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"Aging is closely associated with physical disability that mostly causes by the onset of degenerative diseases. Due to the increasing mean age in most of the societies, the relationship between nutrition and aging is growing interest. The study aims to investigate the association of diet and biological age. A cross sectional study was conducted amongst male elderly (60 years and over) living in Jakarta. Eighty-four subjects were selected randomly. Biological age was determined by measuring skin wrinkling using skin microtopograph and serum dehydroepiandrosterone sulfate (DHEAS). Data collection was done using interviewer-administrated structured questionnaire and semi quantitatvive food frequency questionnaire (FFQ). After adjustment for age, elderly with high sosioeconomic status had higher energy, protein, meat, fish, and egg intakes. Low sosioeconomic class ad more extensive hand skin wrinkling and although not significant, arm sites. Serum DHEAS level was similar, respectively for high and low socioeconomic class. Serum DHEAS was positively correlated with the vitamin c intake and negatively correlated with cereal consumption. Skin wrinkling was positively collerated with cereal consumption. Since the design of this study was cross sectional, further studies are recommended to elaborate the protective effect of vitamin C and damaging effect of high cereal consumption on biological age as indicated by serum DHEAS levels and skin wrinkling."

"Dengan meningkatnya populasi lanjut usia (lansia) di Indonesia, menjaga kualitas kesehatan, termasuk kesehatan kulit, menjadi semakin penting. Penurunan hormon DHEA, prekursor estrogen dan androgen, berkaitan dengan penuaan kulit. Tanda-tanda penuaan contohnya kerutan dan kekenduran kulit dipengaruhi oleh kadar DHEA yang menurun. Penelitian ini bertujuan untuk mengumpulkan data dasar kadar DHEA pada populasi lansia di Indonesia sebagai peluang untuk terapi suplementasi dalam memperlambat gejala penuaan kulit. Studi potong lintang dilakukan untuk melihat hubungan kadar DHEA-S dengan kerutan dan kekenduran yang dilakukan pada 30 perempuan dan 30 laki-laki lansia. Dilakukan anamnesis, pemeriksaan fisik, pengambilan foto wajah 5 posisi, dan pengambilan serum DHEA-S. Penilaian derajat kerutan dan kekenduran dilakukan dengan membandingkan foto subjek dengan Bazin Skin Aging Atlas: Asian Type. Pada studi ini tidak didapatkan perbedaan kadar DHEA-S yang bermakna secara statistik pada laki-laki dibandingkan dengan perempuan (p=0,941). Selain itu, kadar DHEA-S tidak berhubungan bermakna secara statistik dengan kerutan dahi (p=0,499), crow’s feet (p=0,888), kekenduran wajah (p=0,769), dan derajat kekenduran leher (p=0,568). Terdapat kecenderungan, semakin berat derajat kerutan dahi dan crow’s feet, nilai rerata DHEA-S semakin rendah. Juga terdapat pola kecenderungan bahwa dengan meningkatnya derajat keparahan kekenduran leher, nilai rerata kadar DHEA-S yang terdeteksi semakin rendah. Pada penelitian ini disimpulkan tidak terdapat hubungan antara kadar DHEA-S dengan derajat keparahan kerutan dan kekenduran di dahi, crow’s feet's, wajah bagian bawah, dan leher pada laki-laki dan perempuan lansia.

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With the increasing elderly population in Indonesia, maintaining health quality, including skin health, becomes increasingly important. The decline of DHEA hormone, a precursor to estrogen and androgen, is associated with skin aging. Signs of aging such as wrinkles and skin sagging are influenced by decreasing DHEA levels. This study aims to collect baseline data on DHEA levels in the elderly population in Indonesia as an opportunity for supplementation therapy to slow down skin aging symptoms. A cross-sectional study was conducted to examine the association between DHEA-S levels and wrinkles and sagging in 30 elderly women and 30 elderly men. Anamnesis, physical examinations, facial photographs from 5 angles, and serum DHEA-S sampling were conducted. The degree of wrinkles and sagging was assessed by comparing the subject's photos with the Bazin Skin Aging Atlas: Asian Type. This study found no statistically significant difference in DHEA-S levels between men and women (p=0.941). Additionally, DHEA-S levels were not statistically significantly related to forehead wrinkles (p=0.499), crow’s feet (p=0.888), facial sagging (p=0.769), and neck sagging degree (p=0.568). There was a tendency for lower average DHEA-S values with increased severity of forehead wrinkles and crow’s feet. There was also a trend indicating that as the severity of neck sagging increased, the average detected DHEA-S levels decreased. This study concluded that there is no relationship between DHEA-S levels and the severity of wrinkles and sagging in the forehead, crow’s feet, lower face, and neck in elderly men and women."

