

low-risk group who were in the range of probability predictions of worsening renal functions, which is 11-26 % (moderate and high risk valued 27 to 49.5 % and 50-80 %)."

"Latar Belakang: Luka bakar listrik berpotensi untuk menjadi penyebab terjadinya gagal multiorgan dengan angka mortalitas dan morbiditas yang tinggi. Kombinasi antara luka bakar pada kulit yang luas serta kerusakan organ dalam menyebabkan meningkatnya kebutuhan cairan akibat banyaknya cairan yang hilang. Kerusakan pada jantung dan otot dapat menyebabkan myoglobulinuria. Myoglobin menyebabkan obsruksi dan vasokontriksi serta mebyebabkan gagal ginjal. Resusitasi cairan menggunakan metode parkland dan titrasi diharapkan dapat merehidrasi, mengembalikan fungsi ginjal serta mencegah komplikasi pada ginjal akibat myoglobin pada urin. Penelitian ini bertujuan untuk mengevaluasi angka kejadian gagal ginjal pada pasien luka bakar listrik yang di resusitasi dengan formula parkland dan titrasi. Metode: Penelitian ini merupakan studi retrospektif pada pasien luka bakar listrik yang dirawat di Unit Luka Bakar RSCM Jakarta dari Januari 2010 hingga Januari 2014. Data yang dikumpulkan meliputi identitas, jumlah cairan saat resusitasi 24 jam pertama, nilai kreatinin hari pertama dan ketiga, warna urin, riwayat gagal ginjal, waktu kejadian dan kedatangan pasien ke RS dan luas luka bakar. Kami bagi menjadi dua kelompok, kelompok AKI dan non-AKI dengan menggunakan kriteria RIFLE. Dilakukan penghitungan Parkland Score pada masing-masing kelompok dan dibandingkan menggunakan analisa t-test. Hasil: Terdapat 49 pasien luka bakar listrik yang memenuhi kriteria inklusi. 36 pasien datang dengan myoglobulinuria. 64.8% (n=24) pasien tidak mengalami gagal ginjal tapi 35.1% mengalami gagal ginjal (n=13). Pada metode T Test didapatkan hasil bermakna antara penggunaan parkland score dengan angka kejadian gagal ginjal (P<0.05). variable lainnya seperti umur, waktu keterlambatan, berat badan serta luas luka bakar tidak memberikan hasil yang bermakna. Tidak adanya hubungan bermakna antara hemoglobinuria dengan kejadian gagal ginjal. kesimpulan: Resusitasi cairan yang adekuat sangat penting dalam manajeman dini luka bakar. Formula parkland sudah banyak digunakan sebagai dasar perhitungan cairan resusitasi. Terdapat hasil yang bermakna pada hubungan antara pemberian cairan menggunakan formula parland dan titrasi dengan angka kejadian gagal ginjal. Study ini membuktikan bahwa pemberian cairan berdasarkan formula parkland dan titrasi dapat menurunkan angka kejadian gagal ginjal pada luka bakar listrik. Myoglobulinuria sendiri tidak menunjukkan hubungan dengan angka kejadian gagal ginjal akut, kemungkinan disebabkan karena myoglobulinuria sendiri hanya merupakan salah satu faktor penyebab gagal gagal ginjal pada luka bakar listrik.

---

Background: Electrical burn injury has potential cause of multisystem injury with high morbidity and mortality. The combination of extensive burns and significant internal injury in cases of severe high voltage electrical injury leads to increase fluid requirements due to fluid extravasation and ongoing fluid losses, Cardiac complication and muscle destruction that cause myoglobinuria. Myoglobin causes renal obstruction and intrarenal vasoconstriction and could result in acute kidney injury. Fluid resuscitation using parkland titration method is applied to rehidrate, restore renal function and prevent further damage caused by myoglobin. The study aimed to evaluate the incidence of Acute Kidney Injury related to the first 24 hour fluid resuscitation using the parkland formula and titration method in electrical burn injury.

Method: This is a retrospective cohort design, recruited from medical records in Cipto Mangunkusumo Hospital from january 2010 to january 2014. Data will be collected at baseline and after resuscitation. Patients information included age, time of refferal, cause of burn, resuscitation fluid , urine production, urine colour, serum creatinin level at day 1-3. We divide all electrical burn injury patients into two group, AKI (Acute Kidney Injury) group and non-AKI group, using RIFLE classification. Then we compare the fluid resuscitation using Parkland score within two group. We also compare other risk factor contributing AKI in electrical burn injury including delayed time characteristic.

Results: A total of 49 patiens of electrical burn injury mets the study inculsion criteria, 36 patients presented with myoglobulinuria during admission to the hospital. 64.8% (n=24) did not have AKI while 35.1% had AKI (n=13). Independent T test showed significant differences between parkland score and the occurence of Acute Kidney Injury (P < 0,05). Other variables such as age, delayed time, weight and percentage of burn did not show any significant differences related to acute kidney injury. The presence of hemoglobinuria supposed to increase the number of acute kidney injury but in contrary it did not have significance result related to acute kidney injury (P>0.05).

Conclusions: Adequate resuscitation is essential in a succesful early burn management.. Parkland formula had been used widely as guidelines for fluid resuscitation. There is a significant result relating th use of parkland formula with titration and acute kidney injury. This study confimed that administering resuscitation fluid according to the parkland formula and maintaning the hidration using titration method could decreased the number of acute kidney injury. Clearly, Myoglobinurea alone can not be held accountable as predictor of an acute kidney injury, it is only one of several causes of acute kidney injury."

"ABSTRACTThis study was carried out to ascertain the effect ofessential amino acids supplementation in renal failure patients ondialysis. 22 renal failure patients on dialysis without any signsand symptoms of G.I. disorders, liver disease, uncontrolleddiabetic mellitus were recruited to . the study. 11 patients servedas subjects and received essential amino acids supplementation, 11others served as control group who received placebo. The subjectshad undergone basic physical examination, biochemical assessment(Hb, transferrin, ureum and creatinine) and dietary assessment atthe beginning and at the end of the study. The study cone 1 udedthat the essential amino acids supplementation given to renalfailure patients on dialysis has significantly increased thetransferrin value, this may suggest an improvement of the proteinstatus of the patients. The study a 1 so pointed out that theincreased in transferrin as an effect of the essential amino acidssupplementation didt:l.'t cause an extra burden to the kidneys.Further investigations are needed to reconfirm this finding"