"Olahraga merupakan salah satu bentuk aktivitas fisik yang bertujuan untuk meningkatkan kesehatan dan kebugaran tubuh. Kebiasaan berolahraga secara teratur disebut dapat memperlambat munculnya tanda penuaan, contohnya ialah kerutan kulit. Meski demikian, belum banyak ditemukan studi yang mempelajari hubungan antara kebiasaan berolahraga dengan kondisi kerutan kulit wajah, khususnya di Indonesia. Karena itu, penelitian dengan desain potong lintang yang melibatkan 146 perempuan Indonesia ini dilakukan untuk menganalisis hubungan antara kebiasaan olahraga dengan nilai dan derajat kerutan kulit pada subjek penelitian. Analisis data yang dilakukan menunjukan hasil komparasi yang tidak berbeda bermakna antara variabel kerutan kulit wajah dengan kebiasaan olahraga pada responden. Mengacu pada hal tersebut, dalam penelitian ini dapat disimpulkan bahwa tidak ditemukan hubungan yang bermakna secara statistik antara kebiasaan olahraga dengan kondisi kerutan kulit wajah pada perempuan Indonesia.

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Exercise, the one of physical activity subcategory, has been proven to improve body’s health and fitness. For this, some researcher wrote that regular exercise can also prevent the manifestation of skin aging, such as skin wrinkles. Unfortunately, there are very few researches that learned the association between habitual exercise and face wrinkles, especially in Indonesia. Therefore, we conducted a study that involved 146 Indonesian females to analyze the association between habitual physical exercise and subject’s face wrinkles. Unfortunately, there was no significant association between subject’s exercise habits and their face wrinkles condition. Referring to this, we concluded that there was found insignificant association between subject’s exercise habits (total duration per week) and face wrinkle conditions (value and degree) in this study."

"Penuaan kulit dapat terjadi pada setiap individu dan menjadi suatu proses fisiologis yang tidak bisa dihindari seiring bertambahnya usia. Efek yang paling tampak sebagai penanda penuaan kulit wajah adalah kerutan yang ditandai dengan munculnya garis halus atau lekukan lebih dalam pada permukaan kulit wajah. Polimorfisme genetik dapat dijadikan sebagai penanda daerah genomik yang menjadi pembawa sifat penting pada individu. Adapun informasi mengenai hubungan antara varian gen dan fenotipe kulit terutama kerutan wajah masih sangat terbatas. Genome-wide association study (GWAS) digunakan pada penelitian ini untuk mengidentifikasi marka genetik pembentukan kerutan wajah pada populasi perempuan dewasa yang tinggal di Jakarta. Penelitian ini dilakukan secara observasional analitik. Hasil GWAS menunjukkan terdapat lima SNPs yang memiliki suggestive association level, dengan dua SNP hits teratas berada pada daerah gen ALCAM yaitu rs1044240 (P=9,461x10-7) berlokasi pada daerah pengkode (varian missense) dan rs2049217 (P=4,047x10-7) pada daerah intron. Berdasarkan analisis pengayaan fungsi gen diketahui bahwa ekspresi gen ALCAM pada jaringan kulit berkorelasi dengan fibroblas. Fibroblast senescence itu sendiri diketahui bermanifestasi pada penuaan kulit sebagai kerutan. Perlu dilakukan replikasi dan sampel yang lebih besar untuk memvalidasi hasil asosiasi genotipe-fenotipe kerutan serta pengayaan SNP dan gen.

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Skin aging can occur in every individual and becomes a physiological process that cannot be avoided as people get older. The most visible effect as a marker of facial skin aging is wrinkles which are characterized by the appearance of fine lines or deeper indentations on the surface of the facial skin. Genetic polymorphisms can be used as markers of genomic regions that carry important traits in individuals. Information regarding the relationship between gene variants and skin phenotypes, especially facial wrinkles, is still very limited. Genome-wide association study (GWAS) was used in this research to identify genetic markers with the formation of facial wrinkles in adult female population living in Jakarta. This research was conducted in an analytical observational. The GWAS results showed that five SNPs had a suggestive association level, with the top two hits SNPs in the region of ALCAM gene, namely rs1044240 (P=9.461x10-7) located in the coding region (missense variant) and rs2049217 (P=4.047x10-7) in the intron region. Based on gene functional enrichment analysis, it is known that ALCAM gene expression in skin tissue is correlated with fibroblasts. Fibroblast senescence itself is known to manifest in skin aging as wrinkles. Replication and larger samples are needed to validate the results of the genotype-wrinkle phenotype association and also SNPs and gene enrichment."

"Latar belakang: Penuaan kulit adalah proses biologis yang terdiri dari dua mekanisme dasar yang kompleks, yaitu faktor intrinsik dan ekstrinsik. Aktivitas merokok diketahui sebagai salah satu faktor determinan terhadap kerusakan sel, selain paparan sinar ultraviolet. Beberapa penelitian sebelumnya telah menunjukkan korelasi antara frekuensi merokok terhadap penuaan dini yang ditandai dengan kerutan pada wajah, namun penelitian di Indonesia masih terbatas. Oleh karena itu, penulis tertarik untuk mengangkat topik terkait pengaruh aktivitas merokok terhadap tingkat kerutan wajah pada masyarakat Jabodetabek. Metode: Penelitian ini mengggunakan design cross-sectional dengan total sampel sebanyak 95 responden yang tinggal di Jabodetabek. Terdapat beberapa variabel yang diidentifikasi, seperti variabel demografi, sosioekonomi, aktivitas merokok, dan kerutan wajah. Aktivitas merokok pada responden dikelompokkan berdasarkan jumlah konsumsi batang rokok per hari. Sedangkan kerutan kulit wajah pada responden dinilai menggunakan alat Visioscan® VC 20plus. Data hasil penelitian akan diolah dan dianalisis menggunakan program statistical package for the sosial science (SPSS) ver. 25.0 dengan derajat kepercayaan 95% (α = 0,05) meliputi analisis univariat dan bivariat. Hasil dikatakan signifikan apabila nilai p < 0.05. Hasil: Sebanyak 66 orang (69,5%) responden penelitian merupakan perokok ringan dengan konsumsi 1 sampai 10 batang rokok/hari. sedangkan profil kerutan wajah responden penelitian di dominasi dengan tingkat keparahan sangat berkerut sebanyak 75 orang (78,9%). Akan tetapi hasil uji bivariat antara aktivitas merokok dengan tingkat keparahan kerutan wajah menunjukkan hasil yang tidak signifikan secara statistik (p = 0,389). Kesimpulan: Pada penelitian ini, tidak ditemukan hubungan bermakna antara aktivitas merokok dengan tingkat keparahan kerutan wajah.

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Introduction: Skin aging is a biological process that consists of two complex basic mechanisms, namely intrinsic and extrinsic factors. Smoking activity is known as one of the determinants of cell damage, besides exposure to ultraviolet light. Several previous studies have shown a correlation between smoking frequency and premature aging which is characterized by wrinkles on the face, but research in Indonesia is still limited. Therefore, the authors are interested in raising the topic related to the influence of smoking activity on the level of facial wrinkles in the Jabodetabek community. Method: This study uses a cross-sectional design with a total sample of 95 respondents who live in Greater Jakarta. There are several variables identified, such as demographic, socioeconomic, smoking activity, and facial wrinkles. The smoking activity of the respondents was grouped based on the number of cigarettes consumed per day. Meanwhile, the wrinkles on the facial skin of the respondents were assessed using the Visioscan® VC 20plus tool. The research data will be processed and analyzed using the statistical package for the social science (SPSS) ver. 25.0 with 95% confidence level (α = 0.05) including univariate and bivariate analysis. The results are said to be significant if the p value <0.05. Result: As many as 66 people (69.5%) of the study respondents were light smokers with consumption of 1 to 10 cigarettes/day. while the facial wrinkles profile of the study respondents was dominated by the severity of very wrinkled as many as 75 people (78.9%). However, the results of the bivariate test between smoking activity and the severity of facial wrinkles showed results that were not statistically significant (p = 0.389). Conclusion: In this study, no significant association was found between smoking activity and the severity of facial wrinkles."

"Ekstrak plasenta dapat digunakan sebagai pengobatan dan kosmetika, seperti produk perawatan kulit dan menghambat penuaan kulit. Ekstrak Plasenta mengandung komponenkomponen seperti asam amino yang dapat meningkatkan produksi kolagen pada fibroblast kulit. Vitamin C merupakan antioksidan yang paling sering dijumpai dan memiliki peran dalam biosintesis kolagen sehingga memiliki fungsi antiaging. Penelitian ini bertujuan untuk mengetahui profil penetrasi serum ekstrak plasenta dengan keberadaaan Vitamin C. Ekstrak Plasenta diformulasikan ke dalam bentuk sediaan serum untuk kulit dikombinasikan dengan Vitamin C dengan kadar 5% dan 10% (Formula C2 dan C3) dan diamati kemampuan penetrasinya ke dalam kulit dibandingkan dengan serum ekstrak plasenta tanpa Vitamin C (Formula C1) menggunakan Sel Difusi Franz selama 6 (enam) jam. Diperoleh hasil uji penetrasi Serum C1 sebesar 113,69 mg/cm2 dengan fluks sebesar 15,7 mg/cm2.jam, Serum C2 sebesar 97,52 mg/cm2 dengan fluks sebesar 11,6 mg/cm2.jam, dan Serum C3 sebesar 80,26 mg/cm2 dengan fluks sebesar 9,5 mg/cm2.jam. Dalam penelitian ini disimpulkan bahwa keberadaan vitamin C pada formulasi serum ekstrak plasenta dapat menurunkan kemampuan penetrasinya, yang disebabkan oleh sifat hidrofilisitasnya.

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Placenta extract can be used as a treatment and cosmetics, such as skin care products, and inhibit skin aging. Placenta extract contains components such as amino acids that can increase collagen production in skin fibroblasts. Vitamin C is the most commonly found antioxidant and has a role in collagen biosynthesis so that it has an antiaging function. This study aims to determine the serum penetration profile of placental extract with the presence of Vitamin C. Placenta extract was formulated into serum dosage form for the skin combined with Vitamin C with levels of 5% and 10% (Formula C2 and C3) and observed its penetration ability into the skin compared to serum of placenta extract without Vitamin C (Formula C1) using Franz Diffusion Cells for 6 (six) hours. The results of penetration test for Serum were 113,69 mg/cm2 with a flux of 15,7 mg/cm2.hr for Serum C1, 97,52 mg/cm2 with a flux of 11,6 mg/cm2.hr for Serum C2, and 80,26 mg/cm2 with a flux of 9,5 mg/cm2.hr for Serum C3. This study concluded that the presence of Vitamin C in the serum formulation of placenta extract can reduce its penetration ability, which is due to its hydrophilicity properties."

"Kulit sebagai organ terbesar dan terluar dari tubuh manusia yang langsung berhadapan dengan lingkungan luar menjadi pertahanan fisik lini pertama sekaligus tempat kolonisasi mikrobiota komensal dalam mencegah invasi patogen. Identifikasi komposisi mikrobiota kulit menarik dilakukan untuk mengetahui interaksi antar mikrobiota sehingga mikrobiota kulit komensal yang bersifat probiotik dapat dikembangkan menjadi bahan aktif terapeutik mikrobioma kulit untuk menjaga kesehatan kulit. Keberagaman mikrobiota kulit dipengaruhi oleh beberapa faktor, salah satunya adalah faktor etnis. Penelitian ini mempelajari pengaruh faktor etnis pada dewasa muda pria dan wanita yang mewakili etnis Papua, Jawa, dan keturunan Tionghoa terhadap profil mikrobioma kulit. DNA genomik mikrobiota dari sampel kulit wajah diekstraksi dan disekuens dengan metode Next Generation Sequencing lalu dilakukan analisis diversitas alfa dan beta. Berdasarkan analisis alfa dengan indeks OTU yang dterobservasi, Shannon, dan Faiths PD, diversitas dalam grup tertinggi terdapat pada grup etnis Papua dan terendah pada grup etnis keturunan Tionghoa, namun diversitas alfa ketiga grup tidak berbeda signifikan secara statistik. Analisis beta dilakukan berdasarkan kualitatif dan kuantitatif menunjukkan pengaruh faktor etnis pada profil mikrobioma kulit antar etnis yang signifikan secara statistik serta pengelompokkan yang baik berdasarkan hasil PCoA pada indeks Jaccard, disimilaritas Bray Curtis, Unweighted, dan Weighted. Bakteri yang bersifat komensal dan dominan selanjutnya dapat dikembangkan menjadi bacterial cocktail maupun formula postbiotik untuk terapi mikrobiota kulit dengan pertimbangan interaksi komposisi mikrobiota kulit pada etnis terkait.

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Skin as the largest and the outermost part of human body that directly exposed to the outer environment serves as the first physical barrier and colonised by commensal bacteria to prevent pathogen invasion. Identifying composition of commensal skin microbiota is interesting to know the interaction between the microbiota so the commensal skin microbiota who has probiotic effect can be developed as active substance of skin microbiome therapeutic to maintain skin health. The skin microbiome diversity is influenced by several factors, one of them is ethnicity. This study shows the influence of ethnicity factor in Papuans, Javanese, and Chinese descent young adults on skin microbiome profiles. The microbiota genomic DNA are extracted from the face skin samples and sequenced with Next Generation Sequencing method to be further analysed on its alpha and beta diversity. According to alpha diversity analysis with observed OTU, Shannon, and Faiths PD indices, the greatest alpha diversity shown in Papuans, while the smallest is shown in the Chinese descent group, but alpha diversity differences between three groups are not statistically significant. Beta diversity was assessed by the use of Jaccard index, Bray Curtis dissimilarity, Unweighted and Weighted Unifrac with PCoA shows the difference skin microbiome profiles according to ethnicity and is statistically significant between ethnic group. The characterised commensal and dominant bacteria can be further developed as bacterial cocktail and postbiotic formula as skin microbiome therapeutic with interaction between skin microbiota composition within each ethnicity taking into account."

"ABSTRAK Latar belakang dan tujuan: Prevalensi xerosis pada lanjut usia (lansia) berkisar antara30-85%. Tatalaksana xerosis yang tidak adekuat dapat menimbulkan komplikasi. Ureasebagai humektan dan lanolin 10% dalam petrolatum yang bersifat oklusif dan emolienmampu memperbaiki hidrasi kulit. Penelitian ini bertujuan membandingkan efektivitasdan efek samping krim yang mengandung urea 10% dengan lanolin 10%/petrolatumpada pengobatan xerosis lansia.Metode: Penelitian uji klinis acak tersamar ganda dilakukan pada 35 orang penghunisuatu panti lansia di Jakarta. Evaluasi skin capacitance (SC), specified symptoms sumscore (SSRC), dan derajat gatal dilakukan pada awal terapi, minggu kedua dan keempat.Setelah prakondisi selama dua minggu, setiap subjek penelitian mendapatkan pelembapyang berbeda secara acak pada kedua tungkai bawah.Hasil: Persentase peningkatan nilai SC setelah empat minggu lebih besar pada tungkaiyang mendapat krim urea 10% dibandingkan lanolin 10%/petrolatum (64,54% vs.58,98%; p=0,036). Persentase penurunan SSRC setelah empat minggu tidak berbedaantara kedua kelompok perlakuan (100%; p=0,089). Derajat gatal pada minggu keduamenurun pada kedua kelompok, hingga menjadi tidak gatal pada seluruh SP (100%)setelah minggu keempat. Efek samping rasa lengket lebih banyak ditemukan padakelompok krim urea 10% daripada lanolin10%/petrolatum, tetapi tidak bermakna secarastatistik.Kesimpulan: Pelembap yang mengandung urea 10% meningkatkan SC lebih besarsecara bermakna daripada lanolin 10%/petrolatum setelah empat minggu pengolesanpada tungkai lansia yang xerotik. Efek samping tersering adalah rasa lengket yang lebihsering ditemukan pada lanolin 10%/petrolatum, tetapi tidak berbeda antar kelompok perlakuan.ABSTRACT Background and objectives: The prevalence of xerosis among elderly is 30-85%.

Inadequate treatment may result in complications. Urea as a humectant and 10% lanolin

in petrolatum as an occlusive agent and emollient can restore skin hydration. This study

aimed at comparing the efficacy and side effects of cream containing 10% urea and 10%

lanolin/petrolatum in the treatment of xerosis in elderly

Methods: A randomized, double blind clinical trial was conducted in 35 elderly from a

nursing home in Jakarta. Evaluation of skin capacitance (SC), specified symptoms sum

score (SSRC), and pruritic degree were measured at baseline, week-2 and -4 after the

start of therapy. Following a 2-week precondition period, each subject received a

random moisturizer for each limb, to be applied twice daily.

Results: The percentage of SC increase at week-4 was significantly higher in limb

receiving cream containing 10% urea than 10% lanolin/petrolatum (64.54% vs. 58.98%;

p=0.036). The percentage of SSRC decrease at week-4 did not differ between groups

(100%; p=0.089). Pruritus was equally improved in both groups at week-2, and

completely diminished at week-4. Sticky feel was more frequent in

lanolin10%/petrolatum than 10% urea cream, although not statistically significant.

Conclusion: After four-week application, moisturizer containing 10% urea gave higher

percentage of SC increase than 10% lanolin/petrolatum in the xerotic limbs of the

elderly. Sticky feeling was more frequently found in 10% lanolin/petrolatum group, but statistically not significant."